This term is obsolete.

GO:0003942 JSON

N-acetyl-gamma-glutamyl-phosphate reductase activity

Molecular Function

Definition (GO:0003942 GONUTS page)

Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.

41,366 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating) related
N-acetylglutamate 5-semialdehyde dehydrogenase activity related
N-acetylglutamic gamma-semialdehyde dehydrogenase activity related
reductase, acetyl-gamma-glutamyl phosphate related
N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating) related
NAGSA dehydrogenase activity broad
N-acetyl-glutamate semialdehyde dehydrogenase activity related

Ancestor Chart

Ancestor chart for GO:0003942
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Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 5270 BI1_MYCMD GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.2.1.38
InterPro IPR000706 N-acetyl-gamma-glutamyl-phosphate reductase, type 1
InterPro IPR010136 N-acetyl-gamma-glutamyl-phosphate reductase, type 2
InterPro IPR011241 Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase
InterPro IPR023013 N-acetyl-gamma-glutamyl-phosphate reductase, active site
MetaCyc N-ACETYLGLUTPREDUCT-RXN
RHEA 21588

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:43474 hydrogenphosphate
has_participant CHEBI CHEBI:57936 N-acetyl-L-gamma-glutamyl phosphate(3-)
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:29123 2-acetamido-5-oxopentanoate
has_participant CHEBI CHEBI:57783 NADPH(4-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0003942 based on ALL annotations
The top 100 of 163 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acetyl-gamma-glutamyl-phosphate reductase activity
4,792.49 100.00 41,347 41,347
NADP+ binding
2,276.96 42.86 33,654 70,834
L-arginine biosynthetic process
484.58 10.10 40,901 404,507
NAD binding
163.37 3.41 40,356 1,183,877
acetylglutamate kinase activity
219.03 2.32 1,859 40,675
N-acetyl-gamma-aminoadipyl-phosphate reductase activity
4,792.49 1.96 811 811
lysine biosynthetic process via aminoadipic acid
129.92 1.54 1,423 52,492
alpha-amino acid metabolic process
58.20 0.95 1,721 141,727
mitochondrial matrix
38.26 0.68 1,764 220,932
arginine biosynthetic process via ornithine
41.42 0.67 1,188 137,451
Totals 254346 115847915
No co-occurrence statistics for GO:0003942 based on MANUAL annotations
The top 10 of 10 co-occurring terms
Co-occurring Term PR S% #Together #Compared
N-acetyl-gamma-glutamyl-phosphate reductase activity
83,031.35 100.00 17 17
acetylglutamate kinase activity
10,460.64 12.50 16 127
positive regulation of siderophore biosynthetic process
41,515.68 5.56 1 2
L-arginine biosynthetic process
2,840.11 3.42 17 497
ornithine biosynthetic process
448.82 0.50 1 185
mitochondrial matrix
314.44 0.38 16 4,225
arginine biosynthetic process via ornithine
261.93 0.30 1 317
regulation of DNA-templated transcription
3.47 0.00 1 23,906
mitochondrion
3.39 0.00 2 48,955
cellular_component
1.33 0.00 1 62,590
Totals 73 140821

Change Log

Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM N-acetylglutamate 5-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetyl-glutamate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM reductase, acetyl-gamma-glutamyl phosphate
2020-10-08 Deleted SYNONYM N-acetylglutamic gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetylglutamate 5-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM N-acetylglutamic gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM N-acetyl-glutamate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
Timestamp Action Category Detail
2003-03-19 Updated TERM N-acetyl-gamma-glutamyl-phosphate reductase activity
2002-02-06 Updated TERM N-acetyl-gamma-glutamyl-phosphate reductase
2001-04-03 Updated TERM N-acetyl-gamma-glutamyl-phosphate reductase
2001-03-30 Added TERM N-acetyl-gamma-glutamyl-phosphate reductase
Timestamp Action Category Detail
2020-10-08 Deleted SYNONYM N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM N-acetylglutamate 5-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetyl-glutamate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM reductase, acetyl-gamma-glutamyl phosphate
2020-10-08 Deleted SYNONYM N-acetylglutamic gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetylglutamate 5-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM N-acetylglutamic gamma-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM N-acetyl-glutamate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
2020-10-08 Added SYNONYM reductase, acetyl-gamma-glutamyl phosphate
2020-10-08 Added SYNONYM N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2008-05-13 Added DEFINITION Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
2007-11-08 Added SYNONYM N-acetylglutamate 5-semialdehyde dehydrogenase activity
2007-11-08 Added SYNONYM N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)
2007-11-08 Added SYNONYM N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)
2007-11-08 Added SYNONYM NAGSA dehydrogenase activity
2007-11-08 Added SYNONYM reductase, acetyl-gamma-glutamyl phosphate
2007-11-08 Deleted SYNONYM NAGSA dehydrogenase activity
2007-11-08 Added SYNONYM N-acetylglutamic gamma-semialdehyde dehydrogenase activity
2007-09-06 Added SYNONYM NAGSA dehydrogenase activity
2007-09-06 Added SYNONYM N-acetyl-glutamate semialdehyde dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2018-07-13 Added XREF RHEA:21588
2018-07-13 Deleted XREF RHEA:21591
2011-09-16 Added XREF RHEA:21591
2003-10-27 Added XREF MetaCyc:N-ACETYLGLUTPREDUCT-RXN
2001-03-30 Added XREF EC:1.2.1.38
Timestamp Action Category Detail
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