This term is obsolete.

GO:0003678 JSON

DNA helicase activity

Molecular Function

Definition (GO:0003678 GONUTS page)

Unwinding of a DNA helix, driven by ATP hydrolysis.

Secondary IDs

GO:0003679, GO:0004003

2,778,591 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
ATP-dependent DNA helicase activity exact

Ancestor Chart

Ancestor chart for GO:0003678
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0003678

Child Term Relationship to
GO:0003678
single-stranded DNA helicase activity
is_a
regulation of DNA helicase activity
regulates
DNA helicase complex
capable_of
5'-3' DNA helicase activity
is_a
four-way junction helicase activity
is_a
forked DNA-dependent helicase activity
is_a
double-stranded DNA helicase activity
is_a
positive regulation of DNA helicase activity
positively_regulates
3'-5' DNA helicase activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A0G2JTU1 10116 A0A0G2JTU1_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6IBW5 10116 A6IBW5_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KC96 10116 A6KC96_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6KFV6 10116 A6KFV6_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein B5DFJ3 10116 B5DFJ3_RAT GO:0004386 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZDS8 10116 D3ZDS8_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZG52 10116 DNA2_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein D3ZS47 10116 D3ZS47_RAT GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein E1BB03 9913 ZRAB3_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024
NOT-qualified manual protein E1BMP7 9913 DNA2_BOVIN GO:0003678 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024

Cross-references

Database ID Description
InterPro IPR000085 Holliday junction branch migration complex subunit RuvA
InterPro IPR000212 DNA helicase, UvrD/REP type
InterPro IPR001161 Helicase XPB/Ssl2
InterPro IPR001177 DNA helicase E1, C-terminal, Papillomavirus
InterPro IPR001945 RAD3/XPD
InterPro IPR004609 ATP-dependent DNA helicase RecG
InterPro IPR005160 Ku70/Ku80 C-terminal arm
InterPro IPR005259 Primosomal protein N'
InterPro IPR005751 ATP-dependent DNA helicase PcrA
InterPro IPR005752 ATP-dependent DNA helicase Rep

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003678 based on ALL annotations
The top 100 of 2,060 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA helicase activity
352.01 100.00 553,794 553,794
DNA duplex unwinding
202.95 52.45 472,473 819,479
3'-5' DNA helicase activity
257.51 39.44 255,398 349,121
single-stranded 3'-5' DNA helicase activity
227.91 37.62 261,999 404,658
forked DNA-dependent helicase activity
226.25 37.28 260,408 405,142
double-stranded DNA helicase activity
226.15 37.27 260,397 405,312
four-way junction helicase activity
199.94 35.77 272,090 479,025
recombinational repair
279.61 29.20 174,903 220,192
helicase activity
102.71 28.68 522,432 1,790,484
DNA unwinding involved in DNA replication
256.99 22.62 136,694 187,230
Totals 8345275 172775654
No co-occurrence statistics for GO:0003678 based on MANUAL annotations
The top 100 of 802 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA helicase activity
1,074.71 100.00 1,202 1,202
R2TP complex
857.60 18.78 237 297
box C/D snoRNP assembly
390.65 14.66 237 652
Swr1 complex
321.03 13.32 233 780
Ino80 complex
302.06 12.96 233 829
DNA duplex unwinding
274.56 12.79 245 959
NuA4 histone acetyltransferase complex
170.26 9.63 237 1,496
positive regulation of mitotic recombination
1,064.66 8.81 106 107
establishment of sister chromatid cohesion
1,063.85 8.15 98 99
regulation of double-strand break repair via homologous recombination
440.68 7.30 98 239
Totals 6326 98922

Change Log

Timestamp Action Category Detail
2022-06-26 Deleted XREF EC:3.6.4.12
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2021-07-04 Added DEFINITION Unwinding of a DNA helix, driven by ATP hydrolysis.
2021-05-15 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-02-24 Deleted RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2020-11-24 Deleted RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2020-07-19 Added XREF Reactome:R-HSA-5693589
2019-05-25 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2019-05-25 Added SYNONYM ATP-dependent DNA helicase activity
2019-05-25 Added XREF EC:3.6.4.12
Timestamp Action Category Detail
2003-03-19 Updated TERM DNA helicase activity
2002-02-06 Updated TERM DNA helicase
2001-04-03 Updated TERM DNA helicase
2001-03-30 Added TERM DNA helicase
Timestamp Action Category Detail
2021-07-04 Deleted DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2021-07-04 Added DEFINITION Unwinding of a DNA helix, driven by ATP hydrolysis.
2019-05-25 Added SYNONYM ATP-dependent DNA helicase activity
2019-05-25 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
2019-05-25 Added DEFINITION Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix.
2010-09-03 Deleted DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix.
2010-09-03 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix.
2008-10-02 Added DEFINITION Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix.
2008-10-02 Deleted DEFINITION Catalysis of the unwinding of a DNA duplex.
2008-05-13 Added DEFINITION Catalysis of the unwinding of a DNA duplex.
2008-05-12 Deleted DEFINITION Catalysis of the unwinding of a DNA duplex.
2007-07-27 Updated DEFINITION Catalysis of the unwinding of a DNA duplex.
2007-05-27 Updated DEFINITION Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix.
2004-04-01 Updated DEFINITION Catalysis of the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied.
2003-03-26 Added DEFINITION Catalysis of the the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied.
Timestamp Action Category Detail
2021-05-15 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2021-02-24 Deleted RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2020-11-24 Deleted RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2019-05-25 Added RELATION is a GO:0008094 (ATP-dependent activity, acting on DNA)
2017-09-19 Added RELATION is a GO:0140097 (catalytic activity, acting on DNA)
2012-01-29 Added RELATION part of GO:0032508 (DNA duplex unwinding)
2008-04-01 Updated RELATION is a GO:0004386 (helicase activity)
Timestamp Action Category Detail
2022-06-26 Deleted XREF EC:3.6.4.12
2020-07-19 Added XREF Reactome:R-HSA-5693589
2019-05-25 Added XREF EC:3.6.4.12
Timestamp Action Category Detail
2019-05-25 Added SECONDARY GO:0004003 (ATP-dependent DNA helicase activity)
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