This term is obsolete.

GO:0001837 JSON

epithelial to mesenchymal transition

Biological Process

Definition (GO:0001837 GONUTS page)

A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. PMID:14701881

10,143 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
epithelial-mesenchymal transition exact
EMT exact
mesenchymal cell differentiation from epithelial cell exact

Ancestor Chart

Ancestor chart for GO:0001837
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0001837

Child Term Relationship to
GO:0001837
negative regulation of epithelial to mesenchymal transition
negatively_regulates
positive regulation of epithelial to mesenchymal transition
positively_regulates
clearance of cells from fusion plate by epithelial to mesenchymal transition
is_a
mesodermal to mesenchymal transition involved in gastrulation
is_a
regulation of epithelial to mesenchymal transition
regulates
cardiac epithelial to mesenchymal transition
is_a
neural crest formation
is_a
epicardial cell to mesenchymal cell transition
is_a

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0001837 epithelial to mesenchymal transition Only in Taxon 6072 Eumetazoa

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZKY9 10116 A0A8I5ZKY9_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZPU7 10116 A0A8I5ZPU7_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5ZR99 10116 A0A8I5ZR99_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A6W3 10116 A0A8I6A6W3_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6GA69 10116 A0A8I6GA69_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K3T1 10116 A6K3T1_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6K3T3 10116 A6K3T3_RAT GO:0001837 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-Ontology Relations

Relation Other Ontology ID Term
has_primary_input CL CL:0000066 epithelial cell
results_in_acquisition_of_features_of CL CL:0008019 mesenchymal cell

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0001837 based on ALL annotations
The top 100 of 2,328 co-occurring terms
Co-occurring Term PR S% #Together #Compared
epithelial to mesenchymal transition
34,916.49 100.00 5,583 5,583
type II transforming growth factor beta receptor binding
28,129.23 25.56 1,521 1,888
transforming growth factor beta receptor activity
12,222.09 17.03 1,390 3,971
transforming growth factor beta binding
10,386.03 15.68 1,390 4,673
regulation of transforming growth factor beta receptor signaling pathway
12,946.93 15.66 1,191 3,212
neuroblast delamination
34,860.54 11.16 623 624
neuroblast division in subventricular zone
27,570.31 10.84 623 789
positive regulation of epithelial to mesenchymal transition
6,535.93 9.92 973 5,198
positive regulation of SMAD protein signal transduction
7,483.55 8.94 742 3,462
glycosaminoglycan binding
4,010.07 8.31 1,291 11,241
Totals 46920 304083
No co-occurrence statistics for GO:0001837 based on MANUAL annotations
The top 100 of 2,097 co-occurring terms
Co-occurring Term PR S% #Together #Compared
epithelial to mesenchymal transition
2,990.28 100.00 432 432
type II transforming growth factor beta receptor binding
1,610.15 22.28 119 221
positive regulation of SMAD protein signal transduction
1,201.01 16.96 98 244
cardiac epithelial to mesenchymal transition
1,201.83 15.08 84 209
negative regulation of epithelial cell proliferation
745.93 14.71 114 457
regulation of transforming growth factor beta2 production
2,893.82 13.82 60 62
cardiac muscle cell proliferation
1,027.91 13.30 77 224
transforming growth factor beta receptor binding
1,732.68 13.00 62 107
positive regulation of epithelial to mesenchymal transition
717.36 12.96 95 396
positive regulation of integrin biosynthetic process
2,790.92 12.84 56 60
Totals 5019 27327

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
2016-09-17 Deleted RELATION is a GO:0000904 (obsolete cell morphogenesis involved in differentiation)
2016-09-17 Added SYNONYM mesenchymal cell differentiation from epithelial cell
2016-09-17 Added RELATION is a GO:0048762 (mesenchymal cell differentiation)
2016-09-17 Deleted RELATION part of GO:0014031 (mesenchymal cell development)
2009-05-03 Deleted RELATION is a GO:0051239 (regulation of multicellular organismal process)
2009-04-07 Added RELATION is a GO:0051239 (regulation of multicellular organismal process)
2009-02-01 Deleted RELATION is a GO:0060232 (delamination)
2008-10-02 Added RELATION is a GO:0000904 (obsolete cell morphogenesis involved in differentiation)
2008-10-02 Deleted RELATION is a GO:0014031 (mesenchymal cell development)
Timestamp Action Category Detail
2004-03-11 Added TERM epithelial to mesenchymal transition
Timestamp Action Category Detail
2016-09-17 Added SYNONYM mesenchymal cell differentiation from epithelial cell
2008-05-13 Added DEFINITION A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2008-05-12 Deleted DEFINITION A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2007-08-09 Added SYNONYM epithelial-mesenchymal transition
2007-08-09 Added SYNONYM EMT
2007-08-09 Deleted SYNONYM EMT
2007-08-09 Deleted SYNONYM epithelial-mesenchymal transition
2007-04-07 Added SYNONYM EMT
2007-04-07 Added SYNONYM epithelial-mesenchymal transition
2007-01-16 Updated DEFINITION A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
2004-03-11 Added DEFINITION A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes migratory.
Timestamp Action Category Detail
2016-09-17 Deleted RELATION is a GO:0000904 (obsolete cell morphogenesis involved in differentiation)
2016-09-17 Added RELATION is a GO:0048762 (mesenchymal cell differentiation)
2016-09-17 Deleted RELATION part of GO:0014031 (mesenchymal cell development)
2009-05-03 Deleted RELATION is a GO:0051239 (regulation of multicellular organismal process)
2009-04-07 Added RELATION is a GO:0051239 (regulation of multicellular organismal process)
2009-02-01 Deleted RELATION is a GO:0060232 (delamination)
2008-10-02 Added RELATION is a GO:0000904 (obsolete cell morphogenesis involved in differentiation)
2008-10-02 Deleted RELATION is a GO:0014031 (mesenchymal cell development)
2008-10-02 Added RELATION part of GO:0014031 (mesenchymal cell development)
2008-04-14 Added RELATION is a GO:0060232 (delamination)
2008-04-01 Updated RELATION is a GO:0014031 (mesenchymal cell development)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:6072 (Eumetazoa)
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