This term is obsolete.

GO:0048008 JSON

platelet-derived growth factor receptor signaling pathway

Biological Process

Definition (GO:0048008 GONUTS page)

The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

179,773 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PDGFR signaling pathway exact
PDGF receptor signalling pathway exact
PDGF receptor signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0048008
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048008

Child Term Relationship to
GO:0048008
negative regulation of platelet-derived growth factor receptor signaling pathway
negatively_regulates
platelet-derived growth factor receptor activity
part_of
VEGF-activated platelet-derived growth factor receptor signaling pathway
is_a
platelet-derived growth factor receptor-beta signaling pathway
is_a
platelet-derived growth factor receptor-alpha signaling pathway
is_a
positive regulation of platelet-derived growth factor receptor signaling pathway
positively_regulates
regulation of platelet-derived growth factor receptor signaling pathway
regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A1L8GFH0 8355 A0A1L8GFH0_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GM33 8355 A0A1L8GM33_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A337SFE2 9685 A0A337SFE2_FELCA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A4X1TC65 9823 A0A4X1TC65_PIG GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F8GVB2 13616 A0A5F8GVB2_MONDO GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A6I8N475 9258 A0A6I8N475_ORNAN GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3MPB6 9615 A0A8I3MPB6_CANLF GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5ZQX3 10116 A0A8I5ZQX3_RAT GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AEX6 10116 A0A8I6AEX6_RAT GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8V1A1G5 9031 A0A8V1A1G5_CHICK GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR027288 Platelet-derived growth factor receptor beta
InterPro IPR027290 Platelet-derived growth factor receptor alpha

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0048008 based on ALL annotations
The top 100 of 1,417 co-occurring terms
Co-occurring Term PR S% #Together #Compared
platelet-derived growth factor receptor signaling pathway
25,030.66 100.00 7,788 7,788
platelet-derived growth factor receptor binding
23,565.58 54.09 4,359 4,630
positive regulation of cell division
4,317.13 14.90 4,069 23,592
positive regulation of ERK1 and ERK2 cascade
3,272.99 11.94 4,504 34,445
platelet-derived growth factor binding
9,539.37 11.09 1,053 2,763
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
2,803.99 10.28 4,330 38,653
smooth muscle cell migration
11,692.30 10.16 895 1,916
plasminogen activation
6,747.84 8.00 795 2,949
face morphogenesis
6,637.67 7.51 738 2,783
positive regulation of cell migration
1,691.20 6.44 4,513 66,795
Totals 67882 1128539
No co-occurrence statistics for GO:0048008 based on MANUAL annotations
The top 100 of 1,233 co-occurring terms
Co-occurring Term PR S% #Together #Compared
platelet-derived growth factor receptor signaling pathway
5,316.05 100.00 243 243
platelet-derived growth factor receptor binding
3,767.28 32.14 90 127
skeletal system morphogenesis
1,228.50 12.91 55 238
face morphogenesis
1,077.26 10.85 46 227
smooth muscle cell migration
2,300.97 10.32 29 67
smooth muscle tissue development
1,732.19 9.57 29 89
luteinization
2,658.02 9.33 25 50
female gonad development
1,050.48 8.75 33 167
fibroblast migration
1,136.53 8.68 31 145
roof of mouth development
681.54 8.20 45 351
Totals 2232 25814

Change Log

Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2008-04-01 Updated RELATION is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
2007-08-09 Deleted SYNONYM PDGF receptor signalling pathway
2007-08-09 Added SYNONYM PDGFR signaling pathway
2007-08-09 Added SYNONYM PDGF receptor signalling pathway
2007-08-09 Added SYNONYM PDGF receptor signaling pathway
2007-08-09 Deleted SYNONYM PDGFR signaling pathway
Timestamp Action Category Detail
2004-02-12 Updated TERM platelet-derived growth factor receptor signaling pathway
2002-07-11 Added TERM PDGF receptor signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Deleted DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
2007-08-09 Deleted SYNONYM PDGF receptor signalling pathway
2007-08-09 Added SYNONYM PDGFR signaling pathway
2007-08-09 Added SYNONYM PDGF receptor signalling pathway
2007-08-09 Added SYNONYM PDGF receptor signaling pathway
2007-08-09 Deleted SYNONYM PDGFR signaling pathway
2007-08-09 Deleted SYNONYM PDGF receptor signaling pathway
2004-04-19 Added SYNONYM PDGF receptor signaling pathway
2004-04-19 Added SYNONYM PDGF receptor signalling pathway
2004-04-19 Added SYNONYM PDGFR signaling pathway
2004-04-16 Deleted SYNONYM PDGF receptor signaling pathway
2004-04-16 Deleted SYNONYM PDGF receptor signalling pathway
2004-04-16 Deleted SYNONYM PDGFR signaling pathway
2004-02-12 Added SYNONYM PDGF receptor signaling pathway
2004-02-12 Added SYNONYM PDGFR signaling pathway
2003-11-13 Added SYNONYM PDGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
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