{"numberOfHits":1,"results":[{"id":"GO:0045252","isObsolete":false,"name":"oxoglutarate dehydrogenase complex","definition":{"text":"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present.","xrefs":[{"dbCode":"PMID","dbId":"10672230"}]},"comment":"The catalytic activities of the individual components of this complex are represented by the molecular function terms 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591' (E1), 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' (E2), and 'dihydrolipoyl dehydrogenase activity ; GO:0004148' (E3). The overall catalytic activity of the complex is represented by the molecular function term 'oxoglutarate dehydrogenase (NAD+) activity ; GO:0034602'.","synonyms":[{"name":"KGDHC","type":"exact"},{"name":"dihydrolipoamide S-succinyltransferase complex","type":"exact"},{"name":"alpha-ketoglutarate dehydrogenase complex","type":"exact"}],"replaces":[{"id":"GO:0009354","type":"consider"},{"id":"GO:0005947","type":"replaced_by"},{"id":"GO:0009353","type":"replaced_by"},{"id":"GO:0045241","type":"replaced_by"},{"id":"GO:0045248","type":"replaced_by"}],"subsets":["goslim_pir"],"history":[{"timestamp":"2024-09-05","action":"Added","category":"CONSTRAINT","text":"in_taxon NCBITaxon:131567 (cellular organisms)"},{"timestamp":"2024-02-24","action":"Added","category":"XREF","text":"Wikipedia:Oxoglutarate_dehydrogenase_complex"},{"timestamp":"2024-02-24","action":"Deleted","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2024-02-24","action":"Added","category":"SYNONYM","text":"KGDHC"},{"timestamp":"2024-02-24","action":"Added","category":"DEFINITION","text":"A multi-enzyme complex that catalyzes the oxidative decarboxylation of alpha-ketoglutarate (also known as 2-oxoglutarate) to form succinyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present."},{"timestamp":"2024-02-24","action":"Added","category":"SYNONYM","text":"alpha-ketoglutarate dehydrogenase complex"},{"timestamp":"2024-02-24","action":"Added","category":"RELATION","text":"is a GO:0045239 (tricarboxylic acid cycle heteromeric enzyme complex)"},{"timestamp":"2024-01-30","action":"Added","category":"RELATION","text":"capable of GO:0034602 (oxoglutarate dehydrogenase (NAD+) activity)"},{"timestamp":"2024-01-30","action":"Deleted","category":"RELATION","text":"capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity)"},{"timestamp":"2024-01-30","action":"Deleted","category":"RELATION","text":"capable of GO:0004148 (dihydrolipoyl dehydrogenase activity)"},{"timestamp":"2024-01-30","action":"Deleted","category":"RELATION","text":"is a GO:1990234 (transferase complex)"},{"timestamp":"2024-01-30","action":"Deleted","category":"RELATION","text":"capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)"},{"timestamp":"2022-11-22","action":"Added","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2022-11-22","action":"Deleted","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase  (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2022-01-12","action":"Added","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) (E1), dihydrolipoamide S-succinyltransferase  (E2) and dihydrolipoamide dehydrogenase (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2022-01-12","action":"Deleted","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2015-06-18","action":"Added","category":"RELATION","text":"capable of GO:0004149 (dihydrolipoyllysine-residue succinyltransferase activity)"},{"timestamp":"2015-06-18","action":"Added","category":"RELATION","text":"capable of GO:0004591 (oxoglutarate dehydrogenase (succinyl-transferring) activity)"},{"timestamp":"2015-06-18","action":"Added","category":"RELATION","text":"capable of GO:0004148 (dihydrolipoyl dehydrogenase activity)"},{"timestamp":"2013-11-28","action":"Added","category":"RELATION","text":"is a GO:1990234 (transferase complex)"},{"timestamp":"2013-08-15","action":"Added","category":"RELATION","text":"is a GO:0045240 (alpha-ketoacid dehydrogenase complex)"},{"timestamp":"2013-08-15","action":"Deleted","category":"RELATION","text":"is a GO:0044424 (obsolete intracellular part)"},{"timestamp":"2013-08-15","action":"Deleted","category":"RELATION","text":"is a GO:0043234 (protein complex)"},{"timestamp":"2013-04-18","action":"Updated","category":"SUBSET","text":"goslim_pir"},{"timestamp":"2008-06-09","action":"Added","category":"SUBSET","text":"goslim_pir"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0043234 (protein complex)"},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0044424 (obsolete intracellular part)"},{"timestamp":"2007-08-09","action":"Deleted","category":"SYNONYM","text":"dihydrolipoamide S-succinyltransferase complex"},{"timestamp":"2007-08-09","action":"Added","category":"SYNONYM","text":"dihydrolipoamide S-succinyltransferase complex"},{"timestamp":"2005-08-10","action":"Added","category":"SYNONYM","text":"dihydrolipoamide S-succinyltransferase complex"},{"timestamp":"2005-02-02","action":"Updated","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)."},{"timestamp":"2004-07-22","action":"Updated","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix."},{"timestamp":"2003-10-23","action":"Updated","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix (GO:0005759)."},{"timestamp":"2002-11-27","action":"Added","category":"DEFINITION","text":"A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; GO:0004591 ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; GO:0004149 ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; GO:0004148 ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide within the mitochondrial matrix (GO:0005759)."},{"timestamp":"2002-05-10","action":"Added","category":"TERM","text":"oxoglutarate dehydrogenase complex"}],"xRefs":[{"dbCode":"InterPro","dbId":"IPR006255","name":"Dihydrolipoamide succinyltransferase"},{"dbCode":"Wikipedia","dbId":"Oxoglutarate_dehydrogenase_complex"}],"taxonConstraints":[{"ancestorId":"GO:0045252","ancestorName":"oxoglutarate dehydrogenase complex","relationship":"only_in_taxon","taxId":"131567","taxIdType":"NCBITaxon","taxName":"cellular organisms"}],"aspect":"cellular_component","usage":"Unrestricted","blacklist":[{"goId":"GO:0045252","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A0A096MJ18","taxonId":"10116","entityName":"A0A096MJ18_RAT","ancestorGoId":"GO:0005737"},{"goId":"GO:0045252","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: 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