GO:0003743
JSON
translation initiation factor activity
Molecular Function
Definition (GO:0003743 GONUTS page)
Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.
Secondary IDs
GO:0003744, GO:0003745
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Binding term considerations | Link |
Taxon Constraints
The use of this term should conform to the following taxon constraints:
Ancestor GO ID | Ancestor GO Term Name | Relationship | Taxon ID | Taxon | Reference(s) |
---|---|---|---|---|---|
GO:0003743 | translation initiation factor activity | Only in Taxon | 131567 | cellular organisms |
More information on taxon constraints in GO is available here
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y7T8 | 10116 | A0A8I5Y7T8_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I5YBE4 | 10116 | A0A8I5YBE4_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HXN4 | 10116 | A6HXN4_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HXN5 | 10116 | A6HXN5_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6HXN7 | 10116 | A6HXN7_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6JXC6 | 10116 | A6JXC6_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D3ZJ50 | 10116 | D3ZJ50_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | D4A417 | 10116 | D4A417_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P9WNV7 | 83332 | DNAJ2_MYCTU | GO:0010468 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:15207487 | |
NOT-qualified manual | protein | Q3KR54 | 10116 | ADAD1_RAT | GO:0006417 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR000178 | Translation initiation factor IF-2, bacterial-like |
InterPro | IPR001040 | Translation Initiation factor eIF- 4e |
InterPro | IPR001253 | Translation initiation factor 1A (eIF-1A) |
InterPro | IPR001288 | Translation initiation factor 3 |
InterPro | IPR001950 | SUI1 domain |
InterPro | IPR002735 | Translation initiation factor IF2/IF5 domain |
InterPro | IPR004368 | Translation initiation factor IF-1 |
InterPro | IPR004458 | Translation initiation factor 2, beta subunit |
InterPro | IPR004544 | Translation initiation factor aIF-2, archaea |
InterPro | IPR005872 | Archaeal/bacterial translation initiation factor SUI1 |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0016146 | obsolete protein-synthesizing GTPase activity, initiation | consider GO:0003743 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003743 based on ALL annotations
The top 100 of 3,262 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
translation initiation factor activity
|
439.21 | 100.00 | 443,837 | 443,837 |
translational initiation
|
386.09 | 87.40 | 440,929 | 501,599 |
ribosome binding
|
110.18 | 15.22 | 123,874 | 493,807 |
eukaryotic translation initiation factor 3 complex
|
433.38 | 14.04 | 62,424 | 63,264 |
formation of cytoplasmic translation initiation complex
|
439.21 | 11.33 | 50,305 | 50,305 |
cytoplasmic translational initiation
|
433.07 | 11.03 | 49,048 | 49,744 |
eukaryotic 48S preinitiation complex
|
439.15 | 10.97 | 48,672 | 48,679 |
eukaryotic 43S preinitiation complex
|
438.56 | 9.97 | 44,239 | 44,305 |
ribosome disassembly
|
145.54 | 8.47 | 45,358 | 136,881 |
formation of translation preinitiation complex
|
361.04 | 7.59 | 34,230 | 41,641 |
Totals | 3053842 | 112164251 |
No co-occurrence statistics for GO:0003743 based on MANUAL annotations
The top 100 of 418 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
translation initiation factor activity
|
301.12 | 100.00 | 4,290 | 4,290 |
translational initiation
|
254.14 | 50.32 | 2,380 | 2,820 |
eukaryotic translation initiation factor 4F complex
|
291.91 | 17.64 | 761 | 785 |
eukaryotic translation initiation factor 3 complex
|
187.79 | 15.80 | 749 | 1,201 |
cytoplasmic translational initiation
|
243.10 | 11.49 | 507 | 628 |
translation initiation factor binding
|
169.63 | 11.00 | 516 | 916 |
eukaryotic translation initiation factor 2B complex
|
297.16 | 10.47 | 450 | 456 |
eukaryotic translation initiation factor 2 complex
|
291.08 | 10.10 | 435 | 450 |
RNA 7-methylguanosine cap binding
|
203.81 | 9.37 | 421 | 622 |
eukaryotic translation initiation factor 3 complex, eIF3m
|
300.32 | 8.79 | 377 | 378 |
Totals | 18345 | 507772 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
2019-04-01 | Added | XREF | Reactome:R-HSA-72697 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72722 |
2019-04-01 | Added | XREF | Reactome:R-HSA-72621 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72697 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72621 |
2019-04-01 | Added | XREF | Reactome:R-HSA-72722 |
2018-12-11 | Added | XREF | reactome:R-HSA-72722 |
2018-12-11 | Added | XREF | reactome:R-HSA-72621 |
2018-12-11 | Added | XREF | reactome:R-HSA-72697 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-06-09 | Updated | TERM | translation initiation factor activity |
2010-06-08 | Updated | TERM | translation initiation factor activity |
2003-03-19 | Updated | TERM | translation initiation factor activity |
2002-02-06 | Updated | TERM | translation initiation factor |
2001-04-03 | Updated | TERM | translation initiation factor |
2001-03-30 | Added | TERM | translation initiation factor |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-05-13 | Added | DEFINITION | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2008-05-12 | Deleted | DEFINITION | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2007-07-11 | Deleted | SYNONYM | protein-synthesizing GTPase activity, initiation |
2005-08-10 | Added | SYNONYM | protein-synthesizing GTPase activity, initiation |
2003-07-24 | Updated | DEFINITION | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2002-11-27 | Updated | DEFINITION | Any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
2001-08-06 | Added | DEFINITION | any of a group of soluble proteins functioning in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2010-12-01 | Deleted | RELATION | part of GO:0045948 (positive regulation of translational initiation) |
2010-06-15 | Added | RELATION | part of GO:0006413 (translational initiation) |
2010-06-15 | Added | RELATION | part of GO:0045948 (positive regulation of translational initiation) |
2010-06-14 | Deleted | RELATION | part of GO:0006413 (translational initiation) |
2010-06-14 | Deleted | RELATION | part of GO:0045948 (positive regulation of translational initiation) |
2010-06-08 | Added | RELATION | part of GO:0045948 (positive regulation of translational initiation) |
2010-06-08 | Added | RELATION | part of GO:0006413 (translational initiation) |
2008-04-01 | Updated | RELATION | is a GO:0008135 (translation factor activity, RNA binding) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2019-04-01 | Added | XREF | Reactome:R-HSA-72697 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72722 |
2019-04-01 | Added | XREF | Reactome:R-HSA-72621 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72697 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-72621 |
2019-04-01 | Added | XREF | Reactome:R-HSA-72722 |
2018-12-11 | Added | XREF | reactome:R-HSA-72722 |
2018-12-11 | Added | XREF | reactome:R-HSA-72621 |
2018-12-11 | Added | XREF | reactome:R-HSA-72697 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-09-05 | Added | CONSTRAINT | in_taxon NCBITaxon:131567 (cellular organisms) |
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