This term is obsolete.

GO:0000906 JSON

6,7-dimethyl-8-ribityllumazine synthase activity

Molecular Function

Definition (GO:0000906 GONUTS page)

Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. PMID:7559556

41,843 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
lumazine synthase activity broad

Ancestor Chart

Ancestor chart for GO:0000906
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein Q9VNA3 7227 Q9VNA3_DROME GO:0016740 Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. IPR016093|IPR036300
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q0E8K5 7227 Q0E8K5_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7JY99 7227 Q7JY99_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7KV84 7227 Q7KV84_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q7YTX2 7227 Q7YTX2_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I939 7227 Q8I939_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593
NOT-qualified manual protein Q8I940 7227 Q8I940_DROME GO:0016740 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593

Cross-references

Database ID Description
EC 2.5.1.78
InterPro IPR034964 Lumazine synthase
MetaCyc LUMAZINESYN-RXN
RHEA 26152

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58830 (2S)-2-hydroxy-3-oxobutyl phosphate(2-)
has_participant CHEBI CHEBI:58201 6,7-dimethyl-8-(1-D-ribityl)lumazine(1-)
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:15934 5-amino-6-(D-ribitylamino)uracil
has_participant CHEBI CHEBI:15377 water

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0000906 based on ALL annotations
The top 100 of 177 co-occurring terms
Co-occurring Term PR S% #Together #Compared
6,7-dimethyl-8-ribityllumazine synthase activity
4,749.86 100.00 41,718 41,718
riboflavin synthase complex
4,575.61 96.28 41,697 43,285
riboflavin biosynthetic process
584.95 12.31 41,704 338,644
mitochondrial intermembrane space
78.43 1.15 1,527 92,473
transferase activity
27.82 0.59 41,663 7,114,403
cytosol
11.95 0.25 35,197 13,989,509
riboflavin synthase activity
5.03 0.05 44 41,543
riboflavin binding
92.23 0.04 18 927
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
3.29 0.04 35 50,547
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
1.82 0.02 26 68,009
Totals 204681 44195338
No co-occurrence statistics for GO:0000906 based on MANUAL annotations
The top 9 of 9 co-occurring terms
Co-occurring Term PR S% #Together #Compared
6,7-dimethyl-8-ribityllumazine synthase activity
11,665.56 100.00 121 121
riboflavin biosynthetic process
2,683.52 23.00 121 526
mitochondrial intermembrane space
115.73 0.93 15 1,512
riboflavin binding
333.30 0.65 1 35
riboflavin synthase activity
101.44 0.43 1 115
cytoplasm
7.15 0.06 121 197,513
cytosol
4.43 0.04 34 89,580
protein binding
0.28 0.00 1 41,833
nucleus
0.11 0.00 2 208,176
Totals 417 539411

Change Log

Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:26152
2018-02-03 Added RELATION is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
2018-02-03 Deleted RELATION is a GO:0016867 (intramolecular acyltransferase activity)
2017-08-13 Deleted XREF EC:5.4
2017-08-13 Added XREF EC:2.5.1.78
2017-08-13 Added XREF MetaCyc:LUMAZINESYN-RXN
2016-10-03 Added XREF EC:5.4
2016-10-03 Deleted XREF EC:5.4.-.-
2010-09-03 Added DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
Timestamp Action Category Detail
2003-03-19 Updated TERM 6,7-dimethyl-8-ribityllumazine synthase activity
2003-02-15 Added TERM 6,7-dimethyl-8-ribityllumazine synthase
Timestamp Action Category Detail
2010-09-03 Added DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2008-05-13 Added DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2008-04-30 Added SYNONYM lumazine synthase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate.
2003-03-26 Added DEFINITION Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4- phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + Pi.
Timestamp Action Category Detail
2018-02-03 Added RELATION is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups)
2018-02-03 Deleted RELATION is a GO:0016867 (intramolecular acyltransferase activity)
2008-04-01 Updated RELATION is a GO:0016867 (intramolecular acyltransferase activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:26152
2017-08-13 Deleted XREF EC:5.4
2017-08-13 Added XREF EC:2.5.1.78
2017-08-13 Added XREF MetaCyc:LUMAZINESYN-RXN
2016-10-03 Added XREF EC:5.4
2016-10-03 Deleted XREF EC:5.4.-.-
2003-02-15 Added XREF EC:5.4.-.-
Timestamp Action Category Detail
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