GO:0003911
JSON
DNA ligase (NAD+) activity
Molecular Function
Definition (GO:0003911 GONUTS page)
Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
polydeoxyribonucleotide synthase (NAD(+)) activity | related |
polynucleotide ligase (nicotinamide adenine dinucleotide) | related |
polynucleotide synthetase activity | related |
DNA ligase (NAD) | related |
polynucleotide ligase (NAD) | related |
polynucleotide ligase (NAD(+)) activity | related |
polydeoxyribonucleotide synthase (NAD+) activity | related |
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) | related |
deoxyribonucleic ligase | broad |
deoxyribonucleic joinase | broad |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.5.1.2 | |
InterPro | IPR001679 | NAD-dependent DNA ligase |
InterPro | IPR004149 | Zinc-finger, NAD-dependent DNA ligase C4-type |
InterPro | IPR004150 | NAD-dependent DNA ligase, OB-fold |
InterPro | IPR013839 | NAD-dependent DNA ligase, adenylation |
InterPro | IPR013840 | NAD-dependent DNA ligase, N-terminal |
InterPro | IPR020923 | DNA ligase B |
MetaCyc | DNA-LIGASE-NAD+-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003911 based on ALL annotations
The top 100 of 200 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (NAD+) activity
|
3,799.09 | 100.00 | 51,312 | 51,312 |
base-excision repair, DNA ligation
|
3,592.73 | 72.48 | 38,807 | 41,036 |
DNA metabolic process
|
285.84 | 7.42 | 43,395 | 576,758 |
DNA replication
|
117.75 | 3.09 | 48,766 | 1,573,447 |
DNA repair
|
70.57 | 1.86 | 49,833 | 2,682,566 |
ligase activity
|
62.79 | 1.65 | 50,639 | 3,064,099 |
cytosol
|
10.74 | 0.28 | 38,798 | 13,724,995 |
metal ion binding
|
6.87 | 0.18 | 43,004 | 23,771,070 |
DNA binding
|
6.79 | 0.18 | 27,610 | 15,456,294 |
dioxygenase activity
|
3.68 | 0.09 | 669 | 689,815 |
Totals | 393828 | 114687401 |
No co-occurrence statistics for GO:0003911 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (NAD+) activity
|
35,883.31 | 100.00 | 36 | 36 |
base-excision repair, DNA ligation
|
19,321.78 | 53.03 | 35 | 65 |
DNA ligation
|
598.06 | 1.41 | 3 | 180 |
DNA ligation involved in DNA repair
|
394.32 | 0.79 | 1 | 91 |
peptidoglycan-based cell wall
|
45.36 | 0.12 | 1 | 791 |
NAD+ binding
|
44.30 | 0.12 | 1 | 810 |
cytosol
|
14.91 | 0.04 | 35 | 84,217 |
magnesium ion binding
|
12.24 | 0.03 | 1 | 2,931 |
DNA binding
|
2.96 | 0.01 | 1 | 12,130 |
protein binding
|
0.86 | 0.00 | 1 | 41,817 |
Totals | 116 | 274996 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2022-09-01 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD+) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Deleted | SYNONYM | DNA ligase (NAD) |
2020-10-08 | Deleted | SYNONYM | polynucleotide synthetase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | DNA ligase (NAD+) activity |
2003-09-06 | Updated | TERM | DNA ligase (NAD) activity |
2003-03-19 | Updated | TERM | DNA ligase (NAD+) activity |
2002-02-06 | Updated | TERM | DNA ligase (NAD+) |
2001-04-03 | Updated | TERM | DNA ligase (NAD+) |
2001-03-30 | Added | TERM | DNA ligase (NAD+) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2022-09-01 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD+) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Deleted | SYNONYM | DNA ligase (NAD) |
2020-10-08 | Deleted | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD+) activity |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2020-10-08 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2020-10-08 | Deleted | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2020-10-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2020-10-08 | Added | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2020-10-08 | Added | SYNONYM | DNA ligase (NAD) |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
2007-11-08 | Added | SYNONYM | deoxyribonucleic repair enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic-joining enzyme |
2007-11-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2007-11-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2007-11-08 | Added | SYNONYM | polynucleotide ligase |
2007-11-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2007-11-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2007-11-08 | Added | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2007-11-08 | Added | SYNONYM | polynucleotide synthetase activity |
2007-11-08 | Added | SYNONYM | DNA ligase (NAD) |
2007-11-08 | Added | SYNONYM | DNA-joining enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleate ligase |
2007-09-06 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2007-09-06 | Added | SYNONYM | DNA joinase activity |
2007-09-06 | Added | SYNONYM | DNA repair enzyme activity |
2007-09-06 | Added | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2007-09-06 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2007-09-06 | Added | SYNONYM | polynucleotide ligase (NAD+) activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0003909 (DNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-05-21 | Added | XREF | MetaCyc:DNA-LIGASE-NAD+-RXN |
2009-05-21 | Deleted | XREF | MetaCyc:DNA-LIGASE-(NAD(+))-RXN |
2003-10-27 | Added | XREF | MetaCyc:DNA-LIGASE-(NAD(+))-RXN |
2001-03-30 | Added | XREF | EC:6.5.1.2 |
Timestamp | Action | Category | Detail |
---|
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