GO:0060079
JSON
excitatory postsynaptic potential
Biological Process
Definition (GO:0060079 GONUTS page)
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| regulation of EPSP | related |
| regulation of excitatory post-synaptic membrane potential | exact |
Ancestor Chart
Ancestor chart for GO:0060079
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0060079
| Child Term | Relationship to GO:0060079 |
|---|---|
|
modulation of excitatory postsynaptic potential
|
regulates |
|
positive regulation of excitatory postsynaptic potential
|
positively_regulates |
|
negative regulation of excitatory postsynaptic potential
|
negatively_regulates |
|
mini excitatory postsynaptic potential
|
is_a |
|
excitatory extracellular ligand-gated monoatomic ion channel activity
|
part_of |
|
evoked excitatory postsynaptic potential
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
| Ontology Development Project | |
|---|---|
| signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
| Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
|---|---|---|---|---|---|
| GO:0060079 | excitatory postsynaptic potential | Only in Taxon | 33208 | Metazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | P05067-PRO_0000000092 | 9606 | A4_HUMAN | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18216187 | |
| NOT-qualified manual | protein | Q03391 | 10090 | NMDE4_MOUSE | GO:0060079 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12832518 | |
| NOT-qualified manual | protein | Q62645 | 10116 | NMDE4_RAT | GO:0060079 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
| NOT-qualified manual | protein | Q9NFU0 | 7227 | FMR1_DROME | GO:0007268 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:12086643 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0060079 based on ALL annotations
The top 100 of 2,213 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
excitatory postsynaptic potential
|
4,890.72 | 100.00 | 40,708 | 40,708 |
|
acetylcholine-gated monoatomic cation-selective channel activity
|
4,890.54 | 65.42 | 26,633 | 26,634 |
|
regulation of postsynaptic membrane potential
|
4,417.62 | 62.56 | 27,294 | 30,217 |
|
extracellular ligand-gated monoatomic ion channel activity
|
1,571.00 | 28.81 | 29,982 | 93,338 |
|
extracellularly ATP-gated monoatomic cation channel activity
|
4,890.72 | 21.13 | 8,600 | 8,600 |
|
purinergic nucleotide receptor activity
|
4,758.39 | 19.33 | 7,911 | 8,131 |
|
purinergic nucleotide receptor signaling pathway
|
4,695.45 | 19.28 | 7,911 | 8,240 |
|
response to ATP
|
4,464.45 | 18.53 | 7,677 | 8,410 |
|
postsynaptic membrane
|
823.86 | 15.92 | 30,259 | 179,628 |
|
postsynapse
|
1,173.92 | 13.84 | 10,028 | 41,778 |
| Totals | 457646 | 9686689 | ||
No co-occurrence statistics for GO:0060079 based on MANUAL annotations
The top 100 of 1,611 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
excitatory postsynaptic potential
|
6,882.01 | 100.00 | 205 | 205 |
|
NMDA selective glutamate receptor complex
|
4,525.15 | 37.65 | 96 | 146 |
|
NMDA glutamate receptor activity
|
3,222.79 | 30.57 | 96 | 205 |
|
long-term synaptic potentiation
|
1,648.02 | 19.71 | 108 | 451 |
|
synaptic transmission, glutamatergic
|
807.85 | 10.58 | 106 | 903 |
|
glutamate-gated calcium ion channel activity
|
2,842.57 | 8.19 | 19 | 46 |
|
calcium ion transmembrane import into cytosol
|
4,333.11 | 7.91 | 17 | 27 |
|
transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
|
578.09 | 7.78 | 105 | 1,250 |
|
postsynaptic density membrane
|
541.28 | 7.32 | 105 | 1,335 |
|
regulation of monoatomic cation transmembrane transport
|
2,580.75 | 6.52 | 15 | 40 |
| Totals | 1807 | 17900 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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- Other
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
| 2016-06-15 | Added | RELATION | has part GO:0098976 (excitatory chemical synaptic transmission) |
| 2016-01-20 | Added | RELATION | part of GO:0099565 (chemical synaptic transmission, postsynaptic) |
| 2015-07-11 | Deleted | RELATION | is a GO:0051899 (membrane depolarization) |
| 2015-07-11 | Updated | TERM | excitatory postsynaptic potential |
| 2015-07-11 | Added | DEFINITION | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2015-07-11 | Deleted | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2012-12-13 | Added | SYNONYM | regulation of excitatory post-synaptic membrane potential |
| 2010-12-17 | Deleted | SYNONYM | EPSP |
| 2010-12-17 | Added | SYNONYM | regulation of EPSP |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2015-07-11 | Updated | TERM | excitatory postsynaptic potential |
| 2007-03-17 | Added | TERM | regulation of excitatory postsynaptic membrane potential |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2015-07-11 | Added | DEFINITION | A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2015-07-11 | Deleted | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2012-12-13 | Added | SYNONYM | regulation of excitatory post-synaptic membrane potential |
| 2010-12-17 | Deleted | SYNONYM | EPSP |
| 2010-12-17 | Added | SYNONYM | regulation of EPSP |
| 2010-12-17 | Deleted | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2010-12-17 | Added | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2008-05-13 | Added | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2008-05-12 | Deleted | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2007-08-09 | Deleted | SYNONYM | EPSP |
| 2007-08-09 | Added | SYNONYM | EPSP |
| 2007-03-27 | Updated | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2007-03-20 | Added | DEFINITION | Any process that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP) which is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential. |
| 2007-03-17 | Added | SYNONYM | EPSP |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2016-06-15 | Added | RELATION | has part GO:0098976 (excitatory chemical synaptic transmission) |
| 2016-01-20 | Added | RELATION | part of GO:0099565 (chemical synaptic transmission, postsynaptic) |
| 2015-07-11 | Deleted | RELATION | is a GO:0051899 (membrane depolarization) |
| 2008-04-01 | Updated | RELATION | is a GO:0060078 (regulation of postsynaptic membrane potential) |
| 2008-04-01 | Updated | RELATION | is a GO:0051899 (membrane depolarization) |
| Timestamp | Action | Category | Detail |
|---|
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33208 (Metazoa) |
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