This term is obsolete.
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.

GO:0002419 JSON

T cell mediated cytotoxicity directed against tumor cell target

Biological Process

Definition (GO:0002419 GONUTS page)

The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. PMID:16730260

Comments

Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.

12 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
T-cell mediated cytotoxicity directed against tumor cell target exact
T-lymphocyte mediated cytotoxicity directed against tumor cell target exact
T lymphocyte mediated cytotoxicity directed against tumor cell target exact

Ancestor Chart

Ancestor chart for GO:0002419
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Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0002419

Child Term Relationship to
GO:0002419
negative regulation of T cell mediated cytotoxicity directed against tumor cell target
negatively_regulates
regulation of T cell mediated cytotoxicity directed against tumor cell target
regulates
positive regulation of T cell mediated cytotoxicity directed against tumor cell target
positively_regulates

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0002419 T cell mediated cytotoxicity directed against tumor cell target Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5ZNM6 10116 A0A8I5ZNM6_RAT GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6J3R4 10116 A6J3R4_RAT GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZLP3 10116 D3ZLP3_RAT GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O95727 9606 CRTAM_HUMAN GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15811952
NOT-qualified manual protein P55281 10116 CAD17_RAT GO:0002456 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q6AYP5 10116 CADM1_RAT GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein Q9BY67 9606 CADM1_HUMAN GO:0001913 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15811952
NOT-qualified manual protein Q9R100 10090 CAD17_MOUSE GO:0002456 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15688343

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0002419 based on ALL annotations
The top 59 of 59 co-occurring terms
Co-occurring Term PR S% #Together #Compared
T cell mediated cytotoxicity directed against tumor cell target
19,815,486.00 100.00 10 10
TAP binding
10,568,260.00 47.06 8 15
positive regulation of CD8-positive, alpha-beta T cell activation
5,871,255.50 27.59 8 27
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
1,933,218.10 9.52 8 82
positive regulation of memory T cell activation
1,781,167.20 8.79 8 89
TAP complex binding
1,569,543.40 7.77 8 101
CD8 receptor binding
1,390,560.50 6.90 8 114
positive regulation of CD8-positive, alpha-beta T cell proliferation
1,390,560.50 6.90 8 114
protection from natural killer cell mediated cytotoxicity
1,288,812.10 6.40 8 123
CD8-positive, alpha-beta T cell activation
1,022,734.80 5.10 8 155
Totals 359 89783663
No co-occurrence statistics for GO:0002419 based on MANUAL annotations
The top 55 of 55 co-occurring terms
Co-occurring Term PR S% #Together #Compared
T cell mediated cytotoxicity directed against tumor cell target
176,441.62 100.00 8 8
TAP binding
117,627.75 54.55 6 9
positive regulation of CD8-positive, alpha-beta T cell activation
105,864.97 50.00 6 10
positive regulation of memory T cell activation
70,576.65 35.29 6 15
MHC class I protein complex
66,165.61 33.33 6 16
CD8 receptor binding
62,273.52 31.58 6 17
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
58,813.88 30.00 6 18
positive regulation of CD8-positive, alpha-beta T cell proliferation
50,411.90 26.09 6 21
CD8-positive, alpha-beta T cell activation
37,808.92 20.00 6 28
antigen processing and presentation of endogenous peptide antigen via MHC class I
35,288.32 18.75 6 30
Totals 240 445207

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2008-05-13 Added DEFINITION The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-05-12 Deleted DEFINITION The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-04-01 Updated RELATION is a GO:0002424 (T cell mediated immune response to tumor cell)
2008-04-01 Updated RELATION is a GO:0001913 (T cell mediated cytotoxicity)
2007-08-09 Deleted SYNONYM T-cell mediated cytotoxicity directed against tumor cell target
2007-08-09 Deleted SYNONYM T-lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Deleted SYNONYM T lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Added SYNONYM T-lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Added SYNONYM T-cell mediated cytotoxicity directed against tumor cell target
Timestamp Action Category Detail
2006-09-21 Added TERM T cell mediated cytotoxicity directed against tumor cell target
Timestamp Action Category Detail
2008-05-13 Added DEFINITION The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2008-05-12 Deleted DEFINITION The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2007-08-09 Deleted SYNONYM T-cell mediated cytotoxicity directed against tumor cell target
2007-08-09 Deleted SYNONYM T-lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Deleted SYNONYM T lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Added SYNONYM T-lymphocyte mediated cytotoxicity directed against tumor cell target
2007-08-09 Added SYNONYM T-cell mediated cytotoxicity directed against tumor cell target
2007-08-09 Added SYNONYM T lymphocyte mediated cytotoxicity directed against tumor cell target
2006-09-22 Added DEFINITION The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.
2006-09-21 Added SYNONYM T lymphocyte mediated cytotoxicity directed against tumor cell target
2006-09-21 Added SYNONYM T-cell mediated cytotoxicity directed against tumor cell target
2006-09-21 Added SYNONYM T-lymphocyte mediated cytotoxicity directed against tumor cell target
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0002424 (T cell mediated immune response to tumor cell)
2008-04-01 Updated RELATION is a GO:0001913 (T cell mediated cytotoxicity)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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