GO:0060228
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phosphatidylcholine-sterol O-acyltransferase activator activity
Molecular Function
Definition (GO:0060228 GONUTS page)
Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. PMID:4335615
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
LCAT activator activity | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0060228 based on ALL annotations
The top 100 of 316 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphatidylcholine-sterol O-acyltransferase activator activity
|
53,978.44 | 100.00 | 3,671 | 3,671 |
acylglycerol homeostasis
|
52,238.62 | 94.27 | 3,573 | 3,692 |
phospholipid efflux
|
42,703.36 | 79.09 | 3,670 | 4,639 |
extracellular vesicle
|
41,449.60 | 75.21 | 3,573 | 4,653 |
high-density lipoprotein particle
|
22,017.21 | 40.79 | 3,671 | 9,000 |
chylomicron
|
21,091.98 | 39.05 | 3,666 | 9,382 |
low-density lipoprotein particle
|
20,898.16 | 36.04 | 3,081 | 7,958 |
very-low-density lipoprotein particle
|
17,412.56 | 32.26 | 3,671 | 11,380 |
cholesterol efflux
|
14,485.01 | 26.83 | 3,671 | 13,680 |
lipoprotein metabolic process
|
12,322.65 | 22.62 | 3,525 | 15,441 |
Totals | 56677 | 393716 |
No co-occurrence statistics for GO:0060228 based on MANUAL annotations
The top 100 of 295 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
phosphatidylcholine-sterol O-acyltransferase activator activity
|
15,859.92 | 100.00 | 89 | 89 |
acylglycerol homeostasis
|
14,190.46 | 85.86 | 85 | 95 |
chylomicron
|
11,928.83 | 74.58 | 88 | 117 |
phospholipid efflux
|
8,407.67 | 52.69 | 88 | 166 |
high-density lipoprotein particle
|
7,351.73 | 46.35 | 89 | 192 |
very-low-density lipoprotein particle
|
6,689.73 | 42.18 | 89 | 211 |
low-density lipoprotein particle
|
7,289.65 | 42.05 | 74 | 161 |
cholesterol transfer activity
|
4,763.39 | 29.93 | 88 | 293 |
cholesterol efflux
|
3,835.69 | 24.18 | 89 | 368 |
extracellular vesicle
|
3,808.17 | 23.74 | 85 | 354 |
Totals | 1411 | 9183 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-16 | Deleted | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2022-09-16 | Added | DEFINITION | Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. |
2010-06-15 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2010-06-14 | Deleted | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2010-06-08 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2009-02-25 | Deleted | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2009-02-22 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2008-05-13 | Added | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2008-05-12 | Deleted | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2008-04-01 | Updated | RELATION | is a GO:0008047 (enzyme activator activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-02-25 | Added | TERM | phosphatidylcholine-sterol O-acyltransferase activator activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-16 | Deleted | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2022-09-16 | Added | DEFINITION | Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. |
2008-05-13 | Added | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2008-05-12 | Deleted | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
2008-03-20 | Added | SYNONYM | LCAT activator activity |
2008-03-11 | Added | DEFINITION | Increases the activity of phosphatidylcholine-sterol O-acyltransferase, an enzyme that converts cholesterol and phosphatidylcholine (lecithins) to cholesteryl esters and lyso-phosphatidylcholines. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-15 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2010-06-14 | Deleted | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2010-06-08 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2009-02-25 | Deleted | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2009-02-22 | Added | RELATION | positively regulates GO:0004607 (phosphatidylcholine-sterol O-acyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0008047 (enzyme activator activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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