This term is obsolete.

GO:0001518 JSON

voltage-gated sodium channel complex

Cellular Component

Definition (GO:0001518 GONUTS page)

A sodium channel in a cell membrane whose opening is governed by the membrane potential.

38,404 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
voltage-sensitive sodium channel complex exact
voltage-dependent sodium channel complex exact
voltage gated sodium channel complex exact

Ancestor Chart

Ancestor chart for GO:0001518
Chart options
Ancestor chart

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016020 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A022QST3 4155 A0A022QST3_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A022S0M6 4155 A0A022S0M6_ERYGU GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059AQE2 71139 A0A059AQE2_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A059B0U9 71139 A0A059B0U9_EUCGR GO:0005886 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
InterPro IPR001696 Voltage gated sodium channel, alpha subunit
InterPro IPR008051 Voltage gated sodium channel, alpha-1 subunit
InterPro IPR008052 Voltage gated sodium channel, alpha-4 subunit, mammalian
InterPro IPR008053 Voltage gated sodium channel, alpha-5 subunit
InterPro IPR008054 Voltage gated sodium channel, alpha-8 subunit
InterPro IPR010526 Sodium ion transport-associated domain
InterPro IPR027098 Sodium channel subunit beta-1/beta-3
NIF_Subcellular sao785001660

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0001518 based on ALL annotations
The top 100 of 456 co-occurring terms
Co-occurring Term PR S% #Together #Compared
voltage-gated sodium channel complex
5,117.85 100.00 38,090 38,090
voltage-gated sodium channel activity
4,883.09 87.07 34,612 36,276
membrane depolarization during action potential
5,078.68 67.05 25,674 25,872
neuronal action potential
4,725.89 53.60 21,365 23,137
sodium channel activity
1,722.97 22.52 15,423 45,812
monoatomic cation channel activity
1,019.22 16.38 18,285 91,815
monoatomic ion channel complex
606.26 10.51 18,335 154,778
low voltage-gated calcium channel activity
4,891.30 9.93 3,800 3,976
calcium ion import
3,472.20 9.53 3,800 5,601
sodium ion transmembrane transport
471.64 9.16 35,625 386,573
Totals 362264 16712457
No co-occurrence statistics for GO:0001518 based on MANUAL annotations
The top 100 of 270 co-occurring terms
Co-occurring Term PR S% #Together #Compared
voltage-gated sodium channel complex
3,539.18 100.00 365 365
membrane depolarization during action potential
2,999.30 60.98 250 295
neuronal action potential
2,513.33 52.69 245 345
low voltage-gated calcium channel activity
2,685.98 21.68 85 112
cardiac muscle cell action potential involved in contraction
2,780.78 19.95 77 98
calcium ion import
1,643.88 18.36 85 183
sodium ion transmembrane transport
452.67 12.24 270 2,111
voltage-gated sodium channel activity
1,374.93 12.00 54 139
positive regulation of calcium ion-dependent exocytosis
1,020.12 10.08 49 170
membrane depolarization during cardiac muscle cell action potential
2,769.79 9.60 36 46
Totals 2466 28558

Change Log

Timestamp Action Category Detail
2022-08-26 Deleted RELATION part of GO:0005887 (integral component of plasma membrane)
2018-02-18 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2018-02-18 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2016-10-05 Added RELATION is a GO:0044459 (obsolete plasma membrane part)
2016-10-05 Deleted RELATION is a GO:0098797 (plasma membrane protein complex)
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-06-18 Added RELATION capable of GO:0005248 (voltage-gated sodium channel activity)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2010-02-04 Added XREF NIF_Subcellular:sao785001660
2008-08-24 Deleted RELATION is a GO:0043234 (protein complex)
Timestamp Action Category Detail
2002-10-24 Updated TERM voltage-gated sodium channel complex
2002-02-06 Updated TERM voltage-gated sodium channel
2001-04-03 Updated TERM voltage-gated sodium channel
2001-03-30 Added TERM voltage-gated sodium channel
Timestamp Action Category Detail
2008-05-13 Added DEFINITION A sodium channel in a cell membrane whose opening is governed by the membrane potential.
2008-05-12 Deleted DEFINITION A sodium channel in a cell membrane whose opening is governed by the membrane potential.
2007-08-09 Added SYNONYM voltage-dependent sodium channel complex
2007-08-09 Added SYNONYM voltage gated sodium channel complex
2007-08-09 Deleted SYNONYM voltage gated sodium channel complex
2007-08-09 Added SYNONYM voltage-sensitive sodium channel complex
2007-08-09 Deleted SYNONYM voltage-sensitive sodium channel complex
2007-08-09 Deleted SYNONYM voltage-dependent sodium channel complex
2004-12-18 Added SYNONYM voltage-dependent sodium channel complex
2004-12-13 Added SYNONYM voltage gated sodium channel complex
2004-04-19 Added SYNONYM voltage-sensitive sodium channel complex
2004-04-16 Deleted SYNONYM voltage-sensitive sodium channel complex
2002-11-27 Updated DEFINITION A sodium channel in a cell membrane whose opening is governed by the membrane potential.
2002-10-24 Added SYNONYM voltage-sensitive sodium channel complex
2001-08-06 Added DEFINITION A sodium channel in a cell membrane whose opening is goverened by the membrane potential
Timestamp Action Category Detail
2022-08-26 Deleted RELATION part of GO:0005887 (integral component of plasma membrane)
2018-02-18 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2018-02-18 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2016-10-05 Added RELATION is a GO:0044459 (obsolete plasma membrane part)
2016-10-05 Deleted RELATION is a GO:0098797 (plasma membrane protein complex)
2015-06-25 Deleted RELATION is a GO:0044459 (obsolete plasma membrane part)
2015-06-18 Added RELATION capable of GO:0005248 (voltage-gated sodium channel activity)
2015-05-11 Added RELATION is a GO:0098797 (plasma membrane protein complex)
2008-08-24 Deleted RELATION is a GO:0043234 (protein complex)
2008-08-24 Added RELATION is a GO:0034706 (sodium channel complex)
2008-04-01 Updated RELATION part of GO:0005887 (integral component of plasma membrane)
2008-04-01 Updated RELATION is a GO:0043234 (protein complex)
2008-04-01 Updated RELATION is a GO:0044459 (obsolete plasma membrane part)
Timestamp Action Category Detail
2010-02-04 Added XREF NIF_Subcellular:sao785001660
Timestamp Action Category Detail
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