This term is obsolete.

GO:0000166 JSON

nucleotide binding

Molecular Function

Definition (GO:0000166 GONUTS page)

Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

29,604,365 annotations

Ancestor Chart

Ancestor chart for GO:0000166
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000166

Child Term Relationship to
GO:0000166
pyrimidine nucleotide binding
is_a
methyl-CpNpG binding
is_a
methyl-CpNpN binding
is_a
methyl-CpG binding
is_a
cyclic nucleotide binding
is_a
flavin adenine dinucleotide binding
is_a
purine nucleotide binding
is_a
deoxyribonucleotide binding
is_a
ribonucleotide binding
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q28283 9615 TRIB2_CANLF GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9342215
NOT-qualified manual protein Q5GLH2 9913 TRIB2_BOVIN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q5R669 9601 TRIB2_PONAB GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q7Z7A4 9606 PXK_HUMAN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:16142408
NOT-qualified manual protein Q8K4K3 10090 TRIB2_MOUSE GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q92519 9606 TRIB2_HUMAN GO:0000166 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR000683 Gfo/Idh/MocA-like oxidoreductase, N-terminal
InterPro IPR000924 Glutamyl/glutaminyl-tRNA synthetase
InterPro IPR001114 Adenylosuccinate synthetase
InterPro IPR001412 Aminoacyl-tRNA synthetase, class I, conserved site
InterPro IPR002300 Aminoacyl-tRNA synthetase, class Ia
InterPro IPR002301 Isoleucine-tRNA ligase
InterPro IPR002302 Leucine-tRNA ligase
InterPro IPR002303 Valine-tRNA ligase
InterPro IPR002305 Aminoacyl-tRNA synthetase, class Ic
InterPro IPR002306 Tryptophan-tRNA ligase

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CHEBI CHEBI:36976 nucleotide

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000166 based on ALL annotations
The top 100 of 5,750 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nucleotide binding
105.85 100.00 1,841,736 1,841,736
RNA-templated transcription
42.30 6.96 143,236 358,442
RNA-dependent RNA polymerase activity
42.29 6.96 143,236 358,456
viral RNA genome replication
38.16 6.17 127,526 353,725
flavin adenine dinucleotide binding
12.36 5.86 193,951 1,660,475
oxidoreductase activity
6.10 5.25 685,673 11,906,003
5'-3' RNA polymerase activity
40.21 4.90 98,101 258,232
NADP binding
12.98 4.09 106,341 867,427
nucleotide metabolic process
28.00 3.94 81,450 307,900
dihydrolipoyl dehydrogenase activity
84.37 3.77 70,109 87,954
Totals 8802685 138185191
No co-occurrence statistics for GO:0000166 based on MANUAL annotations
The top 100 of 535 co-occurring terms
Co-occurring Term PR S% #Together #Compared
nucleotide binding
9,033.56 100.00 143 143
poly-ADP-D-ribose modification-dependent protein binding
3,011.19 5.59 9 27
meiotic spindle checkpoint signaling
6,022.37 5.44 8 12
ADP-D-ribose modification-dependent protein binding
5,269.58 4.73 7 12
positive regulation of DNA ligation
2,168.05 3.70 6 25
histone reader activity
671.92 3.53 9 121
mitotic G2/M transition checkpoint
466.02 3.40 13 252
histone chaperone activity
843.13 3.32 7 75
2-dehydro-3-deoxygluconokinase activity
3,474.45 3.31 5 13
regulation of isotype switching
2,822.99 3.25 5 16
Totals 598 22227

GO Slims

This term is present in the following GO Consortium-maintained GO slims:

GO slim name Total Number of Terms in Slim
goslim_metagenomics 111
goslim_pir 439
goslim_plant 97
goslim_chembl 296

Change Log

Timestamp Action Category Detail
2023-09-12 Added RELATION is a GO:1901363 (heterocyclic compound binding)
2023-09-12 Deleted RELATION is a GO:0036094 (small molecule binding)
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2021-05-24 Added DEFINITION Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2020-02-28 Deleted XREF MIPS_funcat:16.19
2019-05-04 Added XREF MIPS_funcat:16.19
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_plant
Timestamp Action Category Detail
2003-06-10 Updated TERM nucleotide binding
2003-03-19 Updated TERM nucleotide binding activity
2002-02-06 Updated TERM nucleotide binding
2001-04-03 Updated TERM nucleotide binding
2001-03-30 Added TERM nucleotide binding
Timestamp Action Category Detail
2021-05-24 Deleted DEFINITION Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2021-05-24 Added DEFINITION Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2010-10-11 Added DEFINITION Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
2010-10-11 Deleted DEFINITION Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2009-07-03 Added DEFINITION Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2009-07-03 Deleted DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2008-05-13 Added DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2008-05-12 Deleted DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2007-10-25 Updated DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety.
2003-04-24 Updated DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety.
2003-03-26 Updated DEFINITION Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety.
2002-11-27 Updated DEFINITION Interacting selectively and stoichiometrically with a nucleotide: any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety.
2001-08-06 Added DEFINITION Physical interaction with a nucleotide: any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety.
Timestamp Action Category Detail
2023-09-12 Added RELATION is a GO:1901363 (heterocyclic compound binding)
2023-09-12 Deleted RELATION is a GO:0036094 (small molecule binding)
2012-08-24 Added RELATION is a GO:1901265 (nucleoside phosphate binding)
2012-01-19 Deleted RELATION is a GO:0005488 (binding)
2012-01-19 Added RELATION is a GO:0036094 (small molecule binding)
2011-10-28 Added RELATION has part GO:0016502 (nucleotide receptor activity)
2008-04-01 Updated RELATION is a GO:0005488 (binding)
Timestamp Action Category Detail
2020-02-28 Deleted XREF MIPS_funcat:16.19
2019-05-04 Added XREF MIPS_funcat:16.19
Timestamp Action Category Detail
2015-05-19 Deleted SUBSET goslim_ChEMBL
2015-05-19 Added SUBSET goslim_chembl
2015-05-11 Added SUBSET goslim_ChEMBL
2013-04-18 Updated SUBSET goslim_plant
2013-04-18 Updated SUBSET goslim_metagenomics
2013-04-18 Updated SUBSET goslim_pir
2012-02-17 Added SUBSET goslim_metagenomics
2010-12-05 Deleted SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_plant
2008-06-09 Added SUBSET goslim_generic
2008-06-09 Added SUBSET goslim_pir
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.