{"numberOfHits":1,"results":[{"id":"GO:0003906","isObsolete":false,"name":"DNA-(apurinic or apyrimidinic site) endonuclease activity","definition":{"text":"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).","xrefs":[{"dbCode":"Wikipedia","dbId":"AP_endonuclease"}]},"comment":"Note that this term is does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. Class II AP endonuclease is a nuclease, but not Class I, III and IV.","synonyms":[{"name":"apurinic deoxyendoribonuclease activity","type":"exact"},{"name":"UV endonuclease","type":"broad"},{"name":"apyrimidinic deoxyendoribonuclease activity","type":"exact"},{"name":"apurinic/apyrimidinic endodeoxyribonuclease activity","type":"exact"},{"name":"endonuclease VIII activity","type":"related"},{"name":"abasic deoxyendoribonuclease activity","type":"exact"},{"name":"deoxyribonuclease (apurinic or apyrimidinic) activity","type":"exact"},{"name":"AP deoxyendoribonuclease activity","type":"exact"}],"replaces":[{"id":"GO:0006286","type":"consider"},{"id":"GO:0008845","type":"consider"}],"children":[{"id":"GO:0052720","relation":"is_a"},{"id":"GO:0140078","relation":"is_a"}],"history":[{"timestamp":"2021-10-30","action":"Deleted","category":"RELATION","text":"is a GO:0004519 (endonuclease activity)"},{"timestamp":"2021-06-18","action":"Added","category":"RELATION","text":"is a GO:0004519 (endonuclease activity)"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-110375"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-5649711"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-5649725"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-5649725"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-110375"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-5649711"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-5649711"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-110375"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-5649725"},{"timestamp":"2018-03-10","action":"Deleted","category":"SYNONYM","text":"AP lyase activity"},{"timestamp":"2018-03-10","action":"Deleted","category":"XREF","text":"MetaCyc:4.2.99.18-RXN"},{"timestamp":"2018-03-10","action":"Deleted","category":"XREF","text":"EC:4.2.99.18"},{"timestamp":"2018-03-10","action":"Deleted","category":"RELATION","text":"is a GO:0016835 (carbon-oxygen lyase activity)"},{"timestamp":"2018-03-10","action":"Added","category":"SYNONYM","text":"AP deoxyendoribonuclease activity"},{"timestamp":"2018-03-10","action":"Added","category":"SYNONYM","text":"abasic deoxyendoribonuclease activity"},{"timestamp":"2018-03-10","action":"Added","category":"SYNONYM","text":"apurinic deoxyendoribonuclease activity"},{"timestamp":"2018-03-10","action":"Added","category":"SYNONYM","text":"apyrimidinic deoxyendoribonuclease activity"},{"timestamp":"2018-03-10","action":"Added","category":"SYNONYM","text":"apurinic/apyrimidinic endodeoxyribonuclease activity"},{"timestamp":"2018-03-10","action":"Deleted","category":"SYNONYM","text":"DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity"},{"timestamp":"2018-03-10","action":"Deleted","category":"SYNONYM","text":"endodeoxyribonuclease (apurinic or apyrimidinic) activity"},{"timestamp":"2018-03-10","action":"Deleted","category":"SYNONYM","text":"AP site-DNA 5'-phosphomonoester-lyase activity"},{"timestamp":"2018-03-10","action":"Updated","category":"TERM","text":"DNA-(apurinic or apyrimidinic site) endonuclease activity"},{"timestamp":"2017-09-19","action":"Added","category":"RELATION","text":"is a GO:0140097 (catalytic activity, acting on DNA)"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"AP endonuclease class I activity"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"micrococcus luteus UV endonuclease"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"phage-T4 UV endonuclease"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"Micrococcus luteus UV endonuclease activity"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"Phage-T(4) UV endonuclease activity"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"E. coli endonuclease III activity"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"X-ray endonuclease III"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"Phage-T4 UV endonuclease activity"},{"timestamp":"2017-07-28","action":"Deleted","category":"SYNONYM","text":"E. coli endonuclease III"},{"timestamp":"2017-07-28","action":"Added","category":"SYNONYM","text":"UV endonuclease"},{"timestamp":"2017-07-28","action":"Deleted","category":"DEFINITION","text":"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate."