GO:0003883
JSON
CTP synthase activity
Molecular Function
Definition (GO:0003883 GONUTS page)
Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. PMID:12354108
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
UTP--ammonia ligase activity | related |
UTP:ammonia ligase (ADP-forming) | related |
CTP synthetase activity | related |
uridine triphosphate aminase activity | related |
cytidine triphosphate synthetase activity | related |
cytidine 5'-triphosphate synthetase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.3.4.2 | |
InterPro | IPR004468 | CTP synthase |
InterPro | IPR017456 | CTP synthase, N-terminal |
InterPro | IPR033828 | CTP synthase GATase domain |
MetaCyc | CTPSYN-RXN | |
RHEA | 26426 | |
Reactome | R-HSA-504054 | |
Reactome | R-HSA-73647 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:46398 | UTP(4-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:29985 | L-glutamate(1-) |
has_participant | CHEBI | CHEBI:37563 | CTP(4-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:456216 | ADP(3-) |
has_participant | CHEBI | CHEBI:30616 | ATP(4-) |
has_participant | CHEBI | CHEBI:58359 | L-glutamine zwitterion |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003883 based on ALL annotations
The top 100 of 338 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
CTP synthase activity
|
3,388.41 | 100.00 | 57,531 | 57,531 |
CTP biosynthetic process
|
1,764.26 | 51.88 | 57,144 | 109,750 |
'de novo' CTP biosynthetic process
|
1,858.46 | 51.79 | 51,939 | 94,697 |
pyrimidine nucleobase biosynthetic process
|
1,757.58 | 51.49 | 56,730 | 109,369 |
identical protein binding
|
430.61 | 12.69 | 56,748 | 446,538 |
pyrimidine nucleotide biosynthetic process
|
405.74 | 11.97 | 57,438 | 479,672 |
glutaminase activity
|
400.62 | 9.98 | 22,417 | 189,601 |
glutamine metabolic process
|
336.98 | 9.75 | 47,753 | 480,166 |
cytoophidium
|
3,382.20 | 9.46 | 5,446 | 5,456 |
ligase activity
|
60.64 | 1.79 | 54,839 | 3,064,099 |
Totals | 610124 | 166696479 |
No co-occurrence statistics for GO:0003883 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
CTP synthase activity
|
4,501.04 | 100.00 | 287 | 287 |
CTP biosynthetic process
|
4,334.34 | 95.97 | 286 | 297 |
pyrimidine nucleobase biosynthetic process
|
2,931.39 | 64.38 | 282 | 433 |
cytoophidium
|
4,086.47 | 23.47 | 69 | 76 |
identical protein binding
|
144.57 | 3.21 | 282 | 8,780 |
B cell proliferation
|
156.11 | 1.32 | 6 | 173 |
T cell proliferation
|
125.61 | 1.21 | 6 | 215 |
notochord development
|
53.27 | 0.44 | 2 | 169 |
phospholipid biosynthetic process
|
32.15 | 0.35 | 2 | 280 |
pyrimidine nucleotide metabolic process
|
115.41 | 0.31 | 1 | 39 |
Totals | 1356 | 697325 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | XREF | RHEA:26426 |
2022-02-17 | Deleted | XREF | RHEA:16597 |
2022-02-17 | Added | DEFINITION | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
2022-02-17 | Deleted | DEFINITION | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
2020-10-08 | Deleted | SYNONYM | UTP:ammonia ligase (ADP-forming) |
2020-10-08 | Deleted | SYNONYM | UTP--ammonia ligase activity |
2020-10-08 | Deleted | SYNONYM | CTP synthetase activity |
2020-10-08 | Added | SYNONYM | UTP:ammonia ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | uridine triphosphate aminase activity |
2020-10-08 | Deleted | SYNONYM | uridine triphosphate aminase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | CTP synthase activity |
2002-02-06 | Updated | TERM | CTP synthase |
2001-04-03 | Updated | TERM | CTP synthase |
2001-03-30 | Added | TERM | CTP synthase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | DEFINITION | Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. |
2022-02-17 | Deleted | DEFINITION | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
2020-10-08 | Deleted | SYNONYM | UTP:ammonia ligase (ADP-forming) |
2020-10-08 | Deleted | SYNONYM | UTP--ammonia ligase activity |
2020-10-08 | Deleted | SYNONYM | CTP synthetase activity |
2020-10-08 | Added | SYNONYM | UTP:ammonia ligase (ADP-forming) |
2020-10-08 | Added | SYNONYM | uridine triphosphate aminase activity |
2020-10-08 | Deleted | SYNONYM | uridine triphosphate aminase activity |
2020-10-08 | Deleted | SYNONYM | cytidine triphosphate synthetase activity |
2020-10-08 | Deleted | SYNONYM | cytidine 5'-triphosphate synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine 5'-triphosphate synthetase activity |
2020-10-08 | Added | SYNONYM | UTP--ammonia ligase activity |
2020-10-08 | Added | SYNONYM | CTP synthetase activity |
2020-10-08 | Added | SYNONYM | cytidine triphosphate synthetase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
2007-11-08 | Added | SYNONYM | UTP:ammonia ligase (ADP-forming) |
2007-11-08 | Added | SYNONYM | uridine triphosphate aminase activity |
2007-11-08 | Added | SYNONYM | cytidine triphosphate synthetase activity |
2007-11-08 | Added | SYNONYM | cytidine 5'-triphosphate synthetase activity |
2007-09-06 | Added | SYNONYM | CTP synthetase activity |
2007-09-06 | Added | SYNONYM | UTP--ammonia ligase activity |
2003-10-30 | Updated | DEFINITION | Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP. |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: ATP + UTP + ammonia = ADP + phosphate + CTP. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-02-17 | Added | XREF | RHEA:26426 |
2022-02-17 | Deleted | XREF | RHEA:16597 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-504054 |
2019-04-01 | Added | XREF | Reactome:R-HSA-73647 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-73647 |
2019-04-01 | Added | XREF | Reactome:R-HSA-504054 |
2018-12-11 | Added | XREF | reactome:R-HSA-504054 |
2018-12-11 | Added | XREF | reactome:R-HSA-73647 |
2018-07-13 | Deleted | XREF | RHEA:16600 |
2018-07-13 | Added | XREF | RHEA:16597 |
2012-09-14 | Added | XREF | RHEA:16600 |
2003-10-27 | Added | XREF | MetaCyc:CTPSYN-RXN |
2001-03-30 | Added | XREF | EC:6.3.4.2 |
Timestamp | Action | Category | Detail |
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