GO:0140358
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P-type transmembrane transporter activity
Molecular Function
Definition (GO:0140358 GONUTS page)
Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. PMID:18075584 PMID:25918123
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
E1-E2 ATPase | exact |
P-type ATPase | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0140358
Child Term | Relationship to GO:0140358 |
---|---|
P-type ion transporter activity
|
is_a |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR006544 | P-type ATPase, subfamily V |
TC | 3.A.3 | |
Wikipedia | P-type_ATPase |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0140358 based on ALL annotations
The top 100 of 308 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
P-type transmembrane transporter activity
|
17,563.64 | 100.00 | 11,099 | 11,099 |
polyamine transmembrane transporter activity
|
4,049.70 | 12.95 | 2,531 | 10,977 |
extraction of mislocalized protein from ER membrane
|
17,563.64 | 11.40 | 1,265 | 1,265 |
membrane protein dislocase activity
|
13,061.73 | 10.97 | 1,265 | 1,701 |
ATPase-coupled monoatomic cation transmembrane transporter activity
|
1,304.09 | 7.41 | 10,888 | 146,641 |
intracellular calcium ion homeostasis
|
1,292.63 | 7.21 | 8,599 | 116,839 |
P-type ion transporter activity
|
1,342.15 | 7.10 | 5,546 | 72,576 |
polyamine transmembrane transport
|
1,173.88 | 5.45 | 2,531 | 37,869 |
regulation of autophagosome size
|
5,519.67 | 3.94 | 478 | 1,521 |
regulation of mitochondrion organization
|
2,455.52 | 3.40 | 478 | 3,419 |
Totals | 111190 | 121601129 |
No co-occurrence statistics for GO:0140358 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
P-type transmembrane transporter activity
|
161,474.88 | 100.00 | 8 | 8 |
recycling endosome membrane
|
1,660.41 | 1.03 | 8 | 778 |
polyamine transmembrane transport
|
1,755.16 | 1.01 | 1 | 92 |
early endosome membrane
|
1,525.15 | 0.94 | 8 | 847 |
polyamine transmembrane transporter activity
|
1,441.74 | 0.84 | 1 | 112 |
late endosome membrane
|
769.84 | 0.48 | 8 | 1,678 |
ATPase-coupled monoatomic cation transmembrane transporter activity
|
469.40 | 0.28 | 1 | 344 |
intracellular calcium ion homeostasis
|
73.70 | 0.05 | 1 | 2,191 |
membrane
|
2.64 | 0.00 | 1 | 61,077 |
Totals | 37 | 67127 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2024-03-21 | Deleted | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2021-04-24 | Deleted | XREF | EC:7.2.2.- |
2021-04-22 | Added | XREF | EC:7.2.2.- |
2020-12-11 | Deleted | DEFINITION | Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane. |
2020-12-11 | Added | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2020-12-11 | Added | XREF | Wikipedia:P-type_ATPase |
2019-06-29 | Added | XREF | TC:3.A.3 |
2019-06-29 | Added | SYNONYM | E1-E2 ATPase |
2019-06-29 | Added | SYNONYM | P-type ATPase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-29 | Added | TERM | P-type transmembrane transporter activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2024-03-21 | Deleted | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2020-12-11 | Deleted | DEFINITION | Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane. |
2020-12-11 | Added | DEFINITION | Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. |
2019-06-29 | Added | SYNONYM | E1-E2 ATPase |
2019-06-29 | Added | SYNONYM | P-type ATPase |
2019-06-29 | Added | DEFINITION | Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-06-29 | Added | RELATION | is a GO:0042626 (ATPase-coupled transmembrane transporter activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-04-24 | Deleted | XREF | EC:7.2.2.- |
2021-04-22 | Added | XREF | EC:7.2.2.- |
2020-12-11 | Added | XREF | Wikipedia:P-type_ATPase |
2019-06-29 | Added | XREF | TC:3.A.3 |
Timestamp | Action | Category | Detail |
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