GO:0070062
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extracellular exosome
Cellular Component
Definition (GO:0070062 GONUTS page)
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. PMID:15908444 PMID:17641064 PMID:19442504 PMID:19498381 PMID:22418571 PMID:24009894
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
extracellular vesicular exosome | exact |
exosome | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0070062
Child Term | Relationship to GO:0070062 |
---|---|
extracellular exosome complex
|
part_of |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q99470 | 9606 | SDF2_HUMAN | GO:0005576 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | A0A0G2JY81 | 10116 | A0A0G2JY81_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A7U3L4H9 | 10116 | A0A7U3L4H9_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AAN5 | 10116 | A0A8I6AAN5_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A1Z7L0 | 7227 | A1Z7L0_DROME | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:35714143 | |
NOT-qualified manual | protein | A4QNU9 | 7955 | A4QNU9_DANRE | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:22292055 | |
NOT-qualified manual | protein | A6HTD8 | 10116 | A6HTD8_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HWX9 | 10116 | A6HWX9_RAT | GO:0005615 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K8X7 | 10116 | A6K8X7_RAT | GO:0005576 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B0BNL6 | 10116 | ARRD1_RAT | GO:0070062 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
UniProtKB-SubCell | SL-0466 | Exosome |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070062 based on ALL annotations
The top 100 of 9,613 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellular exosome
|
4,061.22 | 100.00 | 48,000 | 48,000 |
clathrin-coated endocytic vesicle
|
1,865.18 | 7.39 | 3,884 | 8,457 |
negative regulation of amyloid precursor protein biosynthetic process
|
3,770.06 | 7.22 | 3,483 | 3,752 |
clathrin complex
|
1,462.69 | 7.07 | 3,880 | 10,773 |
clathrin light chain binding
|
835.37 | 6.16 | 3,879 | 18,858 |
amyloid-beta binding
|
788.77 | 5.69 | 3,575 | 18,407 |
endoplasmic reticulum-Golgi intermediate compartment
|
440.54 | 5.45 | 4,745 | 43,743 |
clathrin coat of trans-Golgi network vesicle
|
730.36 | 5.24 | 3,302 | 18,361 |
clathrin coat of coated pit
|
670.91 | 5.10 | 3,301 | 19,982 |
receptor-mediated endocytosis
|
392.86 | 4.72 | 4,050 | 41,867 |
Totals | 223092 | 9133034 |
No co-occurrence statistics for GO:0070062 based on MANUAL annotations
The top 100 of 8,008 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extracellular exosome
|
482.01 | 100.00 | 2,680 | 2,680 |
extracellular region
|
23.98 | 4.08 | 493 | 9,908 |
protein binding
|
19.71 | 4.00 | 1,710 | 41,817 |
blood microparticle
|
272.23 | 3.94 | 109 | 193 |
cadherin binding
|
63.22 | 3.90 | 141 | 1,075 |
focal adhesion
|
36.45 | 3.73 | 184 | 2,433 |
identical protein binding
|
18.83 | 3.09 | 343 | 8,780 |
multivesicular body, internal vesicle
|
416.74 | 3.08 | 83 | 96 |
ficolin-1-rich granule lumen
|
318.75 | 3.01 | 82 | 124 |
collagen-containing extracellular matrix
|
25.21 | 2.98 | 174 | 3,327 |
Totals | 13624 | 350407 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-22 | Added | RELATION | part of GO:0005615 (extracellular space) |
2017-04-06 | Deleted | RELATION | part of GO:0005576 (extracellular region) |
2016-10-14 | Added | DEFINITION | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
2016-10-14 | Deleted | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2016-10-14 | Deleted | DEFINITION | A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
2016-06-22 | Added | RELATION | part of GO:0005576 (extracellular region) |
2016-06-22 | Added | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2016-03-31 | Deleted | RELATION | is a GO:0065010 (extracellular membrane-bounded organelle) |
2016-03-31 | Deleted | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2015-05-19 | Added | SYNONYM | exosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-03-20 | Updated | TERM | extracellular exosome |
2008-10-06 | Added | TERM | extracellular vesicular exosome |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-10-14 | Added | DEFINITION | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
2016-10-14 | Deleted | DEFINITION | A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
2015-05-19 | Added | SYNONYM | exosome |
2015-05-19 | Deleted | DEFINITION | A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. |
2015-05-19 | Added | DEFINITION | A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. |
2015-03-20 | Added | SYNONYM | extracellular vesicular exosome |
2008-10-06 | Added | DEFINITION | A membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2017-05-22 | Added | RELATION | part of GO:0005615 (extracellular space) |
2017-04-06 | Deleted | RELATION | part of GO:0005576 (extracellular region) |
2016-10-14 | Deleted | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2016-06-22 | Added | RELATION | part of GO:0005576 (extracellular region) |
2016-06-22 | Added | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2016-03-31 | Deleted | RELATION | is a GO:0065010 (extracellular membrane-bounded organelle) |
2016-03-31 | Deleted | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
2014-10-25 | Added | RELATION | is a GO:1903561 (extracellular vesicle) |
2008-10-06 | Added | RELATION | is a GO:0065010 (extracellular membrane-bounded organelle) |
2008-10-06 | Added | RELATION | is a GO:0031988 (membrane-bounded vesicle) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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