GO:0000175
JSON
3'-5'-RNA exonuclease activity
Molecular Function
Definition (GO:0000175 GONUTS page)
Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
3'-5' exoribonuclease activity | exact |
3'-5'-exoribonuclease activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000175
Child Term | Relationship to GO:0000175 |
---|---|
poly(A)-specific ribonuclease activity
|
is_a |
3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
|
is_a |
exoribonuclease II activity
|
is_a |
exosome (RNase complex)
|
capable_of |
poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0B4KFF6 | 7227 | A0A0B4KFF6_DROME | GO:0004518 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:25392983 | |
NOT-qualified manual | protein | A0A0G2K5A0 | 10116 | A0A0G2K5A0_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A0G2K5G5 | 10116 | A0A0G2K5G5_RAT | GO:0004527 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5Y5D3 | 10116 | A0A8I5Y5D3_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZNY7 | 10116 | A0A8I5ZNY7_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A3V5 | 10116 | A0A8I6A3V5_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A842 | 10116 | A0A8I6A842_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AAC4 | 10116 | A0A8I6AAC4_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6AB24 | 10116 | A0A8I6AB24_RAT | GO:0004532 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6ACW3 | 10116 | A0A8I6ACW3_RAT | GO:0004540 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR020873 | 3'-5' exoribonuclease YhaM |
InterPro | IPR022894 | Oligoribonuclease |
InterPro | IPR028591 | DIS3-like exonuclease 2 |
InterPro | IPR037433 | ISG20, DEDDh 3'-5' exonuclease domain |
InterPro | IPR045092 | Exosome complex exonuclease Rrp6-like |
InterPro | IPR046436 | Nidovirus 3'-5' exoribonuclease domain |
InterPro | IPR047201 | ERI-1-like, DEDDh 3'-5' exonuclease domain |
Reactome | R-HSA-430028 | |
Reactome | R-HSA-6791222 | |
Reactome | R-HSA-6791227 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000175 based on ALL annotations
The top 100 of 1,122 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3'-5'-RNA exonuclease activity
|
1,055.27 | 100.00 | 184,729 | 184,729 |
polyribonucleotide nucleotidyltransferase activity
|
1,046.72 | 25.87 | 47,898 | 48,289 |
mRNA catabolic process
|
302.63 | 18.46 | 63,066 | 219,909 |
tRNA nucleotidyltransferase activity
|
977.33 | 13.70 | 25,594 | 27,635 |
rRNA catabolic process
|
346.46 | 13.05 | 32,897 | 100,199 |
RNA catabolic process
|
119.01 | 8.44 | 46,412 | 411,540 |
exonuclease activity
|
100.41 | 8.21 | 69,056 | 725,769 |
RNA exonuclease activity, producing 5'-phosphomonoesters
|
714.31 | 7.19 | 13,760 | 20,328 |
RNA nuclease activity
|
86.26 | 5.00 | 21,061 | 257,653 |
nuclear exosome (RNase complex)
|
248.15 | 4.93 | 10,835 | 46,076 |
Totals | 1348366 | 55613927 |
No co-occurrence statistics for GO:0000175 based on MANUAL annotations
The top 100 of 392 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
3'-5'-RNA exonuclease activity
|
853.80 | 100.00 | 1,513 | 1,513 |
exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
|
358.74 | 19.37 | 400 | 952 |
nuclear exosome (RNase complex)
|
198.12 | 11.83 | 294 | 1,267 |
nuclear polyadenylation-dependent antisense transcript catabolic process
|
821.32 | 11.64 | 177 | 184 |
histone mRNA catabolic process
|
620.63 | 11.45 | 181 | 249 |
nuclear polyadenylation-dependent snoRNA catabolic process
|
657.05 | 11.30 | 177 | 230 |
nuclear polyadenylation-dependent snRNA catabolic process
|
657.05 | 11.30 | 177 | 230 |
nuclear polyadenylation-dependent CUT catabolic process
|
630.61 | 11.29 | 178 | 241 |
polyribonucleotide nucleotidyltransferase activity
|
848.69 | 10.96 | 166 | 167 |
mRNA catabolic process
|
209.95 | 10.21 | 225 | 915 |
Totals | 7357 | 139272 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-12 | Deleted | XREF | EC:3.1.13.- |
