GO:0047617
JSON
fatty acyl-CoA hydrolase activity
Molecular Function
Definition (GO:0047617 GONUTS page)
Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
Secondary IDs
GO:0008778, GO:0016291, GO:0016292
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
thioesterase II | related |
thioesterase B | related |
acyl coenzyme A thioesterase activity | related |
acyl coenzyme A hydrolase activity | related |
acyl-CoA hydrolase activity | broad |
acyl-CoA thioesterase activity | exact |
acyl-CoA thioesterase I activity | narrow |
acyl-CoA thioesterase II activity | narrow |
acyl-CoA thiolesterase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0047617
Child Term | Relationship to GO:0047617 |
---|---|
short-chain fatty acyl-CoA hydrolase activity
|
is_a |
medium-chain fatty acyl-CoA hydrolase activity
|
is_a |
long-chain fatty acyl-CoA hydrolase activity
|
is_a |
very long-chain fatty acyl-CoA hydrolase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | E9PTA2 | 10116 | TRPM2_RAT | GO:0016787 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | O94759 | 9606 | TRPM2_HUMAN | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q62226 | 10090 | SHH_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113 | |
NOT-qualified manual | protein | Q63673 | 10116 | SHH_RAT | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q91YD4 | 10090 | TRPM2_MOUSE | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q9NHA8 | 7227 | BGBP3_DROME | GO:0016787 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 3.1.2.20 | |
InterPro | IPR003703 | Acyl-CoA thioesterase |
InterPro | IPR039298 | Acyl-coenzyme A thioesterase 13 |
MetaCyc | ACYL-COA-HYDROLASE-RXN | |
RHEA | 16781 | |
Reactome | R-HSA-5690042 | |
Reactome | R-HSA-5690043 | |
Reactome | R-HSA-5690066 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:77636 | fatty acyl-CoA(4-) |
has_participant | CHEBI | CHEBI:28868 | fatty acid anion |
has_participant | CHEBI | CHEBI:57287 | coenzyme A(4-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0044466 | obsolete glutaryl-CoA hydrolase activity | replaced_by GO:0047617 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0047617 based on ALL annotations
The top 100 of 371 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fatty acyl-CoA hydrolase activity
|
1,343.91 | 100.00 | 147,446 | 147,446 |
acyl-CoA metabolic process
|
497.18 | 18.42 | 39,574 | 106,972 |
fatty acid catabolic process
|
465.62 | 13.36 | 26,324 | 75,978 |
thiolester hydrolase activity
|
340.73 | 10.15 | 21,338 | 84,161 |
acyl-CoA hydrolase activity
|
287.68 | 7.37 | 14,897 | 69,593 |
peroxisomal matrix
|
266.67 | 3.30 | 5,620 | 28,323 |
fatty acid metabolic process
|
36.10 | 2.18 | 15,436 | 574,647 |
peroxisome
|
23.58 | 1.15 | 4,757 | 271,113 |
hydrolase activity
|
12.33 | 0.91 | 107,172 | 11,680,370 |
carboxylic ester hydrolase activity
|
6.96 | 0.34 | 1,474 | 284,775 |
Totals | 414671 | 56229596 |
No co-occurrence statistics for GO:0047617 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
fatty acyl-CoA hydrolase activity
|
1,456.69 | 100.00 | 969 | 969 |
acyl-CoA metabolic process
|
968.30 | 38.03 | 456 | 686 |
fatty acid catabolic process
|
511.39 | 12.95 | 165 | 470 |
peroxisomal matrix
|
202.12 | 5.77 | 87 | 627 |
fatty acid metabolic process
|
85.31 | 4.27 | 132 | 2,254 |
very long-chain fatty acid metabolic process
|
190.00 | 1.89 | 21 | 161 |
long-chain fatty acyl-CoA hydrolase activity
|
124.86 | 1.76 | 21 | 245 |
long-chain fatty acid metabolic process
|
50.69 | 1.27 | 19 | 546 |
acetyl-CoA hydrolase activity
|
312.15 | 1.18 | 12 | 56 |
short-chain fatty acid metabolic process
|
693.66 | 1.02 | 10 | 21 |