},{"timestamp":"2017-07-28","action":"Added","category":"DEFINITION","text":"Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)."},{"timestamp":"2017-07-28","action":"Deleted","category":"RELATION","text":"is a GO:0004520 (DNA endonuclease activity)"},{"timestamp":"2014-01-29","action":"Added","category":"RELATION","text":"is a GO:0004520 (DNA endonuclease activity)"},{"timestamp":"2008-11-07","action":"Deleted","category":"SYNONYM","text":"E.coli endonuclease III activity"},{"timestamp":"2008-11-07","action":"Added","category":"SYNONYM","text":"E. coli endonuclease III activity"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016835 (carbon-oxygen lyase activity)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"micrococcus luteus UV endonuclease"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"phage-T4 UV endonuclease"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"X-ray endonuclease III"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"E. coli endonuclease III"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"AP site-DNA 5'-phosphomonoester-lyase activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"Phage-T4 UV endonuclease activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"endodeoxyribonuclease (apurinic or apyrimidinic) activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"Phage-T(4) UV endonuclease activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"AP endonuclease class I activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"AP lyase activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"Micrococcus luteus UV endonuclease activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"E.coli endonuclease III activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"deoxyribonuclease (apurinic or apyrimidinic) activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"endonuclease VIII activity"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"endonuclease VIII activity"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"endonuclease VIII activity"},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:4.2.99.18-RXN"},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"DNA-(apurinic or apyrimidinic site) lyase activity"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"DNA-(apurinic or apyrimidinic site) lyase"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"DNA-(apurinic or apyrimidinic site) lyase"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"DNA-(apurinic or apyrimidinic site) lyase"},{"timestamp":"2001-03-30","action":"Added","category":"XREF","text":"EC:4.2.99.18"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR000214","name":"Zinc finger, DNA glycosylase/AP lyase-type"},{"dbCode":"InterPro","dbId":"IPR005759","name":"Endonuclease III"},{"dbCode":"InterPro","dbId":"IPR012092","name":"8-oxoguanine DNA glycosylase/AP lyase Ogg"},{"dbCode":"InterPro","dbId":"IPR012319","name":"Formamidopyrimidine-DNA glycosylase, catalytic domain"},{"dbCode":"InterPro","dbId":"IPR015254","name":"N-glycosylase/DNA lyase-like"},{"dbCode":"InterPro","dbId":"IPR015886","name":"DNA glycosylase/AP lyase, H2TH DNA-binding"},{"dbCode":"InterPro","dbId":"IPR015887","name":"DNA glycosylase/AP lyase, zinc finger domain, DNA-binding site"},{"dbCode":"InterPro","dbId":"IPR016544","name":"N-glycosylase/DNA lyase"},{"dbCode":"InterPro","dbId":"IPR020629","name":"Formamidopyrimidine-DNA glycosylase"},{"dbCode":"InterPro","dbId":"IPR030841","name":"Endonuclease III-like protein 1"},{"dbCode":"InterPro","dbId":"IPR039253","name":"Aprataxin and PNK-like factor"},{"dbCode":"InterPro","dbId":"IPR047587","name":"DNA-(apurinic or apyrimidinic site) endonuclease"},{"dbCode":"Reactome","dbId":"R-HSA-110375"},{"dbCode":"Reactome","dbId":"R-HSA-5649711"},{"dbCode":"Reactome","dbId":"R-HSA-5649725"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0003906","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0003906","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"Q5NVR0","taxonId":"9601","entityName":"HMCES_PONAB","ancestorGoId":"GO:0003906"},{"goId":"GO:0003906","reason":"2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096","category":"NOT-qualified 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manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0003906","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8R1M0","taxonId":"10090","entityName":"HMCES_MOUSE","ancestorGoId":"GO:0003906"},{"goId":"GO:0003906","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:30554877","category":"NOT-qualified manual","entityType":"protein","entityId":"Q96FZ2","taxonId":"9606","entityName":"HMCES_HUMAN","ancestorGoId":"GO:0003906"}]}],"pageInfo":null}