This term is obsolete.

GO:0004043 JSON

L-aminoadipate-semialdehyde dehydrogenase activity

Molecular Function

Definition (GO:0004043 GONUTS page)

Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.

1,722 annotations

Synonyms

Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.

Synonym Type
alpha-aminoadipate reductase activity related
alpha-aminoadipate-semialdehyde dehydrogenase activity related
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity related
L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase related
L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity related
2-aminoadipic semialdehyde dehydrogenase activity related
aminoadipate-semialdehyde dehydrogenase activity related
AAR related
aminoadipate semialdehyde dehydrogenase activity related
L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity related

Ancestor Chart

Ancestor chart for GO:0004043
Chart options
Ancestor chart

Annotation Guidance

Usage of this term is subject to the following annotation guidelines:

Annotating to catalytic activities using the IPI evidence code Link
Describing enzyme functions that catalyse multi-stage reactions Link

Annotation Blacklist

This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:

Category Entity Type Entity ID Taxon ID Entity Name Ancestor GO ID Reason Rule/Method ID
IEA Review protein O63264 4957 ZBI1_ZYGBI GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03879 559292 MBI4_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03880 162425 ANI1_EMEND GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein P03882 559292 SCE1_YEAST GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q0H8X2 237631 BI1_USTMA GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
IEA Review protein Q35127 367110 MBI1_NEUCR GO:0016491 Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012.
NOT-qualified manual protein A0A1D8PT92 237561 A0A1D8PT92_CANAL GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein A0MTA1 7955 APEX1_DANRE GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163
NOT-qualified manual protein A7EKP7 665079 A7EKP7_SCLS1 GO:0016491 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033
NOT-qualified manual protein P02521 9031 ARLY1_CHICK GO:0003824 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884

Cross-references

Database ID Description
EC 1.2.1.31
InterPro IPR014397 L-2-aminoadipate reductase
MetaCyc 1.2.1.31-RXN
RHEA 12308
Reactome R-HSA-70941

Cross-Ontology Relations

Relation Other Ontology ID Term
has_participant CHEBI CHEBI:58321 L-allysine zwitterion
has_participant CHEBI CHEBI:58672 L-2-aminoadipate(1-)
has_participant CHEBI CHEBI:57540 NAD(1-)
has_participant CHEBI CHEBI:15377 water
has_participant CHEBI CHEBI:15378 hydron
has_participant CHEBI CHEBI:57945 NADH(2-)

Co-occurring Terms

These tables show the number of times the term listed in the table has been co-annotated.

No co-occurrence statistics for GO:0004043 based on ALL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-aminoadipate-semialdehyde dehydrogenase activity
113,932.66 100.00 1,711 1,711
lysine biosynthetic process via aminoadipic acid
2,737.01 2.38 1,224 50,951
lysine biosynthetic process
575.07 0.50 1,655 327,889
phosphopantetheine binding
545.59 0.48 1,024 213,836
small molecule metabolic process
344.14 0.30 1,005 332,722
phenylalanine racemase (ATP-hydrolyzing) activity
1,176.99 0.23 5 484
ornithine racemase activity
2,293.95 0.16 3 149
biosynthetic process
118.47 0.10 1,585 1,524,289
indole alkaloid biosynthetic process
289.54 0.08 2 787
betaine-aldehyde dehydrogenase (NAD+) activity
50.80 0.04 5 11,214
Totals 10266 294655388
No co-occurrence statistics for GO:0004043 based on MANUAL annotations
The top 6 of 6 co-occurring terms
Co-occurring Term PR S% #Together #Compared
L-aminoadipate-semialdehyde dehydrogenase activity
322,949.75 100.00 4 4
lysine biosynthetic process
25,496.03 7.69 3 38
lysine biosynthetic process via aminoadipic acid
2,900.75 0.90 3 334
cell redox homeostasis
137.13 0.04 1 2,355
cytosol
3.83 0.00 1 84,217
cytoplasm
1.80 0.00 1 179,389
Totals 13 266337

