Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
GO:0002419
JSON
T cell mediated cytotoxicity directed against tumor cell target
Biological Process
Definition (GO:0002419 GONUTS page)
The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. PMID:16730260
Comments
Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
T-cell mediated cytotoxicity directed against tumor cell target | exact |
T-lymphocyte mediated cytotoxicity directed against tumor cell target | exact |
T lymphocyte mediated cytotoxicity directed against tumor cell target | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0002419
Child Term | Relationship to GO:0002419 |
---|---|
negative regulation of T cell mediated cytotoxicity directed against tumor cell target
|
negatively_regulates |
regulation of T cell mediated cytotoxicity directed against tumor cell target
|
regulates |
positive regulation of T cell mediated cytotoxicity directed against tumor cell target
|
positively_regulates |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0002419 | T cell mediated cytotoxicity directed against tumor cell target | Only in Taxon | 7742 | Vertebrata |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5ZNM6 | 10116 | A0A8I5ZNM6_RAT | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6J3R4 | 10116 | A6J3R4_RAT | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZLP3 | 10116 | D3ZLP3_RAT | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | O95727 | 9606 | CRTAM_HUMAN | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15811952 | |
NOT-qualified manual | protein | P55281 | 10116 | CAD17_RAT | GO:0002456 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q6AYP5 | 10116 | CADM1_RAT | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | Q9BY67 | 9606 | CADM1_HUMAN | GO:0001913 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15811952 | |
NOT-qualified manual | protein | Q9R100 | 10090 | CAD17_MOUSE | GO:0002456 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:15688343 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0002419 based on ALL annotations
The top 59 of 59 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
T cell mediated cytotoxicity directed against tumor cell target
|
19,815,486.00 | 100.00 | 10 | 10 |
TAP binding
|
10,568,260.00 | 47.06 | 8 | 15 |
positive regulation of CD8-positive, alpha-beta T cell activation
|
5,871,255.50 | 27.59 | 8 | 27 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
|
1,933,218.10 | 9.52 | 8 | 82 |
positive regulation of memory T cell activation
|
1,781,167.20 | 8.79 | 8 | 89 |
TAP complex binding
|
1,569,543.40 | 7.77 | 8 | 101 |
CD8 receptor binding
|
1,390,560.50 | 6.90 | 8 | 114 |
positive regulation of CD8-positive, alpha-beta T cell proliferation
|
1,390,560.50 | 6.90 | 8 | 114 |
protection from natural killer cell mediated cytotoxicity
|
1,288,812.10 | 6.40 | 8 | 123 |
CD8-positive, alpha-beta T cell activation
|
1,022,734.80 | 5.10 | 8 | 155 |
Totals | 359 | 89783663 |
No co-occurrence statistics for GO:0002419 based on MANUAL annotations
The top 55 of 55 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
T cell mediated cytotoxicity directed against tumor cell target
|
176,441.62 | 100.00 | 8 | 8 |
TAP binding
|
117,627.75 | 54.55 | 6 | 9 |
positive regulation of CD8-positive, alpha-beta T cell activation
|
105,864.97 | 50.00 | 6 | 10 |
positive regulation of memory T cell activation
|
70,576.65 | 35.29 | 6 | 15 |
MHC class I protein complex
|
66,165.61 | 33.33 | 6 | 16 |
CD8 receptor binding
|
62,273.52 | 31.58 | 6 | 17 |
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
|
58,813.88 | 30.00 | 6 | 18 |
positive regulation of CD8-positive, alpha-beta T cell proliferation
|
50,411.90 | 26.09 | 6 | 21 |
CD8-positive, alpha-beta T cell activation
|
37,808.92 | 20.00 | 6 | 28 |
antigen processing and presentation of endogenous peptide antigen via MHC class I
|
35,288.32 | 18.75 | 6 | 30 |
Totals | 240 | 445207 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
2008-05-13 | Added | DEFINITION | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
2008-05-12 | Deleted | DEFINITION | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
2008-04-01 | Updated | RELATION | is a GO:0002424 (T cell mediated immune response to tumor cell) |
2008-04-01 | Updated | RELATION | is a GO:0001913 (T cell mediated cytotoxicity) |
2007-08-09 | Deleted | SYNONYM | T-cell mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Deleted | SYNONYM | T-lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Deleted | SYNONYM | T lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Added | SYNONYM | T-lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Added | SYNONYM | T-cell mediated cytotoxicity directed against tumor cell target |
Timestamp | Action | Category | Detail |
---|---|---|---|
2006-09-21 | Added | TERM | T cell mediated cytotoxicity directed against tumor cell target |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
2008-05-12 | Deleted | DEFINITION | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
2007-08-09 | Deleted | SYNONYM | T-cell mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Deleted | SYNONYM | T-lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Deleted | SYNONYM | T lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Added | SYNONYM | T-lymphocyte mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Added | SYNONYM | T-cell mediated cytotoxicity directed against tumor cell target |
2007-08-09 | Added | SYNONYM | T lymphocyte mediated cytotoxicity directed against tumor cell target |
2006-09-22 | Added | DEFINITION | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. |
2006-09-21 | Added | SYNONYM | T lymphocyte mediated cytotoxicity directed against tumor cell target |
2006-09-21 | Added | SYNONYM | T-cell mediated cytotoxicity directed against tumor cell target |
2006-09-21 | Added | SYNONYM | T-lymphocyte mediated cytotoxicity directed against tumor cell target |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0002424 (T cell mediated immune response to tumor cell) |
2008-04-01 | Updated | RELATION | is a GO:0001913 (T cell mediated cytotoxicity) |
Timestamp | Action | Category | Detail |
---|
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:7742 (Vertebrata) |
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