This term is obsolete.

GO:0000175 JSON

3'-5'-RNA exonuclease activity

Molecular Function

Definition (GO:0000175 GONUTS page)

Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.

241,460 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
3'-5' exoribonuclease activity exact
3'-5'-exoribonuclease activity exact

Ancestor Chart

Ancestor chart for GO:0000175
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000175

Child Term Relationship to
GO:0000175
poly(A)-specific ribonuclease activity
is_a
3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
is_a
exoribonuclease II activity
is_a
exosome (RNase complex)
capable_of
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0B4KFF6 7227 A0A0B4KFF6_DROME GO:0004518 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983
NOT-qualified manual protein A0A0G2K5A0 10116 A0A0G2K5A0_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A0G2K5G5 10116 A0A0G2K5G5_RAT GO:0004527 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5Y5D3 10116 A0A8I5Y5D3_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZNY7 10116 A0A8I5ZNY7_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A3V5 10116 A0A8I6A3V5_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A842 10116 A0A8I6A842_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AAC4 10116 A0A8I6AAC4_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6AB24 10116 A0A8I6AB24_RAT GO:0004532 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6ACW3 10116 A0A8I6ACW3_RAT GO:0004540 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR020873 3'-5' exoribonuclease YhaM
InterPro IPR022894 Oligoribonuclease
InterPro IPR028591 DIS3-like exonuclease 2
InterPro IPR037433 ISG20, DEDDh 3'-5' exonuclease domain
InterPro IPR045092 Exosome complex exonuclease Rrp6-like
InterPro IPR046436 Nidovirus 3'-5' exoribonuclease domain
InterPro IPR047201 ERI-1-like, DEDDh 3'-5' exonuclease domain
Reactome R-HSA-430028
Reactome R-HSA-6791222
Reactome R-HSA-6791227

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000175 based on ALL annotations
The top 100 of 1,122 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3'-5'-RNA exonuclease activity
1,055.27 100.00 184,729 184,729
polyribonucleotide nucleotidyltransferase activity
1,046.72 25.87 47,898 48,289
mRNA catabolic process
302.63 18.46 63,066 219,909
tRNA nucleotidyltransferase activity
977.33 13.70 25,594 27,635
rRNA catabolic process
346.46 13.05 32,897 100,199
RNA catabolic process
119.01 8.44 46,412 411,540
exonuclease activity
100.41 8.21 69,056 725,769
RNA exonuclease activity, producing 5'-phosphomonoesters
714.31 7.19 13,760 20,328
RNA nuclease activity
86.26 5.00 21,061 257,653
nuclear exosome (RNase complex)
248.15 4.93 10,835 46,076
Totals 1348366 55613927
No co-occurrence statistics for GO:0000175 based on MANUAL annotations
The top 100 of 392 co-occurring terms
Co-occurring Term PR S% #Together #Compared
3'-5'-RNA exonuclease activity
853.80 100.00 1,513 1,513
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
358.74 19.37 400 952
nuclear exosome (RNase complex)
198.12 11.83 294 1,267
nuclear polyadenylation-dependent antisense transcript catabolic process
821.32 11.64 177 184
histone mRNA catabolic process
620.63 11.45 181 249
nuclear polyadenylation-dependent snoRNA catabolic process
657.05 11.30 177 230
nuclear polyadenylation-dependent snRNA catabolic process
657.05 11.30 177 230
nuclear polyadenylation-dependent CUT catabolic process
630.61 11.29 178 241
polyribonucleotide nucleotidyltransferase activity
848.69 10.96 166 167
mRNA catabolic process
209.95 10.21 225 915
Totals 7357 139272

