GO:0003995
JSON
acyl-CoA dehydrogenase activity
Molecular Function
Definition (GO:0003995 GONUTS page)
Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein].
Secondary IDs
GO:0019109
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
fatty-acyl-CoA dehydrogenase activity | related |
acyl-CoA reductase activity | exact |
acyl coenzyme A dehydrogenase activity | exact |
general acyl CoA dehydrogenase activity | related |
fatty acyl coenzyme A dehydrogenase activity | related |
acyl CoA dehydrogenase activity | exact |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0003995
Child Term | Relationship to GO:0003995 |
---|---|
medium-chain fatty acyl-CoA dehydrogenase activity
|
is_a |
glutaryl-CoA dehydrogenase activity
|
is_a |
long-chain fatty acyl-CoA dehydrogenase activity
|
is_a |
short-chain fatty acyl-CoA dehydrogenase activity
|
is_a |
very-long-chain fatty acyl-CoA dehydrogenase activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
InterPro | IPR006089 | Acyl-CoA dehydrogenase, conserved site |
InterPro | IPR008670 | Long-chain-fatty-acyl-CoA reductase, LuxC |
InterPro | IPR015396 | Acyl-CoA dehydrogenase, C-terminal, bacterial-type |
InterPro | IPR034178 | Isobutyryl-CoA dehydrogenase |
InterPro | IPR034183 | Isovaleryl-CoA dehydrogenase |
InterPro | IPR045008 | Acyl-coenzyme A oxidase 4-like |
InterPro | IPR047634 | Acyl-CoA dehydrogenase FadE |
MetaCyc | ACYLCOADEHYDROG-RXN | |
RHEA | 44704 | |
Reactome | R-HSA-109341 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58307 | FADH2(2-) |
has_participant | CHEBI | CHEBI:57692 | FAD(3-) |
has_participant | CHEBI | CHEBI:65111 | 3-substituted propionyl-CoA(4-) |
has_participant | CHEBI | CHEBI:58856 | 2,3-trans-enoyl CoA(4-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Replaces
This term can be used instead of these obsolete terms:
GO Identifier | GO Term Name | Reason |
---|---|---|
GO:0102393 | obsolete decanoyl-[acp] 2-dehydrogenase activity | replaced_by GO:0003995 |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0003995 based on ALL annotations
The top 100 of 795 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acyl-CoA dehydrogenase activity
|
547.64 | 100.00 | 355,959 | 355,959 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase
|
340.08 | 25.18 | 105,902 | 170,536 |
oxidoreductase activity, acting on the CH-CH group of donors
|
208.97 | 24.93 | 148,857 | 390,105 |
flavin adenine dinucleotide binding
|
104.34 | 18.61 | 316,349 | 1,660,475 |
fatty-acyl-CoA binding
|
172.79 | 4.38 | 17,222 | 54,583 |
glutaryl-CoA dehydrogenase activity
|
363.84 | 4.34 | 15,779 | 23,750 |
fatty-acyl-CoA biosynthetic process
|
328.55 | 4.25 | 15,572 | 25,956 |
short-chain fatty acyl-CoA dehydrogenase activity
|
516.07 | 4.10 | 14,644 | 15,540 |
L-leucine catabolic process
|
94.42 | 3.43 | 14,623 | 84,816 |
cellular catabolic process
|
547.08 | 2.98 | 10,603 | 10,614 |
Totals | 1514973 | 162833476 |
No co-occurrence statistics for GO:0003995 based on MANUAL annotations
The top 95 of 95 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
acyl-CoA dehydrogenase activity
|
2,725.31 | 100.00 | 474 | 474 |
fatty acid beta-oxidation using acyl-CoA dehydrogenase
|
1,164.89 | 32.17 | 268 | 627 |
short-chain fatty acyl-CoA dehydrogenase activity
|
748.13 | 2.74 | 14 | 51 |
medium-chain fatty acyl-CoA dehydrogenase activity
|
495.51 | 1.93 | 10 | 55 |
very-long-chain fatty acyl-CoA dehydrogenase activity
|
465.30 | 1.38 | 7 | 41 |
butyrate catabolic process
|
465.30 | 1.38 | 7 | 41 |
long-chain fatty acyl-CoA dehydrogenase activity
|
545.06 | 1.20 | 6 | 30 |
medium-chain fatty acid metabolic process
|
851.66 | 1.03 | 5 | 16 |
short-chain 2-methyl fatty acyl-CoA dehydrogenase activity
|
1,557.32 | 0.84 | 4 | 7 |
medium-chain fatty acid catabolic process
|
87.35 | 0.80 | 5 | 156 |
Totals | 1421 | 965360 |
Change Log
- All changes
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- Term
- Term
- Definition / Synonyms
- Definition / Synonyms
- Relationships
- Relationships
