GO:0000724
JSON
double-strand break repair via homologous recombination
Biological Process
Definition (GO:0000724 GONUTS page)
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. PMID:10357855
Secondary IDs
GO:0016924
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
HRR | exact |
Rhp51-dependent recombinational repair | exact |
Rad51-dependent recombinational repair | exact |
homologous recombinational repair | exact |
homology-directed repair | exact |
HDR | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0000724
Child Term | Relationship to GO:0000724 |
---|---|
positive regulation of double-strand break repair via homologous recombination
|
positively_regulates |
DNA synthesis involved in double-strand break repair via homologous recombination
|
part_of |
replication-born double-strand break repair via sister chromatid exchange
|
is_a |
double-strand break repair via synthesis-dependent strand annealing
|
is_a |
negative regulation of double-strand break repair via homologous recombination
|
negatively_regulates |
double-strand break repair via transcription-associated homologous recombination
|
is_a |
double-strand break repair via break-induced replication
|
is_a |
regulation of double-strand break repair via homologous recombination
|
regulates |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Guidance for interpreting DNA repair investigations | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I6A2U2 | 10116 | A0A8I6A2U2_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GI31 | 10116 | A0A8I6GI31_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J8M3 | 10116 | A6J8M3_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K9T7 | 10116 | A6K9T7_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | A8VU90 | 10090 | ANKL1_MOUSE | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503 | |
NOT-qualified manual | protein | D3ZAQ9 | 10116 | D3ZAQ9_RAT | GO:0006302 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006281 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A332 | 10116 | D4A332_RAT | GO:0006974 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR004585 | DNA recombination/repair protein Rad52 |
InterPro | IPR011941 | DNA recombination/repair protein Rad51 |
InterPro | IPR014140 | DNA helicase subunit AddB |
InterPro | IPR015187 | BRCA2, OB1 |
InterPro | IPR015525 | Breast cancer type 2 susceptibility protein |
InterPro | IPR026846 | E3 SUMO-protein ligase Nse2 (Mms21) |
InterPro | IPR027131 | Structural maintenance of chromosomes protein 5 |
InterPro | IPR028730 | Zinc finger FYVE domain-containing protein 26 |
InterPro | IPR029392 | AP-5 complex subunit sigma-1 |
InterPro | IPR030547 | DNA repair protein XRCC2 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000724 based on ALL annotations
The top 100 of 2,072 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
double-strand break repair via homologous recombination
|
962.95 | 100.00 | 202,439 | 202,439 |
exodeoxyribonuclease V activity
|
801.49 | 11.72 | 24,308 | 29,205 |
exodeoxyribonuclease V complex
|
527.38 | 10.92 | 24,305 | 44,379 |
site of double-strand break
|
394.28 | 10.57 | 25,246 | 61,659 |
Smc5-Smc6 complex
|
752.23 | 9.08 | 18,866 | 24,151 |
3'-5' DNA helicase activity
|
119.55 | 8.53 | 43,345 | 349,121 |
DNA unwinding involved in DNA replication
|
138.15 | 7.40 | 26,861 | 187,230 |
single-stranded DNA binding
|
90.69 | 6.95 | 42,383 | 450,028 |
four-way junction helicase activity
|
87.05 | 6.79 | 43,303 | 479,025 |
telomere maintenance
|
163.51 | 5.84 | 16,554 | 97,490 |
Totals | 1530263 | 19462647 |
No co-occurrence statistics for GO:0000724 based on MANUAL annotations
The top 100 of 1,243 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
double-strand break repair via homologous recombination
|
261.07 | 100.00 | 4,948 | 4,948 |
DNA replication factor A complex
|
252.21 | 23.37 | 1,166 | 1,207 |
damaged DNA binding
|
149.56 | 22.21 | 1,317 | 2,299 |
nucleotide-excision repair
|
145.03 | 21.65 | 1,296 | 2,333 |
single-stranded telomeric DNA binding
|
221.33 | 18.18 | 930 | 1,097 |
telomere maintenance via telomerase
|
191.29 | 17.62 | 932 | 1,272 |
meiotic cell cycle
|
141.59 | 16.49 | 948 | 1,748 |
four-way junction helicase activity
|
217.45 | 12.95 | 658 | 790 |
single-stranded DNA binding
|
63.83 | 12.76 | 1,042 | 4,262 |
site of double-strand break
|
112.24 | 12.25 | 724 | 1,684 |
Totals | 28679 | 405873 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-30 | Added | SYNONYM | HDR |
2009-10-30 | Added | SYNONYM | homology-directed repair |
2009-02-05 | Added | SYNONYM | Rad51-dependent recombinational repair |
2009-02-05 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-05 | Deleted | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-01 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-01 | Deleted | SYNONYM | Rad51-dependent recombinational repair |
2009-02-01 | Deleted | SYNONYM | Rhp51-dependent recombinational repair |
2009-01-31 | Added | SYNONYM | Rad51-dependent recombinational repair |
2009-01-31 | Added | SYNONYM | Rhp51-dependent recombinational repair |
Timestamp | Action | Category | Detail |
---|---|---|---|
2002-09-25 | Added | TERM | double-strand break repair via homologous recombination |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-10-30 | Added | SYNONYM | HDR |
2009-10-30 | Added | SYNONYM | homology-directed repair |
2009-02-05 | Added | SYNONYM | Rad51-dependent recombinational repair |
2009-02-05 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-05 | Deleted | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-01 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2009-02-01 | Deleted | SYNONYM | Rad51-dependent recombinational repair |
2009-02-01 | Deleted | SYNONYM | Rhp51-dependent recombinational repair |
2009-01-31 | Added | SYNONYM | Rad51-dependent recombinational repair |
2009-01-31 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2009-01-31 | Deleted | SYNONYM | Rhp51-dependent recombinational repair |
2008-06-30 | Added | SYNONYM | Rhp51-dependent recombinational repair |
2008-05-13 | Added | DEFINITION | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
2008-05-12 | Deleted | DEFINITION | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
2007-08-09 | Deleted | SYNONYM | HRR |
2007-08-09 | Deleted | SYNONYM | homologous recombinational repair |
2007-08-09 | Added | SYNONYM | homologous recombinational repair |
2007-08-09 | Added | SYNONYM | HRR |
2004-07-12 | Added | SYNONYM | HRR |
2004-07-12 | Added | SYNONYM | homologous recombinational repair |
2003-04-24 | Updated | DEFINITION | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
2002-11-27 | Added | DEFINITION | The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or non-reciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0000725 (recombinational repair) |
2008-04-01 | Updated | RELATION | is a GO:0006302 (double-strand break repair) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2007-01-15 | Added | SECONDARY | GO:0016924 (double-strand break repair via homologous recombination) |
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