Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
GO:0097191
JSON
extrinsic apoptotic signaling pathway
Biological Process
Definition (GO:0097191 GONUTS page)
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. PMID:17340152
Comments
Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
extrinsic apoptotic signalling pathway | exact |
death receptor-mediated apoptosis | narrow |
extrinsic apoptotic signaling pathway in presence of ligand | narrow |
extrinsic apoptosis | narrow |
extrinsic apoptotic pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0097191
Child Term | Relationship to GO:0097191 |
---|---|
death-inducing signaling complex assembly
|
part_of |
regulation of extrinsic apoptotic signaling pathway
|
regulates |
extrinsic apoptotic signaling pathway in absence of ligand
|
is_a |
positive regulation of extrinsic apoptotic signaling pathway
|
positively_regulates |
B cell receptor apoptotic signaling pathway
|
is_a |
ripoptosome assembly involved in extrinsic apoptotic signaling pathway
|
part_of |
extrinsic apoptotic signaling pathway via death domain receptors
|
is_a |
fibroblast growth factor receptor apoptotic signaling pathway
|
is_a |
negative regulation of extrinsic apoptotic signaling pathway
|
negatively_regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating cell death and apoptosis using the new guidelines | Link |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0097191 | extrinsic apoptotic signaling pathway | Never in Taxon | 4896 | Schizosaccharomyces pombe | |
GO:0097191 | extrinsic apoptotic signaling pathway | Only in Taxon | 33154 | Opisthokonta |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A1D5Q3B3 | 9544 | A0A1D5Q3B3_MACMU | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2YB08 | 9595 | A0A2I2YB08_GORGO | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2J8LBR9 | 9598 | A0A2J8LBR9_PANTR | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2U9DQQ6 | 7955 | A0A2U9DQQ6_DANRE | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A3Q2LIL1 | 9796 | A0A3Q2LIL1_HORSE | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A9L0RP63 | 9796 | A0A9L0RP63_HORSE | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B8A526 | 7955 | B8A526_DANRE | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | F1SV36 | 9823 | F1SV36_PIG | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | F1SV37 | 9823 | F1SV37_PIG | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | F6RKH7 | 9258 | F6RKH7_ORNAN | GO:0006915 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
Reactome | R-HSA-5357769 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0097191 based on ALL annotations
The top 100 of 2,104 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extrinsic apoptotic signaling pathway
|
26,162.51 | 100.00 | 7,574 | 7,574 |
CD27 receptor binding
|
25,470.38 | 14.52 | 1,104 | 1,134 |
CD95 death-inducing signaling complex
|
13,981.93 | 11.61 | 978 | 1,830 |
tumor necrosis factor receptor superfamily complex
|
23,504.29 | 10.95 | 840 | 935 |
death receptor binding
|
9,457.57 | 10.00 | 920 | 2,545 |
caspase binding
|
9,421.72 | 9.08 | 820 | 2,277 |
positive regulation of membrane protein ectodomain proteolysis
|
7,122.11 | 8.55 | 839 | 3,082 |
regulation of T cell cytokine production
|
21,375.89 | 8.45 | 652 | 798 |
positive regulation of extrinsic apoptotic signaling pathway
|
4,483.39 | 7.41 | 875 | 5,106 |
positive regulation of oligodendrocyte differentiation
|
8,048.12 | 7.27 | 658 | 2,139 |
Totals | 49261 | 392041 |
No co-occurrence statistics for GO:0097191 based on MANUAL annotations
The top 100 of 1,946 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
extrinsic apoptotic signaling pathway
|
3,520.03 | 100.00 | 401 | 401 |
type III transforming growth factor beta receptor binding
|
2,309.32 | 22.64 | 103 | 157 |
positive regulation of SMAD protein signal transduction
|
1,623.53 | 21.20 | 113 | 245 |
negative regulation of macrophage cytokine production
|
1,898.24 | 21.06 | 103 | 191 |
type II transforming growth factor beta receptor binding
|
1,686.34 | 20.08 | 103 | 215 |
salivary gland morphogenesis
|
1,450.25 | 18.80 | 103 | 250 |
response to progesterone
|
1,180.84 | 17.24 | 105 | 313 |
positive regulation of epithelial to mesenchymal transition
|
955.18 | 15.63 | 108 | 398 |
regulation of transforming growth factor beta2 production
|
3,406.48 | 14.89 | 60 | 62 |
negative regulation of epithelial cell proliferation
|
800.01 | 13.85 | 105 | 462 |
Totals | 5616 | 34438 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-5357769 |
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33154 (Opisthokonta) |
2022-03-14 | Added | DEFINITION | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
2012-05-31 | Added | RELATION | has part GO:0001552 (ovarian follicle atresia) |
2012-04-14 | Added | SYNONYM | extrinsic apoptotic signalling pathway |
2012-03-29 | Added | SYNONYM | extrinsic apoptosis |
2011-11-26 | Added | RELATION | is a GO:0097190 (apoptotic signaling pathway) |
2011-11-26 | Added | SYNONYM | extrinsic apoptotic pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-11-26 | Added | TERM | extrinsic apoptotic signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-03-14 | Added | DEFINITION | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
2022-03-14 | Deleted | DEFINITION | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
2012-04-14 | Added | SYNONYM | extrinsic apoptotic signalling pathway |
2012-03-29 | Added | SYNONYM | extrinsic apoptosis |
2011-11-26 | Added | SYNONYM | extrinsic apoptotic pathway |
2011-11-26 | Added | SYNONYM | extrinsic apoptotic signaling pathway in presence of ligand |
2011-11-26 | Added | DEFINITION | A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. |
2011-11-26 | Added | SYNONYM | death receptor-mediated apoptosis |
Timestamp | Action | Category | Detail |
---|---|---|---|
2012-05-31 | Added | RELATION | has part GO:0001552 (ovarian follicle atresia) |
2011-11-26 | Added | RELATION | is a GO:0097190 (apoptotic signaling pathway) |
2011-11-26 | Added | RELATION | is a GO:0007166 (cell surface receptor signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-12-05 | Added | XREF | Reactome:R-HSA-5357769 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe) |
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:33154 (Opisthokonta) |
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