This term is obsolete.

GO:0000900 JSON

mRNA regulatory element binding translation repressor activity

Molecular Function

Definition (GO:0000900 GONUTS page)

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. PMID:29061112 PMID:7523370

11,156 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
translation repressor activity, mRNA regulatory element binding exact
translation repressor activity, nucleic acid binding broad

Ancestor Chart

Ancestor chart for GO:0000900
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y7T8 10116 A0A8I5Y7T8_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBE4 10116 A0A8I5YBE4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN4 10116 A6HXN4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN5 10116 A6HXN5_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN7 10116 A6HXN7_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JXC6 10116 A6JXC6_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJ50 10116 D3ZJ50_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A417 10116 D4A417_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q15170 9606 TCAL1_HUMAN GO:0010629 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:7971997

Cross-references

Database ID Description
InterPro IPR040396 Polyadenylate-binding protein-interacting protein 2-like
Reactome R-HSA-5690886

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000900 based on ALL annotations
The top 100 of 648 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA regulatory element binding translation repressor activity
17,555.73 100.00 11,104 11,104
translation factor activity, RNA binding
16,720.50 72.79 8,388 8,807
negative regulation of cytoplasmic translation
16,086.04 70.72 8,395 9,162
translation regulator activity
6,168.74 31.56 8,398 23,900
translation repressor activity
5,500.51 12.64 1,941 6,195
mRNA 3'-UTR binding
2,269.46 12.48 8,689 67,215
negative regulation of translational initiation
1,519.61 6.27 2,057 23,764
neuron projection
727.95 4.09 8,358 201,568
regulation of translation
472.44 2.68 10,219 379,733
negative regulation of translation
351.51 1.88 2,660 132,850
Totals 101366 8868735
No co-occurrence statistics for GO:0000900 based on MANUAL annotations
The top 100 of 538 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA regulatory element binding translation repressor activity
6,459.00 100.00 200 200
negative regulation of cytoplasmic translation
4,913.59 51.88 124 163
translation factor activity, RNA binding
4,468.72 47.04 119 172
negative regulation of oskar mRNA translation
2,740.18 6.39 14 33
oocyte microtubule cytoskeleton polarization
2,269.38 5.80 13 37
mRNA 3'-UTR binding
346.79 5.26 144 2,682
mRNA 5'-UTR binding
801.12 5.11 16 129
imaginal disc-derived wing margin morphogenesis
1,166.21 5.02 13 72
negative regulation of cytoplasmic translational elongation
5,871.81 4.98 10 11
regulation of translation at synapse, modulating synaptic transmission
5,382.50 4.95 10 12
Totals 1672 33075

Change Log

Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-5690886
2024-11-05 Deleted XREF Reactome:R-HSA-5690886
2024-11-03 Added XREF Reactome:R-HSA-5690886
2024-11-02 Deleted XREF Reactome:R-HSA-5690886
2024-11-01 Added XREF Reactome:R-HSA-5690886
2024-10-26 Deleted XREF Reactome:R-HSA-5690886
2024-10-09 Added XREF Reactome:R-HSA-5690886
2024-10-08 Deleted XREF Reactome:R-HSA-5690886
2024-09-21 Added XREF Reactome:R-HSA-5690886
2024-09-20 Deleted XREF Reactome:R-HSA-5690886
Timestamp Action Category Detail
2022-02-17 Updated TERM mRNA regulatory element binding translation repressor activity
2018-02-18 Updated TERM translation repressor activity, mRNA regulatory element binding
2003-03-25 Updated TERM translation repressor activity, nucleic acid binding
2003-03-19 Updated TERM translation repressor, nucleic acid binding activity
2002-07-30 Added TERM translation repressor, nucleic acid binding
Timestamp Action Category Detail
2022-02-17 Added SYNONYM translation repressor activity, mRNA regulatory element binding
2018-02-18 Added SYNONYM translation repressor activity, nucleic acid binding
2012-10-29 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
2012-10-29 Deleted DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2008-05-13 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2008-05-12 Deleted DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2002-11-27 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
Timestamp Action Category Detail
2009-10-21 Deleted RELATION is a GO:0008135 (translation factor activity, RNA binding)
2009-10-21 Added RELATION is a GO:0090079 (translation regulator activity, nucleic acid binding)
2008-04-01 Updated RELATION is a GO:0030371 (translation repressor activity)
2008-04-01 Updated RELATION is a GO:0008135 (translation factor activity, RNA binding)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-5690886
2024-11-05 Deleted XREF Reactome:R-HSA-5690886
2024-11-03 Added XREF Reactome:R-HSA-5690886
2024-11-02 Deleted XREF Reactome:R-HSA-5690886
2024-11-01 Added XREF Reactome:R-HSA-5690886
2024-10-26 Deleted XREF Reactome:R-HSA-5690886
2024-10-09 Added XREF Reactome:R-HSA-5690886
2024-10-08 Deleted XREF Reactome:R-HSA-5690886
2024-09-21 Added XREF Reactome:R-HSA-5690886
2024-09-20 Deleted XREF Reactome:R-HSA-5690886
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Timestamp Action Category Detail
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