This term is obsolete.

GO:0140358 JSON

P-type transmembrane transporter activity

Molecular Function

Definition (GO:0140358 GONUTS page)

Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. PMID:18075584 PMID:25918123

361,634 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
E1-E2 ATPase exact
P-type ATPase exact

Ancestor Chart

Ancestor chart for GO:0140358
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140358

Child Term Relationship to
GO:0140358
P-type ion transporter activity
is_a

Cross-references

Database ID Description
InterPro IPR006544 P-type ATPase, subfamily V
TC 3.A.3
Wikipedia P-type_ATPase

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140358 based on ALL annotations
The top 100 of 303 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type transmembrane transporter activity
17,239.85 100.00 11,494 11,494
polyamine transmembrane transporter activity
3,997.82 13.11 2,664 11,488
extraction of mislocalized protein from ER membrane
17,239.85 11.23 1,291 1,291
membrane protein dislocase activity
12,894.93 10.82 1,291 1,726
ATPase-coupled monoatomic cation transmembrane transporter activity
1,301.73 7.54 11,274 149,311
P-type ion transporter activity
1,361.17 7.32 5,737 72,662
intracellular calcium ion homeostasis
1,286.47 7.31 8,932 119,697
polyamine transmembrane transport
1,196.54 5.64 2,664 38,383
regulation of autophagosome size
5,318.09 3.85 484 1,569
regulation of mitochondrion organization
2,467.21 3.36 484 3,382
Totals 110296 120377706
No co-occurrence statistics for GO:0140358 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type transmembrane transporter activity
176,441.62 100.00 8 8
polyamine transmembrane transport
7,959.77 4.44 6 133
polyamine transmembrane transporter activity
6,919.28 3.87 6 153
ATPase-coupled monoatomic cation transmembrane transporter activity
2,771.33 1.56 6 382
recycling endosome membrane
1,664.54 0.94 8 848
early endosome membrane
1,551.14 0.88 8 910
late endosome membrane
751.21 0.43 8 1,879
intracellular calcium ion homeostasis
441.84 0.25 6 2,396
membrane
2.67 0.00 1 66,063
Totals 57 72772

Change Log

Timestamp Action Category Detail
2024-03-21 Deleted DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2024-03-21 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2021-04-24 Deleted XREF EC:7.2.2.-
2021-04-22 Added XREF EC:7.2.2.-
2020-12-11 Added XREF Wikipedia:P-type_ATPase
2020-12-11 Deleted DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2020-12-11 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2019-06-29 Added XREF TC:3.A.3
2019-06-29 Added TERM P-type transmembrane transporter activity
2019-06-29 Added SYNONYM P-type ATPase
Timestamp Action Category Detail
2019-06-29 Added TERM P-type transmembrane transporter activity
Timestamp Action Category Detail
2024-03-21 Deleted DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2024-03-21 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2020-12-11 Deleted DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2020-12-11 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2019-06-29 Added SYNONYM P-type ATPase
2019-06-29 Added DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2019-06-29 Added SYNONYM E1-E2 ATPase
Timestamp Action Category Detail
2019-06-29 Added RELATION is a GO:0042626 (ATPase-coupled transmembrane transporter activity)
Timestamp Action Category Detail
2021-04-24 Deleted XREF EC:7.2.2.-
2021-04-22 Added XREF EC:7.2.2.-
2020-12-11 Added XREF Wikipedia:P-type_ATPase
2019-06-29 Added XREF TC:3.A.3
Timestamp Action Category Detail
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