GO:0000124
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SAGA complex
Cellular Component
Definition (GO:0000124 GONUTS page)
A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). PMID:10637607 PMID:17337012 PMID:19056896 PMID:20838651 PMID:33004486
Secondary IDs
GO:0000125, GO:0030914
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
STAGA complex | related |
PCAF histone acetylase-associated complex | narrow |
PCAF complex | narrow |
SPT3-TAF9-GCN5 acetylase complex | related |
SPT3-TAF9-PCAF acetylase complex | narrow |
STAGA coactivator complex | related |
Spt-Ada-Gcn5-acetyltransferase complex | exact |
Ancestor Chart
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0000124 | SAGA complex | Only in Taxon | 2759 | Eukaryota |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y7L4 | 10116 | A0A8I5Y7L4_RAT | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q14TE9 | 10116 | Q14TE9_RAT | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q63177 | 10116 | Q63177_RAT | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q64511 | 10090 | TOP2B_MOUSE | GO:0005694 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:11835579 | |
NOT-qualified manual | protein | Q8NFT6 | 9606 | DBF4B_HUMAN | GO:0000785 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15668232 | |
NOT-qualified manual | protein | Q9URY0 | 284812 | YTM1_SCHPO | GO:0000785 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:36423630 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR018783 | Transcription factor, enhancer of yellow 2 |
InterPro | IPR021950 | Transcription factor Spt20 |
InterPro | IPR037782 | Transcriptional activator Spt7 |
InterPro | IPR037794 | Transcription initiation factor TFIID subunit 12 |
InterPro | IPR037796 | Transcription initiation factor TFIID subunit 6 |
InterPro | IPR037802 | SAGA-associated factor 29 |
InterPro | IPR037804 | SAGA-associated factor 73 |
InterPro | IPR039460 | STAGA complex 65 subunit gamma |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000124 based on ALL annotations
The top 100 of 795 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SAGA complex
|
3,516.19 | 100.00 | 56,355 | 56,355 |
transcription factor TFIID complex
|
1,039.16 | 18.86 | 19,305 | 65,322 |
RNA polymerase II preinitiation complex assembly
|
1,314.57 | 18.58 | 15,199 | 40,654 |
SLIK (SAGA-like) complex
|
3,516.19 | 15.55 | 8,766 | 8,766 |
RNA polymerase II general transcription initiation factor activity
|
787.81 | 13.72 | 14,722 | 65,708 |
transcription coactivator activity
|
523.07 | 12.69 | 26,130 | 175,653 |
SAGA-type complex
|
1,737.09 | 11.64 | 7,444 | 15,068 |
DUBm complex
|
3,183.31 | 7.89 | 4,485 | 4,954 |
transcription initiation at RNA polymerase II promoter
|
360.37 | 6.94 | 9,968 | 97,260 |
protein heterodimerization activity
|
252.55 | 6.27 | 18,697 | 260,315 |
Totals | 368019 | 23315385 |
No co-occurrence statistics for GO:0000124 based on MANUAL annotations
The top 100 of 323 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
SAGA complex
|
989.16 | 100.00 | 1,427 | 1,427 |
transcription factor TFIID complex
|
238.21 | 15.51 | 433 | 1,798 |
RNA polymerase II general transcription initiation factor activity
|
175.05 | 12.18 | 401 | 2,266 |
transcription coactivator activity
|
131.53 | 11.71 | 707 | 5,317 |
DUBm complex
|
760.14 | 10.58 | 156 | 203 |
transcription initiation at RNA polymerase II promoter
|
133.56 | 8.42 | 261 | 1,933 |
RNA polymerase II preinitiation complex assembly
|
127.88 | 6.61 | 170 | 1,315 |
DNA repair-dependent chromatin remodeling
|
336.59 | 6.06 | 98 | 288 |
promoter-specific chromatin binding
|
158.54 | 5.74 | 117 | 730 |
transcription factor TFTC complex
|
803.08 | 5.67 | 82 | 101 |
Totals | 6311 | 173778 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2021-08-06 | Deleted | DEFINITION | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8. |
2021-08-06 | Added | DEFINITION | A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
