{"numberOfHits":1,"results":[{"id":"GO:0008922","isObsolete":false,"name":"long-chain fatty acid [acyl-carrier-protein] ligase activity","definition":{"text":"Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.","xrefs":[{"dbCode":"EC","dbId":"6.2.1.20"}]},"comment":"While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283).","synonyms":[{"name":"acyl-[acyl-carrier-protein] synthetase activity","type":"related"},{"name":"long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity","type":"related"},{"name":"long-chain-fatty-acid-acyl-carrier-protein ligase activity","type":"related"},{"name":"acyl-acyl-carrier-proteinsynthetase activity","type":"related"},{"name":"long-chain-fatty-acid-[acyl-carrier protein] ligase activity","type":"exact"},{"name":"acyl-acyl-carrier-protein synthetase activity","type":"related"},{"name":"long-chain-fatty-acid-ACP ligase activity","type":"exact"},{"name":"stearoyl-ACP synthetase activity","type":"related"},{"name":"long-chain-fatty-acid-[acyl-carrier-protein] ligase activity","type":"exact"},{"name":"long-chain fatty acid-[acyl-carrier-protein] ligase activity","type":"exact"},{"name":"acyl-acyl carrier protein synthetase","type":"broad"},{"name":"acyl-ACP synthetase activity","type":"exact"}],"replaces":[{"id":"GO:0103062","type":"replaced_by"}],"secondaryIds":["GO:0010300"],"history":[{"timestamp":"2023-12-15","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."},{"timestamp":"2023-12-15","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: a long-chain fatty acid + ATP + holo-[ACP] = a long-chain fatty acyl-[ACP] + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons."},{"timestamp":"2023-01-18","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is a fatty acid with an aliphatic tail of 13 to 21 carbons."},{"timestamp":"2023-01-18","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22."},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"acyl-acyl-carrier-proteinsynthetase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"acyl-acyl-carrier-protein synthetase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"acyl-acyl-carrier-proteinsynthetase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"stearoyl-ACP synthetase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"acyl-acyl-carrier-protein synthetase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-acyl-carrier-protein ligase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"long-chain-fatty-acid-acyl-carrier-protein ligase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"stearoyl-ACP synthetase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"acyl-[acyl-carrier-protein] synthetase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"acyl-[acyl-carrier-protein] synthetase activity"},{"timestamp":"2020-06-22","action":"Added","category":"XREF","text":"RHEA:45588"},{"timestamp":"2019-06-20","action":"Deleted","category":"XREF","text":"KEGG:R07325"},{"timestamp":"2019-06-20","action":"Added","category":"XREF","text":"KEGG_REACTION:R07325"},{"timestamp":"2018-03-05","action":"Deleted","category":"RELATION","text":"is a GO:0016878 (acid-thiol ligase activity)"},{"timestamp":"2012-06-20","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18."},{"timestamp":"2012-06-20","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22."},{"timestamp":"2012-02-04","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18."},{"timestamp":"2012-02-04","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]."},{"timestamp":"2011-05-03","action":"Added","category":"XREF","text":"KEGG:R07325"},{"timestamp":"2010-05-13","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-[acyl-carrier-protein] ligase activity"},{"timestamp":"2010-05-13","action":"Updated","category":"TERM","text":"long-chain fatty acid [acyl-carrier-protein] ligase activity"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0015645 (fatty acid ligase activity)"},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016878 (acid-thiol ligase activity)"},{"timestamp":"2008-01-07","action":"Added","category":"SYNONYM","text":"long-chain fatty acid-[acyl-carrier-protein] ligase activity"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"acyl-acyl-carrier-protein synthetase activity"},{"timestamp":"2007-12-14","action":"Added","category":"SECONDARY","text":"GO:0010300 (acyl-ACP synthetase activity)"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"acyl-acyl-carrier-proteinsynthetase activity"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-acyl-carrier-protein ligase activity"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"stearoyl-ACP