{"numberOfHits":1,"results":[{"id":"GO:0004822","isObsolete":false,"name":"isoleucine-tRNA ligase activity","definition":{"text":"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+.","xrefs":[{"dbCode":"EC","dbId":"6.1.1.5"},{"dbCode":"RHEA","dbId":"11060"}]},"synonyms":[{"name":"isoleucine-tRNA synthetase activity","type":"related"},{"name":"isoleucyl-transfer RNA synthetase activity","type":"related"},{"name":"isoleucyl-transfer ribonucleate synthetase activity","type":"related"},{"name":"isoleucine-transfer RNA ligase activity","type":"related"},{"name":"L-isoleucine:tRNAIle ligase (AMP-forming)","type":"related"},{"name":"isoleucyl-tRNA synthetase activity","type":"exact"},{"name":"isoleucine translase activity","type":"related"}],"history":[{"timestamp":"2022-09-01","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)."},{"timestamp":"2022-09-01","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H+."},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"isoleucine-tRNA synthetase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"isoleucine-transfer RNA ligase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"isoleucine-tRNA synthetase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"isoleucine translase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"isoleucine translase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"L-isoleucine:tRNAIle ligase (AMP-forming)"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"isoleucyl-transfer ribonucleate synthetase 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activity"},{"timestamp":"2019-06-20","action":"Deleted","category":"XREF","text":"KEGG:R03656"},{"timestamp":"2019-06-20","action":"Added","category":"XREF","text":"KEGG_REACTION:R03656"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-379893"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-380176"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-380176"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-379893"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-379893"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-380176"},{"timestamp":"2018-07-13","action":"Added","category":"XREF","text":"RHEA:11060"},{"timestamp":"2018-07-13","action":"Deleted","category":"XREF","text":"RHEA:11063"},{"timestamp":"2010-10-11","action":"Added","category":"XREF","text":"KEGG:R03656"},{"timestamp":"2010-10-11","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)."},{"timestamp":"2010-10-11","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)."},{"timestamp":"2010-10-11","action":"Added","category":"XREF","text":"RHEA:11063"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0004812 (aminoacyl-tRNA ligase activity)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"isoleucyl-transfer ribonucleate synthetase 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activity"},{"timestamp":"2003-12-16","action":"Added","category":"SYNONYM","text":"isoleucyl-tRNA synthetase activity"},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN"},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"isoleucine-tRNA ligase activity"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"isoleucine-tRNA ligase"},{"timestamp":"2001-11-07","action":"Updated","category":"TERM","text":"isoleucine-tRNA ligase"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"isoleucine--tRNA ligase"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"isoleucine--tRNA 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