GO:0002221
JSON
pattern recognition receptor signaling pathway
Biological Process
Definition (GO:0002221 GONUTS page)
The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. PMID:15199967
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
PRR signaling pathway | exact |
pathogen receptor signaling pathway | exact |
pathogen receptor signalling pathway | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0002221
Child Term | Relationship to GO:0002221 |
---|---|
cytoplasmic pattern recognition receptor signaling pathway
|
is_a |
regulation of pattern recognition receptor signaling pathway
|
regulates |
pathogen-associated molecular pattern receptor signaling pathway
|
is_a |
cell surface pattern recognition receptor signaling pathway
|
is_a |
positive regulation of pattern recognition receptor signaling pathway
|
positively_regulates |
peptidoglycan recognition protein signaling pathway
|
is_a |
toll-like receptor signaling pathway
|
is_a |
GO Discussions
The GO editorial group is intending to improve the information provided in this area of the GO. If you would like to be involved in discussions regarding this development activity, please email the GO Consortium. Please note that it is still appropriate to use this term for curation or analysis purpose:
Ontology Development Project | |
---|---|
signalling | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0002221 | pattern recognition receptor signaling pathway | Never in Taxon | 4895 | Schizosaccharomyces |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | Q9VJN5 | 7227 | WEK_DROME | GO:0002218 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:16782008 | |
NOT-qualified manual | protein | Q9XF04 | 3702 | CLV3_ARATH | GO:0002221 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000270 from this reference: PMID:22923673 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0052033 | obsolete pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response | consider GO:0002221 |
GO:0052169 | obsolete pathogen-associated molecular pattern dependent modulation by symbiont of host innate immune response | consider GO:0002221 |
GO:0052257 | obsolete pathogen-associated molecular pattern dependent induction by organism of innate immune response of other organism involved in symbiotic interaction | consider GO:0002221 |
GO:0052308 | obsolete pathogen-associated molecular pattern dependent modulation by organism of innate immune response in other organism involved in symbiotic interaction | consider GO:0002221 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0002221 based on ALL annotations
The top 100 of 514 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pattern recognition receptor signaling pathway
|
191,868.88 | 100.00 | 1,016 | 1,016 |
nucleotide-binding oligomerization domain containing 2 signaling pathway
|
62,234.40 | 16.40 | 253 | 780 |
cGAS/STING signaling pathway
|
115,934.90 | 15.16 | 171 | 283 |
positive regulation of dendritic cell antigen processing and presentation
|
68,919.65 | 12.41 | 162 | 451 |
cellular response to muramyl dipeptide
|
42,665.25 | 10.59 | 171 | 769 |
response to peptidoglycan
|
50,315.27 | 10.43 | 150 | 572 |
positive regulation of xenophagy
|
43,840.28 | 10.36 | 162 | 709 |
regulation of purine nucleotide metabolic process
|
191,868.89 | 9.06 | 92 | 92 |
STING complex
|
189,713.06 | 8.65 | 88 | 89 |
response to muramyl dipeptide
|
28,950.63 | 8.15 | 153 | 1,014 |
Totals | 11232 | 211423 |
No co-occurrence statistics for GO:0002221 based on MANUAL annotations
The top 100 of 425 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
pattern recognition receptor signaling pathway
|
8,847.94 | 100.00 | 146 | 146 |
positive regulation of interleukin-1 beta production
|
1,445.16 | 12.34 | 49 | 300 |
pyroptotic inflammatory response
|
1,474.66 | 10.90 | 35 | 210 |
canonical inflammasome complex
|
2,949.31 | 7.56 | 13 | 39 |
NLRP1 inflammasome complex
|
1,983.16 | 6.81 | 13 | 58 |
positive regulation of inflammatory response
|
658.53 | 6.18 | 39 | 524 |
nucleotide-binding oligomerization domain containing 2 signaling pathway
|
2,010.90 | 5.56 | 10 | 44 |
response to muramyl dipeptide
|
1,301.17 | 4.90 | 10 | 68 |
positive regulation of cytokine production involved in immune response
|
963.64 | 4.66 | 11 | 101 |
endopeptidase activator activity
|
597.33 | 4.36 | 16 | 237 |
Totals | 874 | 13627 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
2022-07-26 | Deleted | SYNONYM | PAMP receptor signaling pathway |
2022-07-26 | Deleted | RELATION | is a GO:0002764 (immune response-regulating signaling pathway) |
2022-07-26 | Added | RELATION | is a GO:0002758 (innate immune response-activating signaling pathway) |
2022-03-14 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2021-05-15 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2021-05-15 | Added | RELATION | is a GO:0002764 (immune response-regulating signaling pathway) |
2020-03-15 | Deleted | SYNONYM | Changed parent, see https://github.com/geneontology/go-ontology/issues/18588. |
2020-02-22 | Deleted | RELATION | is a GO:0002758 (innate immune response-activating signaling pathway) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-09-21 | Added | TERM | pattern recognition receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-26 | Deleted | SYNONYM | PAMP receptor signaling pathway |
2022-03-14 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2022-03-14 | Added | DEFINITION | The series of molecular signals initiated by a ligand binding to a pattern recognition receptor (PRR), and ending with the regulation of a downstream cellular process, e.g. transcription. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2020-03-15 | Deleted | SYNONYM | Changed parent, see https://github.com/geneontology/go-ontology/issues/18588. |
2020-02-22 | Added | SYNONYM | Changed parent, see https://github.com/geneontology/go-ontology/issues/18588. |
2020-02-22 | Added | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2020-02-22 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. |
2020-01-26 | Added | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species. |
2020-01-26 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2013-06-12 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. |
2013-06-12 | Added | DEFINITION | Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells. |
2008-05-13 | Added | DEFINITION | Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. |
2008-05-12 | Deleted | DEFINITION | Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. |
2007-08-09 | Added | SYNONYM | PRR signaling pathway |
2007-08-09 | Added | SYNONYM | pathogen receptor signaling pathway |
2007-08-09 | Added | SYNONYM | pathogen receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | pathogen receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | pathogen receptor signalling pathway |
2007-08-09 | Deleted | SYNONYM | PAMP receptor signaling pathway |
2007-08-09 | Deleted | SYNONYM | PRR signaling pathway |
2007-08-09 | Added | SYNONYM | PAMP receptor signaling pathway |
2006-09-22 | Added | DEFINITION | Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens. |
2006-09-21 | Added | SYNONYM | pathogen receptor signalling pathway |
2006-09-21 | Added | SYNONYM | PRR signaling pathway |
2006-09-21 | Added | SYNONYM | pathogen receptor signaling pathway |
2006-09-21 | Added | SYNONYM | PAMP receptor signaling pathway |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-07-26 | Deleted | RELATION | is a GO:0002764 (immune response-regulating signaling pathway) |
2022-07-26 | Added | RELATION | is a GO:0002758 (innate immune response-activating signaling pathway) |
2021-05-15 | Deleted | RELATION | is a GO:0007165 (signal transduction) |
2021-05-15 | Added | RELATION | is a GO:0002764 (immune response-regulating signaling pathway) |
2020-02-22 | Deleted | RELATION | is a GO:0002758 (innate immune response-activating signaling pathway) |
2020-02-22 | Added | RELATION | is a GO:0007165 (signal transduction) |
2010-04-14 | Deleted | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2010-02-20 | Added | RELATION | is a GO:0023034 (intracellular signaling pathway) |
2008-04-01 | Updated | RELATION | is a GO:0002758 (innate immune response-activating signaling pathway) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | never_in_taxon NCBITaxon:4895 (Schizosaccharomyces) |
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