2023-11-01 | Added | XREF | Reactome:R-HSA-9836585 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9836822 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9822437 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9822437 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9836822 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9836585 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9836822 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9836585 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9822437 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Updated | TERM | 3'-5'-RNA exonuclease activity |
2004-02-26 | Updated | TERM | 3'-5'-exoribonuclease activity |
2003-03-19 | Updated | TERM | 3'-5' exoribonuclease activity |
2002-02-06 | Updated | TERM | 3'-5' exoribonuclease |
2001-04-03 | Updated | TERM | 3'-5' exoribonuclease |
2001-03-30 | Added | TERM | 3'-5' exoribonuclease |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-12-18 | Added | SYNONYM | 3'-5'-exoribonuclease activity |
2008-05-13 | Added | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
2007-08-09 | Added | SYNONYM | 3'-5' exoribonuclease activity |
2007-08-09 | Deleted | SYNONYM | 3'-5' exoribonuclease activity |
2004-04-19 | Added | SYNONYM | 3'-5' exoribonuclease activity |
2004-04-16 | Deleted | SYNONYM | 3'-5' exoribonuclease activity |
2004-02-26 | Added | SYNONYM | 3'-5' exoribonuclease activity |
2003-03-26 | Updated | DEFINITION | Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
2001-08-06 | Added | DEFINITION | Ribonuclease that catalyzes sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008408 (3'-5' exonuclease activity) |
2008-04-01 | Updated | RELATION | is a GO:0016896 (RNA exonuclease activity, producing 5'-phosphomonoesters) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-06-12 | Deleted | XREF | EC:3.1.13.- |
2023-11-01 | Added | XREF | Reactome:R-HSA-9836585 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9836822 |
2023-11-01 | Added | XREF | Reactome:R-HSA-9822437 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9822437 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9836822 |
2023-10-28 | Deleted | XREF | Reactome:R-HSA-9836585 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9836822 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9836585 |
2023-10-23 | Added | XREF | Reactome:R-HSA-9822437 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9836585 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9822437 |
2023-10-10 | Deleted | XREF | Reactome:R-HSA-9836822 |
2023-09-23 | Added | XREF | Reactome:R-HSA-9836585 |
2023-09-23 | Added | XREF | Reactome:R-HSA-9822437 |
2023-09-23 | Added | XREF | Reactome:R-HSA-9836822 |
2021-01-04 | Deleted | XREF | EC:3.1.13 |
2021-01-04 | Added | XREF | EC:3.1.13.- |
2020-12-17 | Added | XREF | Reactome:R-HSA-9694632 |
2020-07-19 | Deleted | XREF | Reactome:R-HSA-6791218 |
2020-07-19 | Added | XREF | Reactome:R-HSA-9682603 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6791218 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6791227 |
2019-04-01 | Added | XREF | Reactome:R-HSA-430028 |
2019-04-01 | Added | XREF | Reactome:R-HSA-6791222 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-430028 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6791218 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6791222 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-6791227 |
2018-12-11 | Added | XREF | reactome:R-HSA-6791218 |
2018-12-11 | Added | XREF | reactome:R-HSA-6791227 |
2018-12-11 | Added | XREF | reactome:R-HSA-6791222 |
2018-12-11 | Added | XREF | reactome:R-HSA-430028 |
2016-10-03 | Added | XREF | EC:3.1.13 |
2016-10-03 | Deleted | XREF | EC:3.1.13.- |
2001-03-30 | Added | XREF | EC:3.1.13.- |
Timestamp | Action | Category | Detail |
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