This term is obsolete.

GO:0070330 JSON

aromatase activity

Molecular Function

Definition (GO:0070330 GONUTS page)

Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone.

8,504 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
estrogen synthetase activity narrow

Ancestor Chart

Ancestor chart for GO:0070330
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A087X1C5 9606 CP2D7_HUMAN GO:0070330 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18838503
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0016705 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683
NOT-qualified manual protein A0A2U8U1P3 7227 A0A2U8U1P3_DROME GO:0004497 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683

Cross-references

Database ID Description
EC 1.14.14.14
InterPro IPR023206 Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase
RHEA 38191
RHEA 38195

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0034811 obsolete benzo(a)pyrene 9,10-dioxygenase activity replaced_by GO:0070330
GO:0034813 obsolete benzo(a)pyrene 7,8-dioxygenase activity replaced_by GO:0070330

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0070330 based on ALL annotations
The top 100 of 235 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aromatase activity
23,439.19 100.00 8,454 8,454
NADPH-hemoprotein reductase activity
5,436.95 18.16 3,851 16,602
female gonad development
10,064.35 15.62 1,666 3,880
steroid 17-alpha-monooxygenase activity
6,477.56 14.55 1,987 7,190
progesterone metabolic process
6,116.04 14.11 1,987 7,615
response to estradiol
6,145.44 12.66 1,662 6,339
hormone biosynthetic process
3,509.43 10.07 1,987 13,271
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
1,891.97 7.68 5,178 64,149
epoxygenase P450 pathway
2,924.84 5.00 650 5,209
arachidonate epoxygenase activity
2,914.76 4.99 650 5,227
Totals 92596 54703711
No co-occurrence statistics for GO:0070330 based on MANUAL annotations
The top 91 of 91 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aromatase activity
32,826.35 100.00 43 43
female gonad development
5,567.04 15.68 29 171
estrogen biosynthetic process
4,689.48 8.79 8 56
response to estradiol
1,781.27 5.27 28 516
positive regulation of estradiol secretion
2,854.47 4.71 4 46
coumarin 7-hydroxylase activity
16,413.17 4.44 2 4
response to aromatase inhibitor
16,413.17 4.44 2 4
androgen catabolic process
8,206.59 4.08 2 8
regulation of animal organ morphogenesis
8,206.59 4.08 2 8
negative regulation of chronic inflammatory response
4,689.48 3.64 2 14
Totals 280 426704

Change Log

Timestamp Action Category Detail
2024-11-08 Deleted XREF UM-BBD_reactionID:r1137
2024-11-08 Deleted XREF UM-BBD_reactionID:r1132
2024-06-27 Added XREF UM-BBD_reactionID:r1132
2024-06-27 Added XREF UM-BBD_reactionID:r1137
2024-06-26 Added DEFINITION Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone.
2024-06-26 Deleted DEFINITION Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
2024-06-26 Added XREF RHEA:38191
2024-06-26 Added XREF RHEA:38195
2024-06-26 Added XREF EC:1.14.14.14
2024-06-26 Deleted XREF UM-BBD_enzymeID:e0551
Timestamp Action Category Detail
2009-02-15 Added TERM aromatase activity
Timestamp Action Category Detail
2024-06-26 Added DEFINITION Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone.
2024-06-26 Deleted DEFINITION Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
2009-02-15 Added SYNONYM estrogen synthetase activity
2009-02-15 Added DEFINITION Catalysis of the reduction of an aliphatic ring to yield an aromatic ring.
Timestamp Action Category Detail
2009-02-15 Added RELATION is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen)
Timestamp Action Category Detail
2024-11-08 Deleted XREF UM-BBD_reactionID:r1137
2024-11-08 Deleted XREF UM-BBD_reactionID:r1132
2024-06-27 Added XREF UM-BBD_reactionID:r1132
2024-06-27 Added XREF UM-BBD_reactionID:r1137
2024-06-26 Added XREF RHEA:38191
2024-06-26 Added XREF RHEA:38195
2024-06-26 Added XREF EC:1.14.14.14
2024-06-26 Deleted XREF UM-BBD_enzymeID:e0551
2024-06-26 Deleted XREF RHEA:17149
2024-06-26 Deleted XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2024-06-26 Deleted XREF EC:1.14.14.1
2020-06-22 Added XREF RHEA:17149
2009-02-15 Added XREF UM-BBD_enzymeID:e0551
2009-02-15 Added XREF MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN
2009-02-15 Added XREF EC:1.14.14.1
Timestamp Action Category Detail
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