GO:0000077
JSON
DNA damage checkpoint signaling
Biological Process
Definition (GO:0000077 GONUTS page)
A signal transduction process that contributes to a DNA damage checkpoint.
Secondary IDs
GO:0072422
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
DNA damage checkpoint | exact |
signal transduction involved in DNA damage checkpoint | exact |
DNA damage response, signal transduction resulting in cell cycle arrest | narrow |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000077
Child Term | Relationship to GO:0000077 |
---|---|
negative regulation of DNA damage checkpoint
|
negatively_regulates |
positive regulation of DNA damage checkpoint
|
positively_regulates |
regulation of DNA damage checkpoint
|
regulates |
mitotic DNA damage checkpoint signaling
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8L2QY15 | 10116 | A0A8L2QY15_RAT | GO:0000077 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J3X1 | 10116 | A6J3X1_RAT | GO:0000077 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | D3ZXP3 | 10116 | D3ZXP3_RAT | GO:0000077 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O70191 | 10090 | ATF5_MOUSE | GO:0051726 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12130540 | |
NOT-qualified manual | protein | P27661 | 10090 | H2AX_MOUSE | GO:0000077 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11934988 | |
NOT-qualified manual | protein | Q4KWZ6 | 9031 | MD2L2_CHICK | GO:0000077 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15988022 | |
NOT-qualified manual | protein | Q6P788 | 10116 | ATF5_RAT | GO:0051726 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR003011 | Cell cycle checkpoint protein, Rad1 |
InterPro | IPR003021 | Rad1/Rec1/Rad17 |
InterPro | IPR007150 | Checkpoint protein Hus1/Mec3 |
InterPro | IPR007268 | Rad9/Ddc1 |
InterPro | IPR016255 | eIF-2-alpha kinase Gcn2 |
InterPro | IPR016256 | Serine/threonine-protein kinase Rad53 |
InterPro | IPR016580 | Cell cycle checkpoint, Hus1 |
InterPro | IPR016587 | DNA damage checkpoint control protein Rad17 |
InterPro | IPR018324 | Checkpoint protein Rad17/Rad24, fungi/metazoa |
InterPro | IPR018622 | DNA damage checkpoint protein, Lcd1 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000077 based on ALL annotations
The top 100 of 1,683 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA damage checkpoint signaling
|
4,726.36 | 100.00 | 41,245 | 41,245 |
checkpoint clamp complex
|
4,709.97 | 31.32 | 12,930 | 12,975 |
mitotic intra-S DNA damage checkpoint signaling
|
1,717.65 | 15.35 | 8,657 | 23,821 |
mitotic DNA replication checkpoint signaling
|
1,429.11 | 14.55 | 9,036 | 29,884 |
cellular response to ionizing radiation
|
3,098.98 | 13.07 | 5,789 | 8,829 |
histone H3K79 methyltransferase activity
|
3,057.92 | 10.45 | 4,571 | 7,065 |
meiotic DNA integrity checkpoint signaling
|
4,691.49 | 9.45 | 3,902 | 3,931 |
DNA replication checkpoint signaling
|
1,366.32 | 9.27 | 4,950 | 17,123 |
telomere maintenance
|
449.32 | 7.16 | 9,268 | 97,490 |
histone H3K79 trimethyltransferase activity
|
4,084.45 | 6.35 | 2,647 | 3,063 |
Totals | 333307 | 17867028 |
No co-occurrence statistics for GO:0000077 based on MANUAL annotations
The top 100 of 1,042 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA damage checkpoint signaling
|
1,717.82 | 100.00 | 752 | 752 |
checkpoint clamp complex
|
619.46 | 12.36 | 119 | 330 |
mitotic DNA replication checkpoint signaling
|
369.54 | 12.19 | 165 | 767 |
DNA clamp loader activity
|
290.05 | 9.79 | 142 | 841 |
histone H3K79 methyltransferase activity
|
1,717.82 | 9.71 | 73 | 73 |
DNA repair
|
162.90 | 8.92 | 453 | 4,777 |
telomere maintenance
|
221.43 | 8.75 | 161 | 1,249 |
subtelomeric heterochromatin formation
|
575.16 | 8.32 | 75 | 224 |
chromosome
|
114.52 | 5.03 | 128 | 1,920 |