- Cross-references
- Cross-references
- Other
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-07 | Deleted | XREF | MetaCyc:RXN-13624 |
2023-12-15 | Added | XREF | MetaCyc:RXN-13624 |
2023-08-08 | Deleted | XREF | EC:1.3.-.- |
2023-08-08 | Deleted | XREF | MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN |
2023-08-08 | Added | XREF | RHEA:44704 |
2023-08-08 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+. |
2023-08-08 | Added | DEFINITION | Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. |
2022-06-20 | Deleted | SYNONYM | long-chain acyl coenzyme A dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl CoA dehydrogenase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-03-19 | Updated | TERM | acyl-CoA dehydrogenase activity |
2002-02-06 | Updated | TERM | acyl-CoA dehydrogenase |
2001-04-03 | Updated | TERM | acyl-CoA dehydrogenase |
2001-03-30 | Added | TERM | acyl-CoA dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2023-08-08 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+. |
2023-08-08 | Added | DEFINITION | Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. |
2022-06-20 | Deleted | SYNONYM | long-chain acyl coenzyme A dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl CoA dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl-CoA:acceptor 2,3-oxidoreductase activity |
2022-06-20 | Deleted | SYNONYM | long-chain acyl-CoA dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | medium-chain acyl-CoA dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | acyl-CoA:(acceptor) 2,3-oxidoreductase activity |
2022-06-20 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
2022-06-20 | Deleted | SYNONYM | acyl coenzyme A dehydrogenase activity |
2022-06-20 | Added | SYNONYM | acyl coenzyme A dehydrogenase activity |
2022-06-20 | Added | SYNONYM | acyl CoA dehydrogenase activity |
2022-06-20 | Deleted | SYNONYM | medium-chain acyl-coenzyme A dehydrogenase activity |
2022-06-20 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + oxidized [electron-transfer flavoprotein]= 2,3-dehydroacyl-CoA + reduced [electron-transfer flavoprotein] + H+. |
2020-10-08 | Deleted | SYNONYM | acyl dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | medium-chain acyl-coenzyme A dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | long-chain acyl-CoA dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | long-chain acyl coenzyme A dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | general acyl CoA dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | fatty-acyl-CoA dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | fatty acyl coenzyme A dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:acceptor 2,3-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | acyl-CoA:(acceptor) 2,3-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | acyl coenzyme A dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | acyl CoA dehydrogenase activity |
2020-10-08 | Added | SYNONYM | general acyl CoA dehydrogenase activity |
2020-10-08 | Added | SYNONYM | acyl-CoA:(acceptor) 2,3-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | medium-chain acyl-coenzyme A dehydrogenase activity |
2020-10-08 | Added | SYNONYM | long-chain acyl-CoA dehydrogenase activity |
2020-10-08 | Added | SYNONYM | acyl-CoA:acceptor 2,3-oxidoreductase activity |
2020-10-08 | Added | SYNONYM | acyl CoA dehydrogenase activity |
2020-10-08 | Added | SYNONYM | acyl dehydrogenase activity |
2020-10-08 | Added | SYNONYM | fatty acyl coenzyme A dehydrogenase activity |
2020-10-08 | Added | SYNONYM | fatty-acyl-CoA dehydrogenase activity |
2020-10-08 | Added | SYNONYM | acyl coenzyme A dehydrogenase activity |
2020-10-08 | Added | SYNONYM | long-chain acyl coenzyme A dehydrogenase activity |
2009-11-11 | Added | SYNONYM | acyl-CoA reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
2007-11-08 | Added | SYNONYM | acyl coenzyme A dehydrogenase activity |
2007-11-08 | Added | SYNONYM | long-chain acyl-CoA dehydrogenase activity |
