{"numberOfHits":1,"results":[{"id":"GO:0052925","isObsolete":false,"name":"dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity","definition":{"text":"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.","xrefs":[{"dbCode":"RHEA","dbId":"29527"}]},"synonyms":[{"name":"man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity","type":"related"},{"name":"dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity","type":"related"}],"replaces":[{"id":"GO:0004584","type":"consider"}],"history":[{"timestamp":"2022-09-01","action":"Deleted","category":"DEFINITION","text":"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."},{"timestamp":"2022-09-01","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H+ + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity"},{"timestamp":"2020-10-08","action":"Added","category":"SYNONYM","text":"dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity"},{"timestamp":"2020-10-08","action":"Deleted","category":"SYNONYM","text":"dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity"},{"timestamp":"2019-06-20","action":"Deleted","category":"XREF","text":"KEGG:R06258"},{"timestamp":"2019-06-20","action":"Added","category":"XREF","text":"KEGG_REACTION:R06258"},{"timestamp":"2018-07-13","action":"Deleted","category":"XREF","text":"RHEA:29530"},{"timestamp":"2018-07-13","action":"Added","category":"XREF","text":"RHEA:29527"},{"timestamp":"2012-03-01","action":"Added","category":"RELATION","text":"is a GO:0000033 (alpha-1,3-mannosyltransferase activity)"},{"timestamp":"2012-03-01","action":"Added","category":"XREF","text":"MetaCyc:RXN-5466"},{"timestamp":"2012-03-01","action":"Added","category":"XREF","text":"EC:2.4.1.258"},{"timestamp":"2012-03-01","action":"Added","category":"SYNONYM","text":"dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase activity"},{"timestamp":"2012-03-01","action":"Added","category":"SYNONYM","text":"man(5)GlcNAc(2)-PP-Dol mannosyltransferase activity"},{"timestamp":"2012-03-01","action":"Added","category":"XREF","text":"KEGG:R06258"},{"timestamp":"2012-03-01","action":"Added","category":"DEFINITION","text":"Catalysis of the reaction: an alpha-D-man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl D-mannosyl phosphate = H(+) + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate."},{"timestamp":"2012-03-01","action":"Added","category":"TERM","text":"dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"},{"timestamp":"2012-03-01","action":"Added","category":"XREF","text":"RHEA:29530"}],"xRefs":[{"dbCode":"EC","dbId":"2.4.1.258"},{"dbCode":"KEGG_REACTION","dbId":"R06258"},{"dbCode":"MetaCyc","dbId":"RXN-5466"},{"dbCode":"RHEA","dbId":"29527"}],"xRelations":[{"id":"CHEBI:15378","term":"hydron","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:15378","relation":"has_participant"},{"id":"CHEBI:57683","term":"dolichyl phosphate(2-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:57683","relation":"has_participant"},{"id":"CHEBI:132516","term":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:132516","relation":"has_participant"},{"id":"CHEBI:58211","term":"dolichyl beta-D-mannosyl phosphate(1-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:58211","relation":"has_participant"},{"id":"CHEBI:132515","term":"alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc(PP-Dol)(2-)","namespace":"CHEBI","url":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:132515","relation":"has_participant"}],"annotationGuidelines":[{"description":"Annotating to catalytic activities using the IPI evidence code","url":"http://wiki.geneontology.org/index.php/Annotations_to_Catalytic_activity_with_IPI"},{"description":"Describing enzyme functions that catalyse multi-stage reactions","url":"http://www.geneontology.org/page/molecular-function-ontology-guidelines#gran"}],"aspect":"molecular_function","usage":"Unrestricted","blacklist":[{"goId":"GO:0052925","reason":"Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins.","category":"IEA Review","methodId":"IPR016093|IPR036300","entityType":"protein","entityId":"Q9VNA3","taxonId":"7227","entityName":"Q9VNA3_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0052925","reason":"Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins.","category":"IEA Review","methodId":"IPR016093|IPR036300","entityType":"protein","entityId":"Q9VNA3","taxonId":"7227","entityName":"Q9VNA3_DROME","ancestorGoId":"GO:0016757"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified manual","entityType":"protein","entityId":"A6KJI3","taxonId":"10116","entityName":"A6KJI3_RAT","ancestorGoId":"GO:0016757"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"D6WQD5","taxonId":"7070","entityName":"D6WQD5_TRICA","ancestorGoId":"GO:0016757"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified manual","entityType":"protein","entityId":"P02521","taxonId":"9031","entityName":"ARLY1_CHICK","ancestorGoId":"GO:0003824"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q0E8K5","taxonId":"7227","entityName":"Q0E8K5_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096","category":"NOT-qualified 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manual","entityType":"protein","entityId":"Q7KGG1","taxonId":"7227","entityName":"Q7KGG1_DROME","ancestorGoId":"GO:0003824"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7KV84","taxonId":"7227","entityName":"Q7KV84_DROME","ancestorGoId":"GO:0016740"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033","category":"NOT-qualified manual","entityType":"protein","entityId":"Q7Q9P6","taxonId":"7165","entityName":"Q7Q9P6_ANOGA","ancestorGoId":"GO:0016757"},{"goId":"GO:0052925","reason":"1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884","category":"NOT-qualified 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