This term is obsolete.
Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

GO:0002317 JSON

plasma cell differentiation

Biological Process

Definition (GO:0002317 GONUTS page)

The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.

Comments

Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.

339 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
plasma cell development related

Ancestor Chart

Ancestor chart for GO:0002317
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002317

Child Term Relationship to
GO:0002317
negative regulation of plasma cell differentiation
negatively_regulates
regulation of plasma cell differentiation
regulates
positive regulation of plasma cell differentiation
positively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0002317 plasma cell differentiation Only in Taxon 40674 Mammalia

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q05028 10116 PDGFB_RAT GO:0030097 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000786 plasma cell

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0002317 based on ALL annotations
The top 100 of 334 co-occurring terms
Co-occurring Term PR S% #Together #Compared
plasma cell differentiation
596,852.00 100.00 332 332
lymphocyte activation involved in immune response
459,576.00 21.69 77 100
mucosa-associated lymphoid tissue development
464,916.28 20.96 74 95
post-embryonic digestive tract morphogenesis
405,202.30 20.16 74 109
negative regulation of plasma cell differentiation
455,661.20 20.06 71 93
regulation of memory T cell differentiation
450,813.75 20.00 71 94
keratinocyte activation
298,426.00 18.83 77 154
B cell receptor apoptotic signaling pathway
267,195.38 18.03 77 172
response to cisplatin
252,514.31 17.62 77 182
negative regulation of mononuclear cell proliferation
261,583.27 16.78 71 162
Totals 6827 331150
No co-occurrence statistics for GO:0002317 based on MANUAL annotations
The top 100 of 298 co-occurring terms
Co-occurring Term PR S% #Together #Compared
plasma cell differentiation
74,291.21 100.00 19 19
lymphocyte activation involved in immune response
74,291.21 21.05 4 4
transcription preinitiation complex assembly
74,291.21 21.05 4 4
B cell receptor apoptotic signaling pathway
49,527.47 19.05 4 6
keratinocyte activation
49,527.47 19.05 4 6
negative regulation of plasma cell differentiation
44,574.72 14.29 3 5
regulation of memory T cell differentiation
37,145.61 13.64 3 6
mononuclear cell proliferation
37,145.61 13.64 3 6
response to Gram-positive bacterium
13,507.49 13.04 6 33
post-embryonic digestive tract morphogenesis
27,859.20 12.50 3 8
Totals 291 4173

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:40674 (Mammalia)
2010-12-17 Added DEFINITION The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2010-12-17 Deleted DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2010-10-15 Added SYNONYM plasma cell development
2008-05-13 Added DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2008-05-12 Deleted DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2008-04-01 Updated RELATION is a GO:0002313 (mature B cell differentiation involved in immune response)
2006-09-22 Added DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2006-09-21 Added TERM plasma cell differentiation
Timestamp Action Category Detail
2006-09-21 Added TERM plasma cell differentiation
Timestamp Action Category Detail
2010-12-17 Added DEFINITION The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2010-12-17 Deleted DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2010-10-15 Added SYNONYM plasma cell development
2008-05-13 Added DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2008-05-12 Deleted DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
2006-09-22 Added DEFINITION The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002313 (mature B cell differentiation involved in immune response)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:40674 (Mammalia)
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