GO:0000906
JSON
6,7-dimethyl-8-ribityllumazine synthase activity
Molecular Function
Definition (GO:0000906 GONUTS page)
Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. PMID:7559556
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
lumazine synthase activity | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | Q9VNA3 | 7227 | Q9VNA3_DROME | GO:0016740 | Requested by Helen Attrill. https://github.com/geneontology/go-annotation/issues/3377PMID:28597544: 'SDF2 and SDF2L1 associate with ERdj3 and act as components in the BiP chaperone cycle to prevent the aggregation of misfolded proteins.'They are not enzymes and are ER resident proteins, not membrane or extracellular proteins. | IPR016093|IPR036300 |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q0E8K5 | 7227 | Q0E8K5_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7JY99 | 7227 | Q7JY99_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7KV84 | 7227 | Q7KV84_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q7YTX2 | 7227 | Q7YTX2_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I939 | 7227 | Q8I939_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 | |
NOT-qualified manual | protein | Q8I940 | 7227 | Q8I940_DROME | GO:0016740 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:16545593 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 2.5.1.78 | |
InterPro | IPR034964 | Lumazine synthase |
MetaCyc | LUMAZINESYN-RXN | |
RHEA | 26152 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15934 | 5-amino-6-(D-ribitylamino)uracil |
has_participant | CHEBI | CHEBI:58830 | (2S)-2-hydroxy-3-oxobutyl phosphate(2-) |
has_participant | CHEBI | CHEBI:58201 | 6,7-dimethyl-8-(1-D-ribityl)lumazine(1-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0000906 based on ALL annotations
The top 100 of 172 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
6,7-dimethyl-8-ribityllumazine synthase activity
|
4,738.43 | 100.00 | 41,140 | 41,140 |
riboflavin synthase complex
|
4,563.84 | 96.27 | 41,119 | 42,692 |
riboflavin biosynthetic process
|
586.84 | 12.38 | 41,126 | 332,069 |
mitochondrial intermembrane space
|
80.37 | 1.17 | 1,504 | 88,673 |
transferase activity
|
26.91 | 0.57 | 41,085 | 7,234,614 |
cytosol
|
12.00 | 0.25 | 34,762 | 13,724,995 |
riboflavin synthase activity
|
5.09 | 0.05 | 44 | 40,940 |
riboflavin binding
|
93.83 | 0.04 | 18 | 909 |
3,4-dihydroxy-2-butanone-4-phosphate synthase activity
|
3.34 | 0.04 | 35 | 49,728 |
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
|
1.84 | 0.02 | 26 | 66,984 |
Totals | 201905 | 44083286 |
No co-occurrence statistics for GO:0000906 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
6,7-dimethyl-8-ribityllumazine synthase activity
|
11,331.57 | 100.00 | 114 | 114 |
riboflavin biosynthetic process
|
2,604.43 | 22.98 | 114 | 496 |
mitochondrial intermembrane space
|
121.50 | 1.00 | 15 | 1,399 |
riboflavin binding
|
354.11 | 0.69 | 1 | 32 |
riboflavin synthase activity
|
104.92 | 0.45 | 1 | 108 |
cytoplasm
|
7.20 | 0.06 | 114 | 179,389 |
cell redox homeostasis
|
4.81 | 0.04 | 1 | 2,355 |
cytosol
|
4.57 | 0.04 | 34 | 84,217 |
proteasome-mediated ubiquitin-dependent protein catabolic process
|
0.99 | 0.01 | 1 | 11,393 |
protein binding
|
0.27 | 0.00 | 1 | 41,817 |
Totals | 398 | 513596 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:26152 |
2018-02-03 | Added | RELATION | is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups) |
2018-02-03 | Deleted | RELATION | is a GO:0016867 (intramolecular acyltransferase activity) |
2017-08-13 | Added | XREF | MetaCyc:LUMAZINESYN-RXN |
2017-08-13 | Added | XREF | EC:2.5.1.78 |
2017-08-13 | Deleted | XREF | EC:5.4 |
2016-10-03 | Deleted | XREF | EC:5.4.-.- |
2016-10-03 | Added | XREF | EC:5.4 |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | 6,7-dimethyl-8-ribityllumazine synthase activity |
2003-02-15 | Added | TERM | 6,7-dimethyl-8-ribityllumazine synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2008-04-30 | Added | SYNONYM | lumazine synthase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate. |
2003-03-26 | Added | DEFINITION | Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4- phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + Pi. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-02-03 | Added | RELATION | is a GO:0016765 (transferase activity, transferring alkyl or aryl (other than methyl) groups) |
2018-02-03 | Deleted | RELATION | is a GO:0016867 (intramolecular acyltransferase activity) |
2008-04-01 | Updated | RELATION | is a GO:0016867 (intramolecular acyltransferase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:26152 |
2017-08-13 | Added | XREF | MetaCyc:LUMAZINESYN-RXN |
2017-08-13 | Added | XREF | EC:2.5.1.78 |
2017-08-13 | Deleted | XREF | EC:5.4 |
2016-10-03 | Deleted | XREF | EC:5.4.-.- |
2016-10-03 | Added | XREF | EC:5.4 |
2003-02-15 | Added | XREF | EC:5.4.-.- |
Timestamp | Action | Category | Detail |
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