GO:0070330
JSON
aromatase activity
Molecular Function
Definition (GO:0070330 GONUTS page)
Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
estrogen synthetase activity | narrow |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 5270 | BI1_MYCMD | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A087X1C5 | 9606 | CP2D7_HUMAN | GO:0070330 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18838503 | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0016705 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 | |
NOT-qualified manual | protein | A0A2U8U1P3 | 7227 | A0A2U8U1P3_DROME | GO:0004497 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11179683 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.14.14.14 | |
InterPro | IPR023206 | Bifunctional cytochrome P450/NADPH--cytochrome P450 reductase |
RHEA | 38191 | |
RHEA | 38195 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0034811 | obsolete benzo(a)pyrene 9,10-dioxygenase activity | replaced_by GO:0070330 |
GO:0034813 | obsolete benzo(a)pyrene 7,8-dioxygenase activity | replaced_by GO:0070330 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0070330 based on ALL annotations
The top 100 of 235 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aromatase activity
|
23,439.19 | 100.00 | 8,454 | 8,454 |
NADPH-hemoprotein reductase activity
|
5,436.95 | 18.16 | 3,851 | 16,602 |
female gonad development
|
10,064.35 | 15.62 | 1,666 | 3,880 |
steroid 17-alpha-monooxygenase activity
|
6,477.56 | 14.55 | 1,987 | 7,190 |
progesterone metabolic process
|
6,116.04 | 14.11 | 1,987 | 7,615 |
response to estradiol
|
6,145.44 | 12.66 | 1,662 | 6,339 |
hormone biosynthetic process
|
3,509.43 | 10.07 | 1,987 | 13,271 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
|
1,891.97 | 7.68 | 5,178 | 64,149 |
epoxygenase P450 pathway
|
2,924.84 | 5.00 | 650 | 5,209 |
arachidonate epoxygenase activity
|
2,914.76 | 4.99 | 650 | 5,227 |
Totals | 92596 | 54703711 |
No co-occurrence statistics for GO:0070330 based on MANUAL annotations
The top 91 of 91 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aromatase activity
|
32,826.35 | 100.00 | 43 | 43 |
female gonad development
|
5,567.04 | 15.68 | 29 | 171 |
estrogen biosynthetic process
|
4,689.48 | 8.79 | 8 | 56 |
response to estradiol
|
1,781.27 | 5.27 | 28 | 516 |
positive regulation of estradiol secretion
|
2,854.47 | 4.71 | 4 | 46 |
coumarin 7-hydroxylase activity
|
16,413.17 | 4.44 | 2 | 4 |
response to aromatase inhibitor
|
16,413.17 | 4.44 | 2 | 4 |
androgen catabolic process
|
8,206.59 | 4.08 | 2 | 8 |
regulation of animal organ morphogenesis
|
8,206.59 | 4.08 | 2 | 8 |
negative regulation of chronic inflammatory response
|
4,689.48 | 3.64 | 2 | 14 |
Totals | 280 | 426704 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-08 | Deleted | XREF | UM-BBD_reactionID:r1137 |
2024-11-08 | Deleted | XREF | UM-BBD_reactionID:r1132 |
2024-06-27 | Added | XREF | UM-BBD_reactionID:r1132 |
2024-06-27 | Added | XREF | UM-BBD_reactionID:r1137 |
2024-06-26 | Added | DEFINITION | Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone. |
2024-06-26 | Deleted | DEFINITION | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
2024-06-26 | Added | XREF | RHEA:38191 |
2024-06-26 | Added | XREF | RHEA:38195 |
2024-06-26 | Added | XREF | EC:1.14.14.14 |
2024-06-26 | Deleted | XREF | UM-BBD_enzymeID:e0551 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-15 | Added | TERM | aromatase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-26 | Added | DEFINITION | Catalysis of the reaction: 3 O2 + 3 reduced [NADPH--hemoprotein reductase] + testosterone = 17beta-estradiol + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase]. Also converts androst-4-ene-3,17-dione into estrone. |
2024-06-26 | Deleted | DEFINITION | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
2009-02-15 | Added | SYNONYM | estrogen synthetase activity |
2009-02-15 | Added | DEFINITION | Catalysis of the reduction of an aliphatic ring to yield an aromatic ring. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-15 | Added | RELATION | is a GO:0016712 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-11-08 | Deleted | XREF | UM-BBD_reactionID:r1137 |
2024-11-08 | Deleted | XREF | UM-BBD_reactionID:r1132 |
2024-06-27 | Added | XREF | UM-BBD_reactionID:r1132 |
2024-06-27 | Added | XREF | UM-BBD_reactionID:r1137 |
2024-06-26 | Added | XREF | RHEA:38191 |
2024-06-26 | Added | XREF | RHEA:38195 |
2024-06-26 | Added | XREF | EC:1.14.14.14 |
2024-06-26 | Deleted | XREF | UM-BBD_enzymeID:e0551 |
2024-06-26 | Deleted | XREF | RHEA:17149 |
2024-06-26 | Deleted | XREF | MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN |
2024-06-26 | Deleted | XREF | EC:1.14.14.1 |
2020-06-22 | Added | XREF | RHEA:17149 |
2009-02-15 | Added | XREF | UM-BBD_enzymeID:e0551 |
2009-02-15 | Added | XREF | MetaCyc:UNSPECIFIC-MONOOXYGENASE-RXN |
2009-02-15 | Added | XREF | EC:1.14.14.1 |
Timestamp | Action | Category | Detail |
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