{"numberOfHits":1,"results":[{"id":"GO:0019787","isObsolete":false,"name":"ubiquitin-like protein transferase activity","definition":{"text":"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein.","xrefs":[{"dbCode":"PMID","dbId":"10806345"},{"dbCode":"PMID","dbId":"10884686"}]},"synonyms":[{"name":"ubiquitin-like-protein ligase activity","type":"narrow"},{"name":"E2","type":"broad"},{"name":"small conjugating protein ligase activity","type":"narrow"},{"name":"ubiquitin-like conjugating enzyme activity","type":"narrow"},{"name":"small conjugating protein transferase activity","type":"exact"},{"name":"small protein conjugating enzyme activity","type":"narrow"},{"name":"E3","type":"related"}],"subsets":["goslim_pir","goslim_drosophila"],"children":[{"id":"GO:0004842","relation":"is_a"},{"id":"GO:0061659","relation":"is_a"},{"id":"GO:0042296","relation":"is_a"},{"id":"GO:0042294","relation":"is_a"},{"id":"GO:0019789","relation":"is_a"},{"id":"GO:0019777","relation":"is_a"},{"id":"GO:0019788","relation":"is_a"},{"id":"GO:0071568","relation":"is_a"},{"id":"GO:0019775","relation":"is_a"},{"id":"GO:0061650","relation":"is_a"},{"id":"GO:0072496","relation":"is_a"}],"secondaryIds":["GO:0008639","GO:0008640"],"history":[{"timestamp":"2023-06-13","action":"Deleted","category":"DEFINITION","text":"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."},{"timestamp":"2023-06-13","action":"Added","category":"RELATION","text":"is a GO:0140096 (catalytic activity, acting on a protein)"},{"timestamp":"2023-06-13","action":"Added","category":"SYNONYM","text":"E2"},{"timestamp":"2023-06-13","action":"Added","category":"DEFINITION","text":"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y = Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."},{"timestamp":"2023-06-13","action":"Deleted","category":"SYNONYM","text":"E2"},{"timestamp":"2023-02-10","action":"Added","category":"RELATION","text":"is a GO:0016755 (aminoacyltransferase activity)"},{"timestamp":"2023-02-10","action":"Deleted","category":"RELATION","text":"is a GO:0140096 (catalytic activity, acting on a protein)"},{"timestamp":"2023-02-10","action":"Deleted","category":"RELATION","text":"is a GO:0016740 (transferase activity)"},{"timestamp":"2019-11-09","action":"Added","category":"SUBSET","text":"goslim_drosophila"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-5678490"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-688137"},{"timestamp":"2019-04-01","action":"Deleted","category":"XREF","text":"reactome:R-HSA-5678490"},{"timestamp":"2019-04-01","action":"Added","category":"XREF","text":"Reactome:R-HSA-688137"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-5678490"},{"timestamp":"2018-12-11","action":"Added","category":"XREF","text":"reactome:R-HSA-688137"},{"timestamp":"2018-07-13","action":"Added","category":"SUBSET","text":"goslim_pir"},{"timestamp":"2017-09-19","action":"Added","category":"RELATION","text":"is a GO:0140096 (catalytic activity, acting on a protein)"},{"timestamp":"2015-01-24","action":"Added","category":"DEFINITION","text":"Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein."},{"timestamp":"2015-01-24","action":"Deleted","category":"DEFINITION","text":"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein."},{"timestamp":"2015-01-24","action":"Added","category":"SYNONYM","text":"small conjugating protein transferase activity"},{"timestamp":"2015-01-24","action":"Updated","category":"TERM","text":"ubiquitin-like protein transferase activity"},{"timestamp":"2014-11-08","action":"Added","category":"SYNONYM","text":"small conjugating protein ligase activity"},{"timestamp":"2014-11-08","action":"Added","category":"SYNONYM","text":"small protein conjugating enzyme activity"},{"timestamp":"2014-11-08","action":"Added","category":"SYNONYM","text":"E3"},{"timestamp":"2014-11-08","action":"Added","category":"SYNONYM","text":"E2"},{"timestamp":"2014-11-08","action":"Deleted","category":"SYNONYM","text":"small protein conjugating enzyme activity"},{"timestamp":"2014-11-08","action":"Deleted","category":"SYNONYM","text":"E2"},{"timestamp":"2014-11-08","action":"Added","category":"RELATION","text":"is a GO:0016740 (transferase activity)"},{"timestamp":"2014-11-08","action":"Updated","category":"TERM","text":"small conjugating protein transferase activity"},{"timestamp":"2014-11-08","action":"Deleted","category":"RELATION","text":"is a GO:0016881 (acid-amino acid ligase activity)"},{"timestamp":"2014-11-08","action":"Added","category":"DEFINITION","text":"Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-SCP + Y --> Y-SCP + X, where both X-SCP and Y-SCP are covalent linkages. SCP represents a small conjugating protein."},{"timestamp":"2014-11-08","action":"Deleted","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase."