This term is obsolete.

GO:0003883 JSON

CTP synthase activity

Molecular Function

Definition (GO:0003883 GONUTS page)

Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate. PMID:12354108

57,839 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
UTP--ammonia ligase activity related
UTP:ammonia ligase (ADP-forming) related
CTP synthetase activity related
uridine triphosphate aminase activity related
cytidine triphosphate synthetase activity related
cytidine 5'-triphosphate synthetase activity related

Ancestor Chart

Ancestor chart for GO:0003883
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.3.4.2
InterPro IPR004468 CTP synthase
InterPro IPR017456 CTP synthase, N-terminal
InterPro IPR033828 CTP synthase GATase domain
MetaCyc CTPSYN-RXN
RHEA 26426
Reactome R-HSA-504054
Reactome R-HSA-73647

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:46398 UTP(4-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:29985 L-glutamate(1-)
has_participant CHEBI CHEBI:37563 CTP(4-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:456216 ADP(3-)
has_participant CHEBI CHEBI:30616 ATP(4-)
has_participant CHEBI CHEBI:58359 L-glutamine zwitterion

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003883 based on ALL annotations
The top 100 of 338 co-occurring terms
Co-occurring Term PR S% #Together #Compared
CTP synthase activity
3,388.41 100.00 57,531 57,531
CTP biosynthetic process
1,764.26 51.88 57,144 109,750
'de novo' CTP biosynthetic process
1,858.46 51.79 51,939 94,697
pyrimidine nucleobase biosynthetic process
1,757.58 51.49 56,730 109,369
identical protein binding
430.61 12.69 56,748 446,538
pyrimidine nucleotide biosynthetic process
405.74 11.97 57,438 479,672
glutaminase activity
400.62 9.98 22,417 189,601
glutamine metabolic process
336.98 9.75 47,753 480,166
cytoophidium
3,382.20 9.46 5,446 5,456
ligase activity
60.64 1.79 54,839 3,064,099
Totals 610124 166696479
No co-occurrence statistics for GO:0003883 based on MANUAL annotations
The top 27 of 27 co-occurring terms
Co-occurring Term PR S% #Together #Compared
CTP synthase activity
4,501.04 100.00 287 287
CTP biosynthetic process
4,334.34 95.97 286 297
pyrimidine nucleobase biosynthetic process
2,931.39 64.38 282 433
cytoophidium
4,086.47 23.47 69 76
identical protein binding
144.57 3.21 282 8,780
B cell proliferation
156.11 1.32 6 173
T cell proliferation
125.61 1.21 6 215
notochord development
53.27 0.44 2 169
phospholipid biosynthetic process
32.15 0.35 2 280
pyrimidine nucleotide metabolic process
115.41 0.31 1 39
Totals 1356 697325

Change Log

Timestamp Action Category Detail
2022-02-17 Added XREF RHEA:26426
2022-02-17 Deleted XREF RHEA:16597
2022-02-17 Added DEFINITION Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
2022-02-17 Deleted DEFINITION Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
2020-10-08 Deleted SYNONYM UTP:ammonia ligase (ADP-forming)
2020-10-08 Deleted SYNONYM UTP--ammonia ligase activity
2020-10-08 Deleted SYNONYM CTP synthetase activity
2020-10-08 Added SYNONYM UTP:ammonia ligase (ADP-forming)
2020-10-08 Added SYNONYM uridine triphosphate aminase activity
2020-10-08 Deleted SYNONYM uridine triphosphate aminase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM CTP synthase activity
2002-02-06 Updated TERM CTP synthase
2001-04-03 Updated TERM CTP synthase
2001-03-30 Added TERM CTP synthase
Timestamp Action Category Detail
2022-02-17 Added DEFINITION Catalysis of the reaction: ATP + UTP + glutamine + H20= ADP + phosphate + CTP + glutamate.
2022-02-17 Deleted DEFINITION Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
2020-10-08 Deleted SYNONYM UTP:ammonia ligase (ADP-forming)
2020-10-08 Deleted SYNONYM UTP--ammonia ligase activity
2020-10-08 Deleted SYNONYM CTP synthetase activity
2020-10-08 Added SYNONYM UTP:ammonia ligase (ADP-forming)
2020-10-08 Added SYNONYM uridine triphosphate aminase activity
2020-10-08 Deleted SYNONYM uridine triphosphate aminase activity
2020-10-08 Deleted SYNONYM cytidine triphosphate synthetase activity
2020-10-08 Deleted SYNONYM cytidine 5'-triphosphate synthetase activity
2020-10-08 Added SYNONYM cytidine 5'-triphosphate synthetase activity
2020-10-08 Added SYNONYM UTP--ammonia ligase activity
2020-10-08 Added SYNONYM CTP synthetase activity
2020-10-08 Added SYNONYM cytidine triphosphate synthetase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
2007-11-08 Added SYNONYM UTP:ammonia ligase (ADP-forming)
2007-11-08 Added SYNONYM uridine triphosphate aminase activity
2007-11-08 Added SYNONYM cytidine triphosphate synthetase activity
2007-11-08 Added SYNONYM cytidine 5'-triphosphate synthetase activity
2007-09-06 Added SYNONYM CTP synthetase activity
2007-09-06 Added SYNONYM UTP--ammonia ligase activity
2003-10-30 Updated DEFINITION Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP.
2002-11-27 Added DEFINITION Catalysis of the reaction: ATP + UTP + ammonia = ADP + phosphate + CTP.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016879 (ligase activity, forming carbon-nitrogen bonds)
Timestamp Action Category Detail
2022-02-17 Added XREF RHEA:26426
2022-02-17 Deleted XREF RHEA:16597
2019-04-01 Deleted XREF reactome:R-HSA-504054
2019-04-01 Added XREF Reactome:R-HSA-73647
2019-04-01 Deleted XREF reactome:R-HSA-73647
2019-04-01 Added XREF Reactome:R-HSA-504054
2018-12-11 Added XREF reactome:R-HSA-504054
2018-12-11 Added XREF reactome:R-HSA-73647
2018-07-13 Deleted XREF RHEA:16600
2018-07-13 Added XREF RHEA:16597
2012-09-14 Added XREF RHEA:16600
2003-10-27 Added XREF MetaCyc:CTPSYN-RXN
2001-03-30 Added XREF EC:6.3.4.2
Timestamp Action Category Detail
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