This term is obsolete.

GO:0004032 JSON

aldose reductase (NADPH) activity

Molecular Function

Definition (GO:0004032 GONUTS page)

Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.

2,617 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
aldehyde reductase activity related
alditol:NADP+ 1-oxidoreductase activity exact
aldose reductase activity related
polyol dehydrogenase (NADP(+)) activity related

Ancestor Chart

Ancestor chart for GO:0004032
Chart options
Ancestor chart

Child Terms

This table lists all terms that are direct descendants (child terms) of GO:0004032

Child Term Relationship to
GO:0004032
D-xylose reductase (NADPH) activity
is_a
L-arabinose reductase (NADPH) activity
is_a

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0A1S4KZV0 6945 A0A1S4KZV0_IXOSC GO:0016616 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033

Cross-references

Database ID Description
EC 1.1.1.21
InterPro IPR044489 Aldo-keto reductase family 3A
KEGG_REACTION R02820
MetaCyc ALDEHYDE-REDUCTASE-RXN
RHEA 12789
Reactome R-HSA-196060
Reactome R-HSA-5652172

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:17522 alditol
has_participant CHEBI CHEBI:15693 aldose
has_participant CHEBI CHEBI:57783 NADPH(4-)
has_participant CHEBI CHEBI:58349 NADP(3-)
has_participant CHEBI CHEBI:15378 hydron

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004032 based on ALL annotations
The top 100 of 285 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aldose reductase (NADPH) activity
114,400.70 100.00 1,704 1,704
daunorubicin metabolic process
65,459.22 11.48 214 374
doxorubicin metabolic process
55,870.11 10.91 210 430
L-glucuronate reductase activity
57,200.35 7.04 129 258
ketosteroid monooxygenase activity
112,065.98 5.63 96 98
D-xylose catabolic process
14,021.01 5.55 157 1,281
glucuronolactone reductase activity
42,430.31 4.30 79 213
D-glucuronate catabolic process to D-xylulose 5-phosphate
27,980.36 4.06 79 323
glyceraldehyde oxidoreductase activity
67,414.70 3.77 66 112
retinoid metabolic process
6,749.16 3.57 141 2,390
Totals 5980 266632
No co-occurrence statistics for GO:0004032 based on MANUAL annotations
The top 100 of 227 co-occurring terms
Co-occurring Term PR S% #Together #Compared
aldose reductase (NADPH) activity
1,176.50 100.00 1,098 1,098
ketosteroid monooxygenase activity
1,147.45 7.18 79 81
daunorubicin metabolic process
1,136.62 5.18 57 59
doxorubicin metabolic process
944.77 4.77 53 66
androsterone dehydrogenase activity
796.99 3.76 42 62
progesterone metabolic process
377.20 3.54 42 131
steroid dehydrogenase activity
559.56 3.42 39 82
bile acid binding
588.25 3.35 38 76
prostaglandin metabolic process
214.94 3.00 38 208
steroid metabolic process
68.26 2.06 34 586
Totals 3197 107681

Change Log

Timestamp Action Category Detail
2024-03-21 Updated TERM aldose reductase (NADPH) activity
2024-03-21 Added SYNONYM alditol:NADP+ 1-oxidoreductase activity
2020-10-08 Deleted SYNONYM aldose reductase activity
2020-10-08 Added SYNONYM aldose reductase activity
2020-10-08 Deleted SYNONYM aldehyde reductase activity
2020-10-08 Added SYNONYM aldehyde reductase activity
2020-06-22 Added XREF RHEA:12789
2019-06-20 Added XREF KEGG_REACTION:R02820
2019-06-20 Deleted XREF KEGG:R02820
2019-04-01 Deleted XREF reactome:R-HSA-196060
Timestamp Action Category Detail
2024-03-21 Updated TERM aldose reductase (NADPH) activity
2011-04-14 Updated TERM alditol:NADP+ 1-oxidoreductase activity
2003-03-19 Updated TERM aldehyde reductase activity
2002-02-06 Updated TERM aldehyde reductase
2001-04-03 Updated TERM aldehyde reductase
2001-03-30 Added TERM aldehyde reductase
Timestamp Action Category Detail
2024-03-21 Added SYNONYM alditol:NADP+ 1-oxidoreductase activity
2020-10-08 Deleted SYNONYM aldose reductase activity
2020-10-08 Added SYNONYM aldose reductase activity
2020-10-08 Deleted SYNONYM aldehyde reductase activity
2020-10-08 Added SYNONYM aldehyde reductase activity
2014-09-03 Added SYNONYM aldehyde reductase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
2007-09-06 Deleted SYNONYM aldose reductase
2007-09-06 Added SYNONYM polyol dehydrogenase (NADP(+)) activity
2007-09-06 Added SYNONYM aldose reductase activity
2007-08-09 Added SYNONYM aldose reductase
2007-08-09 Deleted SYNONYM aldose reductase
2006-03-03 Updated DEFINITION Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
2004-04-19 Added SYNONYM aldose reductase
2004-04-16 Deleted SYNONYM aldose reductase
2003-10-27 Added SYNONYM aldose reductase
2003-08-21 Deleted SYNONYM aldose reductase
2002-11-27 Added DEFINITION Catalysis of the reaction: alditol + NADP+ = aldose + NADPH + H+.
2001-03-30 Added SYNONYM aldose reductase
Timestamp Action Category Detail
2011-04-18 Deleted RELATION is a GO:0004033 (aldo-keto reductase (NADPH) activity)
2011-04-18 Added RELATION is a GO:0008106 (alcohol dehydrogenase (NADP+) activity)
2008-04-01 Updated RELATION is a GO:0004033 (aldo-keto reductase (NADPH) activity)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:12789
2019-06-20 Added XREF KEGG_REACTION:R02820
2019-06-20 Deleted XREF KEGG:R02820
2019-04-01 Deleted XREF reactome:R-HSA-196060
2019-04-01 Deleted XREF reactome:R-HSA-5652172
2019-04-01 Added XREF Reactome:R-HSA-5652172
2019-04-01 Added XREF Reactome:R-HSA-196060
2018-12-11 Added XREF reactome:R-HSA-196060
2018-12-11 Added XREF reactome:R-HSA-5652172
2012-08-24 Added XREF KEGG:R02820
2012-08-24 Deleted XREF KEGG::R02820
2011-04-14 Added XREF KEGG::R02820
2003-10-27 Added XREF MetaCyc:ALDEHYDE-REDUCTASE-RXN
2001-03-30 Added XREF EC:1.1.1.21
Timestamp Action Category Detail
Please Wait...

Not found :(

Sorry, but the Term you were trying to view does not exist.

Reported error:

It looks like this may have been caused by:

  • a mistyped URL
  • an out-of-date link
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.