{"numberOfHits":1,"results":[{"id":"GO:0004354","isObsolete":false,"name":"glutamate dehydrogenase (NADP+) activity","definition":{"text":"Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+.","xrefs":[{"dbCode":"EC","dbId":"1.4.1.4"}]},"comment":"Note that this term has a MetaCyc pathway reference as the pathway only has a single step.","synonyms":[{"name":"L-glutamate dehydrogenase","type":"broad"},{"name":"L-glutamic acid dehydrogenase activity","type":"related"},{"name":"NAD(P)-glutamate dehydrogenase activity","type":"related"},{"name":"NAD(P)H-dependent glutamate dehydrogenase activity","type":"related"},{"name":"L-glutamate:NADP+ oxidoreductase (deaminating)","type":"related"},{"name":"glutamic dehydrogenase activity","type":"broad"},{"name":"glutamic acid dehydrogenase","type":"broad"},{"name":"dehydrogenase, glutamate (nicotinamide adenine dinucleotide 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(deaminating)"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"L-glutamate:NADP+ oxidoreductase (deaminating)"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"NAD(P)H-dependent glutamate dehydrogenase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"L-glutamic acid dehydrogenase activity"},{"timestamp":"2018-07-13","action":"Deleted","category":"XREF","text":"RHEA:11615"},{"timestamp":"2018-07-13","action":"Added","category":"XREF","text":"RHEA:11612"},{"timestamp":"2017-07-12","action":"Deleted","category":"RELATION","text":"is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)"},{"timestamp":"2017-07-12","action":"Added","category":"RELATION","text":"is a GO:0004353 (glutamate dehydrogenase [NAD(P)+] activity)"},{"timestamp":"2011-09-16","action":"Added","category":"XREF","text":"RHEA:11615"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016639 (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"NAD(P)H-dependent glutamate dehydrogenase activity"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"L-glutamate:NADP+ oxidoreductase (deaminating)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"glutamic acid dehydrogenase"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"L-glutamic acid dehydrogenase activity"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"NAD(P)-glutamate dehydrogenase activity"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"L-glutamate dehydrogenase"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"glutamic dehydrogenase activity"},{"timestamp":"2007-07-19","action":"Added","category":"XREF","text":"MetaCyc:GLUTSYNIII-PWY"},{"timestamp":"2004-01-07","action":"Updated","category":"TERM","text":"glutamate dehydrogenase (NADP+) activity"},{"timestamp":"2003-10-30","action":"Updated","category":"DEFINITION","text":"Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+."},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:GLUTDEHYD-RXN"},{"timestamp":"2003-09-06","action":"Updated","category":"TERM","text":"glutamate dehydrogenase (NADP) activity"},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"glutamate dehydrogenase (NADP+) activity"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + ammonia + NADPH + H+."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"glutamate dehydrogenase (NADP+)"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"glutamate dehydrogenase (NADP+)"},{"timestamp":"2001-03-30","action":"Added","category":"XREF","text":"EC:1.4.1.4"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"glutamate dehydrogenase (NADP+)"}],"xRefs":[{"dbCode":"EC","dbId":"1.4.1.4"},{"dbCode":"MetaCyc","dbId":"GLUTDEHYD-RXN"},{"dbCode":"MetaCyc","dbId":"GLUTSYNIII-PWY"},{"dbCode":"RHEA","dbId":"11612"}],"xRelations":[{"id":"CHEBI:15377","term":"water","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15377","relation":"has_participant"},{"id":"CHEBI:15378","term":"hydron","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15378","relation":"has_participant"},{"id":"CHEBI:58349","term":"NADP(3-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58349","relation":"has_participant"},{"id":"CHEBI:16810","term":"2-oxoglutarate(2-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16810","relation":"has_participant"},{"id":"CHEBI:28938","term":"ammonium","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:28938","relation":"has_participant"},{"id":"CHEBI:57783","term":"NADPH(4-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57783","relation":"has_participant"},{"id":"CHEBI:29985","term":"L-glutamate(1-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:29985","relation":"has_participant"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0004354","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. 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