This term is obsolete.

GO:0003743 JSON

translation initiation factor activity

Molecular Function

Definition (GO:0003743 GONUTS page)

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

Secondary IDs

GO:0003744, GO:0003745

451,165 annotations

Ancestor Chart

Ancestor chart for GO:0003743
Chart options
Ancestor chart

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0003743 translation initiation factor activity Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Cross-references

Database ID Description
InterPro IPR000178 Translation initiation factor IF-2, bacterial-like
InterPro IPR001040 Translation Initiation factor eIF- 4e
InterPro IPR001253 Translation initiation factor 1A (eIF-1A)
InterPro IPR001288 Translation initiation factor 3
InterPro IPR001950 SUI1 domain
InterPro IPR002735 Translation initiation factor IF2/IF5 domain
InterPro IPR004368 Translation initiation factor IF-1
InterPro IPR004458 Translation initiation factor 2, beta subunit
InterPro IPR004544 Translation initiation factor aIF-2, archaea
InterPro IPR005872 Archaeal/bacterial translation initiation factor SUI1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0016146 obsolete protein-synthesizing GTPase activity, initiation consider GO:0003743

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003743 based on ALL annotations
The top 100 of 3,272 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translation initiation factor activity
443.94 100.00 446,359 446,359
translational initiation
389.79 87.27 443,287 504,863
ribosome binding
110.62 15.26 126,136 506,182
eukaryotic translation initiation factor 3 complex
438.11 14.59 65,260 66,128
formation of cytoplasmic translation initiation complex
443.94 11.64 51,950 51,950
cytoplasmic translational initiation
437.67 11.32 50,590 51,314
eukaryotic 48S preinitiation complex
443.85 11.26 50,242 50,252
eukaryotic 43S preinitiation complex
443.29 10.22 45,620 45,686
ribosome disassembly
146.75 8.53 45,999 139,154
formation of translation preinitiation complex
363.19 7.74 35,164 42,982
Totals 3084175 114211389
No co-occurrence statistics for GO:0003743 based on MANUAL annotations
The top 100 of 414 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translation initiation factor activity
302.58 100.00 4,665 4,665
translational initiation
255.89 50.36 2,587 3,059
eukaryotic translation initiation factor 4F complex
294.04 17.62 826 850
eukaryotic translation initiation factor 3 complex
188.58 15.52 799 1,282
translation initiation factor binding
172.86 11.10 565 989
cytoplasmic translational initiation
243.81 11.08 531 659
eukaryotic translation initiation factor 2B complex
298.91 10.47 489 495
eukaryotic translation initiation factor 2 complex
294.06 10.32 483 497
RNA 7-methylguanosine cap binding
204.20 9.55 467 692
eukaryotic translation initiation factor 3 complex, eIF3m
301.86 8.96 418 419
Totals 19782 543163

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-04-01 Added XREF Reactome:R-HSA-72722
2019-04-01 Added XREF Reactome:R-HSA-72697
2019-04-01 Added XREF Reactome:R-HSA-72621
2019-04-01 Deleted XREF reactome:R-HSA-72722
2019-04-01 Deleted XREF reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72697
Timestamp Action Category Detail
2010-06-09 Updated TERM translation initiation factor activity
2010-06-08 Updated TERM translation initiation factor activity
2003-03-19 Updated TERM translation initiation factor activity
2002-02-06 Updated TERM translation initiation factor
2001-04-03 Updated TERM translation initiation factor
2001-03-30 Added TERM translation initiation factor
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2008-05-12 Deleted DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2007-07-11 Deleted SYNONYM protein-synthesizing GTPase activity, initiation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, initiation
2003-07-24 Updated DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2002-11-27 Updated DEFINITION Any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2001-08-06 Added DEFINITION any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
Timestamp Action Category Detail
2010-12-01 Deleted RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-15 Added RELATION part of GO:0006413 (translational initiation)
2010-06-15 Added RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-14 Deleted RELATION part of GO:0006413 (translational initiation)
2010-06-14 Deleted RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-08 Added RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-08 Added RELATION part of GO:0006413 (translational initiation)
2008-04-01 Updated RELATION is a GO:0008135 (translation factor activity, RNA binding)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-72722
2019-04-01 Added XREF Reactome:R-HSA-72697
2019-04-01 Added XREF Reactome:R-HSA-72621
2019-04-01 Deleted XREF reactome:R-HSA-72722
2019-04-01 Deleted XREF reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72697
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.