GO:0003678
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DNA helicase activity
Molecular Function
Definition (GO:0003678 GONUTS page)
Unwinding of a DNA helix, driven by ATP hydrolysis.
Secondary IDs
GO:0003679, GO:0004003
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
ATP-dependent DNA helicase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0003678
Child Term | Relationship to GO:0003678 |
---|---|
single-stranded DNA helicase activity
|
is_a |
regulation of DNA helicase activity
|
regulates |
DNA helicase complex
|
capable_of |
5'-3' DNA helicase activity
|
is_a |
four-way junction helicase activity
|
is_a |
forked DNA-dependent helicase activity
|
is_a |
double-stranded DNA helicase activity
|
is_a |
positive regulation of DNA helicase activity
|
positively_regulates |
3'-5' DNA helicase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A0G2JTU1 | 10116 | A0A0G2JTU1_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6IBW5 | 10116 | A6IBW5_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6KC96 | 10116 | A6KC96_RAT | GO:0004386 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6KFV6 | 10116 | A6KFV6_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | B5DFJ3 | 10116 | B5DFJ3_RAT | GO:0004386 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZDS8 | 10116 | D3ZDS8_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZG52 | 10116 | DNA2_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | D3ZS47 | 10116 | D3ZS47_RAT | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | E1BB03 | 9913 | ZRAB3_BOVIN | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 | |
NOT-qualified manual | protein | E1BMP7 | 9913 | DNA2_BOVIN | GO:0003678 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000250 from this reference: GO_REF:0000024 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000085 | Holliday junction branch migration complex subunit RuvA |
InterPro | IPR000212 | DNA helicase, UvrD/REP type |
InterPro | IPR001161 | Helicase XPB/Ssl2 |
InterPro | IPR001177 | DNA helicase E1, C-terminal, Papillomavirus |
InterPro | IPR001945 | RAD3/XPD |
InterPro | IPR004609 | ATP-dependent DNA helicase RecG |
InterPro | IPR005160 | Ku70/Ku80 C-terminal arm |
InterPro | IPR005259 | Primosomal protein N' |
InterPro | IPR005751 | ATP-dependent DNA helicase PcrA |
InterPro | IPR005752 | ATP-dependent DNA helicase Rep |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003678 based on ALL annotations
The top 100 of 2,060 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA helicase activity
|
352.01 | 100.00 | 553,794 | 553,794 |
DNA duplex unwinding
|
202.95 | 52.45 | 472,473 | 819,479 |
3'-5' DNA helicase activity
|
257.51 | 39.44 | 255,398 | 349,121 |
single-stranded 3'-5' DNA helicase activity
|
227.91 | 37.62 | 261,999 | 404,658 |
forked DNA-dependent helicase activity
|
226.25 | 37.28 | 260,408 | 405,142 |
double-stranded DNA helicase activity
|
226.15 | 37.27 | 260,397 | 405,312 |
four-way junction helicase activity
|
199.94 | 35.77 | 272,090 | 479,025 |
recombinational repair
|
279.61 | 29.20 | 174,903 | 220,192 |
helicase activity
|
102.71 | 28.68 | 522,432 | 1,790,484 |
DNA unwinding involved in DNA replication
|
256.99 | 22.62 | 136,694 | 187,230 |
Totals | 8345275 | 172775654 |
No co-occurrence statistics for GO:0003678 based on MANUAL annotations
The top 100 of 802 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA helicase activity
|
1,074.71 | 100.00 | 1,202 | 1,202 |
R2TP complex
|
857.60 | 18.78 | 237 | 297 |
box C/D snoRNP assembly
|
390.65 | 14.66 | 237 | 652 |
Swr1 complex
|
321.03 | 13.32 | 233 | 780 |
Ino80 complex
|
302.06 | 12.96 | 233 | 829 |
DNA duplex unwinding
|
274.56 | 12.79 | 245 | 959 |
NuA4 histone acetyltransferase complex
|
170.26 | 9.63 | 237 | 1,496 |
positive regulation of mitotic recombination
|
1,064.66 | 8.81 | 106 | 107 |
establishment of sister chromatid cohesion
|
1,063.85 | 8.15 | 98 | 99 |
regulation of double-strand break repair via homologous recombination
|
440.68 | 7.30 | 98 | 239 |
Totals | 6326 | 98922 |
Change Log
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- Definition / Synonyms
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-26 | Deleted | XREF | EC:3.6.4.12 |
2021-07-04 | Deleted | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. |
2021-07-04 | Added | DEFINITION | Unwinding of a DNA helix, driven by ATP hydrolysis. |
2021-05-15 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2021-02-24 | Deleted | RELATION | is a GO:0140097 (catalytic activity, acting on DNA) |
2020-11-24 | Deleted | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2020-07-19 | Added | XREF | Reactome:R-HSA-5693589 |
2019-05-25 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2019-05-25 | Added | SYNONYM | ATP-dependent DNA helicase activity |
2019-05-25 | Added | XREF | EC:3.6.4.12 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | DNA helicase activity |
2002-02-06 | Updated | TERM | DNA helicase |
2001-04-03 | Updated | TERM | DNA helicase |
2001-03-30 | Added | TERM | DNA helicase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-07-04 | Deleted | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. |
2021-07-04 | Added | DEFINITION | Unwinding of a DNA helix, driven by ATP hydrolysis. |
2019-05-25 | Added | SYNONYM | ATP-dependent DNA helicase activity |
2019-05-25 | Deleted | DEFINITION | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. |
2019-05-25 | Added | DEFINITION | Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix. |
2010-09-03 | Deleted | DEFINITION | Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. |
2010-09-03 | Added | DEFINITION | Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix. |
2008-10-02 | Added | DEFINITION | Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix. |
2008-10-02 | Deleted | DEFINITION | Catalysis of the unwinding of a DNA duplex. |
2008-05-13 | Added | DEFINITION | Catalysis of the unwinding of a DNA duplex. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the unwinding of a DNA duplex. |
2007-07-27 | Updated | DEFINITION | Catalysis of the unwinding of a DNA duplex. |
2007-05-27 | Updated | DEFINITION | Catalysis of the hydrolysis of an NTP or dNTP to unwind the DNA helix. |
2004-04-01 | Updated | DEFINITION | Catalysis of the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied. |
2003-03-26 | Added | DEFINITION | Catalysis of the the hydrolysis of ATP to unwind the DNA helix at the replication fork, allowing the resulting single strands to be copied. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2021-05-15 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2021-02-24 | Deleted | RELATION | is a GO:0140097 (catalytic activity, acting on DNA) |
2020-11-24 | Deleted | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2019-05-25 | Added | RELATION | is a GO:0008094 (ATP-dependent activity, acting on DNA) |
2017-09-19 | Added | RELATION | is a GO:0140097 (catalytic activity, acting on DNA) |
2012-01-29 | Added | RELATION | part of GO:0032508 (DNA duplex unwinding) |
2008-04-01 | Updated | RELATION | is a GO:0004386 (helicase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-26 | Deleted | XREF | EC:3.6.4.12 |
2020-07-19 | Added | XREF | Reactome:R-HSA-5693589 |
2019-05-25 | Added | XREF | EC:3.6.4.12 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-05-25 | Added | SECONDARY | GO:0004003 (ATP-dependent DNA helicase activity) |
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