GO:0004032
JSON
aldose reductase (NADPH) activity
Molecular Function
Definition (GO:0004032 GONUTS page)
Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
aldehyde reductase activity | related |
alditol:NADP+ 1-oxidoreductase activity | exact |
aldose reductase activity | related |
polyol dehydrogenase (NADP(+)) activity | related |
Ancestor Chart
Child Terms
This table lists all terms that are direct descendants (child terms) of GO:0004032
Child Term | Relationship to GO:0004032 |
---|---|
D-xylose reductase (NADPH) activity
|
is_a |
L-arabinose reductase (NADPH) activity
|
is_a |
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0A1S4KZV0 | 6945 | A0A1S4KZV0_IXOSC | GO:0016616 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.1.1.21 | |
InterPro | IPR044489 | Aldo-keto reductase family 3A |
KEGG_REACTION | R02820 | |
MetaCyc | ALDEHYDE-REDUCTASE-RXN | |
RHEA | 12789 | |
Reactome | R-HSA-196060 | |
Reactome | R-HSA-5652172 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:17522 | alditol |
has_participant | CHEBI | CHEBI:15693 | aldose |
has_participant | CHEBI | CHEBI:57783 | NADPH(4-) |
has_participant | CHEBI | CHEBI:58349 | NADP(3-) |
has_participant | CHEBI | CHEBI:15378 | hydron |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004032 based on ALL annotations
The top 100 of 285 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aldose reductase (NADPH) activity
|
114,400.70 | 100.00 | 1,704 | 1,704 |
daunorubicin metabolic process
|
65,459.22 | 11.48 | 214 | 374 |
doxorubicin metabolic process
|
55,870.11 | 10.91 | 210 | 430 |
L-glucuronate reductase activity
|
57,200.35 | 7.04 | 129 | 258 |
ketosteroid monooxygenase activity
|
112,065.98 | 5.63 | 96 | 98 |
D-xylose catabolic process
|
14,021.01 | 5.55 | 157 | 1,281 |
glucuronolactone reductase activity
|
42,430.31 | 4.30 | 79 | 213 |
D-glucuronate catabolic process to D-xylulose 5-phosphate
|
27,980.36 | 4.06 | 79 | 323 |
glyceraldehyde oxidoreductase activity
|
67,414.70 | 3.77 | 66 | 112 |
retinoid metabolic process
|
6,749.16 | 3.57 | 141 | 2,390 |
Totals | 5980 | 266632 |
No co-occurrence statistics for GO:0004032 based on MANUAL annotations
The top 100 of 227 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
aldose reductase (NADPH) activity
|
1,176.50 | 100.00 | 1,098 | 1,098 |
ketosteroid monooxygenase activity
|
1,147.45 | 7.18 | 79 | 81 |
daunorubicin metabolic process
|
1,136.62 | 5.18 | 57 | 59 |
doxorubicin metabolic process
|
944.77 | 4.77 | 53 | 66 |
androsterone dehydrogenase activity
|
796.99 | 3.76 | 42 | 62 |
progesterone metabolic process
|
377.20 | 3.54 | 42 | 131 |
steroid dehydrogenase activity
|
559.56 | 3.42 | 39 | 82 |
bile acid binding
|
588.25 | 3.35 | 38 | 76 |
prostaglandin metabolic process
|
214.94 | 3.00 | 38 | 208 |
steroid metabolic process
|
68.26 | 2.06 | 34 | 586 |
Totals | 3197 | 107681 |
Change Log
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- Definition / Synonyms
- Definition / Synonyms
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- Cross-references
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Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Updated | TERM | aldose reductase (NADPH) activity |
2024-03-21 | Added | SYNONYM | alditol:NADP+ 1-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | aldose reductase activity |
2020-10-08 | Added | SYNONYM | aldose reductase activity |
2020-10-08 | Deleted | SYNONYM | aldehyde reductase activity |
2020-10-08 | Added | SYNONYM | aldehyde reductase activity |
2020-06-22 | Added | XREF | RHEA:12789 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02820 |
2019-06-20 | Deleted | XREF | KEGG:R02820 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-196060 |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Updated | TERM | aldose reductase (NADPH) activity |
2011-04-14 | Updated | TERM | alditol:NADP+ 1-oxidoreductase activity |
2003-03-19 | Updated | TERM | aldehyde reductase activity |
2002-02-06 | Updated | TERM | aldehyde reductase |
2001-04-03 | Updated | TERM | aldehyde reductase |
2001-03-30 | Added | TERM | aldehyde reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2024-03-21 | Added | SYNONYM | alditol:NADP+ 1-oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | aldose reductase activity |
2020-10-08 | Added | SYNONYM | aldose reductase activity |
2020-10-08 | Deleted | SYNONYM | aldehyde reductase activity |
2020-10-08 | Added | SYNONYM | aldehyde reductase activity |
2014-09-03 | Added | SYNONYM | aldehyde reductase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
2007-09-06 | Deleted | SYNONYM | aldose reductase |
2007-09-06 | Added | SYNONYM | polyol dehydrogenase (NADP(+)) activity |
2007-09-06 | Added | SYNONYM | aldose reductase activity |
2007-08-09 | Added | SYNONYM | aldose reductase |
2007-08-09 | Deleted | SYNONYM | aldose reductase |
2006-03-03 | Updated | DEFINITION | Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+. |
2004-04-19 | Added | SYNONYM | aldose reductase |
2004-04-16 | Deleted | SYNONYM | aldose reductase |
2003-10-27 | Added | SYNONYM | aldose reductase |
2003-08-21 | Deleted | SYNONYM | aldose reductase |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: alditol + NADP+ = aldose + NADPH + H+. |
2001-03-30 | Added | SYNONYM | aldose reductase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2011-04-18 | Deleted | RELATION | is a GO:0004033 (aldo-keto reductase (NADPH) activity) |
2011-04-18 | Added | RELATION | is a GO:0008106 (alcohol dehydrogenase (NADP+) activity) |
2008-04-01 | Updated | RELATION | is a GO:0004033 (aldo-keto reductase (NADPH) activity) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:12789 |
2019-06-20 | Added | XREF | KEGG_REACTION:R02820 |
2019-06-20 | Deleted | XREF | KEGG:R02820 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-196060 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-5652172 |
2019-04-01 | Added | XREF | Reactome:R-HSA-5652172 |
2019-04-01 | Added | XREF | Reactome:R-HSA-196060 |
2018-12-11 | Added | XREF | reactome:R-HSA-196060 |
2018-12-11 | Added | XREF | reactome:R-HSA-5652172 |
2012-08-24 | Added | XREF | KEGG:R02820 |
2012-08-24 | Deleted | XREF | KEGG::R02820 |
2011-04-14 | Added | XREF | KEGG::R02820 |
2003-10-27 | Added | XREF | MetaCyc:ALDEHYDE-REDUCTASE-RXN |
2001-03-30 | Added | XREF | EC:1.1.1.21 |
Timestamp | Action | Category | Detail |
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