This term is obsolete.

GO:0001648 JSON

proteinase-activated receptor activity

Molecular Function

Definition (GO:0001648 GONUTS page)

A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. PMID:11356985 PMID:33742547

4,376 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
proteinase activated receptor activity exact
protease-activated receptor activity exact

Ancestor Chart

Ancestor chart for GO:0001648
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001648

Child Term Relationship to
GO:0001648
thrombin-activated receptor activity
is_a

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A2ARI4 10090 LGR4_MOUSE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21693646
NOT-qualified manual protein B0BLW3 8364 LGR4_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D4AC13 10116 LGR5_RAT GO:0004930 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096
NOT-qualified manual protein E5DHB5 8355 LGR5A_XENLA GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E7FE13 7955 LGR4_DANRE GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MLX5 9913 LGR4_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F1MT22 9913 LGR5_BOVIN GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein F7D3V9 8364 LGR5_XENTR GO:0004930 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein G3QNC0 9595 G3QNC0_GORGO GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:8910290
NOT-qualified manual protein O15529 9606 GPR42_HUMAN GO:0007186 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:12496283

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0001648 based on ALL annotations
The top 85 of 85 co-occurring terms
Co-occurring Term PR S% #Together #Compared
proteinase-activated receptor activity
857,813.30 100.00 231 231
potassium channel activating, G protein-coupled receptor signaling pathway
857,813.25 38.10 88 88
positive regulation of neutrophil mediated killing of gram-negative bacterium
794,605.94 36.97 88 95
positive regulation of renin secretion into blood stream
452,021.34 28.39 88 167
positive regulation of eosinophil degranulation
419,375.40 27.24 88 180
leukocyte proliferation
401,529.62 26.59 88 188
mature conventional dendritic cell differentiation
303,162.94 22.45 88 249
negative regulation of toll-like receptor 3 signaling pathway
290,336.80 21.84 88 260
regulation of chemokine (C-X-C motif) ligand 2 production
210,271.78 17.53 88 359
negative regulation of chemokine production
157,923.78 14.17 88 478
Totals 7571 90072743
No co-occurrence statistics for GO:0001648 based on MANUAL annotations
The top 66 of 66 co-occurring terms
Co-occurring Term PR S% #Together #Compared
proteinase-activated receptor activity
235,255.50 100.00 6 6
potassium channel activating, G protein-coupled receptor signaling pathway
235,255.52 33.33 2 2
positive regulation of neutrophil mediated killing of gram-negative bacterium
117,627.76 14.29 1 2
regulation of chemokine (C-X-C motif) ligand 2 production
39,209.25 12.50 2 12
positive regulation of eosinophil degranulation
58,813.88 11.11 1 4
positive regulation of renin secretion into blood stream
23,525.55 8.33 2 20
positive regulation of glomerular filtration
22,405.29 8.00 2 21
negative regulation of toll-like receptor 3 signaling pathway
29,406.94 7.69 1 8
leukocyte proliferation
17,426.33 6.45 2 27
ligand-gated ion channel signaling pathway
14,703.47 5.56 2 32
Totals 125 248200

Change Log

Timestamp Action Category Detail
2022-04-05 Added SYNONYM proteinase activated receptor activity
2022-04-05 Added SYNONYM protease-activated receptor activity
2022-04-05 Updated TERM proteinase-activated receptor activity
2022-04-05 Added DEFINITION A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2022-04-05 Deleted DEFINITION A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2018-09-08 Deleted DEFINITION A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2018-09-08 Added DEFINITION A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2010-10-07 Added DEFINITION A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2008-04-01 Updated RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
2003-03-19 Updated TERM proteinase activated receptor activity
Timestamp Action Category Detail
2022-04-05 Updated TERM proteinase-activated receptor activity
2003-03-19 Updated TERM proteinase activated receptor activity
2002-01-09 Added TERM proteinase activated receptor
Timestamp Action Category Detail
2022-04-05 Added SYNONYM proteinase activated receptor activity
2022-04-05 Added SYNONYM protease-activated receptor activity
2022-04-05 Added DEFINITION A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it.
2022-04-05 Deleted DEFINITION A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2018-09-08 Deleted DEFINITION A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2018-09-08 Added DEFINITION A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
2010-10-07 Added DEFINITION A G-protein coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0008528 (G protein-coupled peptide receptor activity)
Timestamp Action Category Detail
Timestamp Action Category Detail
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