This term is obsolete.

GO:0003911 JSON

DNA ligase (NAD+) activity

Molecular Function

Definition (GO:0003911 GONUTS page)

Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).

51,353 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
polydeoxyribonucleotide synthase (NAD(+)) activity related
polynucleotide ligase (nicotinamide adenine dinucleotide) related
polynucleotide synthetase activity related
DNA ligase (NAD) related
polynucleotide ligase (NAD) related
polynucleotide ligase (NAD(+)) activity related
polydeoxyribonucleotide synthase (NAD+) activity related
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) related
deoxyribonucleic ligase broad
deoxyribonucleic joinase broad

Ancestor Chart

Ancestor chart for GO:0003911
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.5.1.2
InterPro IPR001679 NAD-dependent DNA ligase
InterPro IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type
InterPro IPR004150 NAD-dependent DNA ligase, OB-fold
InterPro IPR013839 NAD-dependent DNA ligase, adenylation
InterPro IPR013840 NAD-dependent DNA ligase, N-terminal
InterPro IPR020923 DNA ligase B
MetaCyc DNA-LIGASE-NAD+-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003911 based on ALL annotations
The top 100 of 200 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (NAD+) activity
3,799.09 100.00 51,312 51,312
base-excision repair, DNA ligation
3,592.73 72.48 38,807 41,036
DNA metabolic process
285.84 7.42 43,395 576,758
DNA replication
117.75 3.09 48,766 1,573,447
DNA repair
70.57 1.86 49,833 2,682,566
ligase activity
62.79 1.65 50,639 3,064,099
cytosol
10.74 0.28 38,798 13,724,995
metal ion binding
6.87 0.18 43,004 23,771,070
DNA binding
6.79 0.18 27,610 15,456,294
dioxygenase activity
3.68 0.09 669 689,815
Totals 393828 114687401
No co-occurrence statistics for GO:0003911 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (NAD+) activity
35,883.31 100.00 36 36
base-excision repair, DNA ligation
19,321.78 53.03 35 65
DNA ligation
598.06 1.41 3 180
DNA ligation involved in DNA repair
394.32 0.79 1 91
peptidoglycan-based cell wall
45.36 0.12 1 791
NAD+ binding
44.30 0.12 1 810
cytosol
14.91 0.04 35 84,217
magnesium ion binding
12.24 0.03 1 2,931
DNA binding
2.96 0.01 1 12,130
protein binding
0.86 0.00 1 41,817
Totals 116 274996

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2022-09-01 Added SYNONYM polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD+) activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD)
2020-10-08 Deleted SYNONYM DNA ligase (NAD)
2020-10-08 Deleted SYNONYM polynucleotide synthetase activity
Timestamp Action Category Detail
2004-01-07 Updated TERM DNA ligase (NAD+) activity
2003-09-06 Updated TERM DNA ligase (NAD) activity
2003-03-19 Updated TERM DNA ligase (NAD+) activity
2002-02-06 Updated TERM DNA ligase (NAD+)
2001-04-03 Updated TERM DNA ligase (NAD+)
2001-03-30 Added TERM DNA ligase (NAD+)
Timestamp Action Category Detail
2022-09-01 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2022-09-01 Added SYNONYM polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD+) activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD)
2020-10-08 Deleted SYNONYM DNA ligase (NAD)
2020-10-08 Deleted SYNONYM polynucleotide synthetase activity
2020-10-08 Deleted SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD+) activity
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2020-10-08 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (NAD)
2020-10-08 Deleted SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2020-10-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2020-10-08 Added SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2020-10-08 Added SYNONYM DNA ligase (NAD)
2008-05-13 Added DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
2007-11-08 Added SYNONYM deoxyribonucleic repair enzyme
2007-11-08 Added SYNONYM deoxyribonucleic joinase
2007-11-08 Added SYNONYM deoxyribonucleic-joining enzyme
2007-11-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2007-11-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD)
2007-11-08 Added SYNONYM polynucleotide ligase
2007-11-08 Added SYNONYM polynucleotide ligase (NAD)
2007-11-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2007-11-08 Added SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2007-11-08 Added SYNONYM polynucleotide synthetase activity
2007-11-08 Added SYNONYM DNA ligase (NAD)
2007-11-08 Added SYNONYM DNA-joining enzyme
2007-11-08 Added SYNONYM deoxyribonucleic ligase
2007-11-08 Added SYNONYM deoxyribonucleic acid ligase
2007-11-08 Added SYNONYM deoxyribonucleic acid joinase
2007-11-08 Added SYNONYM deoxyribonucleate ligase
2007-09-06 Added SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2007-09-06 Added SYNONYM DNA joinase activity
2007-09-06 Added SYNONYM DNA repair enzyme activity
2007-09-06 Added SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2007-09-06 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2007-09-06 Added SYNONYM polynucleotide ligase (NAD+) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003909 (DNA ligase activity)
Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:DNA-LIGASE-NAD+-RXN
2009-05-21 Deleted XREF MetaCyc:DNA-LIGASE-(NAD(+))-RXN
2003-10-27 Added XREF MetaCyc:DNA-LIGASE-(NAD(+))-RXN
2001-03-30 Added XREF EC:6.5.1.2
Timestamp Action Category Detail
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