This term is obsolete.

GO:0140358 JSON

P-type transmembrane transporter activity

Molecular Function

Definition (GO:0140358 GONUTS page)

Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. PMID:18075584 PMID:25918123

354,696 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
E1-E2 ATPase exact
P-type ATPase exact

Ancestor Chart

Ancestor chart for GO:0140358
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0140358

Child Term Relationship to
GO:0140358
P-type ion transporter activity
is_a

Cross-references

Database ID Description
InterPro IPR006544 P-type ATPase, subfamily V
TC 3.A.3
Wikipedia P-type_ATPase

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0140358 based on ALL annotations
The top 100 of 308 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type transmembrane transporter activity
17,563.64 100.00 11,099 11,099
polyamine transmembrane transporter activity
4,049.70 12.95 2,531 10,977
extraction of mislocalized protein from ER membrane
17,563.64 11.40 1,265 1,265
membrane protein dislocase activity
13,061.73 10.97 1,265 1,701
ATPase-coupled monoatomic cation transmembrane transporter activity
1,304.09 7.41 10,888 146,641
intracellular calcium ion homeostasis
1,292.63 7.21 8,599 116,839
P-type ion transporter activity
1,342.15 7.10 5,546 72,576
polyamine transmembrane transport
1,173.88 5.45 2,531 37,869
regulation of autophagosome size
5,519.67 3.94 478 1,521
regulation of mitochondrion organization
2,455.52 3.40 478 3,419
Totals 111190 121601129
No co-occurrence statistics for GO:0140358 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term PR S% #Together #Compared
P-type transmembrane transporter activity
161,474.88 100.00 8 8
recycling endosome membrane
1,660.41 1.03 8 778
polyamine transmembrane transport
1,755.16 1.01 1 92
early endosome membrane
1,525.15 0.94 8 847
polyamine transmembrane transporter activity
1,441.74 0.84 1 112
late endosome membrane
769.84 0.48 8 1,678
ATPase-coupled monoatomic cation transmembrane transporter activity
469.40 0.28 1 344
intracellular calcium ion homeostasis
73.70 0.05 1 2,191
membrane
2.64 0.00 1 61,077
Totals 37 67127

Change Log

Timestamp Action Category Detail
2024-03-21 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2024-03-21 Deleted DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2021-04-24 Deleted XREF EC:7.2.2.-
2021-04-22 Added XREF EC:7.2.2.-
2020-12-11 Deleted DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2020-12-11 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2020-12-11 Added XREF Wikipedia:P-type_ATPase
2019-06-29 Added XREF TC:3.A.3
2019-06-29 Added SYNONYM E1-E2 ATPase
2019-06-29 Added SYNONYM P-type ATPase
Timestamp Action Category Detail
2019-06-29 Added TERM P-type transmembrane transporter activity
Timestamp Action Category Detail
2024-03-21 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2024-03-21 Deleted DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2020-12-11 Deleted DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
2020-12-11 Added DEFINITION Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and inorganic phosphate (Pi), the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol.
2019-06-29 Added SYNONYM E1-E2 ATPase
2019-06-29 Added SYNONYM P-type ATPase
2019-06-29 Added DEFINITION Primary transporter characterized by auto- (or self-) phosphorylation (hence P) of a key conserved aspartate residue. Catalyzes the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
Timestamp Action Category Detail
2019-06-29 Added RELATION is a GO:0042626 (ATPase-coupled transmembrane transporter activity)
Timestamp Action Category Detail
2021-04-24 Deleted XREF EC:7.2.2.-
2021-04-22 Added XREF EC:7.2.2.-
2020-12-11 Added XREF Wikipedia:P-type_ATPase
2019-06-29 Added XREF TC:3.A.3
Timestamp Action Category Detail
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