},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase."},{"timestamp":"2008-04-27","action":"Updated","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue. This function may be performed alone or in conjunction with an E3, ubiquitin-like protein ligase."},{"timestamp":"2008-04-17","action":"Deleted","category":"RELATION","text":"is a GO:0003824 (catalytic activity)"},{"timestamp":"2008-04-05","action":"Added","category":"RELATION","text":"is a GO:0003824 (catalytic activity)"},{"timestamp":"2008-04-01","action":"Added","category":"SYNONYM","text":"ubiquitin-like conjugating enzyme activity"},{"timestamp":"2008-04-01","action":"Added","category":"SYNONYM","text":"small protein conjugating enzyme activity"},{"timestamp":"2008-04-01","action":"Added","category":"SYNONYM","text":"E2"},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016881 (acid-amino acid ligase activity)"},{"timestamp":"2008-04-01","action":"Added","category":"SECONDARY","text":"GO:0008639 (small protein conjugating enzyme activity)"},{"timestamp":"2008-04-01","action":"Added","category":"SECONDARY","text":"GO:0008640 (ubiquitin-like conjugating enzyme activity)"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"ubiquitin-like-protein ligase activity"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"ubiquitin-like-protein ligase activity"},{"timestamp":"2006-08-25","action":"Updated","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugating protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue."},{"timestamp":"2006-08-22","action":"Updated","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue."},{"timestamp":"2006-08-20","action":"Added","category":"SYNONYM","text":"ubiquitin-like-protein ligase activity"},{"timestamp":"2006-08-20","action":"Updated","category":"TERM","text":"small conjugating protein ligase activity"},{"timestamp":"2006-08-18","action":"Added","category":"DEFINITION","text":"Catalysis of ATP-dependent isopeptide bond formation between the carboxy-terminal  residues of a small conjugahting protein such as ubiquitin or a ubiquitin-like protein, and a substrate lysine residue."},{"timestamp":"2003-03-19","action":"Updated","category":"TERM","text":"ubiquitin-like-protein ligase activity"},{"timestamp":"2001-11-13","action":"Added","category":"TERM","text":"ubiquitin-like-protein ligase"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR007135","name":"Ubiquitin-like-conjugating enzyme Atg3/Atg10"},{"dbCode":"Reactome","dbId":"R-HSA-5678490"},{"dbCode":"Reactome","dbId":"R-HSA-688137"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0019787","reason":"Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins.","category":"IEA Review","methodId":"IPR016093|IPR036300","entityType":"protein","entityId":"Q9VNA3","taxonId":"7227","entityName":"Q9VNA3_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"P53817","taxonId":"10116","entityName":"PLAT3_RAT","ancestorGoId":"GO:0016746"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q0E8K5","taxonId":"7227","entityName":"Q0E8K5_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7JY99","taxonId":"7227","entityName":"Q7JY99_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KGG1","taxonId":"7227","entityName":"Q7KGG1_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KV84","taxonId":"7227","entityName":"Q7KV84_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7SIE0","taxonId":"9103","entityName":"ARLY1_MELGA","ancestorGoId":"GO:0003824"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7YTX2","taxonId":"7227","entityName":"Q7YTX2_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8I939","taxonId":"7227","entityName":"Q8I939_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8I940","taxonId":"7227","entityName":"Q8I940_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8IGI3","taxonId":"7227","entityName":"Q8IGI3_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8MZ84","taxonId":"7227","entityName":"Q8MZ84_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18614531","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8R3U1","taxonId":"10090","entityName":"PLAT3_MOUSE","ancestorGoId":"GO:0016746"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8SXB5","taxonId":"7227","entityName":"Q8SXB5_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:18799622","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9H8T0","taxonId":"9606","entityName":"AKTIP_HUMAN","ancestorGoId":"GO:0019787"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q9VZV9","taxonId":"7227","entityName":"Q9VZV9_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0019787","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"X2J8G3","taxonId":"7227","entityName":"X2J8G3_DROME","ancestorGoId":"GO:0016740"}]}],"pageInfo":null}