GO:0048008
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platelet-derived growth factor receptor signaling pathway
Biological Process
Definition (GO:0048008 GONUTS page)
The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
PDGFR signaling pathway | exact |
PDGF receptor signalling pathway | exact |
PDGF receptor signaling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0048008
Child Term | Relationship to GO:0048008 |
---|---|
negative regulation of platelet-derived growth factor receptor signaling pathway
|
negatively_regulates |
platelet-derived growth factor receptor activity
|
part_of |
VEGF-activated platelet-derived growth factor receptor signaling pathway
|
is_a |
platelet-derived growth factor receptor-beta signaling pathway
|
is_a |
platelet-derived growth factor receptor-alpha signaling pathway
|
is_a |
positive regulation of platelet-derived growth factor receptor signaling pathway
|
positively_regulates |
regulation of platelet-derived growth factor receptor signaling pathway
|
regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A1L8GFH0 | 8355 | A0A1L8GFH0_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GM33 | 8355 | A0A1L8GM33_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A337SFE2 | 9685 | A0A337SFE2_FELCA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A4X1TC65 | 9823 | A0A4X1TC65_PIG | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F8GVB2 | 13616 | A0A5F8GVB2_MONDO | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A6I8N475 | 9258 | A0A6I8N475_ORNAN | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3MPB6 | 9615 | A0A8I3MPB6_CANLF | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I5ZQX3 | 10116 | A0A8I5ZQX3_RAT | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AEX6 | 10116 | A0A8I6AEX6_RAT | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8V1A1G5 | 9031 | A0A8V1A1G5_CHICK | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR027288 | Platelet-derived growth factor receptor beta |
InterPro | IPR027290 | Platelet-derived growth factor receptor alpha |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0048008 based on ALL annotations
The top 100 of 1,417 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
platelet-derived growth factor receptor signaling pathway
|
25,030.66 | 100.00 | 7,788 | 7,788 |
platelet-derived growth factor receptor binding
|
23,565.58 | 54.09 | 4,359 | 4,630 |
positive regulation of cell division
|
4,317.13 | 14.90 | 4,069 | 23,592 |
positive regulation of ERK1 and ERK2 cascade
|
3,272.99 | 11.94 | 4,504 | 34,445 |
platelet-derived growth factor binding
|
9,539.37 | 11.09 | 1,053 | 2,763 |
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
|
2,803.99 | 10.28 | 4,330 | 38,653 |
smooth muscle cell migration
|
11,692.30 | 10.16 | 895 | 1,916 |
plasminogen activation
|
6,747.84 | 8.00 | 795 | 2,949 |
face morphogenesis
|
6,637.67 | 7.51 | 738 | 2,783 |
positive regulation of cell migration
|
1,691.20 | 6.44 | 4,513 | 66,795 |
Totals | 67882 | 1128539 |
No co-occurrence statistics for GO:0048008 based on MANUAL annotations
The top 100 of 1,233 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
platelet-derived growth factor receptor signaling pathway
|
5,316.05 | 100.00 | 243 | 243 |
platelet-derived growth factor receptor binding
|
3,767.28 | 32.14 | 90 | 127 |
skeletal system morphogenesis
|
1,228.50 | 12.91 | 55 | 238 |
face morphogenesis
|
1,077.26 | 10.85 | 46 | 227 |
smooth muscle cell migration
|
2,300.97 | 10.32 | 29 | 67 |
smooth muscle tissue development
|
1,732.19 | 9.57 | 29 | 89 |
luteinization
|
2,658.02 | 9.33 | 25 | 50 |
female gonad development
|
1,050.48 | 8.75 | 33 | 167 |
fibroblast migration
|
1,136.53 | 8.68 | 31 | 145 |
roof of mouth development
|
681.54 | 8.20 | 45 | 351 |
Totals | 2232 | 25814 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2008-05-13 | Added | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2008-05-12 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2008-04-01 | Updated | RELATION | is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway) |
2007-08-09 | Deleted | SYNONYM | PDGF receptor signalling pathway |
2007-08-09 | Added | SYNONYM | PDGFR signaling pathway |
2007-08-09 | Added | SYNONYM | PDGF receptor signalling pathway |
2007-08-09 | Added | SYNONYM | PDGF receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | PDGFR signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-02-12 | Updated | TERM | platelet-derived growth factor receptor signaling pathway |
2002-07-11 | Added | TERM | PDGF receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a platelet-derived growth factor receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2008-05-13 | Added | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2008-05-12 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
2007-08-09 | Deleted | SYNONYM | PDGF receptor signalling pathway |
2007-08-09 | Added | SYNONYM | PDGFR signaling pathway |
2007-08-09 | Added | SYNONYM | PDGF receptor signalling pathway |
2007-08-09 | Added | SYNONYM | PDGF receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | PDGFR signaling pathway |
2007-08-09 | Deleted | SYNONYM | PDGF receptor signaling pathway |
2004-04-19 | Added | SYNONYM | PDGF receptor signaling pathway |
2004-04-19 | Added | SYNONYM | PDGF receptor signalling pathway |
2004-04-19 | Added | SYNONYM | PDGFR signaling pathway |
2004-04-16 | Deleted | SYNONYM | PDGF receptor signaling pathway |
2004-04-16 | Deleted | SYNONYM | PDGF receptor signalling pathway |
2004-04-16 | Deleted | SYNONYM | PDGFR signaling pathway |
2004-02-12 | Added | SYNONYM | PDGF receptor signaling pathway |
2004-02-12 | Added | SYNONYM | PDGFR signaling pathway |
2003-11-13 | Added | SYNONYM | PDGF receptor signalling pathway |
2002-11-27 | Added | DEFINITION | The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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