2007-11-08 | Added | SYNONYM | long-chain acyl coenzyme A dehydrogenase activity |
2007-11-08 | Added | SYNONYM | acyl CoA dehydrogenase activity |
2007-11-08 | Added | SYNONYM | medium-chain acyl-coenzyme A dehydrogenase activity |
2007-11-08 | Added | SYNONYM | acyl-CoA:(acceptor) 2,3-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | acyl-CoA:acceptor 2,3-oxidoreductase activity |
2007-11-08 | Added | SYNONYM | fatty acyl coenzyme A dehydrogenase activity |
2007-11-08 | Added | SYNONYM | fatty-acyl-CoA dehydrogenase activity |
2007-11-08 | Added | SYNONYM | general acyl CoA dehydrogenase activity |
2007-09-06 | Added | SYNONYM | acyl dehydrogenase activity |
2007-09-06 | Added | SYNONYM | medium-chain acyl-CoA dehydrogenase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2022-06-20 | Deleted | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
2022-06-20 | Added | RELATION | is a GO:0052890 (oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor) |
2014-04-03 | Added | RELATION | has part GO:0033539 (fatty acid beta-oxidation using acyl-CoA dehydrogenase) |
2008-04-01 | Updated | RELATION | is a GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-08-07 | Deleted | XREF | MetaCyc:RXN-13624 |
2023-12-15 | Added | XREF | MetaCyc:RXN-13624 |
2023-08-08 | Deleted | XREF | EC:1.3.-.- |
2023-08-08 | Deleted | XREF | MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN |
2023-08-08 | Added | XREF | RHEA:44704 |
2022-06-20 | Deleted | XREF | EC:1.3.99.3 |
2022-06-20 | Added | XREF | EC:1.3.-.- |
2019-04-01 | Deleted | XREF | reactome:R-HSA-109341 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5695989 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77274 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77327 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70800 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5695989 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77299 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77327 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77263 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77345 |
2019-04-01 | Added | XREF | Reactome:R-HSA-109341 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5695980 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70800 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77319 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70859 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77274 |
2019-04-01 | Added | XREF | Reactome:R-HSA-77338 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77263 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70859 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77319 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5695980 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77299 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77345 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-77338 |
2018-12-11 | Added | XREF | reactome:R-HSA-70800 |
2018-12-11 | Added | XREF | reactome:R-HSA-70859 |
2018-12-11 | Added | XREF | reactome:R-HSA-77319 |
2018-12-11 | Added | XREF | reactome:R-HSA-5695980 |
2018-12-11 | Added | XREF | reactome:R-HSA-77299 |
2018-12-11 | Added | XREF | reactome:R-HSA-5695989 |
2018-12-11 | Added | XREF | reactome:R-HSA-77327 |
2018-12-11 | Added | XREF | reactome:R-HSA-77274 |
2018-12-11 | Added | XREF | reactome:R-HSA-77263 |
2018-12-11 | Added | XREF | reactome:R-HSA-77338 |
2018-12-11 | Added | XREF | reactome:R-HSA-77345 |
2018-12-11 | Added | XREF | reactome:R-HSA-109341 |
2011-05-03 | Deleted | XREF | EC:1.3.99.- |
2009-11-11 | Added | XREF | EC:1.3.99.- |
2009-11-11 | Added | XREF | MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN |
2003-10-27 | Added | XREF | MetaCyc:ACYLCOADEHYDROG-RXN |
2001-03-30 | Added | XREF | EC:1.3.99.3 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2009-11-11 | Added | SECONDARY | GO:0019109 (acyl-CoA reductase activity) |
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