This term is obsolete.

GO:0003938 JSON

IMP dehydrogenase activity

Molecular Function

Definition (GO:0003938 GONUTS page)

Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.

61,921 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
inosine monophosphate dehydrogenase activity related
inosine-5'-phosphate dehydrogenase activity related
inosinate dehydrogenase activity related
inosine 5'-monophosphate dehydrogenase activity related
inosine monophosphate oxidoreductase activity related
IMP:NAD+ oxidoreductase activity related
IMP oxidoreductase activity related
inosinic acid dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0003938
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.205
InterPro IPR005990 Inosine-5'-monophosphate dehydrogenase
MetaCyc IMP-DEHYDROG-RXN
RHEA 11708
Reactome R-HSA-73794
Reactome R-HSA-9748945

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:57464 5'-xanthylate(2-)
has_participant CHEBI CHEBI:57945 NADH(2-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:58053 IMP(2-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003938 based on ALL annotations
The top 100 of 258 co-occurring terms
Co-occurring Term PR S% #Together #Compared
IMP dehydrogenase activity
3,158.90 100.00 61,711 61,711
GTP biosynthetic process
1,622.09 48.57 55,520 108,121
GMP biosynthetic process
1,364.62 36.64 43,640 101,020
purine nucleotide biosynthetic process
253.15 7.99 59,894 747,372
GMP reductase activity
1,003.79 5.54 3,878 12,204
IMP salvage
198.24 3.20 3,773 60,121
nucleotide binding
64.31 2.01 37,497 1,841,736
purine ribonucleoside salvage
80.21 1.86 3,983 156,866
oxidoreductase activity
12.98 0.41 48,937 11,906,003
metal ion binding
5.80 0.18 43,670 23,771,070
Totals 381121 111420320
No co-occurrence statistics for GO:0003938 based on MANUAL annotations
The top 54 of 54 co-occurring terms
Co-occurring Term PR S% #Together #Compared
IMP dehydrogenase activity
6,871.27 100.00 188 188
GTP biosynthetic process
6,327.01 91.18 186 202
'de novo' XMP biosynthetic process
916.17 1.87 4 30
lymphocyte proliferation
549.70 1.71 4 50
nucleotide binding
240.25 1.53 5 143
GMP biosynthetic process
179.25 1.46 6 230
GMP reductase activity
1,145.21 1.01 2 12
cellular response to interleukin-4
176.19 0.76 2 78
glycosome
89.24 0.72 3 231
ficolin-1-rich granule lumen
110.83 0.65 2 124
Totals 637 883681

Change Log

Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9748945
2020-10-08 Added SYNONYM IMP oxidoreductase activity
2020-10-08 Added SYNONYM inosine-5'-phosphate dehydrogenase activity
2020-10-08 Added SYNONYM inosine monophosphate dehydrogenase activity
2020-10-08 Added SYNONYM IMP:NAD+ oxidoreductase activity
2020-10-08 Deleted SYNONYM IMP oxidoreductase activity
2020-10-08 Added SYNONYM inosine 5'-monophosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM inosine monophosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM IMP:NAD+ oxidoreductase activity
2020-10-08 Deleted SYNONYM inosine monophosphate oxidoreductase activity
Timestamp Action Category Detail
2003-03-19 Updated TERM IMP dehydrogenase activity
2002-02-06 Updated TERM IMP dehydrogenase
2001-04-03 Updated TERM IMP dehydrogenase
2001-03-30 Added TERM IMP dehydrogenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM IMP oxidoreductase activity
2020-10-08 Added SYNONYM inosine-5'-phosphate dehydrogenase activity
2020-10-08 Added SYNONYM inosine monophosphate dehydrogenase activity
2020-10-08 Added SYNONYM IMP:NAD+ oxidoreductase activity
2020-10-08 Deleted SYNONYM IMP oxidoreductase activity
2020-10-08 Added SYNONYM inosine 5'-monophosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM inosine monophosphate dehydrogenase activity
2020-10-08 Deleted SYNONYM IMP:NAD+ oxidoreductase activity
2020-10-08 Deleted SYNONYM inosine monophosphate oxidoreductase activity
2020-10-08 Deleted SYNONYM inosine 5'-monophosphate dehydrogenase activity
2020-10-08 Added SYNONYM inosine monophosphate oxidoreductase activity
2020-10-08 Deleted SYNONYM inosine-5'-phosphate dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
2007-11-08 Added SYNONYM inosine-5'-phosphate dehydrogenase activity
2007-11-08 Added SYNONYM inosine monophosphate dehydrogenase activity
2007-11-08 Added SYNONYM IMP:NAD+ oxidoreductase activity
2007-09-06 Added SYNONYM IMP oxidoreductase activity
2007-09-06 Added SYNONYM inosine 5'-monophosphate dehydrogenase activity
2007-09-06 Added SYNONYM inosinate dehydrogenase activity
2007-09-06 Added SYNONYM inosinic acid dehydrogenase activity
2007-09-06 Added SYNONYM inosine monophosphate oxidoreductase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2023-04-02 Added XREF Reactome:R-HSA-9748945
2019-04-01 Added XREF Reactome:R-HSA-73794
2019-04-01 Deleted XREF reactome:R-HSA-73794
2018-12-11 Added XREF reactome:R-HSA-73794
2018-07-13 Added XREF RHEA:11708
2018-07-13 Deleted XREF RHEA:11711
2011-09-16 Added XREF RHEA:11711
2003-10-27 Added XREF MetaCyc:IMP-DEHYDROG-RXN
2001-03-30 Added XREF EC:1.1.1.205
Timestamp Action Category Detail
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