For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
GO:0001228
JSON
DNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Function
Definition (GO:0001228 GONUTS page)
A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. PMID:20737563 PMID:27145859
Comments
For usage guidance, see comment in GO:0003700 ; DNA-binding transcription factor activity.
Secondary IDs
GO:0001077, GO:0001205, GO:0001209, GO:0001211, GO:0001212, GO:0001213
Acknowledgement
This term was created by the GO Consortium with support from:
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding | narrow |
metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | narrow |
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | narrow |
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription | narrow |
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | narrow |
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | exact |
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific | narrow |
zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription | narrow |
distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific | narrow |
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0001228
Child Term | Relationship to GO:0001228 |
---|---|
ATF1-ATF4 transcription factor complex
|
capable_of |
ATF4-CREB1 transcription factor complex
|
capable_of |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JVM9 | 10116 | A0A0G2JVM9_RAT | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A287AGK9 | 9823 | A0A287AGK9_PIG | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A2I2ZSU6 | 9595 | A0A2I2ZSU6_GORGO | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A337SMT8 | 9685 | A0A337SMT8_FELCA | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A3Q2H1G8 | 9796 | A0A3Q2H1G8_HORSE | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A3Q2IAT7 | 9796 | A0A3Q2IAT7_HORSE | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F5Y6I5 | 9685 | A0A5F5Y6I5_FELCA | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A5F7ZMS5 | 9544 | A0A5F7ZMS5_MACMU | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8D0U1I9 | 9823 | A0A8D0U1I9_PIG | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A8I3MH06 | 9615 | A0A8I3MH06_CANLF | GO:0000981 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR024830 | Glucocorticoid modulatory element-binding protein 1/2 |
InterPro | IPR027113 | Transcription factor NFYB/HAP3 |
InterPro | IPR037599 | Transcription factor CP2, SAM domain |
InterPro | IPR039791 | Chorion-specific transcription factor GCM |
InterPro | IPR040159 | Suppressor of hairless-like |
InterPro | IPR042917 | Homeobox protein MIXL1 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0001190 | obsolete transcriptional activator activity, RNA polymerase II transcription factor binding | consider GO:0001228 |
GO:0016563 | obsolete transcription activator activity | replaced_by GO:0001228 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0001228 based on ALL annotations
The top 100 of 4,741 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA-binding transcription activator activity, RNA polymerase II-specific
|
1,300.24 | 100.00 | 149,925 | 149,925 |
positive regulation of transcription by RNA polymerase II
|
320.31 | 24.63 | 149,908 | 608,524 |
sequence-specific double-stranded DNA binding
|
397.52 | 10.40 | 20,422 | 66,798 |
RNA polymerase II transcription regulator complex
|
423.28 | 10.08 | 19,110 | 58,702 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
134.33 | 9.95 | 109,366 | 1,058,587 |
CCAAT-binding factor complex
|
913.16 | 8.54 | 13,277 | 18,905 |
negative regulation of transcription by RNA polymerase II
|
107.95 | 5.77 | 23,881 | 287,649 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding
|
104.00 | 5.36 | 20,958 | 262,021 |
brain development
|
182.96 | 4.99 | 10,749 | 76,389 |
regulation of transcription by RNA polymerase II
|
60.97 | 4.60 | 105,273 | 2,244,948 |
Totals | 1251638 | 41602167 |
No co-occurrence statistics for GO:0001228 based on MANUAL annotations
The top 100 of 4,241 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA-binding transcription activator activity, RNA polymerase II-specific
|
313.24 | 100.00 | 4,124 | 4,124 |
sequence-specific double-stranded DNA binding
|
123.42 | 14.98 | 803 | 2,038 |
positive regulation of transcription by RNA polymerase II
|
50.50 | 14.36 | 2,339 | 14,507 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding
|
32.68 | 10.18 | 3,332 | 31,938 |
RNA polymerase II transcription regulatory region sequence-specific DNA binding
|
37.04 | 7.95 | 804 | 6,799 |
negative regulation of transcription by RNA polymerase II
|
28.91 | 6.63 | 786 | 8,516 |
positive regulation of DNA-templated transcription
|
28.47 | 6.40 | 735 | 8,088 |
regulation of transcription by RNA polymerase II
|
20.46 | 6.35 | 2,886 | 44,191 |
sequence-specific DNA binding
|
25.66 | 6.19 | 832 | 10,155 |
DNA-binding transcription repressor activity, RNA polymerase II-specific
|
55.90 | 5.89 | 333 | 1,866 |
Totals | 36047 | 617896 |
Change Log
- All changes
- All changes
- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
- Other
Timestamp | Action | Category | Detail |
