GO:0002576
JSON
platelet degranulation
Biological Process
Definition (GO:0002576 GONUTS page)
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
| Synonym | Type |
|---|---|
| platelet exocytosis | exact |
Ancestor Chart
Ancestor chart for GO:0002576
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0002576
| Child Term | Relationship to GO:0002576 |
|---|---|
|
serotonin secretion by platelet
|
part_of |
|
histamine secretion by platelet
|
part_of |
|
platelet SNARE complex
|
capable_of_part_of |
|
protein secretion by platelet
|
part_of |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
| Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
|---|---|---|---|---|---|
| GO:0002576 | platelet degranulation | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
| Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
|---|---|---|---|---|---|---|---|
| NOT-qualified manual | protein | P96210 | 83332 | ESPG1_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
| NOT-qualified manual | protein | P9WJD1 | 83332 | ESPF_MYCTU | GO:0046903 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:21196469 | |
| NOT-qualified manual | protein | Q62717 | 10116 | CAPS1_RAT | GO:0006887 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
| Database | ID | Description |
|---|---|---|
| Reactome | R-HSA-114608 |
Cross-Ontology Relations
| Relation | Other Ontology | ID | Term |
|---|---|---|---|
| occurs_in | CL | CL:0000233 | platelet |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0002576 based on ALL annotations
The top 100 of 272 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
platelet degranulation
|
525,307.25 | 100.00 | 379 | 379 |
|
regulation of cell diameter
|
510,980.66 | 28.01 | 107 | 110 |
|
negative regulation of myeloid leukocyte differentiation
|
514,363.34 | 24.67 | 94 | 96 |
|
regulation of B cell apoptotic process
|
509,060.62 | 24.61 | 94 | 97 |
|
C-X-C chemokine receptor CXCR4 signaling pathway
|
488,899.78 | 24.35 | 94 | 101 |
|
regulation of monocyte chemotaxis
|
488,899.78 | 24.35 | 94 | 101 |
|
regulation of hemostasis
|
519,658.75 | 24.21 | 92 | 93 |
|
Fc receptor mediated inhibitory signaling pathway
|
453,017.25 | 23.86 | 94 | 109 |
|
regulation of acrosomal vesicle exocytosis
|
525,307.25 | 22.43 | 85 | 85 |
|
phospholipase C-inhibiting G protein-coupled receptor signaling pathway
|
248,707.40 | 21.49 | 107 | 226 |
| Totals | 8221 | 388105 | ||
No co-occurrence statistics for GO:0002576 based on MANUAL annotations
The top 100 of 249 co-occurring terms
| Co-occurring Term | PR | S% | #Together | #Compared |
|---|---|---|---|---|
|
platelet degranulation
|
100,772.21 | 100.00 | 14 | 14 |
|
regulation of hemostasis
|
86,376.19 | 40.00 | 6 | 7 |
|
regulation of acrosomal vesicle exocytosis
|
100,772.23 | 14.29 | 2 | 2 |
|
C-X-C chemokine receptor CXCR4 signaling pathway
|
100,772.23 | 14.29 | 2 | 2 |
|
regulation of monocyte chemotaxis
|
100,772.23 | 14.29 | 2 | 2 |
|
negative regulation of mast cell proliferation
|
30,231.67 | 14.29 | 3 | 10 |
|
protein secretion by platelet
|
67,181.48 | 13.33 | 2 | 3 |
|
regulation of cell diameter
|
67,181.48 | 13.33 | 2 | 3 |
|
regulation of mast cell activation
|
25,193.05 | 13.04 | 3 | 12 |
|
negative regulation of myeloid leukocyte differentiation
|
50,386.11 | 12.50 | 2 | 4 |
| Totals | 199 | 3936 | ||
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-114608 |
| 2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
| 2020-03-15 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-12-17 | Deleted | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-12-03 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-03-27 | Added | RELATION | is a GO:0045055 (regulated exocytosis) |
| 2016-03-27 | Deleted | RELATION | is a GO:0006887 (exocytosis) |
| 2008-05-13 | Added | DEFINITION | The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
| 2008-05-12 | Deleted | DEFINITION | The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
| 2008-04-01 | Updated | RELATION | is a GO:0006887 (exocytosis) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2006-09-21 | Added | TERM | platelet degranulation |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2008-05-13 | Added | DEFINITION | The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
| 2008-05-12 | Deleted | DEFINITION | The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
| 2007-08-09 | Added | SYNONYM | platelet exocytosis |
| 2007-08-09 | Deleted | SYNONYM | platelet exocytosis |
| 2006-09-22 | Added | DEFINITION | The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet. |
| 2006-09-21 | Added | SYNONYM | platelet exocytosis |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2020-03-15 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-12-17 | Deleted | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-12-03 | Added | RELATION | is a GO:0051649 (establishment of localization in cell) |
| 2016-03-27 | Added | RELATION | is a GO:0045055 (regulated exocytosis) |
| 2016-03-27 | Deleted | RELATION | is a GO:0006887 (exocytosis) |
| 2008-04-01 | Updated | RELATION | is a GO:0006887 (exocytosis) |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-12-05 | Added | XREF | Reactome:R-HSA-114608 |
| Timestamp | Action | Category | Detail |
|---|---|---|---|
| 2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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