Change Log

Timestamp Action Category Detail
2024-06-12 Deleted XREF EC:3.1.13.-
2023-11-01 Added XREF Reactome:R-HSA-9836585
2023-11-01 Added XREF Reactome:R-HSA-9836822
2023-11-01 Added XREF Reactome:R-HSA-9822437
2023-10-28 Deleted XREF Reactome:R-HSA-9822437
2023-10-28 Deleted XREF Reactome:R-HSA-9836822
2023-10-28 Deleted XREF Reactome:R-HSA-9836585
2023-10-23 Added XREF Reactome:R-HSA-9836822
2023-10-23 Added XREF Reactome:R-HSA-9836585
2023-10-23 Added XREF Reactome:R-HSA-9822437
Timestamp Action Category Detail
2022-12-18 Updated TERM 3'-5'-RNA exonuclease activity
2004-02-26 Updated TERM 3'-5'-exoribonuclease activity
2003-03-19 Updated TERM 3'-5' exoribonuclease activity
2002-02-06 Updated TERM 3'-5' exoribonuclease
2001-04-03 Updated TERM 3'-5' exoribonuclease
2001-03-30 Added TERM 3'-5' exoribonuclease
Timestamp Action Category Detail
2022-12-18 Added SYNONYM 3'-5'-exoribonuclease activity
2008-05-13 Added DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
2008-05-12 Deleted DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
2007-08-09 Added SYNONYM 3'-5' exoribonuclease activity
2007-08-09 Deleted SYNONYM 3'-5' exoribonuclease activity
2004-04-19 Added SYNONYM 3'-5' exoribonuclease activity
2004-04-16 Deleted SYNONYM 3'-5' exoribonuclease activity
2004-02-26 Added SYNONYM 3'-5' exoribonuclease activity
2003-03-26 Updated DEFINITION Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
2001-08-06 Added DEFINITION Ribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008408 (3'-5' exonuclease activity)
2008-04-01 Updated RELATION is a GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters)
Timestamp Action Category Detail
2024-06-12 Deleted XREF EC:3.1.13.-
2023-11-01 Added XREF Reactome:R-HSA-9836585
2023-11-01 Added XREF Reactome:R-HSA-9836822
2023-11-01 Added XREF Reactome:R-HSA-9822437
2023-10-28 Deleted XREF Reactome:R-HSA-9822437
2023-10-28 Deleted XREF Reactome:R-HSA-9836822
2023-10-28 Deleted XREF Reactome:R-HSA-9836585
2023-10-23 Added XREF Reactome:R-HSA-9836822
2023-10-23 Added XREF Reactome:R-HSA-9836585
2023-10-23 Added XREF Reactome:R-HSA-9822437
2023-10-10 Deleted XREF Reactome:R-HSA-9836585
2023-10-10 Deleted XREF Reactome:R-HSA-9822437
2023-10-10 Deleted XREF Reactome:R-HSA-9836822
2023-09-23 Added XREF Reactome:R-HSA-9836585
2023-09-23 Added XREF Reactome:R-HSA-9822437
2023-09-23 Added XREF Reactome:R-HSA-9836822
2021-01-04 Deleted XREF EC:3.1.13
2021-01-04 Added XREF EC:3.1.13.-
2020-12-17 Added XREF Reactome:R-HSA-9694632
2020-07-19 Deleted XREF Reactome:R-HSA-6791218
2020-07-19 Added XREF Reactome:R-HSA-9682603
2019-04-01 Added XREF Reactome:R-HSA-6791218
2019-04-01 Added XREF Reactome:R-HSA-6791227
2019-04-01 Added XREF Reactome:R-HSA-430028
2019-04-01 Added XREF Reactome:R-HSA-6791222
2019-04-01 Deleted XREF reactome:R-HSA-430028
2019-04-01 Deleted XREF reactome:R-HSA-6791218
2019-04-01 Deleted XREF reactome:R-HSA-6791222
2019-04-01 Deleted XREF reactome:R-HSA-6791227
2018-12-11 Added XREF reactome:R-HSA-6791218
2018-12-11 Added XREF reactome:R-HSA-6791227
2018-12-11 Added XREF reactome:R-HSA-6791222
2018-12-11 Added XREF reactome:R-HSA-430028
2016-10-03 Added XREF EC:3.1.13
2016-10-03 Deleted XREF EC:3.1.13.-
2001-03-30 Added XREF EC:3.1.13.-
Timestamp Action Category Detail
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