This term is obsolete.
For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.

GO:0001228 JSON

DNA-binding transcription activator activity, RNA polymerase II-specific

Molecular Function

Definition (GO:0001228 GONUTS page)

A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. PMID:20737563 PMID:27145859

Comments

For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.

Secondary IDs

GO:0001077, GO:0001205, GO:0001209, GO:0001211, GO:0001212, GO:0001213

Acknowledgement

This term was created by the GO Consortium with support from: ARUK logo

151,930 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding narrow
metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription narrow
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding narrow
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription narrow
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding narrow
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription exact
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific narrow
zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription narrow
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific narrow
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding exact

Ancestor Chart

Ancestor chart for GO:0001228
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001228

Child Term Relationship to
GO:0001228
ATF1-ATF4 transcription factor complex
capable_of
ATF4-CREB1 transcription factor complex
capable_of

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JVM9 10116 A0A0G2JVM9_RAT GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A287AGK9 9823 A0A287AGK9_PIG GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A2I2ZSU6 9595 A0A2I2ZSU6_GORGO GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A337SMT8 9685 A0A337SMT8_FELCA GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A3Q2H1G8 9796 A0A3Q2H1G8_HORSE GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A3Q2IAT7 9796 A0A3Q2IAT7_HORSE GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F5Y6I5 9685 A0A5F5Y6I5_FELCA GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A5F7ZMS5 9544 A0A5F7ZMS5_MACMU GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8D0U1I9 9823 A0A8D0U1I9_PIG GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A8I3MH06 9615 A0A8I3MH06_CANLF GO:0000981 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR024830 Glucocorticoid modulatory element-binding protein 1/2
InterPro IPR027113 Transcription factor NFYB/HAP3
InterPro IPR037599 Transcription factor CP2, SAM domain
InterPro IPR039791 Chorion-specific transcription factor GCM
InterPro IPR040159 Suppressor of hairless-like
InterPro IPR042917 Homeobox protein MIXL1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0001190 obsolete transcriptional activator activity, RNA polymerase II transcription factor binding consider GO:0001228
GO:0016563 obsolete transcription activator activity replaced_by GO:0001228

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0001228 based on ALL annotations
The top 100 of 4,741 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA-binding transcription activator activity, RNA polymerase II-specific
1,300.24 100.00 149,925 149,925
positive regulation of transcription by RNA polymerase II
320.31 24.63 149,908 608,524
sequence-specific double-stranded DNA binding
397.52 10.40 20,422 66,798
RNA polymerase II transcription regulator complex
423.28 10.08 19,110 58,702
RNA polymerase II cis-regulatory region sequence-specific DNA binding
134.33 9.95 109,366 1,058,587
CCAAT-binding factor complex
913.16 8.54 13,277 18,905
negative regulation of transcription by RNA polymerase II
107.95 5.77 23,881 287,649
RNA polymerase II transcription regulatory region sequence-specific DNA binding
104.00 5.36 20,958 262,021
brain development
182.96 4.99 10,749 76,389
regulation of transcription by RNA polymerase II
60.97 4.60 105,273 2,244,948
Totals 1251638 41602167
No co-occurrence statistics for GO:0001228 based on MANUAL annotations
The top 100 of 4,241 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA-binding transcription activator activity, RNA polymerase II-specific
313.24 100.00 4,124 4,124
sequence-specific double-stranded DNA binding
123.42 14.98 803 2,038
positive regulation of transcription by RNA polymerase II
50.50 14.36 2,339 14,507
RNA polymerase II cis-regulatory region sequence-specific DNA binding
32.68 10.18 3,332 31,938
RNA polymerase II transcription regulatory region sequence-specific DNA binding
37.04 7.95 804 6,799
negative regulation of transcription by RNA polymerase II
28.91 6.63 786 8,516
positive regulation of DNA-templated transcription
28.47 6.40 735 8,088
regulation of transcription by RNA polymerase II
20.46 6.35 2,886 44,191
sequence-specific DNA binding
25.66 6.19 832 10,155
DNA-binding transcription repressor activity, RNA polymerase II-specific
55.90 5.89 333 1,866
Totals 36047 617896

Change Log

Timestamp Action Category Detail
2024-11-05 Deleted XREF Reactome:R-HSA-9856604
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Timestamp Action Category Detail
2018-07-29 Updated TERM DNA-binding transcription activator activity, RNA polymerase II-specific
2017-11-03 Updated TERM transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
2015-07-25 Updated TERM transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
2012-04-24 Updated TERM RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
2012-04-17 Added TERM polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
Timestamp Action Category Detail
2020-11-07 Deleted DEFINITION Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2020-11-07 Added DEFINITION A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II.
2020-07-16 Deleted DEFINITION A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2020-07-16 Added DEFINITION Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2020-01-26 Added DEFINITION A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2020-01-26 Deleted DEFINITION A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2018-11-10 Added SYNONYM metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
2018-11-10 Added SYNONYM RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding
2018-11-10 Added SYNONYM zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
2018-11-10 Added SYNONYM RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding
2018-11-10 Added SYNONYM RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding
2018-11-10 Added SYNONYM transcriptional activator activity, metal ion regulated sequence-specific DNA binding
2018-11-10 Added SYNONYM copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
2018-11-10 Added SYNONYM metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
2018-11-10 Added SYNONYM RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding
2018-11-10 Added SYNONYM RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding
2018-10-20 Added SYNONYM RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
2018-10-20 Added SYNONYM sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription
2018-10-20 Added SYNONYM transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
2018-10-20 Added SYNONYM RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
2018-10-20 Added SYNONYM transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
2018-10-20 Added SYNONYM transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
2018-10-20 Added SYNONYM proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
2018-10-20 Added SYNONYM distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific
2018-07-29 Deleted DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
2018-07-29 Added SYNONYM transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
2018-07-29 Added DEFINITION A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
2015-07-25 Added SYNONYM RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
2012-04-17 Added DEFINITION Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter.
Timestamp Action Category Detail
2018-12-15 Added RELATION is a GO:0001216 (DNA-binding transcription activator activity)
2018-08-20 Deleted RELATION part of GO:0006366 (transcription by RNA polymerase II)
2015-05-19 Added RELATION part of GO:0006366 (transcription by RNA polymerase II)
2012-04-17 Added RELATION is a GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific)
2012-04-17 Added RELATION part of GO:0045944 (positive regulation of transcription by RNA polymerase II)
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Timestamp Action Category Detail
2018-11-10 Added SECONDARY GO:0001213 (RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding)
2018-11-10 Added SECONDARY GO:0001212 (RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding)
2018-11-10 Added SECONDARY GO:0001211 (RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding)
2018-11-10 Added SECONDARY GO:0001209 (transcriptional activator activity, metal ion regulated sequence-specific DNA binding)
2018-10-20 Added SECONDARY GO:0001077 (proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific)
2018-10-20 Added SECONDARY GO:0001205 (distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific)
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