GO:0004043
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L-aminoadipate-semialdehyde dehydrogenase activity
Molecular Function
Definition (GO:0004043 GONUTS page)
Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+.
Synonyms
Synonyms are alternative words or phrases closely related in meaning to the term name, with indication of the relationship between the name and synonym given by the synonym scope.
Synonym | Type |
---|---|
alpha-aminoadipate reductase activity | related |
alpha-aminoadipate-semialdehyde dehydrogenase activity | related |
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity | related |
L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase | related |
L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity | related |
2-aminoadipic semialdehyde dehydrogenase activity | related |
aminoadipate-semialdehyde dehydrogenase activity | related |
AAR | related |
aminoadipate semialdehyde dehydrogenase activity | related |
L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity | related |
Ancestor Chart
Annotation Guidance
Usage of this term is subject to the following annotation guidelines:
Annotating to catalytic activities using the IPI evidence code | Link |
Describing enzyme functions that catalyse multi-stage reactions | Link |
Annotation Blacklist
This list aims to correct incorrect annotations to UniProtKB accessions inferred from electronic annotation (IEA) methods that are supplied by the UniProt-GOA project to the GO Consortium:
Category | Entity Type | Entity ID | Taxon ID | Entity Name | Ancestor GO ID | Reason | Rule/Method ID |
---|---|---|---|---|---|---|---|
IEA Review | protein | O63264 | 4957 | ZBI1_ZYGBI | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03879 | 559292 | MBI4_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03880 | 162425 | ANI1_EMEND | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | P03882 | 559292 | SCE1_YEAST | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q0H8X2 | 237631 | BI1_USTMA | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
IEA Review | protein | Q35127 | 367110 | MBI1_NEUCR | GO:0016491 | Proteins appear to be intron-encoded endonucleases that hit InterPro cytochrome b/b6 (IPR016175) and Di-haem cytochrome (IPR016174) entries. Communicated by InterPro 29-05-2012. | |
NOT-qualified manual | protein | A0A1D8PT92 | 237561 | A0A1D8PT92_CANAL | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | A0MTA1 | 7955 | APEX1_DANRE | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000314 from this reference: PMID:18579163 | |
NOT-qualified manual | protein | A7EKP7 | 665079 | A7EKP7_SCLS1 | GO:0016491 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000318 from this reference: GO_REF:0000033 | |
NOT-qualified manual | protein | P02521 | 9031 | ARLY1_CHICK | GO:0003824 | 1 NOT-qualified manual annotation exists with evidence code ECO:0000304 from this reference: PMID:11258884 |
Cross-references
Database | ID | Description |
---|---|---|
EC | 1.2.1.31 | |
InterPro | IPR014397 | L-2-aminoadipate reductase |
MetaCyc | 1.2.1.31-RXN | |
RHEA | 12308 | |
Reactome | R-HSA-70941 |
Cross-Ontology Relations
Relation | Other Ontology | ID | Term |
---|---|---|---|
has_participant | CHEBI | CHEBI:58321 | L-allysine zwitterion |
has_participant | CHEBI | CHEBI:58672 | L-2-aminoadipate(1-) |
has_participant | CHEBI | CHEBI:57540 | NAD(1-) |
has_participant | CHEBI | CHEBI:15377 | water |
has_participant | CHEBI | CHEBI:15378 | hydron |
has_participant | CHEBI | CHEBI:57945 | NADH(2-) |
Co-occurring Terms
These tables show the number of times the term listed in the table has been co-annotated.
