This term is obsolete.

GO:0003911 JSON

DNA ligase (NAD+) activity

Molecular Function

Definition (GO:0003911 GONUTS page)

Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).

52,194 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
deoxyribonucleic acid joinase broad
deoxyribonucleic acid ligase broad
deoxyribonucleic joinase broad
deoxyribonucleic ligase broad
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) related
polynucleotide ligase (NAD(+)) activity related
polynucleotide ligase (NAD) related
DNA ligase (NAD) related
polynucleotide synthetase activity related
polynucleotide ligase (nicotinamide adenine dinucleotide) related

Ancestor Chart

Ancestor chart for GO:0003911
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
NOT-qualified manual protein A0A8I5Y5Z6 10116 A0A8I5Y5Z6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A0A8I6A2T0 10116 A0A8I6A2T0_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein A6I4N6 10116 A6I4N6_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein F7EEB9 10116 F7EEB9_RAT GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q13426 9606 XRCC4_HUMAN GO:0016874 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410
NOT-qualified manual protein Q7KGG1 7227 Q7KGG1_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370
NOT-qualified manual protein Q7SIE0 9103 ARLY1_MELGA GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884
NOT-qualified manual protein Q8MZ84 7227 Q8MZ84_DROME GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370

Cross-references

Database ID Description
EC 6.5.1.2
InterPro IPR001679 NAD-dependent DNA ligase
InterPro IPR004149 Zinc-finger, NAD-dependent DNA ligase C4-type
InterPro IPR004150 NAD-dependent DNA ligase, OB-fold
InterPro IPR013839 NAD-dependent DNA ligase, adenylation
InterPro IPR013840 NAD-dependent DNA ligase, N-terminal
InterPro IPR020923 DNA ligase B
MetaCyc DNA-LIGASE-NAD+-RXN

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003911 based on ALL annotations
The top 100 of 199 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (NAD+) activity
3,799.71 100.00 52,150 52,150
DNA metabolic process
316.83 8.21 43,648 523,465
DNA replication
116.50 3.06 49,606 1,617,907
DNA repair
70.55 1.86 50,666 2,728,712
ligase activity
63.72 1.68 51,471 3,069,286
cytosol
10.68 0.28 39,313 13,989,509
metal ion binding
7.63 0.20 43,705 21,769,638
DNA binding
6.81 0.18 27,946 15,603,631
dioxygenase activity
3.71 0.09 673 689,371
double-strand break repair via nonhomologous end joining
4.17 0.07 85 77,511
Totals 360207 114429192
No co-occurrence statistics for GO:0003911 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term PR S% #Together #Compared
DNA ligase (NAD+) activity
24,336.78 100.00 58 58
DNA ligase activity
1,431.58 1.35 1 17
kinetoplast
235.52 0.82 3 310
DNA ligase (ATP) activity
76.05 0.27 1 320
peptidoglycan-based cell wall
29.97 0.12 1 812
NAD+ binding
24.12 0.09 1 1,009
cytosol
9.51 0.04 35 89,580
magnesium ion binding
8.00 0.03 1 3,041
DNA replication
6.93 0.03 1 3,513
DNA repair
4.32 0.02 1 5,640
Totals 111 550526

Change Log

Timestamp Action Category Detail
2022-09-01 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2022-09-01 Added SYNONYM polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2020-10-08 Added SYNONYM DNA ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
Timestamp Action Category Detail
2004-01-07 Updated TERM DNA ligase (NAD+) activity
2003-09-06 Updated TERM DNA ligase (NAD) activity
2003-03-19 Updated TERM DNA ligase (NAD+) activity
2002-02-06 Updated TERM DNA ligase (NAD+)
2001-04-03 Updated TERM DNA ligase (NAD+)
2001-03-30 Added TERM DNA ligase (NAD+)
Timestamp Action Category Detail
2022-09-01 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2022-09-01 Added SYNONYM polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2020-10-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2020-10-08 Added SYNONYM DNA ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide synthetase activity
2020-10-08 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD)
2020-10-08 Deleted SYNONYM DNA ligase (NAD)
2020-10-08 Added SYNONYM polynucleotide ligase (NAD+) activity
2020-10-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2020-10-08 Added SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD+) activity
2020-10-08 Deleted SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2020-10-08 Deleted SYNONYM polynucleotide synthetase activity
2020-10-08 Deleted SYNONYM polynucleotide ligase (NAD(+)) activity
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2020-10-08 Deleted SYNONYM polydeoxyribonucleotide synthase (NAD)
2020-10-08 Deleted SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2020-10-08 Deleted SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2008-05-13 Added DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
2008-05-12 Deleted DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
2007-11-08 Added SYNONYM polynucleotide synthetase activity
2007-11-08 Added SYNONYM polynucleotide ligase (nicotinamide adenine dinucleotide)
2007-11-08 Added SYNONYM polynucleotide ligase (NAD)
2007-11-08 Added SYNONYM polynucleotide ligase
2007-11-08 Added SYNONYM polydeoxyribonucleotide synthase (NAD)
2007-11-08 Added SYNONYM poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)
2007-11-08 Added SYNONYM deoxyribonucleic-joining enzyme
2007-11-08 Added SYNONYM deoxyribonucleic repair enzyme
2007-11-08 Added SYNONYM deoxyribonucleic ligase
2007-11-08 Added SYNONYM deoxyribonucleic joinase
2007-11-08 Added SYNONYM deoxyribonucleic acid ligase
2007-11-08 Added SYNONYM deoxyribonucleic acid joinase
2007-11-08 Added SYNONYM deoxyribonucleate ligase
2007-11-08 Added SYNONYM DNA-joining enzyme
2007-11-08 Added SYNONYM DNA ligase (NAD)
2007-11-08 Added SYNONYM polynucleotide synthetase (nicotinamide adenine dinucleotide)
2007-09-06 Added SYNONYM DNA joinase activity
2007-09-06 Added SYNONYM polynucleotide ligase (NAD+) activity
2007-09-06 Added SYNONYM DNA repair enzyme activity
2007-09-06 Added SYNONYM Polydeoxyribonucleotide synthase (NAD(+)) activity
2007-09-06 Added SYNONYM polydeoxyribonucleotide synthase (NAD+) activity
2007-09-06 Added SYNONYM polynucleotide ligase (NAD(+)) activity
2002-11-27 Added DEFINITION Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0003909 (DNA ligase activity)
Timestamp Action Category Detail
2009-05-21 Added XREF MetaCyc:DNA-LIGASE-NAD+-RXN
2009-05-21 Deleted XREF MetaCyc:DNA-LIGASE-(NAD(+))-RXN
2003-10-27 Added XREF MetaCyc:DNA-LIGASE-(NAD(+))-RXN
2001-03-30 Added XREF EC:6.5.1.2
Timestamp Action Category Detail
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