This term is obsolete.

GO:0003743 JSON

translation initiation factor activity

Molecular Function

Definition (GO:0003743 GONUTS page)

Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

Secondary IDs

GO:0003744, GO:0003745

448,365 annotations

Ancestor Chart

Ancestor chart for GO:0003743
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Binding term considerations Link

Taxon Constraints

The use of this term should conform to the following taxon constraints:

Ancestor GO ID Ancestor GO Term Name Relationship Taxon ID Taxon Reference(s)
GO:0003743 translation initiation factor activity Only in Taxon 131567 cellular organisms

More information on taxon constraints in GO is available here

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y7T8 10116 A0A8I5Y7T8_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I5YBE4 10116 A0A8I5YBE4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN4 10116 A6HXN4_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN5 10116 A6HXN5_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6HXN7 10116 A6HXN7_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6JXC6 10116 A6JXC6_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D3ZJ50 10116 D3ZJ50_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein D4A417 10116 D4A417_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P9WNV7 83332 DNAJ2_MYCTU GO:0010468 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487
NOT-qualified manual protein Q3KR54 10116 ADAD1_RAT GO:0006417 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096

Cross-references

Database ID Description
InterPro IPR000178 Translation initiation factor IF-2, bacterial-like
InterPro IPR001040 Translation Initiation factor eIF- 4e
InterPro IPR001253 Translation initiation factor 1A (eIF-1A)
InterPro IPR001288 Translation initiation factor 3
InterPro IPR001950 SUI1 domain
InterPro IPR002735 Translation initiation factor IF2/IF5 domain
InterPro IPR004368 Translation initiation factor IF-1
InterPro IPR004458 Translation initiation factor 2, beta subunit
InterPro IPR004544 Translation initiation factor aIF-2, archaea
InterPro IPR005872 Archaeal/bacterial translation initiation factor SUI1

Replaces

This term can be used instead of these obsolete terms:

GO Identifier GO Term Name Reason
GO:0016146 obsolete protein-synthesizing GTPase activity, initiation consider GO:0003743

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003743 based on ALL annotations
The top 100 of 3,262 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translation initiation factor activity
439.21 100.00 443,837 443,837
translational initiation
386.09 87.40 440,929 501,599
ribosome binding
110.18 15.22 123,874 493,807
eukaryotic translation initiation factor 3 complex
433.38 14.04 62,424 63,264
formation of cytoplasmic translation initiation complex
439.21 11.33 50,305 50,305
cytoplasmic translational initiation
433.07 11.03 49,048 49,744
eukaryotic 48S preinitiation complex
439.15 10.97 48,672 48,679
eukaryotic 43S preinitiation complex
438.56 9.97 44,239 44,305
ribosome disassembly
145.54 8.47 45,358 136,881
formation of translation preinitiation complex
361.04 7.59 34,230 41,641
Totals 3053842 112164251
No co-occurrence statistics for GO:0003743 based on MANUAL annotations
The top 100 of 418 co-occurring terms
Co-occurring Term PR S% #Together #Compared
translation initiation factor activity
301.12 100.00 4,290 4,290
translational initiation
254.14 50.32 2,380 2,820
eukaryotic translation initiation factor 4F complex
291.91 17.64 761 785
eukaryotic translation initiation factor 3 complex
187.79 15.80 749 1,201
cytoplasmic translational initiation
243.10 11.49 507 628
translation initiation factor binding
169.63 11.00 516 916
eukaryotic translation initiation factor 2B complex
297.16 10.47 450 456
eukaryotic translation initiation factor 2 complex
291.08 10.10 435 450
RNA 7-methylguanosine cap binding
203.81 9.37 421 622
eukaryotic translation initiation factor 3 complex, eIF3m
300.32 8.79 377 378
Totals 18345 507772

Change Log

Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
2019-04-01 Added XREF Reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72722
2019-04-01 Added XREF Reactome:R-HSA-72621
2019-04-01 Deleted XREF reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72621
2019-04-01 Added XREF Reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72697
Timestamp Action Category Detail
2010-06-09 Updated TERM translation initiation factor activity
2010-06-08 Updated TERM translation initiation factor activity
2003-03-19 Updated TERM translation initiation factor activity
2002-02-06 Updated TERM translation initiation factor
2001-04-03 Updated TERM translation initiation factor
2001-03-30 Added TERM translation initiation factor
Timestamp Action Category Detail
2008-05-13 Added DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2008-05-12 Deleted DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2007-07-11 Deleted SYNONYM protein-synthesizing GTPase activity, initiation
2005-08-10 Added SYNONYM protein-synthesizing GTPase activity, initiation
2003-07-24 Updated DEFINITION Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2002-11-27 Updated DEFINITION Any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
2001-08-06 Added DEFINITION any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
Timestamp Action Category Detail
2010-12-01 Deleted RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-15 Added RELATION part of GO:0006413 (translational initiation)
2010-06-15 Added RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-14 Deleted RELATION part of GO:0006413 (translational initiation)
2010-06-14 Deleted RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-08 Added RELATION part of GO:0045948 (positive regulation of translational initiation)
2010-06-08 Added RELATION part of GO:0006413 (translational initiation)
2008-04-01 Updated RELATION is a GO:0008135 (translation factor activity, RNA binding)
Timestamp Action Category Detail
2019-04-01 Added XREF Reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72722
2019-04-01 Added XREF Reactome:R-HSA-72621
2019-04-01 Deleted XREF reactome:R-HSA-72697
2019-04-01 Deleted XREF reactome:R-HSA-72621
2019-04-01 Added XREF Reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72722
2018-12-11 Added XREF reactome:R-HSA-72621
2018-12-11 Added XREF reactome:R-HSA-72697
Timestamp Action Category Detail
2024-09-05 Added CONSTRAINT in_taxon NCBITaxon:131567 (cellular organisms)
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