{"numberOfHits":1,"results":[{"id":"GO:0008191","isObsolete":false,"name":"metalloendopeptidase inhibitor activity","definition":{"text":"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},"synonyms":[{"name":"metalloproteinase inhibitor","type":"narrow"},{"name":"metalloprotease inhibitor","type":"narrow"}],"history":[{"timestamp":"2021-02-17","action":"Added","category":"DEFINITION","text":"Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2021-02-17","action":"Deleted","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2016-04-14","action":"Deleted","category":"RELATION","text":"is a GO:0048551 (metalloenzyme inhibitor activity)"},{"timestamp":"2016-02-14","action":"Added","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2016-02-14","action":"Deleted","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2016-02-14","action":"Deleted","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2016-02-14","action":"Added","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2010-06-15","action":"Added","category":"RELATION","text":"negatively regulates GO:0004222 (metalloendopeptidase activity)"},{"timestamp":"2010-06-14","action":"Deleted","category":"RELATION","text":"negatively regulates GO:0004222 (metalloendopeptidase activity)"},{"timestamp":"2010-06-08","action":"Added","category":"RELATION","text":"negatively regulates GO:0004222 (metalloendopeptidase activity)"},{"timestamp":"2009-03-16","action":"Added","category":"RELATION","text":"is a GO:0048551 (metalloenzyme inhibitor activity)"},{"timestamp":"2009-02-25","action":"Deleted","category":"RELATION","text":"negatively regulates GO:0004222 (metalloendopeptidase activity)"},{"timestamp":"2009-02-22","action":"Added","category":"RELATION","text":"negatively regulates GO:0004222 (metalloendopeptidase activity)"},{"timestamp":"2008-08-18","action":"Deleted","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2008-08-18","action":"Added","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0004866 (endopeptidase inhibitor activity)"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2004-04-19","action":"Added","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2004-04-19","action":"Added","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2004-04-16","action":"Deleted","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2004-04-16","action":"Deleted","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2004-01-08","action":"Added","category":"DEFINITION","text":"Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide linkages in oligopeptides or polypeptides and contain a chelated metal ion at their active sites which is essential to their catalytic activity."},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"metalloendopeptidase inhibitor activity"},{"timestamp":"2003-03-19","action":"Deleted","category":"SYNONYM","text":"metalloendopeptidase inhibitor"},{"timestamp":"2002-07-09","action":"Added","category":"SYNONYM","text":"metalloprotease inhibitor"},{"timestamp":"2002-07-09","action":"Added","category":"SYNONYM","text":"metalloproteinase inhibitor"},{"timestamp":"2002-07-09","action":"Updated","category":"TERM","text":"metalloendopeptidase inhibitor"},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"metalloprotease inhibitor"},{"timestamp":"2001-08-22","action":"Added","category":"SYNONYM","text":"metalloendopeptidase inhibitor"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"metalloprotease inhibitor"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"metalloprotease inhibitor"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR001820","name":"Protease inhibitor I35 (TIMP)"},{"dbCode":"InterPro","dbId":"IPR019509","name":"Carboxypeptidase inhibitor I68"},{"dbCode":"InterPro","dbId":"IPR022815","name":"Protease inhibitor"},{"dbCode":"InterPro","dbId":"IPR032767","name":"Ascaris metallocarboxypeptidase inhibitor"},{"dbCode":"InterPro","dbId":"IPR039016","name":"Reversion-inducing cysteine-rich protein with Kazal motifs"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"A1Z6V5","taxonId":"7227","entityName":"A1Z6V5_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"C0PVD9","taxonId":"7227","entityName":"C0PVD9_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"M9NEE3","taxonId":"7227","entityName":"M9NEE3_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:9126838","category":"NOT-qualified manual","entityType":"protein","entityId":"P01012","taxonId":"9031","entityName":"OVAL_CHICK","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:16039755","category":"NOT-qualified manual","entityType":"protein","entityId":"P84995","taxonId":"5315","entityName":"GANOD_GANLU","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q3HKQ3","taxonId":"7227","entityName":"Q3HKQ3_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q4V3G2","taxonId":"7227","entityName":"Q4V3G2_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q4V3R8","taxonId":"7227","entityName":"Q4V3R8_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7K1P6","taxonId":"7227","entityName":"Q7K1P6_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7K508","taxonId":"7227","entityName":"Q7K508_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8SYY7","taxonId":"7227","entityName":"Q8SYY7_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9U5W8","taxonId":"7227","entityName":"Q9U5W8_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VA48","taxonId":"7227","entityName":"Q9VA48_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VH46","taxonId":"7227","entityName":"Q9VH46_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VL44","taxonId":"7227","entityName":"Q9VL44_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VLV3","taxonId":"7227","entityName":"Q9VLV3_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VPH9","taxonId":"7227","entityName":"Q9VPH9_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VVW1","taxonId":"7227","entityName":"A76A_DROME","ancestorGoId":"GO:0030414"},{"goId":"GO:0008191","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:19849829","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VWB4","taxonId":"7227","entityName":"Q9VWB4_DROME","ancestorGoId":"GO:0030414"}]}],"pageInfo":null}