synthetase activity"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"acyl-acyl carrier protein synthetase"},{"timestamp":"2007-12-14","action":"Added","category":"SYNONYM","text":"acyl-ACP synthetase activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"acyl-[acyl-carrier-protein] synthetase activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-ACP ligase activity"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-[acyl-carrier protein] ligase activity"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"long-chain-fatty-acid-[acyl-carrier protein] ligase activity"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"long-chain-fatty-acid-ACP ligase activity"},{"timestamp":"2006-11-25","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-[acyl-carrier protein] ligase activity"},{"timestamp":"2006-11-25","action":"Updated","category":"TERM","text":"long-chain-fatty-acid-[acyl-carrier-protein] ligase activity"},{"timestamp":"2004-04-19","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-ACP ligase activity"},{"timestamp":"2004-04-16","action":"Deleted","category":"SYNONYM","text":"long-chain-fatty-acid-ACP ligase activity"},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:ACYLACPSYNTH-RXN"},{"timestamp":"2003-10-27","action":"Added","category":"SYNONYM","text":"long-chain-fatty-acid-ACP ligase activity"},{"timestamp":"2003-10-24","action":"Updated","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]."},{"timestamp":"2003-09-06","action":"Updated","category":"TERM","text":"long-chain-fatty-acid-[acyl-carrier protein] ligase activity"},{"timestamp":"2003-04-24","action":"Updated","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + (acyl-carrier protein) = AMP + diphosphate + acyl-(acyl-carrier protein)."},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"long-chain-fatty-acid-acyl-carrier protein ligase activity"},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"long-chain-fatty-acid-acyl-carrier protein ligase"},{"timestamp":"2001-11-07","action":"Updated","category":"TERM","text":"long-chain-fatty-acid-acyl-carrier protein ligase"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"long-chain-fatty-acid--acyl-carrier protein ligase"},{"timestamp":"2001-03-30","action":"Added","category":"XREF","text":"EC:6.2.1.20"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"long-chain-fatty-acid--acyl-carrier protein ligase"}],"xRefs":[{"dbCode":"EC","dbId":"6.2.1.20"},{"dbCode":"InterPro","dbId":"IPR023775","name":"Bifunctional protein Aas"},{"dbCode":"KEGG_REACTION","dbId":"R07325"},{"dbCode":"MetaCyc","dbId":"ACYLACPSYNTH-RXN"},{"dbCode":"RHEA","dbId":"45588"}],"xRelations":[{"id":"CHEBI:133243","term":"O-[S-(long-chain fatty acyl)pantetheine-4'-phosphoryl]serine(1-) residue","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:133243","relation":"has_participant"},{"id":"CHEBI:64479","term":"O-(pantetheine-4'-phosphoryl)serine(1-) residue","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:64479","relation":"has_participant"},{"id":"CHEBI:456215","term":"adenosine 5'-monophosphate(2-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:456215","relation":"has_participant"},{"id":"CHEBI:33019","term":"diphosphate(3-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:33019","relation":"has_participant"},{"id":"CHEBI:57560","term":"long-chain fatty acid anion","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57560","relation":"has_participant"},{"id":"CHEBI:30616","term":"ATP(4-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:30616","relation":"has_participant"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8I5Y5Z6","taxonId":"10116","entityName":"A0A8I5Y5Z6_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A8I6A2T0","taxonId":"10116","entityName":"A0A8I6A2T0_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A6I4N6","taxonId":"10116","entityName":"A6I4N6_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"F7EEB9","taxonId":"10116","entityName":"F7EEB9_RAT","ancestorGoId":"GO:0016874"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410","category":"NOT-qualified manual","entityType":"protein","entityId":"Q13426","taxonId":"9606","entityName":"XRCC4_HUMAN","ancestorGoId":"GO:0016874"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KGG1","taxonId":"7227","entityName":"Q7KGG1_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SIE0","taxonId":"9103","entityName":"ARLY1_MELGA","ancestorGoId":"GO:0003824"},{"goId":"GO:0008922","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"}]}],"pageInfo":null}