GO:0047057
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vitamin-K-epoxide reductase (warfarin-sensitive) activity
Molecular Function
Definition (GO:0047057 GONUTS page)
Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
vitamin K1 epoxide reductase activity | narrow |
phylloquinone epoxide reductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.17.4.4 | |
InterPro | IPR042406 | Vitamin K epoxide reductase complex subunit 1 |
MetaCyc | 1.1.4.1-RXN | |
RHEA | 57744 | |
Reactome | R-HSA-159790 | |
Reactome | R-HSA-6806647 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:50058 | L-cystine residue |
has_participant | CHEBI | CHEBI:29950 | L-cysteine residue |
has_participant | CHEBI | CHEBI:18067 | phylloquinone |
has_participant | CHEBI | CHEBI:28433 | phyllohydroquinone |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047057 based on ALL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vitamin-K-epoxide reductase (warfarin-sensitive) activity
|
81,941.48 | 100.00 | 2,379 | 2,379 |
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
|
81,727.26 | 95.97 | 2,289 | 2,295 |
vitamin K metabolic process
|
70,763.58 | 86.20 | 2,374 | 2,749 |
vitamin-K-epoxide reductase (warfarin-insensitive) activity
|
81,941.48 | 3.03 | 72 | 72 |
positive regulation of coagulation
|
12,335.28 | 2.08 | 56 | 372 |
blood coagulation
|
1,212.35 | 1.42 | 642 | 43,392 |
bone development
|
473.07 | 0.47 | 57 | 9,873 |
quinone binding
|
309.98 | 0.38 | 2,306 | 609,580 |
peptidyl-glutamic acid carboxylation
|
81,941.48 | 0.29 | 7 | 7 |
endoplasmic reticulum membrane
|
144.11 | 0.18 | 2,214 | 1,258,864 |
Totals | 19598 | 294440227 |
No co-occurrence statistics for GO:0047057 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vitamin-K-epoxide reductase (warfarin-sensitive) activity
|
25,835.98 | 100.00 | 50 | 50 |
vitamin K metabolic process
|
12,790.09 | 49.50 | 50 | 101 |
peptidyl-glutamic acid carboxylation
|
25,835.98 | 14.00 | 7 | 7 |
vitamin-K-epoxide reductase (warfarin-insensitive) activity
|
25,835.98 | 4.00 | 2 | 2 |
positive regulation of coagulation
|
4,697.45 | 3.39 | 2 | 11 |
blood coagulation
|
904.54 | 3.26 | 16 | 457 |
regulation of blood coagulation
|
861.20 | 1.27 | 1 | 30 |
vitamin K biosynthetic process
|
369.09 | 0.84 | 1 | 70 |
bone development
|
236.48 | 0.83 | 4 | 437 |
response to organic cyclic compound
|
48.66 | 0.17 | 1 | 531 |
Totals | 150 | 89087 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-10 | Added | RELATION | is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor) |
2022-05-10 | Deleted | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
2021-06-04 | Deleted | XREF | RHEA:13817 |
2021-06-04 | Added | DEFINITION | Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. |
2021-06-04 | Deleted | DEFINITION | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2021-06-04 | Added | XREF | RHEA:57744 |
2021-05-22 | Added | XREF | EC:1.17.4.4 |
2021-05-22 | Deleted | XREF | EC:1.1.4.1 |
2021-05-22 | Deleted | SYNONYM | 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | phylloquinone epoxide reductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-08-19 | Added | TERM | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-04 | Added | DEFINITION | Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues. |
2021-06-04 | Deleted | DEFINITION | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2021-05-22 | Deleted | SYNONYM | 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | phylloquinone epoxide reductase activity |
2020-10-08 | Deleted | SYNONYM | 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2020-10-08 | Added | SYNONYM | phylloquinone epoxide reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2007-11-08 | Added | SYNONYM | 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity |
2007-09-06 | Added | SYNONYM | phylloquinone epoxide reductase activity |
2007-09-06 | Added | SYNONYM | vitamin K1 epoxide reductase activity |
2004-08-06 | Updated | DEFINITION | Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol. |
2003-08-19 | Added | DEFINITION | Catalysis of the reaction: H2O + oxidized-dithiothreitol + 2-methyl-3-phytyl-14-naphthoquinone = 14-dithiothreitol + 2,3-epoxy-2,3-dihydro-2-methyl-1,4-naphthoquinone. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-05-10 | Added | RELATION | is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor) |
2022-05-10 | Deleted | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
2008-04-01 | Updated | RELATION | is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-06-04 | Deleted | XREF | RHEA:13817 |
2021-06-04 | Added | XREF | RHEA:57744 |
2021-05-22 | Added | XREF | EC:1.17.4.4 |
2021-05-22 | Deleted | XREF | EC:1.1.4.1 |
2019-04-01 | Added | XREF | Reactome:R-HSA-159790 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-159790 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6806647 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6806647 |
2018-12-11 | Added | XREF | reactome:R-HSA-159790 |
2018-12-11 | Added | XREF | reactome:R-HSA-6806647 |
2018-07-13 | Deleted | XREF | RHEA:13820 |
2018-07-13 | Added | XREF | RHEA:13817 |
2011-09-16 | Added | XREF | RHEA:13820 |
2003-10-27 | Added | XREF | MetaCyc:1.1.4.1-RXN |
2003-08-19 | Added | XREF | EC:1.1.4.1 |
Timestamp | Action | Category | Detail |
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