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2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856604 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856550 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856549 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856548 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856546 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856539 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9856604 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9856548 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9856550 |
2024-11-03 | Added | XREF | Reactome:R-HSA-9856539 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-29 | Updated | TERM | DNA-binding transcription activator activity, RNA polymerase II-specific |
2017-11-03 | Updated | TERM | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
2015-07-25 | Updated | TERM | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding |
2012-04-24 | Updated | TERM | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
2012-04-17 | Added | TERM | polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-11-07 | Deleted | DEFINITION | Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2020-11-07 | Added | DEFINITION | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. |
2020-07-16 | Deleted | DEFINITION | A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2020-07-16 | Added | DEFINITION | Interacting selectively and non-covalently with a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2020-01-26 | Added | DEFINITION | A protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2020-01-26 | Deleted | DEFINITION | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2018-11-10 | Added | SYNONYM | metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
2018-11-10 | Added | SYNONYM | RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding |
2018-11-10 | Added | SYNONYM | zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription |
2018-11-10 | Added | SYNONYM | RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding |
2018-11-10 | Added | SYNONYM | RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding |
2018-11-10 | Added | SYNONYM | transcriptional activator activity, metal ion regulated sequence-specific DNA binding |
2018-11-10 | Added | SYNONYM | copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription |
2018-11-10 | Added | SYNONYM | metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription |
2018-11-10 | Added | SYNONYM | RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding |
2018-11-10 | Added | SYNONYM | RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding |
2018-10-20 | Added | SYNONYM | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
2018-10-20 | Added | SYNONYM | sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription |
2018-10-20 | Added | SYNONYM | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
2018-10-20 | Added | SYNONYM | RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription |
2018-10-20 | Added | SYNONYM | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding |
2018-10-20 | Added | SYNONYM | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding |
2018-10-20 | Added | SYNONYM | proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific |
2018-10-20 | Added | SYNONYM | distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific |
2018-07-29 | Deleted | DEFINITION | Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
2018-07-29 | Added | SYNONYM | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
2018-07-29 | Added | DEFINITION | A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units. |
2015-07-25 | Added | SYNONYM | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription |
2012-04-17 | Added | DEFINITION | Interacting selectively and non-covalently with a sequence of DNA that is in the transcription regulatory region for RNA polymerase II (RNAP II) in order to activate or increase the frequency, rate or extent of transcription from the RNAP II promoter. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-12-15 | Added | RELATION | is a GO:0001216 (DNA-binding transcription activator activity) |
2018-08-20 | Deleted | RELATION | part of GO:0006366 (transcription by RNA polymerase II) |
2015-05-19 | Added | RELATION | part of GO:0006366 (transcription by RNA polymerase II) |
2012-04-17 | Added | RELATION | is a GO:0000981 (DNA-binding transcription factor activity, RNA polymerase II-specific) |
2012-04-17 | Added | RELATION | part of GO:0045944 (positive regulation of transcription by RNA polymerase II) |
Timestamp | Action | Category | Detail |
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2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856604 |
2024-11-05 | Deleted | XREF | Reactome:R-HSA-9856550 |
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Timestamp | Action | Category | Detail |
---|---|---|---|
2018-11-10 | Added | SECONDARY | GO:0001213 (RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding) |
2018-11-10 | Added | SECONDARY | GO:0001212 (RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding) |
2018-11-10 | Added | SECONDARY | GO:0001211 (RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding) |
2018-11-10 | Added | SECONDARY | GO:0001209 (transcriptional activator activity, metal ion regulated sequence-specific DNA binding) |
2018-10-20 | Added | SECONDARY | GO:0001077 (proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific) |
2018-10-20 | Added | SECONDARY | GO:0001205 (distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific) |
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