This term is obsolete.

GO:0047617 JSON

fatty acyl-CoA hydrolase activity

Molecular Function

Definition (GO:0047617 GONUTS page)

Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.

Secondary IDs

GO:0008778, GO:0016291, GO:0016292

216,250 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
thioesterase II related
thioesterase B related
acyl coenzyme A thioesterase activity related
acyl coenzyme A hydrolase activity related
acyl-CoA hydrolase activity broad
acyl-CoA thioesterase activity exact
acyl-CoA thioesterase I activity narrow
acyl-CoA thioesterase II activity narrow
acyl-CoA thiolesterase activity exact

Ancestor Chart

Ancestor chart for GO:0047617
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0047617

Child Term Relationship to
GO:0047617
short-chain fatty acyl-CoA hydrolase activity
is_a
medium-chain fatty acyl-CoA hydrolase activity
is_a
long-chain fatty acyl-CoA hydrolase activity
is_a
very long-chain fatty acyl-CoA hydrolase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein E9PTA2 10116 TRPM2_RAT GO:0016787 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein O94759 9606 TRPM2_HUMAN GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q62226 10090 SHH_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113
NOT-qualified manual protein Q63673 10116 SHH_RAT GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q91YD4 10090 TRPM2_MOUSE GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q9NHA8 7227 BGBP3_DROME GO:0016787 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089

Cross-references

Database ID Description
EC 3.1.2.20
InterPro IPR003703 Acyl-CoA thioesterase
InterPro IPR039298 Acyl-coenzyme A thioesterase 13
MetaCyc ACYL-COA-HYDROLASE-RXN
RHEA 16781
Reactome R-HSA-5690042
Reactome R-HSA-5690043
Reactome R-HSA-5690066

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:77636 fatty acyl-CoA(4-)
has_participant CHEBI CHEBI:28868 fatty acid anion
has_participant CHEBI CHEBI:57287 coenzyme A(4-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0044466 obsolete glutaryl-CoA hydrolase activity replaced_by GO:0047617

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0047617 based on ALL annotations
The top 100 of 371 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fatty acyl-CoA hydrolase activity
1,343.91 100.00 147,446 147,446
acyl-CoA metabolic process
497.18 18.42 39,574 106,972
fatty acid catabolic process
465.62 13.36 26,324 75,978
thiolester hydrolase activity
340.73 10.15 21,338 84,161
acyl-CoA hydrolase activity
287.68 7.37 14,897 69,593
peroxisomal matrix
266.67 3.30 5,620 28,323
fatty acid metabolic process
36.10 2.18 15,436 574,647
peroxisome
23.58 1.15 4,757 271,113
hydrolase activity
12.33 0.91 107,172 11,680,370
carboxylic ester hydrolase activity
6.96 0.34 1,474 284,775
Totals 414671 56229596
No co-occurrence statistics for GO:0047617 based on MANUAL annotations
The top 100 of 160 co-occurring terms
Co-occurring Term PR S% #Together #Compared
fatty acyl-CoA hydrolase activity
1,456.69 100.00 969 969
acyl-CoA metabolic process
968.30 38.03 456 686
fatty acid catabolic process
511.39 12.95 165 470
peroxisomal matrix
202.12 5.77 87 627
fatty acid metabolic process
85.31 4.27 132 2,254
very long-chain fatty acid metabolic process
190.00 1.89 21 161
long-chain fatty acyl-CoA hydrolase activity
124.86 1.76 21 245
long-chain fatty acid metabolic process
50.69 1.27 19 546
acetyl-CoA hydrolase activity
312.15 1.18 12 56
short-chain fatty acid metabolic process
693.66 1.02 10 21
Totals 2371 103025

