This term is obsolete.
Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.

GO:0097191 JSON

extrinsic apoptotic signaling pathway

Biological Process

Definition (GO:0097191 GONUTS page)

The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered. PMID:17340152

Comments

Fas acts as a death receptor with a role in apoptosis, but can also act as a non-apoptotic signal transducer.

Acknowledgement

This term was created by the GO Consortium with support from: KRUK image

28,780 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
extrinsic apoptotic signalling pathway exact
death receptor-mediated apoptosis narrow
extrinsic apoptotic signaling pathway in presence of ligand narrow
extrinsic apoptosis narrow
extrinsic apoptotic pathway exact

Ancestor Chart

Ancestor chart for GO:0097191
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0097191

Child Term Relationship to
GO:0097191
death-inducing signaling complex assembly
part_of
regulation of extrinsic apoptotic signaling pathway
regulates
extrinsic apoptotic signaling pathway in absence of ligand
is_a
positive regulation of extrinsic apoptotic signaling pathway
positively_regulates
B cell receptor apoptotic signaling pathway
is_a
ripoptosome assembly involved in extrinsic apoptotic signaling pathway
part_of
extrinsic apoptotic signaling pathway via death domain receptors
is_a
fibroblast growth factor receptor apoptotic signaling pathway
is_a
negative regulation of extrinsic apoptotic signaling pathway
negatively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating cell death and apoptosis using the new guidelines Link

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0097191 extrinsic apoptotic signaling pathway Never in Taxon 4896 Schizosaccharomyces pombe
GO:0097191 extrinsic apoptotic signaling pathway Only in Taxon 33154 Opisthokonta

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A1D5Q3B3 9544 A0A1D5Q3B3_MACMU GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2YB08 9595 A0A2I2YB08_GORGO GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2J8LBR9 9598 A0A2J8LBR9_PANTR GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2U9DQQ6 7955 A0A2U9DQQ6_DANRE GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A3Q2LIL1 9796 A0A3Q2LIL1_HORSE GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A9L0RP63 9796 A0A9L0RP63_HORSE GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B8A526 7955 B8A526_DANRE GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F1SV36 9823 F1SV36_PIG GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F1SV37 9823 F1SV37_PIG GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein F6RKH7 9258 F6RKH7_ORNAN GO:0006915 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
Reactome R-HSA-5357769

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0097191 based on ALL annotations
The top 100 of 2,104 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extrinsic apoptotic signaling pathway
26,162.51 100.00 7,574 7,574
CD27 receptor binding
25,470.38 14.52 1,104 1,134
CD95 death-inducing signaling complex
13,981.93 11.61 978 1,830
tumor necrosis factor receptor superfamily complex
23,504.29 10.95 840 935
death receptor binding
9,457.57 10.00 920 2,545
caspase binding
9,421.72 9.08 820 2,277
positive regulation of membrane protein ectodomain proteolysis
7,122.11 8.55 839 3,082
regulation of T cell cytokine production
21,375.89 8.45 652 798
positive regulation of extrinsic apoptotic signaling pathway
4,483.39 7.41 875 5,106
positive regulation of oligodendrocyte differentiation
8,048.12 7.27 658 2,139
Totals 49261 392041
No co-occurrence statistics for GO:0097191 based on MANUAL annotations
The top 100 of 1,946 co-occurring terms
Co-occurring Term PR S% #Together #Compared
extrinsic apoptotic signaling pathway
3,520.03 100.00 401 401
type III transforming growth factor beta receptor binding
2,309.32 22.64 103 157
positive regulation of SMAD protein signal transduction
1,623.53 21.20 113 245
negative regulation of macrophage cytokine production
1,898.24 21.06 103 191
type II transforming growth factor beta receptor binding
1,686.34 20.08 103 215
salivary gland morphogenesis
1,450.25 18.80 103 250
response to progesterone
1,180.84 17.24 105 313
positive regulation of epithelial to mesenchymal transition
955.18 15.63 108 398
regulation of transforming growth factor beta2 production
3,406.48 14.89 60 62
negative regulation of epithelial cell proliferation
800.01 13.85 105 462
Totals 5616 34438

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5357769
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33154 (Opisthokonta)
2022-03-14 Added DEFINITION The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2022-03-14 Deleted DEFINITION A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2012-05-31 Added RELATION has part GO:0001552 (ovarian follicle atresia)
2012-04-14 Added SYNONYM extrinsic apoptotic signalling pathway
2012-03-29 Added SYNONYM extrinsic apoptosis
2011-11-26 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2011-11-26 Added SYNONYM extrinsic apoptotic pathway
Timestamp Action Category Detail
2011-11-26 Added TERM extrinsic apoptotic signaling pathway
Timestamp Action Category Detail
2022-03-14 Added DEFINITION The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2022-03-14 Deleted DEFINITION A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2012-04-14 Added SYNONYM extrinsic apoptotic signalling pathway
2012-03-29 Added SYNONYM extrinsic apoptosis
2011-11-26 Added SYNONYM extrinsic apoptotic pathway
2011-11-26 Added SYNONYM extrinsic apoptotic signaling pathway in presence of ligand
2011-11-26 Added DEFINITION A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2011-11-26 Added SYNONYM death receptor-mediated apoptosis
Timestamp Action Category Detail
2012-05-31 Added RELATION has part GO:0001552 (ovarian follicle atresia)
2011-11-26 Added RELATION is a GO:0097190 (apoptotic signaling pathway)
2011-11-26 Added RELATION is a GO:0007166 (cell surface receptor signaling pathway)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5357769
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4896 (Schizosaccharomyces pombe)
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:33154 (Opisthokonta)
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