This term is obsolete.

GO:0000900 JSON

mRNA regulatory element binding translation repressor activity

Molecular Function

Definition (GO:0000900 GONUTS page)

Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. PMID:29061112 PMID:7523370

11,451 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
translation repressor activity, mRNA regulatory element binding exact
translation repressor activity, nucleic acid binding broad

Ancestor Chart

Ancestor chart for GO:0000900
Chart options
Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y7T8 10116 A0A8I5Y7T8_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBE4 10116 A0A8I5YBE4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN4 10116 A6HXN4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN5 10116 A6HXN5_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN7 10116 A6HXN7_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JXC6 10116 A6JXC6_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJ50 10116 D3ZJ50_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A417 10116 D4A417_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q15170 9606 TCAL1_HUMAN GO:0010629 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:7971997

Cross-references

Database ID Description
InterPro IPR040396 Polyadenylate-binding protein-interacting protein 2-like
Reactome R-HSA-5690886

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000900 based on ALL annotations
The top 100 of 639 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA regulatory element binding translation repressor activity
17,398.79 100.00 11,389 11,389
translation factor activity, RNA binding
16,601.22 73.18 8,638 9,053
negative regulation of cytoplasmic translation
15,986.03 71.13 8,645 9,409
translation regulator activity
6,114.47 31.62 8,648 24,608
translation repressor activity
5,639.24 12.76 1,981 6,112
mRNA 3'-UTR binding
2,257.32 12.53 8,940 68,907
negative regulation of translational initiation
1,514.42 6.28 2,093 24,046
neuron projection
731.72 4.15 8,604 204,586
regulation of translation
476.57 2.73 10,498 383,261
synapse
331.59 1.89 8,617 452,146
Totals 104098 9090977
No co-occurrence statistics for GO:0000900 based on MANUAL annotations
The top 100 of 535 co-occurring terms
Co-occurring Term PR S% #Together #Compared
mRNA regulatory element binding translation repressor activity
6,565.27 100.00 215 215
negative regulation of cytoplasmic translation
5,126.81 54.72 139 178
translation factor activity, RNA binding
4,724.22 50.75 136 189
negative regulation of oskar mRNA translation
2,896.44 6.41 15 34
mRNA 3'-UTR binding
376.35 5.63 162 2,826
oocyte microtubule cytoskeleton polarization
2,306.72 5.44 13 37
mRNA 5'-UTR binding
772.38 4.78 16 136
imaginal disc-derived wing margin morphogenesis
1,185.40 4.74 13 72
ribosome binding
317.67 4.70 135 2,790
negative regulation of cytoplasmic translational elongation
5,968.43 4.63 10 11
Totals 1792 33576

Change Log

Timestamp Action Category Detail
2025-01-21 Deleted RELATION is a GO:0090079 (obsolete translation regulator activity, nucleic acid binding)
2024-11-06 Added XREF Reactome:R-HSA-5690886
2024-11-05 Deleted XREF Reactome:R-HSA-5690886
2024-11-03 Added XREF Reactome:R-HSA-5690886
2024-11-02 Deleted XREF Reactome:R-HSA-5690886
2024-11-01 Added XREF Reactome:R-HSA-5690886
2024-10-26 Deleted XREF Reactome:R-HSA-5690886
2024-10-09 Added XREF Reactome:R-HSA-5690886
2024-10-08 Deleted XREF Reactome:R-HSA-5690886
2024-09-21 Added XREF Reactome:R-HSA-5690886
Timestamp Action Category Detail
2022-02-17 Updated TERM mRNA regulatory element binding translation repressor activity
2018-02-18 Updated TERM translation repressor activity, mRNA regulatory element binding
2003-03-25 Updated TERM translation repressor activity, nucleic acid binding
2003-03-19 Updated TERM translation repressor, nucleic acid binding activity
2002-07-30 Added TERM translation repressor, nucleic acid binding
Timestamp Action Category Detail
2022-02-17 Added SYNONYM translation repressor activity, mRNA regulatory element binding
2018-02-18 Added SYNONYM translation repressor activity, nucleic acid binding
2012-10-29 Deleted DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2012-10-29 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
2008-05-13 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2008-05-12 Deleted DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
2002-11-27 Added DEFINITION Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid.
Timestamp Action Category Detail
2025-01-21 Deleted RELATION is a GO:0090079 (obsolete translation regulator activity, nucleic acid binding)
2009-10-21 Deleted RELATION is a GO:0008135 (translation factor activity, RNA binding)
2009-10-21 Added RELATION is a GO:0090079 (obsolete translation regulator activity, nucleic acid binding)
2008-04-01 Updated RELATION is a GO:0008135 (translation factor activity, RNA binding)
2008-04-01 Updated RELATION is a GO:0030371 (translation repressor activity)
Timestamp Action Category Detail
2024-11-06 Added XREF Reactome:R-HSA-5690886
2024-11-05 Deleted XREF Reactome:R-HSA-5690886
2024-11-03 Added XREF Reactome:R-HSA-5690886
2024-11-02 Deleted XREF Reactome:R-HSA-5690886
2024-11-01 Added XREF Reactome:R-HSA-5690886
2024-10-26 Deleted XREF Reactome:R-HSA-5690886
2024-10-09 Added XREF Reactome:R-HSA-5690886
2024-10-08 Deleted XREF Reactome:R-HSA-5690886
2024-09-21 Added XREF Reactome:R-HSA-5690886
2024-09-20 Deleted XREF Reactome:R-HSA-5690886
2024-09-19 Added XREF Reactome:R-HSA-5690886
2024-09-13 Deleted XREF Reactome:R-HSA-5690886
2024-09-10 Added XREF Reactome:R-HSA-5690886
2024-09-08 Deleted XREF Reactome:R-HSA-5690886
2024-09-07 Added XREF Reactome:R-HSA-5690886
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2024-05-11 Deleted XREF Reactome:R-HSA-5690886
2024-05-09 Added XREF Reactome:R-HSA-5690886
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2024-05-03 Added XREF Reactome:R-HSA-5690886
2024-05-02 Deleted XREF Reactome:R-HSA-5690886
2024-05-01 Added XREF Reactome:R-HSA-5690886
2024-04-25 Deleted XREF Reactome:R-HSA-5690886
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Timestamp Action Category Detail
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