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2024-07-18 Deleted XREF EC:3.1.2.3
2023-12-15 Updated TERM fatty acyl-CoA hydrolase activity
2023-12-15 Added XREF EC:3.1.2.3
2023-12-15 Added DEFINITION Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
2023-12-15 Added SUBSET goslim_chembl
2023-12-15 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
2023-12-15 Added SYNONYM acyl-CoA hydrolase activity
2020-12-17 Deleted XREF Reactome:R-HSA-6810474
2020-10-08 Added SYNONYM acyl coenzyme A hydrolase activity
2020-10-08 Added SYNONYM acyl coenzyme A thioesterase activity
Timestamp Action Category Detail
2023-12-15 Updated TERM fatty acyl-CoA hydrolase activity
2003-08-27 Added TERM acyl-CoA hydrolase activity
Timestamp Action Category Detail
2023-12-15 Added DEFINITION Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+.
2023-12-15 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
2023-12-15 Added SYNONYM acyl-CoA hydrolase activity
2020-10-08 Added SYNONYM acyl coenzyme A hydrolase activity
2020-10-08 Added SYNONYM acyl coenzyme A thioesterase activity
2020-10-08 Deleted SYNONYM acyl coenzyme A hydrolase activity
2020-10-08 Deleted SYNONYM acyl coenzyme A thioesterase activity
2011-10-29 Added SYNONYM acyl-CoA thioesterase I activity
2011-10-29 Added SYNONYM acyl-CoA thiolesterase activity
2011-10-29 Added SYNONYM acyl-CoA thioesterase II activity
2011-10-29 Added SYNONYM acyl-CoA thioesterase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
2007-11-08 Added SYNONYM thioesterase II
2007-11-08 Added SYNONYM acyl coenzyme A thioesterase activity
2007-11-08 Added SYNONYM acyl coenzyme A hydrolase activity
2007-11-08 Added SYNONYM thioesterase B
2003-08-27 Added DEFINITION Catalysis of the reaction: acyl-CoA + H2O = CoA + a carboxylate.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016289 (acyl-CoA hydrolase activity)
Timestamp Action Category Detail
2024-07-18 Deleted XREF EC:3.1.2.3
2023-12-15 Added XREF EC:3.1.2.3
2020-12-17 Deleted XREF Reactome:R-HSA-6810474
2020-07-19 Deleted XREF EC:3.1.2
2019-04-01 Added XREF Reactome:R-HSA-5690043
2019-04-01 Added XREF Reactome:R-HSA-6810474
2019-04-01 Added XREF Reactome:R-HSA-5690042
2019-04-01 Added XREF Reactome:R-HSA-5690066
2019-04-01 Deleted XREF reactome:R-HSA-5690042
2019-04-01 Deleted XREF reactome:R-HSA-5690066
2019-04-01 Deleted XREF reactome:R-HSA-6810474
2019-04-01 Deleted XREF reactome:R-HSA-5690043
2018-12-11 Added XREF reactome:R-HSA-5690042
2018-12-11 Added XREF reactome:R-HSA-5690043
2018-12-11 Added XREF reactome:R-HSA-6810474
2018-12-11 Added XREF reactome:R-HSA-5690066
2018-07-13 Deleted XREF RHEA:16784
2018-07-13 Added XREF RHEA:16781
2016-10-03 Added XREF EC:3.1.2
2016-10-03 Deleted XREF EC:3.1.2.-
2011-10-29 Added XREF EC:3.1.2.-
2011-09-16 Added XREF RHEA:16784
2003-10-27 Added XREF MetaCyc:ACYL-COA-HYDROLASE-RXN
2003-08-27 Added XREF EC:3.1.2.20
Timestamp Action Category Detail
2023-12-15 Added SUBSET goslim_chembl
2011-10-29 Added SECONDARY GO:0016292 (acyl-CoA thioesterase I activity)
2011-10-29 Added SECONDARY GO:0016291 (acyl-CoA thioesterase activity)
2011-10-29 Added SECONDARY GO:0008778 (acyl-CoA thioesterase II activity)
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