This term is obsolete.

GO:0070062 JSON

extracellular exosome

Cellular Component

Definition (GO:0070062 GONUTS page)

A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. PMID:15908444 PMID:17641064 PMID:19442504 PMID:19498381 PMID:22418571 PMID:24009894

Acknowledgement

This term was created by the GO Consortium with support from: BHF image

50,271 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
exosome exact
extracellular vesicular exosome exact

Ancestor Chart

Ancestor chart for GO:0070062
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0070062

Child Term Relationship to
GO:0070062
extracellular exosome complex
part_of

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q99470 9606 SDF2_HUMAN GO:0005576 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein A0A0G2JY81 10116 A0A0G2JY81_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A7U3L4H9 10116 A0A7U3L4H9_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAN5 10116 A0A8I6AAN5_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A1Z7L0 7227 A1Z7L0_DROME GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143
NOT-qualified manual protein A4QNU9 7955 A4QNU9_DANRE GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055
NOT-qualified manual protein A6HTD8 10116 A6HTD8_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HWX9 10116 A6HWX9_RAT GO:0005615 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K8X7 10116 A6K8X7_RAT GO:0005576 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B0BNL6 10116 ARRD1_RAT GO:0070062 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
UniProtKB-SubCell SL-0466 Exosome

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070062 based on ALL annotations
The top 100 of 9,587 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extracellular exosome
4,055.40 100.00 48,862 48,862
clathrin-coated endocytic vesicle
1,859.68 7.41 3,968 8,653
negative regulation of amyloid precursor protein biosynthetic process
3,770.33 7.27 3,571 3,841
clathrin complex
1,436.86 7.07 3,964 11,188
clathrin light chain binding
826.73 6.16 3,963 19,440
amyloid-beta binding
793.07 5.73 3,663 18,731
endoplasmic reticulum-Golgi intermediate compartment
468.29 5.65 4,866 42,140
clathrin coat of trans-Golgi network vesicle
718.52 5.24 3,386 19,111
clathrin coat of coated pit
660.68 5.11 3,385 20,778
receptor-mediated endocytosis
386.54 4.69 4,136 43,393
Totals 226316 9236232
No co-occurrence statistics for GO:0070062 based on MANUAL annotations
The top 100 of 7,991 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extracellular exosome
523.18 100.00 2,698 2,698
protein binding
21.42 4.00 1,713 41,833
extracellular region
25.20 3.96 492 10,215
blood microparticle
241.80 3.89 110 238
cadherin binding
61.52 3.75 141 1,199
focal adhesion
38.25 3.66 184 2,517
identical protein binding
20.43 3.08 345 8,833
multivesicular body, internal vesicle
452.33 3.06 83 96
ficolin-1-rich granule lumen
345.97 2.99 82 124
collagen-containing extracellular matrix
25.00 2.82 174 3,641
Totals 13566 355286

Change Log

Timestamp Action Category Detail
2017-05-22 Added RELATION part of GO:0005615 (extracellular space)
2017-04-06 Deleted RELATION part of GO:0005576 (extracellular region)
2016-10-14 Deleted RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-10-14 Added DEFINITION A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2016-10-14 Deleted DEFINITION A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2016-06-22 Added RELATION part of GO:0005576 (extracellular region)
2016-06-22 Added RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-03-31 Deleted RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-03-31 Deleted RELATION is a GO:0065010 (extracellular membrane-bounded organelle)
2015-05-19 Added SYNONYM exosome
Timestamp Action Category Detail
2015-03-20 Updated TERM extracellular exosome
2008-10-06 Added TERM extracellular vesicular exosome
Timestamp Action Category Detail
2016-10-14 Added DEFINITION A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2016-10-14 Deleted DEFINITION A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2015-05-19 Added SYNONYM exosome
2015-05-19 Deleted DEFINITION A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
2015-05-19 Added DEFINITION A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2015-03-20 Added SYNONYM extracellular vesicular exosome
2008-10-06 Added DEFINITION A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.
Timestamp Action Category Detail
2017-05-22 Added RELATION part of GO:0005615 (extracellular space)
2017-04-06 Deleted RELATION part of GO:0005576 (extracellular region)
2016-10-14 Deleted RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-06-22 Added RELATION part of GO:0005576 (extracellular region)
2016-06-22 Added RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-03-31 Deleted RELATION is a GO:0031988 (membrane-bounded vesicle)
2016-03-31 Deleted RELATION is a GO:0065010 (extracellular membrane-bounded organelle)
2014-10-25 Added RELATION is a GO:1903561 (extracellular vesicle)
2008-10-06 Added RELATION is a GO:0031988 (membrane-bounded vesicle)
2008-10-06 Added RELATION is a GO:0065010 (extracellular membrane-bounded organelle)
Timestamp Action Category Detail
Timestamp Action Category Detail
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