{"numberOfHits":1,"results":[{"id":"GO:0030674","isObsolete":false,"name":"protein-macromolecule adaptor activity","definition":{"text":"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},"synonyms":[{"name":"protein complex scaffold activity","type":"broad"},{"name":"protein recruiting activity","type":"related"},{"name":"protein-protein adaptor","type":"narrow"},{"name":"protein-containing complex scaffold activity","type":"broad"},{"name":"protein binding, bridging","type":"exact"}],"replaces":[{"id":"GO:0003780","type":"consider"},{"id":"GO:0008077","type":"consider"},{"id":"GO:0008546","type":"consider"},{"id":"GO:0015472","type":"consider"},{"id":"GO:0030022","type":"consider"},{"id":"GO:0030400","type":"consider"},{"id":"GO:0035656","type":"consider"}],"subsets":["goslim_yeast","goslim_chembl"],"children":[{"id":"GO:0035591","relation":"is_a"},{"id":"GO:0043495","relation":"is_a"},{"id":"GO:0140693","relation":"is_a"},{"id":"GO:0140035","relation":"is_a"},{"id":"GO:0140483","relation":"is_a"},{"id":"GO:0005091","relation":"is_a"},{"id":"GO:0140463","relation":"is_a"},{"id":"GO:0005484","relation":"is_a"},{"id":"GO:0005483","relation":"is_a"},{"id":"GO:0008093","relation":"is_a"},{"id":"GO:0140312","relation":"is_a"},{"id":"GO:0003712","relation":"is_a"},{"id":"GO:0001139","relation":"is_a"},{"id":"GO:0141175","relation":"is_a"},{"id":"GO:0001010","relation":"is_a"},{"id":"GO:1990644","relation":"is_a"},{"id":"GO:0140767","relation":"is_a"},{"id":"GO:0140517","relation":"is_a"},{"id":"GO:0160072","relation":"is_a"}],"history":[{"timestamp":"2024-07-16","action":"Added","category":"SYNONYM","text":"protein complex scaffold activity"},{"timestamp":"2024-07-16","action":"Added","category":"SYNONYM","text":"protein-containing complex scaffold activity"},{"timestamp":"2022-08-30","action":"Added","category":"SYNONYM","text":"protein recruiting activity"},{"timestamp":"2022-01-12","action":"Deleted","category":"SUBSET","text":"goslim_generic"},{"timestamp":"2020-09-17","action":"Added","category":"DEFINITION","text":"The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},{"timestamp":"2020-09-17","action":"Deleted","category":"DEFINITION","text":"The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},{"timestamp":"2020-07-19","action":"Deleted","category":"RELATION","text":"is a GO:0005515 (protein binding)"},{"timestamp":"2020-07-05","action":"Added","category":"DEFINITION","text":"The binding activity of a protein that brings together two macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},{"timestamp":"2020-07-05","action":"Deleted","category":"DEFINITION","text":"The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},{"timestamp":"2020-02-07","action":"Deleted","category":"DEFINITION","text":"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."},{"timestamp":"2020-02-07","action":"Added","category":"SYNONYM","text":"protein binding, bridging"},{"timestamp":"2020-02-07","action":"Updated","category":"TERM","text":"protein-macromolecule adaptor activity"},{"timestamp":"2020-02-07","action":"Added","category":"DEFINITION","text":"The binding activity of a protein that brings together another macromolecule in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid."},{"timestamp":"2019-04-18","action":"Deleted","category":"RELATION","text":"has part GO:0140312 (cargo adaptor activity)"},{"timestamp":"2019-04-01","action":"Added","category":"RELATION","text":"has part GO:0140312 (cargo adaptor activity)"},{"timestamp":"2015-05-19","action":"Added","category":"SUBSET","text":"goslim_chembl"},{"timestamp":"2015-05-19","action":"Deleted","category":"SUBSET","text":"goslim_ChEMBL"},{"timestamp":"2015-05-11","action":"Added","category":"SUBSET","text":"goslim_ChEMBL"},{"timestamp":"2013-04-18","action":"Updated","category":"SUBSET","text":"goslim_generic"},{"timestamp":"2013-04-18","action":"Updated","category":"SUBSET","text":"goslim_yeast"},{"timestamp":"2012-10-29","action":"Deleted","category":"DEFINITION","text":"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way."},{"timestamp":"2012-10-29","action":"Added","category":"DEFINITION","text":"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way."},{"timestamp":"2012-02-10","action":"Added","category":"SUBSET","text":"goslim_generic"},{"timestamp":"2011-08-21","action":"Deleted","category":"RELATION","text":"has part GO:0000988 (obsolete transcription factor activity, protein binding)"},{"timestamp":"2011-08-14","action":"Added","category":"SUBSET","text":"goslim_yeast"},{"timestamp":"2011-06-05","action":"Added","category":"RELATION","text":"has part GO:0000988 (obsolete transcription factor activity, protein binding)"},{"timestamp":"2010-12-03","action":"Added","category":"SYNONYM","text":"protein-protein adaptor"},{"timestamp":"2010-12-03","action":"Added","category":"RELATION","text":"is a GO:0060090 (molecular adaptor activity)"},{"timestamp":"2010-12-03","action":"Added","category":"DEFINITION","text":"The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way."},{"timestamp":"2010-12-03","action":"Deleted","category":"DEFINITION","text":"Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2010-12-03","action":"Deleted","category":"SYNONYM","text":"protein-protein adaptor"},{"timestamp":"2009-07-03","action":"Added","category":"DEFINITION","text":"Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2009-07-03","action":"Deleted","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0005515 (protein binding)"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"protein-protein adaptor"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"protein-protein adaptor"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"adhesive extracellular matrix constituent"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"fimbrium-specific chaperone activity"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"microtubule/chromatin interaction"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"protease substrate recruitment factor activity"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"Hsp70/Hsp90 organizing protein activity"},{"timestamp":"2006-02-09","action":"Deleted","category":"SYNONYM","text":"actin cross-linking activity"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"microtubule/chromatin interaction"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"fimbrium-specific chaperone activity"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"adhesive extracellular matrix constituent"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"actin cross-linking activity"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"Hsp70/Hsp90 organizing protein activity"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"protease substrate recruitment factor activity"},{"timestamp":"2005-03-19","action":"Updated","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex, simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2003-06-10","action":"Updated","category":"TERM","text":"protein binding, bridging"},{"timestamp":"2003-04-23","action":"Updated","category":"TERM","text":"protein binding activity, bridging"},{"timestamp":"2003-04-23","action":"Updated","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromolecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2003-04-18","action":"Added","category":"TERM","text":"protein binding, bridging"},{"timestamp":"2003-04-18","action":"Added","category":"DEFINITION","text":"Interacting selectively with two or more protein molecules, or a protein and another macromelecule or complex simultaneously, thereby physically linking the bound proteins or complexes to each other."},{"timestamp":"2003-04-18","action":"Added","category":"SYNONYM","text":"protein-protein adaptor"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR007131","name":"SLA1 homology domain 1, SHD1"},{"dbCode":"InterPro","dbId":"IPR022768","name":"Fascin domain"},{"dbCode":"InterPro","dbId":"IPR024703","name":"Fascin, metazoans"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0030674","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:27775717","category":"NOT-qualified manual","entityType":"protein","entityId":"Q61387","taxonId":"10090","entityName":"CO72L_MOUSE","ancestorGoId":"GO:0030674"}]}],"pageInfo":null}