{"numberOfHits":1,"results":[{"id":"GO:0019786","isObsolete":false,"name":"protein-phosphatidylethanolamide deconjugating activity","definition":{"text":"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue.","xrefs":[{"dbCode":"PMID","dbId":"22240591"},{"dbCode":"PMID","dbId":"22652539"},{"dbCode":"PMID","dbId":"28330855"},{"dbCode":"PMID","dbId":"2882172"},{"dbCode":"PMID","dbId":"28901328"}]},"synonyms":[{"name":"ATG8-PE deconjugation activity","type":"narrow"},{"name":"Atg8-specific protease activity","type":"exact"},{"name":"APG8-specific protease activity","type":"narrow"},{"name":"ATG8-PE hydrolase activity","type":"narrow"},{"name":"Atg8-specific peptidase activity","type":"narrow"},{"name":"APG8-PE hydrolase","type":"related"}],"history":[{"timestamp":"2023-06-13","action":"Deleted","category":"SYNONYM","text":"APG8-specific protease activity"},{"timestamp":"2023-06-13","action":"Added","category":"SYNONYM","text":"Atg8-specific peptidase activity"},{"timestamp":"2023-06-13","action":"Deleted","category":"RELATION","text":"is a GO:0008234 (cysteine-type peptidase activity)"},{"timestamp":"2023-06-13","action":"Added","category":"SYNONYM","text":"ATG8-PE hydrolase activity"},{"timestamp":"2023-06-13","action":"Added","category":"SYNONYM","text":"ATG8-PE deconjugation activity"},{"timestamp":"2023-06-13","action":"Added","category":"SYNONYM","text":"APG8-specific protease activity"},{"timestamp":"2023-06-13","action":"Deleted","category":"RELATION","text":"is a GO:0019783 (ubiquitin-like protein peptidase activity)"},{"timestamp":"2023-06-13","action":"Added","category":"RELATION","text":"is a GO:0016787 (hydrolase activity)"},{"timestamp":"2023-06-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: [protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine. An example of this reaction is the removal of ATG8 from membranes to which it is covalently linked to a phosphatidylethanolamid via its terminal glycine residue."},{"timestamp":"2023-06-13","action":"Deleted","category":"DEFINITION","text":"A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated."},{"timestamp":"2023-06-13","action":"Updated","category":"TERM","text":"protein-phosphatidylethanolamide deconjugating activity"},{"timestamp":"2023-06-13","action":"Added","category":"RELATION","text":"is a GO:0140096 (catalytic activity, acting on a protein)"},{"timestamp":"2022-01-28","action":"Added","category":"RELATION","text":"is a GO:0008234 (cysteine-type peptidase activity)"},{"timestamp":"2022-01-28","action":"Added","category":"DEFINITION","text":"A thiol-dependent isopeptidase activity that cleaves APG8 from a target protein to which it is conjugated."},{"timestamp":"2022-01-28","action":"Added","category":"SYNONYM","text":"Atg8-specific protease activity"},{"timestamp":"2022-01-28","action":"Updated","category":"TERM","text":"Atg8-specific peptidase activity"},{"timestamp":"2022-01-28","action":"Deleted","category":"DEFINITION","text":"Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier."},{"timestamp":"2016-11-15","action":"Added","category":"RELATION","text":"has part GO:0000045 (autophagosome assembly)"},{"timestamp":"2014-06-08","action":"Updated","category":"TERM","text":"Atg8-specific protease activity"},{"timestamp":"2014-06-08","action":"Added","category":"SYNONYM","text":"APG8-specific protease activity"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0019783 (ubiquitin-like protein peptidase activity)"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"APG8-PE hydrolase"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"APG8-PE hydrolase"},{"timestamp":"2005-07-29","action":"Updated","category":"DEFINITION","text":"Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier."},{"timestamp":"2005-07-27","action":"Added","category":"DEFINITION","text":"Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier, from previously modified substrates."},{"timestamp":"2004-04-19","action":"Added","category":"SYNONYM","text":"APG8-PE hydrolase"},{"timestamp":"2004-04-05","action":"Deleted","category":"SYNONYM","text":"APG8-PE hydrolase"},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"APG8-specific protease activity"},{"timestamp":"2002-01-08","action":"Updated","category":"TERM","text":"APG8-specific protease"},{"timestamp":"2001-11-13","action":"Added","category":"SYNONYM","text":"APG8-PE hydrolase"},{"timestamp":"2001-11-13","action":"Added","category":"TERM","text":"APG8 specific protease"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR046792","name":"Peptidase C54, catalytic domain"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0019786","reason":"2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"E9PTA2","taxonId":"10116","entityName":"TRPM2_RAT","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27383051","category":"NOT-qualified manual","entityType":"protein","entityId":"O94759","taxonId":"9606","entityName":"TRPM2_HUMAN","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:10500113","category":"NOT-qualified manual","entityType":"protein","entityId":"Q62226","taxonId":"10090","entityName":"SHH_MOUSE","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"Q63673","taxonId":"10116","entityName":"SHH_RAT","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KGG1","taxonId":"7227","entityName":"Q7KGG1_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SIE0","taxonId":"9103","entityName":"ARLY1_MELGA","ancestorGoId":"GO:0003824"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"Q91YD4","taxonId":"10090","entityName":"TRPM2_MOUSE","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9NHA8","taxonId":"7227","entityName":"BGBP3_DROME","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9NHB0","taxonId":"7227","entityName":"GNBP1_DROME","ancestorGoId":"GO:0016787"},{"goId":"GO:0019786","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:10827089","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VVR4","taxonId":"7227","entityName":"BGBP2_DROME","ancestorGoId":"GO:0016787"}]}],"pageInfo":null}