This term is obsolete.

GO:0000124 JSON

SAGA complex

Cellular Component

Definition (GO:0000124 GONUTS page)

A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). PMID:10637607 PMID:17337012 PMID:19056896 PMID:20838651 PMID:33004486

Secondary IDs

GO:0000125, GO:0030914

57,205 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
STAGA complex related
PCAF histone acetylase-associated complex narrow
PCAF complex narrow
SPT3-TAF9-GCN5 acetylase complex related
SPT3-TAF9-PCAF acetylase complex narrow
STAGA coactivator complex related
Spt-Ada-Gcn5-acetyltransferase complex exact

Ancestor Chart

Ancestor chart for GO:0000124
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0000124 SAGA complex Only in Taxon 2759 Eukaryota

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y7L4 10116 A0A8I5Y7L4_RAT GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q14TE9 10116 Q14TE9_RAT GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q63177 10116 Q63177_RAT GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q64511 10090 TOP2B_MOUSE GO:0005694 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11835579
NOT-qualified manual protein Q8NFT6 9606 DBF4B_HUMAN GO:0000785 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15668232
NOT-qualified manual protein Q9URY0 284812 YTM1_SCHPO GO:0000785 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:36423630

Cross-references

Database ID Description
InterPro IPR018783 Transcription factor, enhancer of yellow 2
InterPro IPR021950 Transcription factor Spt20
InterPro IPR037782 Transcriptional activator Spt7
InterPro IPR037794 Transcription initiation factor TFIID subunit 12
InterPro IPR037796 Transcription initiation factor TFIID subunit 6
InterPro IPR037802 SAGA-associated factor 29
InterPro IPR037804 SAGA-associated factor 73
InterPro IPR039460 STAGA complex 65 subunit gamma

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000124 based on ALL annotations
The top 100 of 795 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SAGA complex
3,516.19 100.00 56,355 56,355
transcription factor TFIID complex
1,039.16 18.86 19,305 65,322
RNA polymerase II preinitiation complex assembly
1,314.57 18.58 15,199 40,654
SLIK (SAGA-like) complex
3,516.19 15.55 8,766 8,766
RNA polymerase II general transcription initiation factor activity
787.81 13.72 14,722 65,708
transcription coactivator activity
523.07 12.69 26,130 175,653
SAGA-type complex
1,737.09 11.64 7,444 15,068
DUBm complex
3,183.31 7.89 4,485 4,954
transcription initiation at RNA polymerase II promoter
360.37 6.94 9,968 97,260
protein heterodimerization activity
252.55 6.27 18,697 260,315
Totals 368019 23315385
No co-occurrence statistics for GO:0000124 based on MANUAL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term PR S% #Together #Compared
SAGA complex
989.16 100.00 1,427 1,427
transcription factor TFIID complex
238.21 15.51 433 1,798
RNA polymerase II general transcription initiation factor activity
175.05 12.18 401 2,266
transcription coactivator activity
131.53 11.71 707 5,317
DUBm complex
760.14 10.58 156 203
transcription initiation at RNA polymerase II promoter
133.56 8.42 261 1,933
RNA polymerase II preinitiation complex assembly
127.88 6.61 170 1,315
DNA repair-dependent chromatin remodeling
336.59 6.06 98 288
promoter-specific chromatin binding
158.54 5.74 117 730
transcription factor TFTC complex
803.08 5.67 82 101
Totals 6311 173778

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2021-08-06 Deleted DEFINITION A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
2021-08-06 Added DEFINITION A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
2021-07-18 Added SYNONYM PCAF histone acetylase-associated complex
2021-07-18 Added SYNONYM STAGA complex
2021-07-18 Added SECONDARY GO:0000125 (PCAF complex)
2021-07-18 Added SECONDARY GO:0030914 (STAGA complex)
2021-07-18 Added SYNONYM SPT3-TAF9-GCN5 acetylase complex
2021-07-18 Added SYNONYM STAGA coactivator complex
2021-07-18 Added SYNONYM SPT3-TAF9-PCAF acetylase complex
Timestamp Action Category Detail
2002-02-06 Updated TERM SAGA complex
2001-04-03 Updated TERM SAGA complex
2001-03-30 Added TERM SAGA complex
Timestamp Action Category Detail
2021-08-06 Deleted DEFINITION A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
2021-08-06 Added DEFINITION A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
2021-07-18 Added SYNONYM PCAF histone acetylase-associated complex
2021-07-18 Added SYNONYM STAGA complex
2021-07-18 Added SYNONYM SPT3-TAF9-GCN5 acetylase complex
2021-07-18 Added SYNONYM STAGA coactivator complex
2021-07-18 Added SYNONYM SPT3-TAF9-PCAF acetylase complex
2021-07-18 Added SYNONYM PCAF complex
2016-08-31 Added DEFINITION A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8.
2016-08-31 Deleted DEFINITION A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery.
2009-03-06 Deleted DEFINITION A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2009-03-06 Added DEFINITION A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery.
2008-05-16 Deleted DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-16 Added DEFINITION A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-15 Deleted DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-15 Added DEFINITION A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-15 Updated DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-14 Updated DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-13 Deleted DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-13 Added DEFINITION A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-13 Added DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2008-05-12 Deleted DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2007-08-09 Added SYNONYM Spt-Ada-Gcn5-acetyltransferase complex
2007-08-09 Deleted SYNONYM Spt-Ada-Gcn5-acetyltransferase complex
2004-04-19 Added SYNONYM Spt-Ada-Gcn5-acetyltransferase complex
2004-04-16 Deleted SYNONYM Spt-Ada-Gcn5-acetyltransferase complex
2004-03-18 Updated DEFINITION A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins.
2002-11-27 Added DEFINITION A large multiprotein complex that is required for the normal transcription of approximately 10% of yeast genes.
2002-11-07 Added SYNONYM Spt-Ada-Gcn5-acetyltransferase complex
Timestamp Action Category Detail
2016-08-31 Added RELATION is a GO:1905368 (peptidase complex)
2016-08-31 Added RELATION capable of GO:0004843 (cysteine-type deubiquitinase activity)
2013-02-13 Deleted RELATION is a GO:0016585 (obsolete chromatin remodeling complex)
2012-01-19 Added RELATION is a GO:0016585 (obsolete chromatin remodeling complex)
2009-03-06 Added RELATION is a GO:0070461 (SAGA-type complex)
2009-03-06 Deleted RELATION is a GO:0000123 (histone acetyltransferase complex)
2008-04-01 Updated RELATION is a GO:0000123 (histone acetyltransferase complex)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:2759 (Eukaryota)
2021-07-18 Added SECONDARY GO:0000125 (PCAF complex)
2021-07-18 Added SECONDARY GO:0030914 (STAGA complex)
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