No co-occurrence statistics for GO:0004043 based on ALL annotations
The top 89 of 89 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-aminoadipate-semialdehyde dehydrogenase activity
|
113,932.66 | 100.00 | 1,711 | 1,711 |
lysine biosynthetic process via aminoadipic acid
|
2,737.01 | 2.38 | 1,224 | 50,951 |
lysine biosynthetic process
|
575.07 | 0.50 | 1,655 | 327,889 |
phosphopantetheine binding
|
545.59 | 0.48 | 1,024 | 213,836 |
small molecule metabolic process
|
344.14 | 0.30 | 1,005 | 332,722 |
phenylalanine racemase (ATP-hydrolyzing) activity
|
1,176.99 | 0.23 | 5 | 484 |
ornithine racemase activity
|
2,293.95 | 0.16 | 3 | 149 |
biosynthetic process
|
118.47 | 0.10 | 1,585 | 1,524,289 |
indole alkaloid biosynthetic process
|
289.54 | 0.08 | 2 | 787 |
betaine-aldehyde dehydrogenase (NAD+) activity
|
50.80 | 0.04 | 5 | 11,214 |
Totals | 10266 | 294655388 |
No co-occurrence statistics for GO:0004043 based on MANUAL annotations
The top 6 of 6 co-occurring terms
Co-occurring Term | PR | S% | #Together | #Compared |
---|---|---|---|---|
L-aminoadipate-semialdehyde dehydrogenase activity
|
322,949.75 | 100.00 | 4 | 4 |
lysine biosynthetic process
|
25,496.03 | 7.69 | 3 | 38 |
lysine biosynthetic process via aminoadipic acid
|
2,900.75 | 0.90 | 3 | 334 |
cell redox homeostasis
|
137.13 | 0.04 | 1 | 2,355 |
cytosol
|
3.83 | 0.00 | 1 | 84,217 |
cytoplasm
|
1.80 | 0.00 | 1 | 179,389 |
Totals | 13 | 266337 |
Change Log
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Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | alpha-aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | 2-aminoadipate semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 2-aminoadipic semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity |
2020-10-08 | Added | SYNONYM | AAR |
2020-10-08 | Deleted | SYNONYM | aminoadipate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-aminoadipate reductase activity |
2020-10-08 | Deleted | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity |
Timestamp | Action | Category | Detail |
---|---|---|---|
2003-09-09 | Updated | TERM | L-aminoadipate-semialdehyde dehydrogenase activity |
2003-03-19 | Updated | TERM | aminoadipate-semialdehyde dehydrogenase activity |
2002-02-06 | Updated | TERM | aminoadipate-semialdehyde dehydrogenase |
2001-04-03 | Updated | TERM | aminoadipate-semialdehyde dehydrogenase |
2001-03-30 | Added | TERM | aminoadipate-semialdehyde dehydrogenase |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-10-08 | Added | SYNONYM | alpha-aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | 2-aminoadipate semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity |
2020-10-08 | Added | SYNONYM | 2-aminoadipic semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity |
2020-10-08 | Added | SYNONYM | AAR |
2020-10-08 | Deleted | SYNONYM | aminoadipate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | alpha-aminoadipate reductase activity |
2020-10-08 | Deleted | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity |
2020-10-08 | Deleted | SYNONYM | 2-aminoadipic semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | 2-aminoadipate semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Deleted | SYNONYM | AAR |
2020-10-08 | Deleted | SYNONYM | L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase |
2020-10-08 | Added | SYNONYM | alpha-aminoadipate reductase activity |
2020-10-08 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity |
2020-10-08 | Added | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2020-10-08 | Added | SYNONYM | L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase |
2020-10-08 | Added | SYNONYM | aminoadipate semialdehyde dehydrogenase activity |
2008-05-13 | Added | DEFINITION | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
2008-05-12 | Deleted | DEFINITION | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
2007-12-06 | Added | SYNONYM | L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase |
2007-09-06 | Added | SYNONYM | 2-aminoadipic semialdehyde dehydrogenase activity |
2007-09-06 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity |
2007-09-06 | Added | SYNONYM | 2-aminoadipate semialdehyde dehydrogenase activity |
2007-09-06 | Deleted | SYNONYM | alpha-aminoadipate reductase |
2007-09-06 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity |
2007-09-06 | Added | SYNONYM | alpha-aminoadipate-semialdehyde dehydrogenase activity |
2007-09-06 | Added | SYNONYM | alpha-aminoadipate reductase activity |
2007-09-06 | Added | SYNONYM | L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity |
2007-09-06 | Added | SYNONYM | aminoadipate semialdehyde dehydrogenase activity |
2007-08-09 | Deleted | SYNONYM | AAR |
2007-08-09 | Deleted | SYNONYM | alpha-aminoadipate reductase |
2007-08-09 | Deleted | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2007-08-09 | Added | SYNONYM | AAR |
2007-08-09 | Added | SYNONYM | alpha-aminoadipate reductase |
2007-08-09 | Added | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2004-12-09 | Added | SYNONYM | alpha-aminoadipate reductase |
2004-12-09 | Added | SYNONYM | AAR |
2004-04-19 | Added | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2004-04-16 | Deleted | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2003-10-27 | Added | SYNONYM | aminoadipate-semialdehyde dehydrogenase activity |
2002-11-27 | Added | DEFINITION | Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+. |
Timestamp | Action | Category | Detail |
---|---|---|---|
2008-04-01 | Updated | RELATION | is a GO:0016620 (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor) |
Timestamp | Action | Category | Detail |
---|---|---|---|
2020-06-22 | Added | XREF | RHEA:12308 |
2019-04-01 | Added | XREF | Reactome:R-HSA-70941 |
2019-04-01 | Deleted | XREF | reactome:R-HSA-70941 |
2018-12-11 | Added | XREF | reactome:R-HSA-70941 |
2003-10-27 | Added | XREF | MetaCyc:1.2.1.31-RXN |
2001-03-30 | Added | XREF | EC:1.2.1.31 |
Timestamp | Action | Category | Detail |
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