{"numberOfHits":1,"results":[{"id":"GO:0006590","isObsolete":false,"name":"thyroid hormone generation","definition":{"text":"The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.","xrefs":[{"dbCode":"ISBN","dbId":"0716720094"}]},"comment":"Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.","children":[{"id":"GO:2000611","relation":"positively_regulates"},{"id":"GO:2000610","relation":"negatively_regulates"},{"id":"GO:2000609","relation":"regulates"}],"history":[{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0042403 (thyroid hormone metabolic process)"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones."},{"timestamp":"2002-08-01","action":"Updated","category":"TERM","text":"thyroid hormone generation"},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"thyroid hormone biosynthesis"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"thyroid hormone biosynthesis"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"thyroid hormone biosynthesis"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR029589","name":"Thyroid peroxidase"},{"dbCode":"InterPro","dbId":"IPR035689","name":"Sodium/iodide cotransporter"}],"taxonConstraints":[{"ancestorId":"GO:0006590","ancestorName":"thyroid hormone generation","relationship":"never_in_taxon","taxId":"4895","taxIdType":"NCBITaxon","taxName":"Schizosaccharomyces"}],"aspect":"biological_process","usage":"Unrestricted"}],"pageInfo":null}