2021-07-18 | Added | SYNONYM | PCAF histone acetylase-associated complex |
2021-07-18 | Added | SYNONYM | STAGA complex |
2021-07-18 | Added | SECONDARY | GO:0000125 (PCAF complex) |
2021-07-18 | Added | SECONDARY | GO:0030914 (STAGA complex) |
2021-07-18 | Added | SYNONYM | SPT3-TAF9-GCN5 acetylase complex |
2021-07-18 | Added | SYNONYM | STAGA coactivator complex |
2021-07-18 | Added | SYNONYM | SPT3-TAF9-PCAF acetylase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-02-06 | Updated | TERM | SAGA complex |
2001-04-03 | Updated | TERM | SAGA complex |
2001-03-30 | Added | TERM | SAGA complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-08-06 | Deleted | DEFINITION | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8. |
2021-08-06 | Added | DEFINITION | A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
2021-07-18 | Added | SYNONYM | PCAF histone acetylase-associated complex |
2021-07-18 | Added | SYNONYM | STAGA complex |
2021-07-18 | Added | SYNONYM | SPT3-TAF9-GCN5 acetylase complex |
2021-07-18 | Added | SYNONYM | STAGA coactivator complex |
2021-07-18 | Added | SYNONYM | SPT3-TAF9-PCAF acetylase complex |
2021-07-18 | Added | SYNONYM | PCAF complex |
2016-08-31 | Added | DEFINITION | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8. |
2016-08-31 | Deleted | DEFINITION | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. |
2009-03-06 | Deleted | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2009-03-06 | Added | DEFINITION | A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery. |
2008-05-16 | Deleted | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-16 | Added | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-15 | Deleted | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-15 | Added | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-15 | Updated | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-14 | Updated | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-13 | Deleted | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-13 | Added | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-13 | Added | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2008-05-12 | Deleted | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2007-08-09 | Added | SYNONYM | Spt-Ada-Gcn5-acetyltransferase complex |
2007-08-09 | Deleted | SYNONYM | Spt-Ada-Gcn5-acetyltransferase complex |
2004-04-19 | Added | SYNONYM | Spt-Ada-Gcn5-acetyltransferase complex |
2004-04-16 | Deleted | SYNONYM | Spt-Ada-Gcn5-acetyltransferase complex |
2004-03-18 | Updated | DEFINITION | A large multiprotein complex that possesses histone acetyltransferase and in involved in regulation of transcription. The budding yeast complex includes Gcn5p, several proteins of the Spt and Ada families, and several TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. |
2002-11-27 | Added | DEFINITION | A large multiprotein complex that is required for the normal transcription of approximately 10% of yeast genes. |
2002-11-07 | Added | SYNONYM | Spt-Ada-Gcn5-acetyltransferase complex |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-08-31 | Added | RELATION | is a GO:1905368 (peptidase complex) |
2016-08-31 | Added | RELATION | capable of GO:0004843 (cysteine-type deubiquitinase activity) |
2013-02-13 | Deleted | RELATION | is a GO:0016585 (obsolete chromatin remodeling complex) |
2012-01-19 | Added | RELATION | is a GO:0016585 (obsolete chromatin remodeling complex) |
2009-03-06 | Added | RELATION | is a GO:0070461 (SAGA-type complex) |
2009-03-06 | Deleted | RELATION | is a GO:0000123 (histone acetyltransferase complex) |
2008-04-01 | Updated | RELATION | is a GO:0000123 (histone acetyltransferase complex) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-05 | Added | CONSTRAINT | in_taxon NCBITaxon:2759 (Eukaryota) |
2021-07-18 | Added | SECONDARY | GO:0000125 (PCAF complex) |
2021-07-18 | Added | SECONDARY | GO:0030914 (STAGA complex) |
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