Change Log

Timestamp Action Category Detail
2020-10-08 Added SYNONYM alpha-aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM 2-aminoadipate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
2020-10-08 Added SYNONYM 2-aminoadipic semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
2020-10-08 Added SYNONYM AAR
2020-10-08 Deleted SYNONYM aminoadipate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-aminoadipate reductase activity
2020-10-08 Deleted SYNONYM L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
Timestamp Action Category Detail
2003-09-09 Updated TERM L-aminoadipate-semialdehyde dehydrogenase activity
2003-03-19 Updated TERM aminoadipate-semialdehyde dehydrogenase activity
2002-02-06 Updated TERM aminoadipate-semialdehyde dehydrogenase
2001-04-03 Updated TERM aminoadipate-semialdehyde dehydrogenase
2001-03-30 Added TERM aminoadipate-semialdehyde dehydrogenase
Timestamp Action Category Detail
2020-10-08 Added SYNONYM alpha-aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM 2-aminoadipate semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
2020-10-08 Added SYNONYM 2-aminoadipic semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
2020-10-08 Added SYNONYM AAR
2020-10-08 Deleted SYNONYM aminoadipate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM alpha-aminoadipate reductase activity
2020-10-08 Deleted SYNONYM L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
2020-10-08 Deleted SYNONYM L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
2020-10-08 Deleted SYNONYM L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
2020-10-08 Deleted SYNONYM 2-aminoadipic semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM 2-aminoadipate semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Deleted SYNONYM AAR
2020-10-08 Deleted SYNONYM L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
2020-10-08 Added SYNONYM alpha-aminoadipate reductase activity
2020-10-08 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
2020-10-08 Added SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2020-10-08 Added SYNONYM L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
2020-10-08 Added SYNONYM aminoadipate semialdehyde dehydrogenase activity
2008-05-13 Added DEFINITION Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
2008-05-12 Deleted DEFINITION Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
2007-12-06 Added SYNONYM L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase
2007-09-06 Added SYNONYM 2-aminoadipic semialdehyde dehydrogenase activity
2007-09-06 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity
2007-09-06 Added SYNONYM 2-aminoadipate semialdehyde dehydrogenase activity
2007-09-06 Deleted SYNONYM alpha-aminoadipate reductase
2007-09-06 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity
2007-09-06 Added SYNONYM alpha-aminoadipate-semialdehyde dehydrogenase activity
2007-09-06 Added SYNONYM alpha-aminoadipate reductase activity
2007-09-06 Added SYNONYM L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity
2007-09-06 Added SYNONYM aminoadipate semialdehyde dehydrogenase activity
2007-08-09 Deleted SYNONYM AAR
2007-08-09 Deleted SYNONYM alpha-aminoadipate reductase
2007-08-09 Deleted SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2007-08-09 Added SYNONYM AAR
2007-08-09 Added SYNONYM alpha-aminoadipate reductase
2007-08-09 Added SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2004-12-09 Added SYNONYM alpha-aminoadipate reductase
2004-12-09 Added SYNONYM AAR
2004-04-19 Added SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2004-04-16 Deleted SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2003-10-27 Added SYNONYM aminoadipate-semialdehyde dehydrogenase activity
2002-11-27 Added DEFINITION Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
Timestamp Action Category Detail
2008-04-01 Updated RELATION is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)
Timestamp Action Category Detail
2020-06-22 Added XREF RHEA:12308
2019-04-01 Added XREF Reactome:R-HSA-70941
2019-04-01 Deleted XREF reactome:R-HSA-70941
2018-12-11 Added XREF reactome:R-HSA-70941
2003-10-27 Added XREF MetaCyc:1.2.1.31-RXN
2001-03-30 Added XREF EC:1.2.1.31
Timestamp Action Category Detail
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