This term is obsolete.

GO:0003678 JSON

DNA helicase activity

Molecular Function

Definition (GO:0003678 GONUTS page)

Unwinding of a DNA helix, driven by ATP hydrolysis.

Secondary IDs

GO:0003679, GO:0004003

2,811,442 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP-dependent DNA helicase activity exact

Ancestor Chart

Ancestor chart for GO:0003678
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003678

Child Term Relationship to
GO:0003678
forked DNA-dependent helicase activity
is_a
four-way junction helicase activity
is_a
double-stranded DNA helicase activity
is_a
3'-5' DNA helicase activity
is_a
5'-3' DNA helicase activity
is_a
DNA helicase complex
capable_of
single-stranded DNA helicase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JTU1 10116 A0A0G2JTU1_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IBW5 10116 A6IBW5_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KC96 10116 A6KC96_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KFV6 10116 A6KFV6_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DFJ3 10116 B5DFJ3_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZDS8 10116 D3ZDS8_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZG52 10116 DNA2_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D3ZS47 10116 D3ZS47_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E1BB03 9913 ZRAB3_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E1BMP7 9913 DNA2_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR000085 Holliday junction branch migration complex subunit RuvA
InterPro IPR000212 DNA helicase, UvrD/REP type
InterPro IPR001161 Helicase XPB/Ssl2
InterPro IPR001177 DNA helicase E1, C-terminal, Papillomavirus
InterPro IPR001945 RAD3/XPD
InterPro IPR004609 ATP-dependent DNA helicase RecG
InterPro IPR005160 Ku70/Ku80 C-terminal arm
InterPro IPR005259 Primosomal protein N'
InterPro IPR005751 ATP-dependent DNA helicase PcrA
InterPro IPR005752 ATP-dependent DNA helicase Rep

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003678 based on ALL annotations
The top 100 of 2,051 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA helicase activity
335.42 100.00 590,770 590,770
3'-5' DNA helicase activity
239.20 36.65 253,925 356,060
single-stranded 3'-5' DNA helicase activity
221.71 36.40 264,432 400,045
forked DNA-dependent helicase activity
220.04 36.06 262,662 400,391
double-stranded DNA helicase activity
219.94 36.04 262,651 400,561
four-way junction helicase activity
189.35 33.79 269,991 478,275
helicase activity
103.04 30.02 549,183 1,787,686
recombinational repair
266.47 27.98 178,186 224,287
DNA helicase complex
335.40 14.41 85,140 85,144
primosome complex
198.60 13.05 84,678 143,016
Totals 7111805 181282871
No co-occurrence statistics for GO:0003678 based on MANUAL annotations
The top 100 of 793 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA helicase activity
1,095.06 100.00 1,289 1,289
R2TP complex
870.00 19.10 259 326
box C/D snoRNP assembly
401.73 14.92 259 706
Swr1 complex
318.04 13.34 255 878
Ino80 complex
315.53 13.29 255 885
NuA4 histone acetyltransferase complex
181.46 9.99 259 1,563
positive regulation of mitotic recombination
1,085.45 8.76 113 114
establishment of sister chromatid cohesion
1,084.63 8.06 104 105
regulation of double-strand break repair via homologous recombination
448.93 7.42 107 261
negative regulation of t-circle formation
989.77 7.24 94 104
Totals 6395 105263

Change Log

Timestamp Action Category Detail
2024-12-05 Deleted RELATION part of GO:0032508 (obsolete DNA duplex unwinding)
2022-06-26 Deleted XREF EC:3.6.4.12
2021-07-04 Added DEFINITION Unwinding of a DNA helix, driven by ATP hydrolysis.
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2021-05-15 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-02-24 Deleted RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2020-11-24 Deleted RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2020-07-19 Added XREF Reactome:R-HSA-5693589
2019-05-25 Added SECONDARY GO:0004003 (ATP-dependent DNA helicase activity)
2019-05-25 Added DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
Timestamp Action Category Detail
2003-03-19 Updated TERM DNA helicase activity
2002-02-06 Updated TERM DNA helicase
2001-04-03 Updated TERM DNA helicase
2001-03-30 Added TERM DNA helicase
Timestamp Action Category Detail
2021-07-04 Added DEFINITION Unwinding of a DNA helix, driven by ATP hydrolysis.
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2019-05-25 Added DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2019-05-25 Added SYNONYM ATP-dependent DNA helicase activity
2019-05-25 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix.
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
2008-10-02 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix.
2008-10-02 Deleted DEFINITION Catalysis of the unwinding of a DNA duplex.
2008-05-13 Added DEFINITION Catalysis of the unwinding of a DNA duplex.
2008-05-12 Deleted DEFINITION Catalysis of the unwinding of a DNA duplex.
2007-07-27 Updated DEFINITION Catalysis of the unwinding of a DNA duplex.
2007-05-27 Updated DEFINITION Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix.
2004-04-01 Updated DEFINITION Catalysis of the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied.
2003-03-26 Added DEFINITION Catalysis of the the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied.
Timestamp Action Category Detail
2024-12-05 Deleted RELATION part of GO:0032508 (obsolete DNA duplex unwinding)
2021-05-15 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-02-24 Deleted RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2020-11-24 Deleted RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2019-05-25 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2017-09-19 Added RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2012-01-29 Added RELATION part of GO:0032508 (obsolete DNA duplex unwinding)
2008-04-01 Updated RELATION is a GO:0004386 (helicase activity)
Timestamp Action Category Detail
2022-06-26 Deleted XREF EC:3.6.4.12
2020-07-19 Added XREF Reactome:R-HSA-5693589
2019-05-25 Added XREF EC:3.6.4.12
Timestamp Action Category Detail
2019-05-25 Added SECONDARY GO:0004003 (ATP-dependent DNA helicase activity)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.