negative regulation of TORC1 signaling
|
127.57 | 3.93 | 58 | 781 |
Totals | 3665 | 57044 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Updated | TERM | DNA damage checkpoint signaling |
2021-03-06 | Added | RELATION | is a GO:0042770 (signal transduction in response to DNA damage) |
2021-03-06 | Added | DEFINITION | A signal transduction process that contributes to a DNA damage checkpoint. |
2021-03-06 | Deleted | DEFINITION | A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. |
2021-03-06 | Added | SECONDARY | GO:0072422 (signal transduction involved in DNA damage checkpoint) |
2021-03-06 | Added | SYNONYM | DNA damage checkpoint |
2021-03-06 | Added | SYNONYM | signal transduction involved in DNA damage checkpoint |
2021-03-06 | Deleted | RELATION | is a GO:0006974 (DNA damage response) |
2010-12-10 | Added | RELATION | is a GO:0006974 (DNA damage response) |
2010-12-10 | Deleted | DEFINITION | A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Updated | TERM | DNA damage checkpoint signaling |
2004-07-22 | Updated | TERM | DNA damage checkpoint |
2003-06-21 | Updated | TERM | DNA damage response, signal transduction resulting in cell cycle arrest |
2002-02-06 | Updated | TERM | DNA damage checkpoint |
2001-04-03 | Updated | TERM | DNA damage checkpoint |
2001-03-30 | Added | TERM | DNA damage checkpoint |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Added | DEFINITION | A signal transduction process that contributes to a DNA damage checkpoint. |
2021-03-06 | Deleted | DEFINITION | A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. |
2021-03-06 | Added | SYNONYM | DNA damage checkpoint |
2021-03-06 | Added | SYNONYM | signal transduction involved in DNA damage checkpoint |
2010-12-10 | Deleted | DEFINITION | A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. |
2010-12-10 | Added | DEFINITION | A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds. |
2008-05-13 | Added | DEFINITION | A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. |
2008-05-12 | Deleted | DEFINITION | A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. |
2007-08-09 | Deleted | SYNONYM | DNA damage response, signal transduction resulting in cell cycle arrest |
2007-08-09 | Added | SYNONYM | DNA damage response, signal transduction resulting in cell cycle arrest |
2004-07-22 | Deleted | SYNONYM | DNA damage checkpoint |
2004-07-22 | Added | SYNONYM | DNA damage response, signal transduction resulting in cell cycle arrest |
2004-04-19 | Added | SYNONYM | DNA damage checkpoint |
2004-04-16 | Deleted | SYNONYM | DNA damage checkpoint |
2003-06-21 | Added | SYNONYM | DNA damage checkpoint |
2003-06-21 | Added | DEFINITION | A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Added | RELATION | is a GO:0042770 (signal transduction in response to DNA damage) |
2021-03-06 | Deleted | RELATION | is a GO:0006974 (DNA damage response) |
2010-12-10 | Added | RELATION | is a GO:0006974 (DNA damage response) |
2010-12-10 | Deleted | RELATION | is a GO:0042770 (signal transduction in response to DNA damage) |
2010-09-26 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2010-04-16 | Added | RELATION | is a GO:0007165 (signal transduction) |
2008-04-01 | Updated | RELATION | is a GO:0042770 (signal transduction in response to DNA damage) |
2008-04-01 | Updated | RELATION | is a GO:0031570 (DNA integrity checkpoint signaling) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-02-25 | Added | XREF | Wikipedia:DNA_damage_checkpoint |
2009-02-25 | Added | XREF | Wikipedia:Postreplication_checkpoint |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-03-06 | Added | SECONDARY | GO:0072422 (signal transduction involved in DNA damage checkpoint) |
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