GO:0003942
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N-acetyl-gamma-glutamyl-phosphate reductase activity
Molecular Function
Definition (GO:0003942 GONUTS page)
Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
N-acetyl-glutamate semialdehyde dehydrogenase activity | related |
reductase, acetyl-gamma-glutamyl phosphate | related |
NAGSA dehydrogenase activity | broad |
N-acetylglutamate 5-semialdehyde dehydrogenase activity | related |
N-acetylglutamic gamma-semialdehyde dehydrogenase activity | related |
N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) | related |
N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.2.1.38 | |
InterPro | IPR000706 | N-acetyl-gamma-glutamyl-phosphate reductase, type 1 |
InterPro | IPR010136 | N-acetyl-gamma-glutamyl-phosphate reductase, type 2 |
InterPro | IPR011241 | Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase |
InterPro | IPR023013 | N-acetyl-gamma-glutamyl-phosphate reductase, active site |
MetaCyc | N-ACETYLGLUTPREDUCT-RXN | |
RHEA | 21588 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:43474 | hydrogenphosphate |
has_participant | CHEBI | CHEBI:57936 | N-acetyl-L-gamma-glutamyl phosphate(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:29123 | 2-acetamido-5-oxopentanoate |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003942 based on ALL annotations
The top 100 of 162 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acetyl-gamma-glutamyl-phosphate reductase activity
|
4,791.42 | 100.00 | 40,685 | 40,685 |
NADP+ binding
|
2,258.27 | 42.49 | 33,036 | 70,093 |
L-arginine biosynthetic process
|
476.42 | 9.93 | 40,240 | 404,701 |
NAD binding
|
163.70 | 3.41 | 39,696 | 1,161,857 |
acetylglutamate kinase activity
|
220.33 | 2.33 | 1,839 | 39,991 |
N-acetyl-gamma-aminoadipyl-phosphate reductase activity
|
4,791.42 | 2.00 | 812 | 812 |
lysine biosynthetic process via aminoadipic acid
|
132.41 | 1.56 | 1,408 | 50,951 |
alpha-amino acid metabolic process
|
82.66 | 1.24 | 1,710 | 99,126 |
mitochondrial matrix
|
37.80 | 0.67 | 1,752 | 222,050 |
arginine biosynthetic process via ornithine
|
34.89 | 0.56 | 984 | 135,128 |
Totals | 250284 | 114187421 |
No co-occurrence statistics for GO:0003942 based on MANUAL annotations
The top 11 of 11 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
N-acetyl-gamma-glutamyl-phosphate reductase activity
|
75,988.18 | 100.00 | 17 | 17 |
acetylglutamate kinase activity
|
10,759.39 | 14.04 | 16 | 113 |
positive regulation of siderophore biosynthetic process
|
37,994.09 | 5.56 | 1 | 2 |
L-arginine biosynthetic process
|
2,748.51 | 3.62 | 17 | 470 |
ornithine biosynthetic process
|
431.75 | 0.52 | 1 | 176 |
mitochondrial matrix
|
309.92 | 0.41 | 16 | 3,923 |
arginine biosynthetic process via ornithine
|
250.79 | 0.31 | 1 | 303 |
carbohydrate transport
|
35.59 | 0.05 | 1 | 2,135 |
regulation of DNA-templated transcription
|
3.51 | 0.00 | 1 | 21,640 |
mitochondrion
|
3.32 | 0.00 | 2 | 45,791 |
Totals | 74 | 137309 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | N-acetyl-glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | N-acetylglutamate 5-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | N-acetylglutamic gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | reductase, acetyl-gamma-glutamyl phosphate |
2020-10-08 | Deleted | SYNONYM | N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | N-acetylglutamic gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | N-acetylglutamate 5-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | N-acetyl-gamma-glutamyl-phosphate reductase activity |
2002-02-06 | Updated | TERM | N-acetyl-gamma-glutamyl-phosphate reductase |
2001-04-03 | Updated | TERM | N-acetyl-gamma-glutamyl-phosphate reductase |
2001-03-30 | Added | TERM | N-acetyl-gamma-glutamyl-phosphate reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Deleted | SYNONYM | N-acetyl-glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | N-acetylglutamate 5-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | N-acetylglutamic gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | reductase, acetyl-gamma-glutamyl phosphate |
2020-10-08 | Deleted | SYNONYM | N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) |
2020-10-08 | Deleted | SYNONYM | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | N-acetylglutamic gamma-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | N-acetylglutamate 5-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) |
2020-10-08 | Added | SYNONYM | N-acetyl-glutamate semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | reductase, acetyl-gamma-glutamyl phosphate |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. |
2007-11-08 | Added | SYNONYM | NAGSA dehydrogenase activity |
2007-11-08 | Added | SYNONYM | N-acetylglutamic gamma-semialdehyde dehydrogenase activity |
2007-11-08 | Added | SYNONYM | N-acetylglutamate 5-semialdehyde dehydrogenase activity |
2007-11-08 | Added | SYNONYM | N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) |
2007-11-08 | Added | SYNONYM | N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) |
2007-11-08 | Added | SYNONYM | reductase, acetyl-gamma-glutamyl phosphate |
2007-11-08 | Deleted | SYNONYM | NAGSA dehydrogenase activity |
2007-09-06 | Added | SYNONYM | N-acetyl-glutamate semialdehyde dehydrogenase activity |
2007-09-06 | Added | SYNONYM | NAGSA dehydrogenase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2018-07-13 | Added | XREF | RHEA:21588 |
2018-07-13 | Deleted | XREF | RHEA:21591 |
2011-09-16 | Added | XREF | RHEA:21591 |
2003-10-27 | Added | XREF | MetaCyc:N-ACETYLGLUTPREDUCT-RXN |
2001-03-30 | Added | XREF | EC:1.2.1.38 |
Timestamp | Action | Category | Detail |
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