Totals | 2371 | 103025 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_chembl | 296 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-18 | Deleted | XREF | EC:3.1.2.3 |
2023-12-15 | Updated | TERM | fatty acyl-CoA hydrolase activity |
2023-12-15 | Added | XREF | EC:3.1.2.3 |
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. |
2023-12-15 | Added | SUBSET | goslim_chembl |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
2023-12-15 | Added | SYNONYM | acyl-CoA hydrolase activity |
2020-12-17 | Deleted | XREF | Reactome:R-HSA-6810474 |
2020-10-08 | Added | SYNONYM | acyl coenzyme A hydrolase activity |
2020-10-08 | Added | SYNONYM | acyl coenzyme A thioesterase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Updated | TERM | fatty acyl-CoA hydrolase activity |
2003-08-27 | Added | TERM | acyl-CoA hydrolase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | DEFINITION | Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. |
2023-12-15 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
2023-12-15 | Added | SYNONYM | acyl-CoA hydrolase activity |
2020-10-08 | Added | SYNONYM | acyl coenzyme A hydrolase activity |
2020-10-08 | Added | SYNONYM | acyl coenzyme A thioesterase activity |
2020-10-08 | Deleted | SYNONYM | acyl coenzyme A hydrolase activity |
2020-10-08 | Deleted | SYNONYM | acyl coenzyme A thioesterase activity |
2011-10-29 | Added | SYNONYM | acyl-CoA thioesterase I activity |
2011-10-29 | Added | SYNONYM | acyl-CoA thiolesterase activity |
2011-10-29 | Added | SYNONYM | acyl-CoA thioesterase II activity |
2011-10-29 | Added | SYNONYM | acyl-CoA thioesterase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
2007-11-08 | Added | SYNONYM | thioesterase II |
2007-11-08 | Added | SYNONYM | acyl coenzyme A thioesterase activity |
2007-11-08 | Added | SYNONYM | acyl coenzyme A hydrolase activity |
2007-11-08 | Added | SYNONYM | thioesterase B |
2003-08-27 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016289 (acyl-CoA hydrolase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-07-18 | Deleted | XREF | EC:3.1.2.3 |
2023-12-15 | Added | XREF | EC:3.1.2.3 |
2020-12-17 | Deleted | XREF | Reactome:R-HSA-6810474 |
2020-07-19 | Deleted | XREF | EC:3.1.2 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5690043 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6810474 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5690042 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5690066 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5690042 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5690066 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6810474 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5690043 |
2018-12-11 | Added | XREF | reactome:R-HSA-5690042 |
2018-12-11 | Added | XREF | reactome:R-HSA-5690043 |
2018-12-11 | Added | XREF | reactome:R-HSA-6810474 |
2018-12-11 | Added | XREF | reactome:R-HSA-5690066 |
2018-07-13 | Deleted | XREF | RHEA:16784 |
2018-07-13 | Added | XREF | RHEA:16781 |
2016-10-03 | Added | XREF | EC:3.1.2 |
2016-10-03 | Deleted | XREF | EC:3.1.2.- |
2011-10-29 | Added | XREF | EC:3.1.2.- |
2011-09-16 | Added | XREF | RHEA:16784 |
2003-10-27 | Added | XREF | MetaCyc:ACYL-COA-HYDROLASE-RXN |
2003-08-27 | Added | XREF | EC:3.1.2.20 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-12-15 | Added | SUBSET | goslim_chembl |
2011-10-29 | Added | SECONDARY | GO:0016292 (acyl-CoA thioesterase I activity) |
2011-10-29 | Added | SECONDARY | GO:0016291 (acyl-CoA thioesterase activity) |
2011-10-29 | Added | SECONDARY | GO:0008778 (acyl-CoA thioesterase II activity) |
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