In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
GO:0048010
JSON
vascular endothelial growth factor receptor signaling pathway
Biological Process
Definition (GO:0048010 GONUTS page)
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Comments
In GO, a gene product with 'vascular endothelial growth factor-activated receptor activity ; GO:0005021' necessarily binds VEGF to transduce a signal. In contrast, the VEGFR refers to PR:000001971. To represent cross-talk between ligands and receptors, signaling pathways in GO are starting to be named after the receptor and/or the signal. GO:0048010 is for annotation of any pathway in which a ligand (VEGF or an alternative growth factor) binds and activates a VEGFR (PR:000001971). For annotation of signaling pathways where a VEGF binds to a cell surface receptor (VEGFR, PDGFR etc.), consider 'vascular endothelial growth factor signaling pathway ; GO:0038084'.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
VEGF receptor signalling pathway | exact |
VEGF receptor signaling pathway | exact |
VEGFR signaling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0048010
Child Term | Relationship to GO:0048010 |
---|---|
vascular endothelial growth factor receptor-3 signaling pathway
|
is_a |
vascular endothelial growth factor receptor-2 signaling pathway
|
is_a |
vascular endothelial growth factor receptor-1 signaling pathway
|
is_a |
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
|
is_a |
positive regulation of vascular endothelial growth factor receptor signaling pathway
|
positively_regulates |
vascular endothelial growth factor receptor signaling pathway involved in lymphatic endothelial cell fate commitment
|
is_a |
regulation of vascular endothelial growth factor receptor signaling pathway
|
regulates |
negative regulation of vascular endothelial growth factor receptor signaling pathway
|
negatively_regulates |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0048010 | vascular endothelial growth factor receptor signaling pathway | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A1L8GFH0 | 8355 | A0A1L8GFH0_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1L8GM33 | 8355 | A0A1L8GM33_XENLA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A337SFE2 | 9685 | A0A337SFE2_FELCA | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A4X1TC65 | 9823 | A0A4X1TC65_PIG | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F8GVB2 | 13616 | A0A5F8GVB2_MONDO | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A6I8N475 | 9258 | A0A6I8N475_ORNAN | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3MPB6 | 9615 | A0A8I3MPB6_CANLF | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I5ZQX3 | 10116 | A0A8I5ZQX3_RAT | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I6AEX6 | 10116 | A0A8I6AEX6_RAT | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8V1A1G5 | 9031 | A0A8V1A1G5_CHICK | GO:0007169 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR009135 | Vascular endothelial growth factor receptor 1 (VEGFR1) |
InterPro | IPR009136 | Vascular endothelial growth factor receptor 2 (VEGFR2) |
Reactome | R-HSA-194138 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0048010 based on ALL annotations
The top 100 of 1,614 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vascular endothelial growth factor receptor signaling pathway
|
15,779.17 | 100.00 | 12,558 | 12,558 |
positive regulation of mast cell chemotaxis
|
15,224.86 | 41.57 | 5,301 | 5,494 |
vascular endothelial growth factor receptor binding
|
15,318.90 | 40.84 | 5,192 | 5,348 |
induction of positive chemotaxis
|
10,927.00 | 36.09 | 5,398 | 7,795 |
sprouting angiogenesis
|
6,970.76 | 34.01 | 7,488 | 16,950 |
chemoattractant activity
|
9,144.29 | 32.84 | 5,415 | 9,344 |
positive regulation of endothelial cell proliferation
|
8,435.02 | 32.50 | 5,691 | 10,646 |
positive regulation of angiogenesis
|
5,021.29 | 25.53 | 7,076 | 22,236 |
vascular endothelial growth factor signaling pathway
|
3,462.59 | 21.12 | 10,658 | 48,569 |
vascular endothelial growth factor binding
|
14,391.99 | 16.26 | 2,075 | 2,275 |
Totals | 210845 | 2854011 |
No co-occurrence statistics for GO:0048010 based on MANUAL annotations
The top 100 of 1,419 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
vascular endothelial growth factor receptor signaling pathway
|
4,935.43 | 100.00 | 286 | 286 |
vascular endothelial growth factor signaling pathway
|
3,810.44 | 33.12 | 105 | 136 |
positive regulation of mast cell chemotaxis
|
4,645.11 | 32.88 | 96 | 102 |
vascular endothelial growth factor receptor binding
|
4,330.14 | 31.10 | 93 | 106 |
induction of positive chemotaxis
|
3,041.96 | 28.24 | 98 | 159 |
sprouting angiogenesis
|
1,661.93 | 27.00 | 165 | 490 |
vascular endothelial growth factor receptor activity
|
3,356.09 | 21.38 | 68 | 100 |
chemoattractant activity
|
1,538.86 | 20.90 | 111 | 356 |
cellular response to vascular endothelial growth factor stimulus
|
1,723.48 | 11.96 | 44 | 126 |
positive regulation of endothelial cell migration
|
846.07 | 10.42 | 60 | 350 |
Totals | 3029 | 33233 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-194138 |
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-02 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2022-03-14 | Deleted | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-02-12 | Updated | TERM | vascular endothelial growth factor receptor signaling pathway |
2002-07-11 | Added | TERM | VEGF receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Deleted | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
2012-02-03 | Added | DEFINITION | Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. |
2012-02-03 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands. |
2010-03-26 | Added | SYNONYM | VEGFR signaling pathway |
2008-05-13 | Added | DEFINITION | The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands. |
2008-05-12 | Deleted | DEFINITION | The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands. |
2007-08-09 | Added | SYNONYM | VEGF receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | VEGF receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | VEGF receptor signaling pathway |
2007-08-09 | Added | SYNONYM | VEGF receptor signaling pathway |
2004-04-19 | Added | SYNONYM | VEGF receptor signaling pathway |
2004-04-19 | Added | SYNONYM | VEGF receptor signalling pathway |
2004-04-16 | Deleted | SYNONYM | VEGF receptor signaling pathway |
2004-04-16 | Deleted | SYNONYM | VEGF receptor signalling pathway |
2004-02-12 | Added | SYNONYM | VEGF receptor signaling pathway |
2003-11-13 | Added | SYNONYM | VEGF receptor signalling pathway |
2002-11-27 | Added | DEFINITION | The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-02-03 | Deleted | RELATION | is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus) |
2011-07-17 | Added | RELATION | is a GO:0035924 (cellular response to vascular endothelial growth factor stimulus) |
2008-04-01 | Updated | RELATION | is a GO:0007169 (cell surface receptor protein tyrosine kinase signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-194138 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-05 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2 (Bacteria) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4751 (Fungi) |
2024-09-02 | Deleted | CONSTRAINT | never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea) |
2024-09-02 | Added | CONSTRAINT | never_in_taxon NCBITaxon:2157 (Archaea) |
2018-11-15 | Deleted | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2018-11-15 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2018-11-08 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2015-12-09 | Added | CONSTRAINT | never_in_taxon NCBITaxon_Union:23 (Fungi or Bacteria or Archaea) |
Not found :(
Sorry, but the Term you were trying to view does not exist.
Reported error:
It looks like this may have been caused by:
- a mistyped URL
- an out-of-date link