This term is obsolete.

GO:0002221 JSON

pattern recognition receptor signaling pathway

Biological Process

Definition (GO:0002221 GONUTS page)

The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. PMID:15199967

48,221 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
PRR signaling pathway exact
pathogen receptor signaling pathway exact
pathogen receptor signalling pathway exact

Ancestor Chart

Ancestor chart for GO:0002221
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002221

Child Term Relationship to
GO:0002221
cytoplasmic pattern recognition receptor signaling pathway
is_a
regulation of pattern recognition receptor signaling pathway
regulates
pathogen-associated molecular pattern receptor signaling pathway
is_a
cell surface pattern recognition receptor signaling pathway
is_a
positive regulation of pattern recognition receptor signaling pathway
positively_regulates
peptidoglycan recognition protein signaling pathway
is_a
toll-like receptor signaling pathway
is_a

GO Discussions

The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:

Ontology Development Project
signalling Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0002221 pattern recognition receptor signaling pathway Never in Taxon 4895 Schizosaccharomyces

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein Q9VJN5 7227 WEK_DROME GO:0002218 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:16782008
NOT-qualified manual protein Q9XF04 3702 CLV3_ARATH GO:0002221 1 NOT-qualified manual annotation exists with evidence code ECO:0000270 from this reference: PMID:22923673

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0052033 obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response consider GO:0002221
GO:0052169 obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response consider GO:0002221
GO:0052257 obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction consider GO:0002221
GO:0052308 obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction consider GO:0002221

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0002221 based on ALL annotations
The top 100 of 514 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pattern recognition receptor signaling pathway
191,868.88 100.00 1,016 1,016
nucleotide-binding oligomerization domain containing 2 signaling pathway
62,234.40 16.40 253 780
cGAS/STING signaling pathway
115,934.90 15.16 171 283
positive regulation of dendritic cell antigen processing and presentation
68,919.65 12.41 162 451
cellular response to muramyl dipeptide
42,665.25 10.59 171 769
response to peptidoglycan
50,315.27 10.43 150 572
positive regulation of xenophagy
43,840.28 10.36 162 709
regulation of purine nucleotide metabolic process
191,868.89 9.06 92 92
STING complex
189,713.06 8.65 88 89
response to muramyl dipeptide
28,950.63 8.15 153 1,014
Totals 11232 211423
No co-occurrence statistics for GO:0002221 based on MANUAL annotations
The top 100 of 425 co-occurring terms
Co-occurring Term PR S% #Together #Compared
pattern recognition receptor signaling pathway
8,847.94 100.00 146 146
positive regulation of interleukin-1 beta production
1,445.16 12.34 49 300
pyroptotic inflammatory response
1,474.66 10.90 35 210
canonical inflammasome complex
2,949.31 7.56 13 39
NLRP1 inflammasome complex
1,983.16 6.81 13 58
positive regulation of inflammatory response
658.53 6.18 39 524
nucleotide-binding oligomerization domain containing 2 signaling pathway
2,010.90 5.56 10 44
response to muramyl dipeptide
1,301.17 4.90 10 68
positive regulation of cytokine production involved in immune response
963.64 4.66 11 101
endopeptidase activator activity
597.33 4.36 16 237
Totals 874 13627

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
2022-07-26 Deleted SYNONYM PAMP receptor signaling pathway
2022-07-26 Deleted RELATION is a GO:0002764 (immune response-regulating signaling pathway)
2022-07-26 Added RELATION is a GO:0002758 (innate immune response-activating signaling pathway)
2022-03-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2021-05-15 Deleted RELATION is a GO:0007165 (signal transduction)
2021-05-15 Added RELATION is a GO:0002764 (immune response-regulating signaling pathway)
2020-03-15 Deleted SYNONYM Changed parent, see https://github.com/geneontology/go-ontology/issues/18588.
2020-02-22 Deleted RELATION is a GO:0002758 (innate immune response-activating signaling pathway)
Timestamp Action Category Detail
2006-09-21 Added TERM pattern recognition receptor signaling pathway
Timestamp Action Category Detail
2022-07-26 Deleted SYNONYM PAMP receptor signaling pathway
2022-03-14 Deleted DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2022-03-14 Added DEFINITION The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2020-03-15 Deleted SYNONYM Changed parent, see https://github.com/geneontology/go-ontology/issues/18588.
2020-02-22 Added SYNONYM Changed parent, see https://github.com/geneontology/go-ontology/issues/18588.
2020-02-22 Added DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2020-02-22 Deleted DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
2020-01-26 Added DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species.
2020-01-26 Deleted DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2013-06-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
2013-06-12 Added DEFINITION Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells.
2008-05-13 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
2008-05-12 Deleted DEFINITION Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
2007-08-09 Added SYNONYM PRR signaling pathway
2007-08-09 Added SYNONYM pathogen receptor signaling pathway
2007-08-09 Added SYNONYM pathogen receptor signalling pathway
2007-08-09 Deleted SYNONYM pathogen receptor signaling pathway
2007-08-09 Deleted SYNONYM pathogen receptor signalling pathway
2007-08-09 Deleted SYNONYM PAMP receptor signaling pathway
2007-08-09 Deleted SYNONYM PRR signaling pathway
2007-08-09 Added SYNONYM PAMP receptor signaling pathway
2006-09-22 Added DEFINITION Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens.
2006-09-21 Added SYNONYM pathogen receptor signalling pathway
2006-09-21 Added SYNONYM PRR signaling pathway
2006-09-21 Added SYNONYM pathogen receptor signaling pathway
2006-09-21 Added SYNONYM PAMP receptor signaling pathway
Timestamp Action Category Detail
2022-07-26 Deleted RELATION is a GO:0002764 (immune response-regulating signaling pathway)
2022-07-26 Added RELATION is a GO:0002758 (innate immune response-activating signaling pathway)
2021-05-15 Deleted RELATION is a GO:0007165 (signal transduction)
2021-05-15 Added RELATION is a GO:0002764 (immune response-regulating signaling pathway)
2020-02-22 Deleted RELATION is a GO:0002758 (innate immune response-activating signaling pathway)
2020-02-22 Added RELATION is a GO:0007165 (signal transduction)
2010-04-14 Deleted RELATION is a GO:0023034 (intracellular signaling pathway)
2010-02-20 Added RELATION is a GO:0023034 (intracellular signaling pathway)
2008-04-01 Updated RELATION is a GO:0002758 (innate immune response-activating signaling pathway)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT never_in_taxon NCBITaxon:4895 (Schizosaccharomyces)
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