GO:0001648
JSON
proteinase-activated receptor activity
Molecular Function
Definition (GO:0001648 GONUTS page)
A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. PMID:11356985 PMID:33742547
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
proteinase activated receptor activity | exact |
protease-activated receptor activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0001648
Child Term | Relationship to GO:0001648 |
---|---|
thrombin-activated receptor activity
|
is_a |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A2ARI4 | 10090 | LGR4_MOUSE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646 | |
NOT-qualified manual | protein | B0BLW3 | 8364 | LGR4_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D4AC13 | 10116 | LGR5_RAT | GO:0004930 | 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096 | |
NOT-qualified manual | protein | E5DHB5 | 8355 | LGR5A_XENLA | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E7FE13 | 7955 | LGR4_DANRE | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MLX5 | 9913 | LGR4_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F1MT22 | 9913 | LGR5_BOVIN | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | F7D3V9 | 8364 | LGR5_XENTR | GO:0004930 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | G3QNC0 | 9595 | G3QNC0_GORGO | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290 | |
NOT-qualified manual | protein | O15529 | 9606 | GPR42_HUMAN | GO:0007186 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0001648 based on ALL annotations
The top 85 of 85 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
proteinase-activated receptor activity
|
857,813.30 | 100.00 | 231 | 231 |
potassium channel activating, G protein-coupled receptor signaling pathway
|
857,813.25 | 38.10 | 88 | 88 |
positive regulation of neutrophil mediated killing of gram-negative bacterium
|
794,605.94 | 36.97 | 88 | 95 |
positive regulation of renin secretion into blood stream
|
452,021.34 | 28.39 | 88 | 167 |
positive regulation of eosinophil degranulation
|
419,375.40 | 27.24 | 88 | 180 |
leukocyte proliferation
|
401,529.62 | 26.59 | 88 | 188 |
mature conventional dendritic cell differentiation
|
303,162.94 | 22.45 | 88 | 249 |
negative regulation of toll-like receptor 3 signaling pathway
|
290,336.80 | 21.84 | 88 | 260 |
regulation of chemokine (C-X-C motif) ligand 2 production
|
210,271.78 | 17.53 | 88 | 359 |
negative regulation of chemokine production
|
157,923.78 | 14.17 | 88 | 478 |
Totals | 7571 | 90072743 |
No co-occurrence statistics for GO:0001648 based on MANUAL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
proteinase-activated receptor activity
|
235,255.50 | 100.00 | 6 | 6 |
potassium channel activating, G protein-coupled receptor signaling pathway
|
235,255.52 | 33.33 | 2 | 2 |
positive regulation of neutrophil mediated killing of gram-negative bacterium
|
117,627.76 | 14.29 | 1 | 2 |
regulation of chemokine (C-X-C motif) ligand 2 production
|
39,209.25 | 12.50 | 2 | 12 |
positive regulation of eosinophil degranulation
|
58,813.88 | 11.11 | 1 | 4 |
positive regulation of renin secretion into blood stream
|
23,525.55 | 8.33 | 2 | 20 |
positive regulation of glomerular filtration
|
22,405.29 | 8.00 | 2 | 21 |
negative regulation of toll-like receptor 3 signaling pathway
|
29,406.94 | 7.69 | 1 | 8 |
leukocyte proliferation
|
17,426.33 | 6.45 | 2 | 27 |
ligand-gated ion channel signaling pathway
|
14,703.47 | 5.56 | 2 | 32 |
Totals | 125 | 248200 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Added | SYNONYM | proteinase activated receptor activity |
2022-04-05 | Added | SYNONYM | protease-activated receptor activity |
2022-04-05 | Updated | TERM | proteinase-activated receptor activity |
2022-04-05 | Added | DEFINITION | A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2022-04-05 | Deleted | DEFINITION | A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2018-09-08 | Deleted | DEFINITION | A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2018-09-08 | Added | DEFINITION | A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2010-10-07 | Added | DEFINITION | A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2008-04-01 | Updated | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
2003-03-19 | Updated | TERM | proteinase activated receptor activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Updated | TERM | proteinase-activated receptor activity |
2003-03-19 | Updated | TERM | proteinase activated receptor activity |
2002-01-09 | Added | TERM | proteinase activated receptor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-04-05 | Added | SYNONYM | proteinase activated receptor activity |
2022-04-05 | Added | SYNONYM | protease-activated receptor activity |
2022-04-05 | Added | DEFINITION | A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. |
2022-04-05 | Deleted | DEFINITION | A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2018-09-08 | Deleted | DEFINITION | A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2018-09-08 | Added | DEFINITION | A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
2010-10-07 | Added | DEFINITION | A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0008528 (G protein-coupled peptide receptor activity) |
Timestamp | Action | Category | Detail |
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Timestamp | Action | Category | Detail |
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