{"numberOfHits":1,"results":[{"id":"GO:0016592","isObsolete":false,"name":"mediator complex","definition":{"text":"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.","xrefs":[{"dbCode":"PMID","dbId":"11454195"},{"dbCode":"PMID","dbId":"16168358"},{"dbCode":"PMID","dbId":"17870225"}]},"synonyms":[{"name":"TRAP complex","type":"narrow"},{"name":"L mediator complex","type":"exact"},{"name":"CDK8-containing TRAP/mediator complex","type":"related"},{"name":"Srb-mediator complex","type":"exact"}],"secondaryIds":["GO:0000119"],"history":[{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"in_taxon NCBITaxon:2759 (Eukaryota)"},{"timestamp":"2020-11-03","action":"Deleted","category":"RELATION","text":"is a GO:0032991 (protein-containing complex)"},{"timestamp":"2020-11-03","action":"Added","category":"RELATION","text":"is a GO:0140513 (nuclear protein-containing complex)"},{"timestamp":"2020-11-03","action":"Deleted","category":"RELATION","text":"part of GO:0005654 (nucleoplasm)"},{"timestamp":"2019-09-12","action":"Added","category":"RELATION","text":"part of GO:0005654 (nucleoplasm)"},{"timestamp":"2019-09-12","action":"Deleted","category":"RELATION","text":"is a GO:0044451 (obsolete nucleoplasm part)"},{"timestamp":"2018-02-18","action":"Added","category":"RELATION","text":"is a GO:0032991 (protein-containing complex)"},{"timestamp":"2018-02-18","action":"Deleted","category":"RELATION","text":"is a GO:0043234 (protein complex)"},{"timestamp":"2012-03-17","action":"Added","category":"RELATION","text":"has part GO:0002929 (MECO complex)"},{"timestamp":"2009-08-06","action":"Deleted","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2009-08-06","action":"Added","category":"DEFINITION","text":"A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins."},{"timestamp":"2009-08-06","action":"Updated","category":"TERM","text":"mediator complex"},{"timestamp":"2009-08-06","action":"Added","category":"SYNONYM","text":"CDK8-containing TRAP/mediator complex"},{"timestamp":"2009-08-06","action":"Added","category":"SECONDARY","text":"GO:0000119 (mediator complex)"},{"timestamp":"2009-08-06","action":"Added","category":"SYNONYM","text":"TRAP complex"},{"timestamp":"2009-08-06","action":"Added","category":"SYNONYM","text":"Srb-mediator complex"},{"timestamp":"2009-08-06","action":"Deleted","category":"SYNONYM","text":"CDK8-containing TRAP/mediator complex"},{"timestamp":"2009-08-06","action":"Added","category":"XREF","text":"Wikipedia:Mediator_(coactivator)"},{"timestamp":"2008-06-07","action":"Deleted","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2008-06-07","action":"Added","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0043234 (protein complex)"},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0044451 (obsolete nucleoplasm part)"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"L mediator complex"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"CDK8-containing TRAP/mediator complex"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"L mediator complex"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"CDK8-containing TRAP/mediator complex"},{"timestamp":"2007-07-23","action":"Added","category":"SYNONYM","text":"L mediator complex"},{"timestamp":"2007-07-23","action":"Added","category":"SYNONYM","text":"CDK8-containing TRAP/mediator complex"},{"timestamp":"2004-12-01","action":"Updated","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16 polypeptides: Srb2, -4, -5, -6, and -7, Med1, -2, -4, -6, -7, and -8, Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2004-11-26","action":"Added","category":"DEFINITION","text":"A multiprotein transcriptional mediator complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and is essential for transcription of most protein-coding genes. The Saccharomyces complex contains a core of core complex consists of 16�polypeptides: Srb2, -4,�-5,�-6,�and -7, Med1, -2,�-4,�-6,�-7,�and -8,�Gal11, Sin4, Rgr1, Rox3, and Pgd1 proteins; mammalian Srb-mediator complexes include homologs of yeast Srb and Med proteins."},{"timestamp":"2002-02-06","action":"Updated","category":"TERM","text":"Srb-mediator complex"},{"timestamp":"2001-04-03","action":"Updated","category":"TERM","text":"Srb-mediator complex"},{"timestamp":"2001-03-30","action":"Added","category":"TERM","text":"Srb-mediator complex"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR007018","name":"Mediator complex, subunit Med6"},{"dbCode":"InterPro","dbId":"IPR008626","name":"Mediator complex, subunit Med15, fungi"},{"dbCode":"InterPro","dbId":"IPR008831","name":"Mediator complex, subunit Med31"},{"dbCode":"InterPro","dbId":"IPR009244","name":"Mediator complex, subunit Med7"},{"dbCode":"InterPro","dbId":"IPR009332","name":"Mediator of RNA polymerase II transcription subunit 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