This term is obsolete.

GO:0047057 JSON

vitamin-K-epoxide reductase (warfarin-sensitive) activity

Molecular Function

Definition (GO:0047057 GONUTS page)

Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.

2,442 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
vitamin K1 epoxide reductase activity narrow
phylloquinone epoxide reductase activity related

Ancestor Chart

Ancestor chart for GO:0047057
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.17.4.4
InterPro IPR042406 Vitamin K epoxide reductase complex subunit 1
MetaCyc 1.1.4.1-RXN
RHEA 57744
Reactome R-HSA-159790
Reactome R-HSA-6806647

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:50058 L-cystine residue
has_participant CHEBI CHEBI:29950 L-cysteine residue
has_participant CHEBI CHEBI:18067 phylloquinone
has_participant CHEBI CHEBI:28433 phyllohydroquinone

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047057 based on ALL annotations
The top 99 of 99 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vitamin-K-epoxide reductase (warfarin-sensitive) activity
81,941.48 100.00 2,379 2,379
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
81,727.26 95.97 2,289 2,295
vitamin K metabolic process
70,763.58 86.20 2,374 2,749
vitamin-K-epoxide reductase (warfarin-insensitive) activity
81,941.48 3.03 72 72
positive regulation of coagulation
12,335.28 2.08 56 372
blood coagulation
1,212.35 1.42 642 43,392
bone development
473.07 0.47 57 9,873
quinone binding
309.98 0.38 2,306 609,580
peptidyl-glutamic acid carboxylation
81,941.48 0.29 7 7
endoplasmic reticulum membrane
144.11 0.18 2,214 1,258,864
Totals 19598 294440227
No co-occurrence statistics for GO:0047057 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vitamin-K-epoxide reductase (warfarin-sensitive) activity
25,835.98 100.00 50 50
vitamin K metabolic process
12,790.09 49.50 50 101
peptidyl-glutamic acid carboxylation
25,835.98 14.00 7 7
vitamin-K-epoxide reductase (warfarin-insensitive) activity
25,835.98 4.00 2 2
positive regulation of coagulation
4,697.45 3.39 2 11
blood coagulation
904.54 3.26 16 457
regulation of blood coagulation
861.20 1.27 1 30
vitamin K biosynthetic process
369.09 0.84 1 70
bone development
236.48 0.83 4 437
response to organic cyclic compound
48.66 0.17 1 531
Totals 150 89087

Change Log

Timestamp Action Category Detail
2022-05-10 Added RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)
2022-05-10 Deleted RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
2021-06-04 Deleted XREF RHEA:13817
2021-06-04 Added DEFINITION Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.
2021-06-04 Deleted DEFINITION Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2021-06-04 Added XREF RHEA:57744
2021-05-22 Added XREF EC:1.17.4.4
2021-05-22 Deleted XREF EC:1.1.4.1
2021-05-22 Deleted SYNONYM 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM phylloquinone epoxide reductase activity
Timestamp Action Category Detail
2003-08-19 Added TERM vitamin-K-epoxide reductase (warfarin-sensitive) activity
Timestamp Action Category Detail
2021-06-04 Added DEFINITION Catalysis of the reaction: phylloquinol + a protein with a disulfide bond = phylloquinone + a protein with reduced L-cysteine residues.
2021-06-04 Deleted DEFINITION Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2021-05-22 Deleted SYNONYM 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Deleted SYNONYM phylloquinone epoxide reductase activity
2020-10-08 Deleted SYNONYM 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Added SYNONYM 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2020-10-08 Added SYNONYM phylloquinone epoxide reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2007-11-08 Added SYNONYM 2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity
2007-09-06 Added SYNONYM phylloquinone epoxide reductase activity
2007-09-06 Added SYNONYM vitamin K1 epoxide reductase activity
2004-08-06 Updated DEFINITION Catalysis of the reaction: 2-methyl-3-phytyl-1,4-naphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.
2003-08-19 Added DEFINITION Catalysis of the reaction: H2O + oxidized-dithiothreitol + 2-methyl-3-phytyl-14-naphthoquinone = 14-dithiothreitol + 2,3-epoxy-2,3-dihydro-2-methyl-1,4-naphthoquinone.
Timestamp Action Category Detail
2022-05-10 Added RELATION is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)
2022-05-10 Deleted RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
2008-04-01 Updated RELATION is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)
Timestamp Action Category Detail
2021-06-04 Deleted XREF RHEA:13817
2021-06-04 Added XREF RHEA:57744
2021-05-22 Added XREF EC:1.17.4.4
2021-05-22 Deleted XREF EC:1.1.4.1
2019-04-01 Added XREF Reactome:R-HSA-159790
2019-04-01 Deleted XREF reactome:R-HSA-159790
2019-04-01 Deleted XREF reactome:R-HSA-6806647
2019-04-01 Added XREF Reactome:R-HSA-6806647
2018-12-11 Added XREF reactome:R-HSA-159790
2018-12-11 Added XREF reactome:R-HSA-6806647
2018-07-13 Deleted XREF RHEA:13820
2018-07-13 Added XREF RHEA:13817
2011-09-16 Added XREF RHEA:13820
2003-10-27 Added XREF MetaCyc:1.1.4.1-RXN
2003-08-19 Added XREF EC:1.1.4.1
Timestamp Action Category Detail
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