{"numberOfHits":1,"results":[{"id":"GO:0047058","isObsolete":false,"name":"vitamin-K-epoxide reductase (warfarin-insensitive) activity","definition":{"text":"Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol.","xrefs":[{"dbCode":"RHEA","dbId":"21560"}]},"synonyms":[{"name":"vitamin K 2,3-epoxide reductase activity","type":"related"}],"history":[{"timestamp":"2022-05-10","action":"Added","category":"RELATION","text":"is a GO:0016728 (oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor)"},{"timestamp":"2022-05-10","action":"Deleted","category":"RELATION","text":"is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)"},{"timestamp":"2021-05-22","action":"Deleted","category":"XREF","text":"EC:1.1.4.2"},{"timestamp":"2021-05-22","action":"Deleted","category":"SYNONYM","text":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity"},{"timestamp":"2021-05-22","action":"Added","category":"XREF","text":"EC:1.17.4.5"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"vitamin K 2,3-epoxide reductase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"vitamin K 2,3-epoxide reductase activity"},{"timestamp":"2018-07-13","action":"Deleted","category":"XREF","text":"RHEA:21563"},{"timestamp":"2018-07-13","action":"Added","category":"XREF","text":"RHEA:21560"},{"timestamp":"2011-09-16","action":"Added","category":"XREF","text":"RHEA:21563"},{"timestamp":"2008-05-13","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."},{"timestamp":"2008-05-12","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."},{"timestamp":"2008-04-01","action":"Updated","category":"RELATION","text":"is a GO:0016900 (obsolete oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)"},{"timestamp":"2007-11-08","action":"Added","category":"SYNONYM","text":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone:oxidized-dithiothreitol oxidoreductase activity"},{"timestamp":"2007-09-06","action":"Added","category":"SYNONYM","text":"vitamin K 2,3-epoxide reductase activity"},{"timestamp":"2004-08-06","action":"Updated","category":"DEFINITION","text":"Catalysis of the reaction: 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone + oxidized dithiothreitol + H2O = 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone + 1,4-dithiothreitol."},{"timestamp":"2003-10-27","action":"Added","category":"XREF","text":"MetaCyc:1.1.4.2-RXN"},{"timestamp":"2003-08-19","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: H2O + oxidized-dithiothreitol + 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone = 14-dithiothreitol + 2,3-epoxy-2,3-dihydro-2-methyl-3-phytyl-1,4-naphthoquinone."},{"timestamp":"2003-08-19","action":"Added","category":"TERM","text":"vitamin-K-epoxide reductase (warfarin-insensitive) activity"},{"timestamp":"2003-08-19","action":"Added","category":"XREF","text":"EC:1.1.4.2"}],"xRefs":[{"dbCode":"EC","dbId":"1.17.4.5"},{"dbCode":"MetaCyc","dbId":"1.1.4.2-RXN"},{"dbCode":"RHEA","dbId":"21560"}],"xRelations":[{"id":"CHEBI:15759","term":"2,3-epoxyphylloquinone","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15759","relation":"has_participant"},{"id":"CHEBI:18320","term":"1,4-dithiothreitol","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18320","relation":"has_participant"},{"id":"CHEBI:18298","term":"3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18298","relation":"has_participant"},{"id":"CHEBI:41837","term":"(4S,5S)-1,2-dithiane-4,5-diol","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:41837","relation":"has_participant"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0047058","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. 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Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"P03880","taxonId":"162425","entityName":"ANI1_EMEND","ancestorGoId":"GO:0016491"},{"goId":"GO:0047058","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.","category":"IEA Review","entityType":"protein","entityId":"P03882","taxonId":"559292","entityName":"SCE1_YEAST","ancestorGoId":"GO:0016491"},{"goId":"GO:0047058","reason":"Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. 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