This term is obsolete.

GO:0000077 JSON

DNA damage checkpoint signaling

Biological Process

Definition (GO:0000077 GONUTS page)

A signal transduction process that contributes to a DNA damage checkpoint.

Secondary IDs

GO:0072422

118,688 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
DNA damage checkpoint exact
signal transduction involved in DNA damage checkpoint exact
DNA damage response, signal transduction resulting in cell cycle arrest narrow

Ancestor Chart

Ancestor chart for GO:0000077
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000077

Child Term Relationship to
GO:0000077
negative regulation of DNA damage checkpoint
negatively_regulates
positive regulation of DNA damage checkpoint
positively_regulates
regulation of DNA damage checkpoint
regulates
mitotic DNA damage checkpoint signaling
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8L2QY15 10116 A0A8L2QY15_RAT GO:0000077 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J3X1 10116 A6J3X1_RAT GO:0000077 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein D3ZXP3 10116 D3ZXP3_RAT GO:0000077 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O70191 10090 ATF5_MOUSE GO:0051726 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12130540
NOT-qualified manual protein P27661 10090 H2AX_MOUSE GO:0000077 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11934988
NOT-qualified manual protein Q4KWZ6 9031 MD2L2_CHICK GO:0000077 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15988022
NOT-qualified manual protein Q6P788 10116 ATF5_RAT GO:0051726 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR003011 Cell cycle checkpoint protein, Rad1
InterPro IPR003021 Rad1/Rec1/Rad17
InterPro IPR007150 Checkpoint protein Hus1/Mec3
InterPro IPR007268 Rad9/Ddc1
InterPro IPR016255 eIF-2-alpha kinase Gcn2
InterPro IPR016256 Serine/threonine-protein kinase Rad53
InterPro IPR016580 Cell cycle checkpoint, Hus1
InterPro IPR016587 DNA damage checkpoint control protein Rad17
InterPro IPR018324 Checkpoint protein Rad17/Rad24, fungi/metazoa
InterPro IPR018622 DNA damage checkpoint protein, Lcd1

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000077 based on ALL annotations
The top 100 of 1,683 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA damage checkpoint signaling
4,726.36 100.00 41,245 41,245
checkpoint clamp complex
4,709.97 31.32 12,930 12,975
mitotic intra-S DNA damage checkpoint signaling
1,717.65 15.35 8,657 23,821
mitotic DNA replication checkpoint signaling
1,429.11 14.55 9,036 29,884
cellular response to ionizing radiation
3,098.98 13.07 5,789 8,829
histone H3K79 methyltransferase activity
3,057.92 10.45 4,571 7,065
meiotic DNA integrity checkpoint signaling
4,691.49 9.45 3,902 3,931
DNA replication checkpoint signaling
1,366.32 9.27 4,950 17,123
telomere maintenance
449.32 7.16 9,268 97,490
histone H3K79 trimethyltransferase activity
4,084.45 6.35 2,647 3,063
Totals 333307 17867028
No co-occurrence statistics for GO:0000077 based on MANUAL annotations
The top 100 of 1,042 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA damage checkpoint signaling
1,717.82 100.00 752 752
checkpoint clamp complex
619.46 12.36 119 330
mitotic DNA replication checkpoint signaling
369.54 12.19 165 767
DNA clamp loader activity
290.05 9.79 142 841
histone H3K79 methyltransferase activity
1,717.82 9.71 73 73
DNA repair
162.90 8.92 453 4,777
telomere maintenance
221.43 8.75 161 1,249
subtelomeric heterochromatin formation
575.16 8.32 75 224
chromosome
114.52 5.03 128 1,920
negative regulation of TORC1 signaling
127.57 3.93 58 781
Totals 3665 57044

Change Log

Timestamp Action Category Detail
2021-03-06 Updated TERM DNA damage checkpoint signaling
2021-03-06 Added RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2021-03-06 Added DEFINITION A signal transduction process that contributes to a DNA damage checkpoint.
2021-03-06 Deleted DEFINITION A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
2021-03-06 Added SECONDARY GO:0072422 (signal transduction involved in DNA damage checkpoint)
2021-03-06 Added SYNONYM DNA damage checkpoint
2021-03-06 Added SYNONYM signal transduction involved in DNA damage checkpoint
2021-03-06 Deleted RELATION is a GO:0006974 (DNA damage response)
2010-12-10 Added RELATION is a GO:0006974 (DNA damage response)
2010-12-10 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
Timestamp Action Category Detail
2021-03-06 Updated TERM DNA damage checkpoint signaling
2004-07-22 Updated TERM DNA damage checkpoint
2003-06-21 Updated TERM DNA damage response, signal transduction resulting in cell cycle arrest
2002-02-06 Updated TERM DNA damage checkpoint
2001-04-03 Updated TERM DNA damage checkpoint
2001-03-30 Added TERM DNA damage checkpoint
Timestamp Action Category Detail
2021-03-06 Added DEFINITION A signal transduction process that contributes to a DNA damage checkpoint.
2021-03-06 Deleted DEFINITION A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
2021-03-06 Added SYNONYM DNA damage checkpoint
2021-03-06 Added SYNONYM signal transduction involved in DNA damage checkpoint
2010-12-10 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2010-12-10 Added DEFINITION A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
2008-05-13 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2008-05-12 Deleted DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
2007-08-09 Deleted SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2007-08-09 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-07-22 Deleted SYNONYM DNA damage checkpoint
2004-07-22 Added SYNONYM DNA damage response, signal transduction resulting in cell cycle arrest
2004-04-19 Added SYNONYM DNA damage checkpoint
2004-04-16 Deleted SYNONYM DNA damage checkpoint
2003-06-21 Added SYNONYM DNA damage checkpoint
2003-06-21 Added DEFINITION A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
Timestamp Action Category Detail
2021-03-06 Added RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2021-03-06 Deleted RELATION is a GO:0006974 (DNA damage response)
2010-12-10 Added RELATION is a GO:0006974 (DNA damage response)
2010-12-10 Deleted RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2010-09-26 Deleted RELATION is a GO:0007165 (signal transduction)
2010-04-16 Added RELATION is a GO:0007165 (signal transduction)
2008-04-01 Updated RELATION is a GO:0042770 (signal transduction in response to DNA damage)
2008-04-01 Updated RELATION is a GO:0031570 (DNA integrity checkpoint signaling)
Timestamp Action Category Detail
2009-02-25 Added XREF Wikipedia:DNA_damage_checkpoint
2009-02-25 Added XREF Wikipedia:Postreplication_checkpoint
Timestamp Action Category Detail
2021-03-06 Added SECONDARY GO:0072422 (signal transduction involved in DNA damage checkpoint)
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