{"numberOfHits":1,"results":[{"id":"GO:0003972","isObsolete":false,"name":"RNA ligase (ATP) activity","definition":{"text":"Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate.","xrefs":[{"dbCode":"EC","dbId":"6.5.1.3"}]},"synonyms":[{"name":"polyribonucleotide synthase (ATP) activity","type":"related"},{"name":"ribonucleic ligase activity","type":"broad"},{"name":"polyribonucleotide ligase activity","type":"related"},{"name":"poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)","type":"related"}],"history":[{"timestamp":"2024-03-28","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + (ribonucleotide)n-3'-hydroxyl + 5'-phospho-(ribonucleotide)m = (ribonucleotide)n+m + AMP + diphosphate."},{"timestamp":"2024-03-28","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)."},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"polyribonucleotide ligase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"polyribonucleotide synthase (ATP) activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"polyribonucleotide synthase (ATP) activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"polyribonucleotide ligase activity"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-5696816"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-5696816"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-5696816"},{"timestamp":"2010-09-03","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)."},{"timestamp":"2010-09-03","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)."},{"timestamp":"2009-05-21","action":"Added","category":"XREF","text":"MetaCyc:RNA-LIGASE-ATP-RXN"},{"timestamp":"2009-05-21","action":"Deleted","category":"XREF","text":"MetaCyc:RNA-LIGASE-(ATP)-RXN"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0008452 (RNA ligase activity)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"polyribonucleotide ligase activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"polyribonucleotide synthase (ATP) activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"ribonucleic ligase activity"},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:RNA-LIGASE-(ATP)-RXN"},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"RNA ligase (ATP) activity"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"RNA ligase (ATP)"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"RNA ligase (ATP)"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"RNA ligase (ATP)"},{"timestamp":"2001-03-30","action":"Added","category":"XREF","text":"EC:6.5.1.3"}],"xRefs":[{"dbCode":"EC","dbId":"6.5.1.3"},{"dbCode":"InterPro","dbId":"IPR012387","name":"tRNA ligase Trl1, fungi"},{"dbCode":"InterPro","dbId":"IPR012647","name":"RNA ligase, Rnl2"},{"dbCode":"InterPro","dbId":"IPR012648","name":"T4 RNA ligase 1"},{"dbCode":"InterPro","dbId":"IPR015965","name":"tRNA ligase, phosphodiesterase"},{"dbCode":"InterPro","dbId":"IPR015966","name":"tRNA ligase, kinase domain, fungi"},{"dbCode":"InterPro","dbId":"IPR038837","name":"tRNA ligase 1"},{"dbCode":"InterPro","dbId":"IPR041211","name":"RNA ligase 1"},{"dbCode":"InterPro","dbId":"IPR044263","name":"RNA ligase 2, viral"},{"dbCode":"MetaCyc","dbId":"RNA-LIGASE-ATP-RXN"},{"dbCode":"Reactome","dbId":"R-HSA-5696816"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8I5Y5Z6","taxonId":"10116","entityName":"A0A8I5Y5Z6_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8I6A2T0","taxonId":"10116","entityName":"A0A8I6A2T0_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A6I4N6","taxonId":"10116","entityName":"A6I4N6_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"F7EEB9","taxonId":"10116","entityName":"F7EEB9_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410","category":"NOT-qualified manual","entityType":"protein","entityId":"Q13426","taxonId":"9606","entityName":"XRCC4_HUMAN","ancestorGoId":"GO:0016874"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KGG1","taxonId":"7227","entityName":"Q7KGG1_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SIE0","taxonId":"9103","entityName":"ARLY1_MELGA","ancestorGoId":"GO:0003824"},{"goId":"GO:0003972","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"}]}],"pageInfo":null}