GO:0001837
JSON
epithelial to mesenchymal transition
Biological Process
Definition (GO:0001837 GONUTS page)
A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. PMID:14701881
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
epithelial-mesenchymal transition | exact |
EMT | exact |
mesenchymal cell differentiation from epithelial cell | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0001837
Child Term | Relationship to GO:0001837 |
---|---|
negative regulation of epithelial to mesenchymal transition
|
negatively_regulates |
positive regulation of epithelial to mesenchymal transition
|
positively_regulates |
clearance of cells from fusion plate by epithelial to mesenchymal transition
|
is_a |
mesodermal to mesenchymal transition involved in gastrulation
|
is_a |
regulation of epithelial to mesenchymal transition
|
regulates |
cardiac epithelial to mesenchymal transition
|
is_a |
neural crest formation
|
is_a |
epicardial cell to mesenchymal cell transition
|
is_a |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0001837 | epithelial to mesenchymal transition | Only in Taxon | 6072 | Eumetazoa |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZKY9 | 10116 | A0A8I5ZKY9_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZPU7 | 10116 | A0A8I5ZPU7_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5ZR99 | 10116 | A0A8I5ZR99_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A6W3 | 10116 | A0A8I6A6W3_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6GA69 | 10116 | A0A8I6GA69_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K3T1 | 10116 | A6K3T1_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6K3T3 | 10116 | A6K3T3_RAT | GO:0001837 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A8XY28 | 6238 | A8XY28_CAEBR | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PL19 | 6945 | B7PL19_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | B7PVH4 | 6945 | B7PVH4_IXOSC | GO:0030154 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_primary_input | CL | CL:0000066 | epithelial cell |
results_in_acquisition_of_features_of | CL | CL:0008019 | mesenchymal cell |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0001837 based on ALL annotations
The top 100 of 2,328 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
epithelial to mesenchymal transition
|
34,916.49 | 100.00 | 5,583 | 5,583 |
type II transforming growth factor beta receptor binding
|
28,129.23 | 25.56 | 1,521 | 1,888 |
transforming growth factor beta receptor activity
|
12,222.09 | 17.03 | 1,390 | 3,971 |
transforming growth factor beta binding
|
10,386.03 | 15.68 | 1,390 | 4,673 |
regulation of transforming growth factor beta receptor signaling pathway
|
12,946.93 | 15.66 | 1,191 | 3,212 |
neuroblast delamination
|
34,860.54 | 11.16 | 623 | 624 |
neuroblast division in subventricular zone
|
27,570.31 | 10.84 | 623 | 789 |
positive regulation of epithelial to mesenchymal transition
|
6,535.93 | 9.92 | 973 | 5,198 |
positive regulation of SMAD protein signal transduction
|
7,483.55 | 8.94 | 742 | 3,462 |
glycosaminoglycan binding
|
4,010.07 | 8.31 | 1,291 | 11,241 |
Totals | 46920 | 304083 |
No co-occurrence statistics for GO:0001837 based on MANUAL annotations
The top 100 of 2,097 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
epithelial to mesenchymal transition
|
2,990.28 | 100.00 | 432 | 432 |
type II transforming growth factor beta receptor binding
|
1,610.15 | 22.28 | 119 | 221 |
positive regulation of SMAD protein signal transduction
|
1,201.01 | 16.96 | 98 | 244 |
cardiac epithelial to mesenchymal transition
|
1,201.83 | 15.08 | 84 | 209 |
negative regulation of epithelial cell proliferation
|
745.93 | 14.71 | 114 | 457 |
regulation of transforming growth factor beta2 production
|
2,893.82 | 13.82 | 60 | 62 |
cardiac muscle cell proliferation
|
1,027.91 | 13.30 | 77 | 224 |
transforming growth factor beta receptor binding
|
1,732.68 | 13.00 | 62 | 107 |
positive regulation of epithelial to mesenchymal transition
|
717.36 | 12.96 | 95 | 396 |
positive regulation of integrin biosynthetic process
|
2,790.92 | 12.84 | 56 | 60 |
Totals | 5019 | 27327 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
2016-09-17 | Deleted | RELATION | is a GO:0000904 (obsolete cell morphogenesis involved in differentiation) |
2016-09-17 | Added | SYNONYM | mesenchymal cell differentiation from epithelial cell |
2016-09-17 | Added | RELATION | is a GO:0048762 (mesenchymal cell differentiation) |
2016-09-17 | Deleted | RELATION | part of GO:0014031 (mesenchymal cell development) |
2009-05-03 | Deleted | RELATION | is a GO:0051239 (regulation of multicellular organismal process) |
2009-04-07 | Added | RELATION | is a GO:0051239 (regulation of multicellular organismal process) |
2009-02-01 | Deleted | RELATION | is a GO:0060232 (delamination) |
2008-10-02 | Added | RELATION | is a GO:0000904 (obsolete cell morphogenesis involved in differentiation) |
2008-10-02 | Deleted | RELATION | is a GO:0014031 (mesenchymal cell development) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-03-11 | Added | TERM | epithelial to mesenchymal transition |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-09-17 | Added | SYNONYM | mesenchymal cell differentiation from epithelial cell |
2008-05-13 | Added | DEFINITION | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
2008-05-12 | Deleted | DEFINITION | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
2007-08-09 | Added | SYNONYM | epithelial-mesenchymal transition |
2007-08-09 | Added | SYNONYM | EMT |
2007-08-09 | Deleted | SYNONYM | EMT |
2007-08-09 | Deleted | SYNONYM | epithelial-mesenchymal transition |
2007-04-07 | Added | SYNONYM | EMT |
2007-04-07 | Added | SYNONYM | epithelial-mesenchymal transition |
2007-01-16 | Updated | DEFINITION | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. |
2004-03-11 | Added | DEFINITION | A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes migratory. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2016-09-17 | Deleted | RELATION | is a GO:0000904 (obsolete cell morphogenesis involved in differentiation) |
2016-09-17 | Added | RELATION | is a GO:0048762 (mesenchymal cell differentiation) |
2016-09-17 | Deleted | RELATION | part of GO:0014031 (mesenchymal cell development) |
2009-05-03 | Deleted | RELATION | is a GO:0051239 (regulation of multicellular organismal process) |
2009-04-07 | Added | RELATION | is a GO:0051239 (regulation of multicellular organismal process) |
2009-02-01 | Deleted | RELATION | is a GO:0060232 (delamination) |
2008-10-02 | Added | RELATION | is a GO:0000904 (obsolete cell morphogenesis involved in differentiation) |
2008-10-02 | Deleted | RELATION | is a GO:0014031 (mesenchymal cell development) |
2008-10-02 | Added | RELATION | part of GO:0014031 (mesenchymal cell development) |
2008-04-14 | Added | RELATION | is a GO:0060232 (delamination) |
2008-04-01 | Updated | RELATION | is a GO:0014031 (mesenchymal cell development) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:6072 (Eumetazoa) |
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