{"numberOfHits":1,"results":[{"id":"GO:0030851","isObsolete":false,"name":"granulocyte differentiation","definition":{"text":"The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.","xrefs":[{"dbCode":"URL","dbId":"http://life.nthu.edu.tw/~g864204/dict-search1.htm"}]},"synonyms":[{"name":"granulocyte cell differentiation","type":"exact"}],"children":[{"id":"GO:0030222","relation":"is_a"},{"id":"GO:0030223","relation":"is_a"},{"id":"GO:0030221","relation":"is_a"},{"id":"GO:0030854","relation":"positively_regulates"},{"id":"GO:0030852","relation":"regulates"},{"id":"GO:0030853","relation":"negatively_regulates"}],"history":[{"timestamp":"2024-12-05","action":"Added","category":"XREF","text":"Reactome:R-HSA-9616222"},{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"in_taxon NCBITaxon:7742 (Vertebrata)"},{"timestamp":"2010-12-01","action":"Added","category":"DEFINITION","text":"The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."},{"timestamp":"2010-12-01","action":"Deleted","category":"DEFINITION","text":"The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0002573 (myeloid leukocyte differentiation)"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"granulocyte cell differentiation"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"granulocyte cell differentiation"},{"timestamp":"2005-02-21","action":"Added","category":"SYNONYM","text":"granulocyte cell differentiation"},{"timestamp":"2005-02-21","action":"Updated","category":"TERM","text":"granulocyte differentiation"},{"timestamp":"2005-01-21","action":"Updated","category":"DEFINITION","text":"The process by which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."},{"timestamp":"2005-01-13","action":"Updated","category":"TERM","text":"granulocyte cell differentiation"},{"timestamp":"2003-09-06","action":"Added","category":"TERM","text":"granulocyte differentiation"},{"timestamp":"2003-09-06","action":"Added","category":"DEFINITION","text":"The process by which a myeloid precursor cell acquires specializes features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils."}],"xRefs":[{"dbCode":"Reactome","dbId":"R-HSA-9616222"}],"xRelations":[{"id":"CL:0000094","term":"granulocyte","namespace":"CL","url":"https://www.ebi.ac.uk/ontology-lookup/?termId=CL:0000094","relation":"results_in_acquisition_of_features_of"}],"taxonConstraints":[{"ancestorId":"GO:0030851","ancestorName":"granulocyte differentiation","relationship":"only_in_taxon","taxId":"7742","taxIdType":"NCBITaxon","taxName":"Vertebrata"}],"aspect":"biological_process","usage":"Unrestricted","blacklist":[{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"A8XY28","taxonId":"6238","entityName":"A8XY28_CAEBR","ancestorGoId":"GO:0030154"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"B7PL19","taxonId":"6945","entityName":"B7PL19_IXOSC","ancestorGoId":"GO:0030154"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"B7PVH4","taxonId":"6945","entityName":"B7PVH4_IXOSC","ancestorGoId":"GO:0030154"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"E9PTS6","taxonId":"10116","entityName":"E9PTS6_RAT","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"O16262","taxonId":"6239","entityName":"NIPI4_CAEEL","ancestorGoId":"GO:0030154"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163","category":"NOT-qualified manual","entityType":"protein","entityId":"P01127","taxonId":"9606","entityName":"PDGFB_HUMAN","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163","category":"NOT-qualified manual","entityType":"protein","entityId":"P05622","taxonId":"10090","entityName":"PGFRB_MOUSE","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"P12919","taxonId":"9685","entityName":"PDGFB_FELCA","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"P31240","taxonId":"10090","entityName":"PDGFB_MOUSE","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"Q05028","taxonId":"10116","entityName":"PDGFB_RAT","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"Q05030","taxonId":"10116","entityName":"PGFRB_RAT","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"Q309C9","taxonId":"10116","entityName":"Q309C9_RAT","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:22139419","category":"NOT-qualified manual","entityType":"protein","entityId":"Q5TYP7","taxonId":"7955","entityName":"Q5TYP7_DANRE","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"Q6Q7I7","taxonId":"9615","entityName":"PDGFB_CANLF","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15607700","category":"NOT-qualified manual","entityType":"protein","entityId":"Q8K1S5","taxonId":"10090","entityName":"KLF11_MOUSE","ancestorGoId":"GO:0030097"},{"goId":"GO:0030851","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024","category":"NOT-qualified manual","entityType":"protein","entityId":"Q95229","taxonId":"9940","entityName":"PDGFB_SHEEP","ancestorGoId":"GO:0030097"}]}],"pageInfo":null}