GO:0000166
JSON
nucleotide binding
Molecular Function
Definition (GO:0000166 GONUTS page)
Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000166
Child Term | Relationship to GO:0000166 |
---|---|
ribonucleotide binding
|
is_a |
flavin adenine dinucleotide binding
|
is_a |
deoxyribonucleotide binding
|
is_a |
methyl-CpNpG binding
|
is_a |
methyl-CpNpN binding
|
is_a |
purine nucleotide binding
|
is_a |
pyrimidine nucleotide binding
|
is_a |
methyl-CpG binding
|
is_a |
cyclic nucleotide binding
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8J8XB91 | 10116 | A0A8J8XB91_RAT | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HAS1 | 10116 | A6HAS1_RAT | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B5DF61 | 10116 | B5DF61_RAT | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q28283 | 9615 | TRIB2_CANLF | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9342215 | |
NOT-qualified manual | protein | Q5GLH2 | 9913 | TRIB2_BOVIN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q5R669 | 9601 | TRIB2_PONAB | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q7Z7A4 | 9606 | PXK_HUMAN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000303 from this reference: PMID:16142408 | |
NOT-qualified manual | protein | Q8K4K3 | 10090 | TRIB2_MOUSE | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | Q92519 | 9606 | TRIB2_HUMAN | GO:0000166 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000683 | Gfo/Idh/MocA-like oxidoreductase, N-terminal |
InterPro | IPR000924 | Glutamyl/glutaminyl-tRNA synthetase |
InterPro | IPR001114 | Adenylosuccinate synthetase |
InterPro | IPR001412 | Aminoacyl-tRNA synthetase, class I, conserved site |
InterPro | IPR002300 | Aminoacyl-tRNA synthetase, class Ia |
InterPro | IPR002301 | Isoleucine-tRNA ligase |
InterPro | IPR002302 | Leucine-tRNA ligase |
InterPro | IPR002303 | Valine-tRNA ligase |
InterPro | IPR002305 | Aminoacyl-tRNA synthetase, class Ic |
InterPro | IPR002306 | Tryptophan-tRNA ligase |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CHEBI | CHEBI:36976 | nucleotide |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000166 based on ALL annotations
The top 100 of 5,705 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nucleotide binding
|
102.89 | 100.00 | 1,925,949 | 1,925,949 |
RNA-templated transcription
|
40.56 | 6.62 | 141,873 | 359,909 |
RNA-dependent RNA polymerase activity
|
40.56 | 6.62 | 141,873 | 359,923 |
viral RNA genome replication
|
36.58 | 5.85 | 126,012 | 354,413 |
flavin adenine dinucleotide binding
|
11.30 | 5.42 | 186,338 | 1,696,922 |
oxidoreductase activity
|
5.99 | 5.30 | 718,015 | 12,339,325 |
5'-3' RNA polymerase activity
|
39.48 | 4.71 | 98,099 | 255,660 |
NADP binding
|
12.90 | 4.11 | 110,848 | 884,170 |
pyruvate metabolic process
|
33.05 | 3.98 | 83,710 | 260,574 |
nucleotide metabolic process
|
26.07 | 3.65 | 78,762 | 310,832 |
Totals | 8862525 | 136796858 |
No co-occurrence statistics for GO:0000166 based on MANUAL annotations
The top 100 of 535 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
nucleotide binding
|
9,734.71 | 100.00 | 145 | 145 |
poly-ADP-D-ribose modification-dependent protein binding
|
3,244.90 | 5.52 | 9 | 27 |
meiotic spindle checkpoint signaling
|
6,489.81 | 5.37 | 8 | 12 |
ADP-D-ribose modification-dependent protein binding
|
5,678.58 | 4.67 | 7 | 12 |
histone reader activity
|
724.07 | 3.50 | 9 | 121 |
histone chaperone activity
|
908.57 | 3.29 | 7 | 75 |
mitotic G2/M transition checkpoint
|
477.55 | 3.27 | 13 | 265 |
2-dehydro-3-deoxygluconokinase activity
|
3,744.12 | 3.27 | 5 | 13 |
regulation of isotype switching
|
3,042.10 | 3.21 | 5 | 16 |
regulation of MAP kinase activity
|
2,212.43 | 3.09 | 5 | 22 |
Totals | 592 | 23022 |
GO Slims
This term is present in the following GO Consortium-maintained GO slims:
GO slim name | Total Number of Terms in Slim |
---|---|
goslim_metagenomics | 111 |
goslim_pir | 438 |
goslim_plant | 97 |
goslim_chembl | 296 |
Change Log
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- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-12 | Added | RELATION | is a GO:1901363 (heterocyclic compound binding) |
2023-09-12 | Deleted | RELATION | is a GO:0036094 (small molecule binding) |
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
2021-05-24 | Added | DEFINITION | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
2020-02-28 | Deleted | XREF | MIPS_funcat:16.19 |
2019-05-04 | Added | XREF | MIPS_funcat:16.19 |
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_plant |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-06-10 | Updated | TERM | nucleotide binding |
2003-03-19 | Updated | TERM | nucleotide binding activity |
2002-02-06 | Updated | TERM | nucleotide binding |
2001-04-03 | Updated | TERM | nucleotide binding |
2001-03-30 | Added | TERM | nucleotide binding |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-24 | Deleted | DEFINITION | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
2021-05-24 | Added | DEFINITION | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
2010-10-11 | Deleted | DEFINITION | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2010-10-11 | Added | DEFINITION | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
2009-07-03 | Added | DEFINITION | Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2009-07-03 | Deleted | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2008-05-13 | Added | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2008-05-12 | Deleted | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2007-10-25 | Updated | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety. |
2003-04-24 | Updated | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. |
2003-03-26 | Updated | DEFINITION | Interacting selectively with a nucleotide, any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. |
2002-11-27 | Updated | DEFINITION | Interacting selectively and stoichiometrically with a nucleotide: any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. |
2001-08-06 | Added | DEFINITION | Physical interaction with a nucleotide: any compound consisting of a nucleoside that is esterified with [ortho]phosphate or an oligophosphate at any hydroxyl group on the glycose moiety. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-09-12 | Added | RELATION | is a GO:1901363 (heterocyclic compound binding) |
2023-09-12 | Deleted | RELATION | is a GO:0036094 (small molecule binding) |
2012-08-24 | Added | RELATION | is a GO:1901265 (nucleoside phosphate binding) |
2012-01-19 | Added | RELATION | is a GO:0036094 (small molecule binding) |
2012-01-19 | Deleted | RELATION | is a GO:0005488 (binding) |
2011-10-28 | Added | RELATION | has part GO:0016502 (nucleotide receptor activity) |
2008-04-01 | Updated | RELATION | is a GO:0005488 (binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-02-28 | Deleted | XREF | MIPS_funcat:16.19 |
2019-05-04 | Added | XREF | MIPS_funcat:16.19 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2015-05-19 | Deleted | SUBSET | goslim_ChEMBL |
2015-05-19 | Added | SUBSET | goslim_chembl |
2015-05-11 | Added | SUBSET | goslim_ChEMBL |
2013-04-18 | Updated | SUBSET | goslim_plant |
2013-04-18 | Updated | SUBSET | goslim_pir |
2013-04-18 | Updated | SUBSET | goslim_metagenomics |
2012-02-17 | Added | SUBSET | goslim_metagenomics |
2010-12-05 | Deleted | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_pir |
2008-06-09 | Added | SUBSET | goslim_generic |
2008-06-09 | Added | SUBSET | goslim_plant |
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