GO:0003911
JSON
DNA ligase (NAD+) activity
Molecular Function
Definition (GO:0003911 GONUTS page)
Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
deoxyribonucleic acid joinase | broad |
deoxyribonucleic acid ligase | broad |
deoxyribonucleic joinase | broad |
deoxyribonucleic ligase | broad |
poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) | related |
polynucleotide ligase (NAD(+)) activity | related |
polynucleotide ligase (NAD) | related |
DNA ligase (NAD) | related |
polynucleotide synthetase activity | related |
polynucleotide ligase (nicotinamide adenine dinucleotide) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
NOT-qualified manual | protein | A0A8I5Y5Z6 | 10116 | A0A8I5Y5Z6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A0A8I6A2T0 | 10116 | A0A8I6A2T0_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | A6I4N6 | 10116 | A6I4N6_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | F7EEB9 | 10116 | F7EEB9_RAT | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000266 from this reference: GO_REF:0000096 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q13426 | 9606 | XRCC4_HUMAN | GO:0016874 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:9242410 | |
NOT-qualified manual | protein | Q7KGG1 | 7227 | Q7KGG1_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 | |
NOT-qualified manual | protein | Q7SIE0 | 9103 | ARLY1_MELGA | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 | |
NOT-qualified manual | protein | Q8MZ84 | 7227 | Q8MZ84_DROME | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000320 from this reference: PMID:11904370 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 6.5.1.2 | |
InterPro | IPR001679 | NAD-dependent DNA ligase |
InterPro | IPR004149 | Zinc-finger, NAD-dependent DNA ligase C4-type |
InterPro | IPR004150 | NAD-dependent DNA ligase, OB-fold |
InterPro | IPR013839 | NAD-dependent DNA ligase, adenylation |
InterPro | IPR013840 | NAD-dependent DNA ligase, N-terminal |
InterPro | IPR020923 | DNA ligase B |
MetaCyc | DNA-LIGASE-NAD+-RXN |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003911 based on ALL annotations
The top 100 of 199 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (NAD+) activity
|
3,799.71 | 100.00 | 52,150 | 52,150 |
DNA metabolic process
|
316.83 | 8.21 | 43,648 | 523,465 |
DNA replication
|
116.50 | 3.06 | 49,606 | 1,617,907 |
DNA repair
|
70.55 | 1.86 | 50,666 | 2,728,712 |
ligase activity
|
63.72 | 1.68 | 51,471 | 3,069,286 |
cytosol
|
10.68 | 0.28 | 39,313 | 13,989,509 |
metal ion binding
|
7.63 | 0.20 | 43,705 | 21,769,638 |
DNA binding
|
6.81 | 0.18 | 27,946 | 15,603,631 |
dioxygenase activity
|
3.71 | 0.09 | 673 | 689,371 |
double-strand break repair via nonhomologous end joining
|
4.17 | 0.07 | 85 | 77,511 |
Totals | 360207 | 114429192 |
No co-occurrence statistics for GO:0003911 based on MANUAL annotations
The top 15 of 15 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
DNA ligase (NAD+) activity
|
24,336.78 | 100.00 | 58 | 58 |
DNA ligase activity
|
1,431.58 | 1.35 | 1 | 17 |
kinetoplast
|
235.52 | 0.82 | 3 | 310 |
DNA ligase (ATP) activity
|
76.05 | 0.27 | 1 | 320 |
peptidoglycan-based cell wall
|
29.97 | 0.12 | 1 | 812 |
NAD+ binding
|
24.12 | 0.09 | 1 | 1,009 |
cytosol
|
9.51 | 0.04 | 35 | 89,580 |
magnesium ion binding
|
8.00 | 0.03 | 1 | 3,041 |
DNA replication
|
6.93 | 0.03 | 1 | 3,513 |
DNA repair
|
4.32 | 0.02 | 1 | 5,640 |
Totals | 111 | 550526 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
- Relationships
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2022-09-01 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2020-10-08 | Added | SYNONYM | DNA ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2004-01-07 | Updated | TERM | DNA ligase (NAD+) activity |
2003-09-06 | Updated | TERM | DNA ligase (NAD) activity |
2003-03-19 | Updated | TERM | DNA ligase (NAD+) activity |
2002-02-06 | Updated | TERM | DNA ligase (NAD+) |
2001-04-03 | Updated | TERM | DNA ligase (NAD+) |
2001-03-30 | Added | TERM | DNA ligase (NAD+) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-09-01 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2022-09-01 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2020-10-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2020-10-08 | Added | SYNONYM | DNA ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD) |
2020-10-08 | Deleted | SYNONYM | DNA ligase (NAD) |
2020-10-08 | Added | SYNONYM | polynucleotide ligase (NAD+) activity |
2020-10-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2020-10-08 | Added | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD+) activity |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2020-10-08 | Deleted | SYNONYM | polynucleotide synthetase activity |
2020-10-08 | Deleted | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2020-10-08 | Deleted | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2020-10-08 | Deleted | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2020-10-08 | Deleted | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
2007-11-08 | Added | SYNONYM | polynucleotide synthetase activity |
2007-11-08 | Added | SYNONYM | polynucleotide ligase (nicotinamide adenine dinucleotide) |
2007-11-08 | Added | SYNONYM | polynucleotide ligase (NAD) |
2007-11-08 | Added | SYNONYM | polynucleotide ligase |
2007-11-08 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD) |
2007-11-08 | Added | SYNONYM | poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming) |
2007-11-08 | Added | SYNONYM | deoxyribonucleic-joining enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic repair enzyme |
2007-11-08 | Added | SYNONYM | deoxyribonucleic ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid ligase |
2007-11-08 | Added | SYNONYM | deoxyribonucleic acid joinase |
2007-11-08 | Added | SYNONYM | deoxyribonucleate ligase |
2007-11-08 | Added | SYNONYM | DNA-joining enzyme |
2007-11-08 | Added | SYNONYM | DNA ligase (NAD) |
2007-11-08 | Added | SYNONYM | polynucleotide synthetase (nicotinamide adenine dinucleotide) |
2007-09-06 | Added | SYNONYM | DNA joinase activity |
2007-09-06 | Added | SYNONYM | polynucleotide ligase (NAD+) activity |
2007-09-06 | Added | SYNONYM | DNA repair enzyme activity |
2007-09-06 | Added | SYNONYM | Polydeoxyribonucleotide synthase (NAD(+)) activity |
2007-09-06 | Added | SYNONYM | polydeoxyribonucleotide synthase (NAD+) activity |
2007-09-06 | Added | SYNONYM | polynucleotide ligase (NAD(+)) activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m). |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0003909 (DNA ligase activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-05-21 | Added | XREF | MetaCyc:DNA-LIGASE-NAD+-RXN |
2009-05-21 | Deleted | XREF | MetaCyc:DNA-LIGASE-(NAD(+))-RXN |
2003-10-27 | Added | XREF | MetaCyc:DNA-LIGASE-(NAD(+))-RXN |
2001-03-30 | Added | XREF | EC:6.5.1.2 |
Timestamp | Action | Category | Detail |
---|
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