This term is obsolete.
Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.

GO:0002574 JSON

thrombocyte differentiation

Biological Process

Definition (GO:0002574 GONUTS page)

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.

Comments

Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220.

494 annotations

Ancestor Chart

Ancestor chart for GO:0002574
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Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0002574 thrombocyte differentiation Only in Taxon 7742 Vertebrata

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A8XY28 6238 A8XY28_CAEBR GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PL19 6945 B7PL19_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein B7PVH4 6945 B7PVH4_IXOSC GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein E9PTS6 10116 E9PTS6_RAT GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein O16262 6239 NIPI4_CAEEL GO:0030154 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P01127 9606 PDGFB_HUMAN GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P05622 10090 PGFRB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000315 from this reference: PMID:11264163
NOT-qualified manual protein P12919 9685 PDGFB_FELCA GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein P31240 10090 PDGFB_MOUSE GO:0030097 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein Q05028 10116 PDGFB_RAT GO:0030097 2 NOT-qualified manual annotations exist with these evidence codes: ECO:0000250, ECO:0000266 from these references: GO_REF:0000024, GO_REF:0000096

Cross-Ontology Relations

Relation Other Ontology ID Term
results_in_acquisition_of_features_of CL CL:0000762 nucleated thrombocyte

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0002574 based on ALL annotations
The top 100 of 183 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thrombocyte differentiation
415,647.75 100.00 469 469
nucleate erythrocyte differentiation
409,752.03 29.51 139 141
leukocyte proliferation
187,925.83 14.86 85 188
macrophage homeostasis
155,639.02 13.91 85 227
platelet morphogenesis
145,991.97 13.58 85 242
common myeloid progenitor cell proliferation
78,829.73 10.41 88 464
regulation of Wnt signaling pathway, calcium modulating pathway
354,070.28 9.64 46 54
histone H2A deubiquitinase activity
68,336.67 9.43 85 517
positive regulation of convergent extension involved in gastrulation
172,250.40 8.61 46 111
myeloid cell apoptotic process
57,168.38 8.48 85 618
Totals 6353 4974199
No co-occurrence statistics for GO:0002574 based on MANUAL annotations
The top 100 of 127 co-occurring terms
Co-occurring Term PR S% #Together #Compared
thrombocyte differentiation
34,913.48 100.00 37 37
nucleate erythrocyte differentiation
26,185.11 15.38 6 8
common myeloid progenitor cell proliferation
4,718.04 7.25 5 37
neutrophil differentiation
2,380.46 5.04 6 88
macrophage homeostasis
11,637.83 4.88 2 6
platelet morphogenesis
11,637.83 4.88 2 6
blood vessel lumenization
2,850.08 4.88 4 49
otolith development
2,407.83 4.40 4 58
neuromast development
2,289.41 4.26 4 61
myeloid cell apoptotic process
2,909.46 3.39 2 24
Totals 241 66676

Change Log

Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
2010-12-17 Added DEFINITION The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2008-04-01 Updated RELATION is a GO:0030099 (myeloid cell differentiation)
2006-09-22 Added DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2006-09-21 Added TERM thrombocyte differentiation
Timestamp Action Category Detail
2006-09-21 Added TERM thrombocyte differentiation
Timestamp Action Category Detail
2010-12-17 Added DEFINITION The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2010-12-17 Deleted DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2008-05-13 Added DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2008-05-12 Deleted DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
2006-09-22 Added DEFINITION The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0030099 (myeloid cell differentiation)
Timestamp Action Category Detail
Timestamp Action Category Detail
2024-03-05 Added CONSTRAINT in_taxon NCBITaxon:7742 (Vertebrata)
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