This term is obsolete.
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.

GO:0048010 JSON

vascular endothelial growth factor receptor signaling pathway

Biological Process

Definition (GO:0048010 GONUTS page)

The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.

Comments

In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.

96,127 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
VEGF receptor signalling pathway exact
VEGF receptor signaling pathway exact
VEGFR signaling pathway exact

Ancestor Chart

Ancestor chart for GO:0048010
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0048010

Child Term Relationship to
GO:0048010
vascular endothelial growth factor receptor-3 signaling pathway
is_a
vascular endothelial growth factor receptor-2 signaling pathway
is_a
vascular endothelial growth factor receptor-1 signaling pathway
is_a
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
is_a
positive regulation of vascular endothelial growth factor receptor signaling pathway
positively_regulates
vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
is_a
regulation of vascular endothelial growth factor receptor signaling pathway
regulates
negative regulation of vascular endothelial growth factor receptor signaling pathway
negatively_regulates

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0048010 vascular endothelial growth factor receptor signaling pathway Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A1L8GFH0 8355 A0A1L8GFH0_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1L8GM33 8355 A0A1L8GM33_XENLA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A337SFE2 9685 A0A337SFE2_FELCA GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A4X1TC65 9823 A0A4X1TC65_PIG GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F8GVB2 13616 A0A5F8GVB2_MONDO GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A6I8N475 9258 A0A6I8N475_ORNAN GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3MPB6 9615 A0A8I3MPB6_CANLF GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I5ZQX3 10116 A0A8I5ZQX3_RAT GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I6AEX6 10116 A0A8I6AEX6_RAT GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8V1A1G5 9031 A0A8V1A1G5_CHICK GO:0007169 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)
InterPro IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
Reactome R-HSA-194138

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0048010 based on ALL annotations
The top 100 of 1,614 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vascular endothelial growth factor receptor signaling pathway
15,779.17 100.00 12,558 12,558
positive regulation of mast cell chemotaxis
15,224.86 41.57 5,301 5,494
vascular endothelial growth factor receptor binding
15,318.90 40.84 5,192 5,348
induction of positive chemotaxis
10,927.00 36.09 5,398 7,795
sprouting angiogenesis
6,970.76 34.01 7,488 16,950
chemoattractant activity
9,144.29 32.84 5,415 9,344
positive regulation of endothelial cell proliferation
8,435.02 32.50 5,691 10,646
positive regulation of angiogenesis
5,021.29 25.53 7,076 22,236
vascular endothelial growth factor signaling pathway
3,462.59 21.12 10,658 48,569
vascular endothelial growth factor binding
14,391.99 16.26 2,075 2,275
Totals 210845 2854011
No co-occurrence statistics for GO:0048010 based on MANUAL annotations
The top 100 of 1,419 co-occurring terms
Co-occurring Term PR S% #Together #Compared
vascular endothelial growth factor receptor signaling pathway
4,935.43 100.00 286 286
vascular endothelial growth factor signaling pathway
3,810.44 33.12 105 136
positive regulation of mast cell chemotaxis
4,645.11 32.88 96 102
vascular endothelial growth factor receptor binding
4,330.14 31.10 93 106
induction of positive chemotaxis
3,041.96 28.24 98 159
sprouting angiogenesis
1,661.93 27.00 165 490
vascular endothelial growth factor receptor activity
3,356.09 21.38 68 100
chemoattractant activity
1,538.86 20.90 111 356
cellular response to vascular endothelial growth factor stimulus
1,723.48 11.96 44 126
positive regulation of endothelial cell migration
846.07 10.42 60 350
Totals 3029 33233

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-194138
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Deleted CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2022-03-14 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Timestamp Action Category Detail
2004-02-12 Updated TERM vascular endothelial growth factor receptor signaling pathway
2002-07-11 Added TERM VEGF receptor signaling pathway
Timestamp Action Category Detail
2022-03-14 Deleted DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
2012-02-03 Added DEFINITION Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2012-02-03 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2010-03-26 Added SYNONYM VEGFR signaling pathway
2008-05-13 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2008-05-12 Deleted DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
2007-08-09 Added SYNONYM VEGF receptor signalling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signalling pathway
2007-08-09 Deleted SYNONYM VEGF receptor signaling pathway
2007-08-09 Added SYNONYM VEGF receptor signaling pathway
2004-04-19 Added SYNONYM VEGF receptor signaling pathway
2004-04-19 Added SYNONYM VEGF receptor signalling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signaling pathway
2004-04-16 Deleted SYNONYM VEGF receptor signalling pathway
2004-02-12 Added SYNONYM VEGF receptor signaling pathway
2003-11-13 Added SYNONYM VEGF receptor signalling pathway
2002-11-27 Added DEFINITION The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
Timestamp Action Category Detail
2012-02-03 Deleted RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2011-07-17 Added RELATION is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
2008-04-01 Updated RELATION is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-194138
Timestamp Action Category Detail
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-05 Deleted CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2 (Bacteria)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:4751 (Fungi)
2024-09-02 Deleted CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
2024-09-02 Added CONSTRAINT never_in_taxon NCBITaxon:2157 (Archaea)
2018-11-15 Deleted CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2018-11-15 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2018-11-08 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2015-12-09 Added CONSTRAINT never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea)
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