This term is obsolete.

GO:0000724 JSON

double-strand break repair via homologous recombination

Biological Process

Definition (GO:0000724 GONUTS page)

The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule. PMID:10357855

Secondary IDs

GO:0016924

309,844 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
HDR exact
homologous recombinational repair exact
Rhp51-dependent recombinational repair exact
HRR exact
homology-directed repair exact
Rad51-dependent recombinational repair exact

Ancestor Chart

Ancestor chart for GO:0000724
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0000724

Child Term Relationship to
GO:0000724
negative regulation of double-strand break repair via homologous recombination
negatively_regulates
double-strand break repair via break-induced replication
is_a
regulation of double-strand break repair via homologous recombination
regulates
double-strand break repair via transcription-associated homologous recombination
is_a
DNA synthesis involved in double-strand break repair via homologous recombination
part_of
double-strand break repair via synthesis-dependent strand annealing
is_a
replication-born double-strand break repair via sister chromatid exchange
is_a
positive regulation of double-strand break repair via homologous recombination
positively_regulates

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Guidance for interpreting DNA repair investigations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I6A2U2 10116 A0A8I6A2U2_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GI31 10116 A0A8I6GI31_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J8M3 10116 A6J8M3_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K9T7 10116 A6K9T7_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein A8VU90 10090 ANKL1_MOUSE GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:27010503
NOT-qualified manual protein D3ZAQ9 10116 D3ZAQ9_RAT GO:0006302 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006281 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A332 10116 D4A332_RAT GO:0006974 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR004585 DNA recombination/repair protein Rad52
InterPro IPR011941 DNA recombination/repair protein Rad51
InterPro IPR014140 DNA helicase subunit AddB
InterPro IPR015187 BRCA2, OB1
InterPro IPR015525 Breast cancer type 2 susceptibility protein
InterPro IPR026846 E3 SUMO-protein ligase Nse2 (Mms21)
InterPro IPR027131 Structural maintenance of chromosomes protein 5
InterPro IPR028730 Zinc finger FYVE domain-containing protein 26
InterPro IPR029392 AP-5 complex subunit sigma-1
InterPro IPR030547 DNA repair protein XRCC2

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000724 based on ALL annotations
The top 100 of 2,051 co-occurring terms
Co-occurring Term PR S% #Together #Compared
double-strand break repair via homologous recombination
948.20 100.00 208,980 208,980
exodeoxyribonuclease V activity
787.21 11.53 24,683 29,731
exodeoxyribonuclease V complex
517.31 10.75 24,679 45,235
site of double-strand break
389.61 10.58 26,064 63,433
Smc5-Smc6 complex
738.89 9.10 19,511 25,038
3'-5' DNA helicase activity
118.69 8.56 44,570 356,060
single-stranded DNA binding
90.38 7.02 43,907 460,652
four-way junction helicase activity
87.01 6.82 43,889 478,275
telomere maintenance
160.26 5.83 17,080 101,053
double-strand break repair
79.80 5.67 30,890 367,027
Totals 1584427 31923467
No co-occurrence statistics for GO:0000724 based on MANUAL annotations
The top 100 of 1,217 co-occurring terms
Co-occurring Term PR S% #Together #Compared
double-strand break repair via homologous recombination
271.14 100.00 5,206 5,206
DNA replication
145.33 27.55 1,883 3,513
DNA replication factor A complex
262.28 22.57 1,184 1,224
damaged DNA binding
150.77 21.34 1,339 2,408
nucleotide-excision repair
149.89 21.03 1,319 2,386
single-stranded telomeric DNA binding
225.99 17.18 926 1,111
telomere maintenance via telomerase
194.00 16.65 928 1,297
meiotic cell cycle
141.03 15.52 943 1,813
single-stranded DNA binding
67.60 13.15 1,133 4,544
four-way junction helicase activity
216.85 12.99 699 874
Totals 30691 426619

Change Log

Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5693538
2009-10-30 Added SYNONYM HDR
2009-10-30 Added SYNONYM homology-directed repair
2009-02-05 Added SYNONYM Rad51-dependent recombinational repair
2009-02-05 Added SYNONYM Rhp51-dependent recombinational repair
2009-02-05 Deleted SYNONYM Rhp51-dependent recombinational repair
2009-02-01 Deleted SYNONYM Rhp51-dependent recombinational repair
2009-02-01 Deleted SYNONYM Rad51-dependent recombinational repair
2009-02-01 Added SYNONYM Rhp51-dependent recombinational repair
2009-01-31 Added SYNONYM Rhp51-dependent recombinational repair
Timestamp Action Category Detail
2002-09-25 Added TERM double-strand break repair via homologous recombination
Timestamp Action Category Detail
2009-10-30 Added SYNONYM HDR
2009-10-30 Added SYNONYM homology-directed repair
2009-02-05 Added SYNONYM Rad51-dependent recombinational repair
2009-02-05 Added SYNONYM Rhp51-dependent recombinational repair
2009-02-05 Deleted SYNONYM Rhp51-dependent recombinational repair
2009-02-01 Deleted SYNONYM Rhp51-dependent recombinational repair
2009-02-01 Deleted SYNONYM Rad51-dependent recombinational repair
2009-02-01 Added SYNONYM Rhp51-dependent recombinational repair
2009-01-31 Added SYNONYM Rhp51-dependent recombinational repair
2009-01-31 Deleted SYNONYM Rhp51-dependent recombinational repair
2009-01-31 Added SYNONYM Rad51-dependent recombinational repair
2008-06-30 Added SYNONYM Rhp51-dependent recombinational repair
2008-05-13 Added DEFINITION The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
2008-05-12 Deleted DEFINITION The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
2007-08-09 Deleted SYNONYM HRR
2007-08-09 Added SYNONYM homologous recombinational repair
2007-08-09 Added SYNONYM HRR
2007-08-09 Deleted SYNONYM homologous recombinational repair
2004-07-12 Added SYNONYM HRR
2004-07-12 Added SYNONYM homologous recombinational repair
2003-04-24 Updated DEFINITION The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
2002-11-27 Added DEFINITION The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or non-reciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0006302 (double-strand break repair)
2008-04-01 Updated RELATION is a GO:0000725 (recombinational repair)
Timestamp Action Category Detail
2024-12-05 Added XREF Reactome:R-HSA-5693538
Timestamp Action Category Detail
2007-01-15 Added SECONDARY GO:0016924 (double-strand break repair via homologous recombination)
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